| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Cabozantinib (S-malate) perturbation in HOP62 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Cabozantinib (S-malate)_HOP62 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.317707 |
| SMAD3 | SMAD family member 3 | 0.0756382 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0729706 |
| PLEC | plectin | 0.0632978 |
| NAV2 | neuron navigator 2 | 0.0484247 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0476042 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0462663 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0369074 |
| SEPTIN9 | septin 9 | 0.0363431 |
| AXL | AXL receptor tyrosine kinase | 0.0336118 |
| OGA | O-GlcNAcase | 0.0330679 |
| VEGFA | vascular endothelial growth factor A | 0.0328276 |
| RNF145 | ring finger protein 145 | 0.0310878 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0305313 |
| RPS6 | ribosomal protein S6 | 0.0294249 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.027597 |
| ACTN4 | actinin, alpha 4 | 0.0263447 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0261509 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0258685 |
| TNS1 | tensin 1 | 0.0258202 |
| MLPH | melanophilin | 0.0247671 |
| RNF149 | ring finger protein 149 | 0.0233098 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.023288 |
| ZNF292 | zinc finger protein 292 | 0.0225346 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.0219971 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0214425 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0212823 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | 0.0207766 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0206739 |
| HELZ | helicase with zinc finger | 0.0205302 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.0203637 |
| NECTIN2 | nectin cell adhesion molecule 2 | 0.020333 |
| CEP250 | centrosomal protein 250kDa | 0.0199706 |
| ZNF148 | zinc finger protein 148 | 0.0198518 |
| IQGAP3 | IQ motif containing GTPase activating protein 3 | 0.0198059 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0192526 |
| PLEKHA2 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 | 0.0192208 |
| PRELID2 | PRELI domain containing 2 | 0.0190839 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0189469 |
| PCMTD1 | protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 | 0.0186615 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0185672 |
| CEP192 | centrosomal protein 192kDa | 0.0185568 |
| YEATS2 | YEATS domain containing 2 | 0.0185554 |
| B2M | beta-2-microglobulin | 0.0185184 |
| RPL23 | ribosomal protein L23 | 0.018493 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0184313 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.0180087 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0179626 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0179236 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0177684 |
| RNF220 | ring finger protein 220 | 0.017542 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0175011 |
| RNF24 | ring finger protein 24 | 0.0174017 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 0.0172817 |
| YTHDC1 | YTH domain containing 1 | 0.0172224 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | 0.0170959 |
| RPS12 | ribosomal protein S12 | 0.0166567 |
| TPM3 | tropomyosin 3 | 0.0163135 |
| FOXO3 | forkhead box O3 | 0.015944 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0158977 |
| DNMBP | dynamin binding protein | 0.0157788 |
| CD109 | CD109 molecule | 0.0157516 |
| NUP58 | nucleoporin 58 | 0.0157356 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | 0.0157159 |
| MIDEAS | mitotic deacetylase associated SANT domain protein | 0.0156396 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.0156019 |
| GRAMD1B | GRAM domain containing 1B | 0.0155423 |
| FLNB | filamin B, beta | 0.0155394 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0155015 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.01549 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0154752 |
| AGRN | agrin | 0.0152771 |
| TNRC6A | trinucleotide repeat containing 6A | 0.015219 |
| PRKCSH | protein kinase C substrate 80K-H | 0.0151904 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0151732 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0151712 |
| MED13L | mediator complex subunit 13-like | 0.0151187 |
| RPL11 | ribosomal protein L11 | 0.0150883 |
| ATXN1 | ataxin 1 | 0.0146587 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0145251 |
| MIS18BP1 | MIS18 binding protein 1 | 0.0144772 |
| TGFB2 | transforming growth factor, beta 2 | 0.0144698 |
| PDGFRB | platelet-derived growth factor receptor, beta polypeptide | 0.0144409 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0144076 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0142127 |
| SETD5 | SET domain containing 5 | 0.0141054 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0140841 |
| CDK19 | cyclin-dependent kinase 19 | 0.0140816 |
| COL6A2 | collagen, type VI, alpha 2 | 0.014038 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0139584 |
| RBM33 | RNA binding motif protein 33 | 0.0139371 |
| AKAP10 | A kinase (PRKA) anchor protein 10 | 0.0137665 |
| GOLGA4 | golgin A4 | 0.0136757 |
| SPRED1 | sprouty-related, EVH1 domain containing 1 | 0.0136635 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0136352 |
| NEK7 | NIMA-related kinase 7 | 0.013603 |
| ZNF638 | zinc finger protein 638 | 0.0135604 |
| HLA-B | major histocompatibility complex, class I, B | 0.0135413 |
| PCBP2 | poly(rC) binding protein 2 | 0.0135036 |
| TENT4A | terminal nucleotidyltransferase 4A | 0.0133238 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.438436 |
| VIM | vimentin | -0.166672 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.152324 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.14427 |
| CDH13 | cadherin 13 | -0.12386 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.116933 |
| IGF2 | insulin-like growth factor 2 | -0.110139 |
| HMGA2 | high mobility group AT-hook 2 | -0.108556 |
| ASPH | aspartate beta-hydroxylase | -0.100168 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0884792 |
| EGR1 | early growth response 1 | -0.0863173 |
| RAI14 | retinoic acid induced 14 | -0.0847009 |
| CCND1 | cyclin D1 | -0.0802989 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0795446 |
| LOX | lysyl oxidase | -0.0785394 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.078465 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0771649 |
| COL5A1 | collagen, type V, alpha 1 | -0.0745666 |
| STC1 | stanniocalcin 1 | -0.073782 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0719189 |
| ENO1 | enolase 1, (alpha) | -0.0655843 |
| DST | dystonin | -0.0639298 |
| CANX | calnexin | -0.0575575 |
| NDRG1 | N-myc downstream regulated 1 | -0.057296 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0562862 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0559725 |
| FMN1 | formin 1 | -0.053796 |
| RRBP1 | ribosome binding protein 1 | -0.0523192 |
| IL1B | interleukin 1, beta | -0.0522597 |
| ACTG1 | actin gamma 1 | -0.0520764 |
| GLIS3 | GLIS family zinc finger 3 | -0.0517931 |
| LAMB3 | laminin, beta 3 | -0.0490732 |
| ANXA2 | annexin A2 | -0.0485048 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.047946 |
| INHBA | inhibin, beta A | -0.0438938 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0428294 |
| LDHA | lactate dehydrogenase A | -0.042538 |
| CALU | calumenin | -0.0423612 |
| COL1A1 | collagen, type I, alpha 1 | -0.0421258 |
| CLMP | CXADR-like membrane protein | -0.0415387 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0398921 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0396664 |
| CAVIN1 | caveolae associated protein 1 | -0.038456 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | -0.0383141 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0375172 |
| TENM2 | teneurin transmembrane protein 2 | -0.0374655 |
| IER3 | immediate early response 3 | -0.0374059 |
| TMSB10 | thymosin beta 10 | -0.0371824 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | -0.0356872 |
| AHNAK | AHNAK nucleoprotein | -0.0353172 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0353107 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0351967 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.035049 |
| HDLBP | high density lipoprotein binding protein | -0.0347418 |
| DIAPH2 | diaphanous-related formin 2 | -0.0344019 |
| TNNC1 | troponin C type 1 (slow) | -0.0340717 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0337385 |
| SEC24D | SEC24 family member D | -0.0333865 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0333421 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0302569 |
| MORF4L2 | mortality factor 4 like 2 | -0.0296897 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | -0.0294447 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0290585 |
| RFX8 | RFX family member 8, lacking RFX DNA binding domain | -0.0290445 |
| MAP1B | microtubule-associated protein 1B | -0.0289487 |
| PTMA | prothymosin, alpha | -0.0282963 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0276519 |
| PGK1 | phosphoglycerate kinase 1 | -0.0269013 |
| NGLY1 | N-glycanase 1 | -0.0268822 |
| NAV3 | neuron navigator 3 | -0.0267183 |
| COL6A3 | collagen, type VI, alpha 3 | -0.0267045 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0265499 |
| ALDH1A3 | aldehyde dehydrogenase 1 family, member A3 | -0.0260561 |
| TPM4 | tropomyosin 4 | -0.0256096 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0255835 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0250194 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0250144 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0248172 |
| TMEM263 | transmembrane protein 263 | -0.0247544 |
| MYO10 | myosin X | -0.0243542 |
| S100A10 | S100 calcium binding protein A10 | -0.0242345 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | -0.0240717 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0234241 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0232196 |
| TLN1 | talin 1 | -0.0229466 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0226418 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.022498 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0224733 |
| THBS2 | thrombospondin 2 | -0.022354 |
| RAB2A | RAB2A, member RAS oncogene family | -0.0222061 |
| CD44 | CD44 molecule (Indian blood group) | -0.0220003 |
| SAMD3 | sterile alpha motif domain containing 3 | -0.0218856 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0218064 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0217762 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0217337 |
| CALR | calreticulin | -0.0216236 |
| HIPK2 | homeodomain interacting protein kinase 2 | -0.021589 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0214773 |
| KLF12 | Kruppel-like factor 12 | -0.0214514 |
| MAP4 | microtubule-associated protein 4 | -0.0213804 |
