| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Cabozantinib (S-malate) perturbation in HT-29 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Cabozantinib (S-malate)_HT-29 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FTL | ferritin, light polypeptide | 0.0720124 |
| RPS6 | ribosomal protein S6 | 0.06734 |
| RPL21 | ribosomal protein L21 | 0.0590756 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0559121 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0555001 |
| GOLGA4 | golgin A4 | 0.0530976 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0472159 |
| OGA | O-GlcNAcase | 0.044367 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0431806 |
| RPS19 | ribosomal protein S19 | 0.0430365 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0430072 |
| RPL23 | ribosomal protein L23 | 0.0415414 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0397402 |
| FAM13A | family with sequence similarity 13, member A | 0.0378022 |
| VEGFA | vascular endothelial growth factor A | 0.0366277 |
| RPL11 | ribosomal protein L11 | 0.0364719 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0363643 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0331738 |
| PCBP2 | poly(rC) binding protein 2 | 0.0328199 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0319135 |
| HYOU1 | hypoxia up-regulated 1 | 0.0303652 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0298096 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0284983 |
| RPL28 | ribosomal protein L28 | 0.0276796 |
| RNF145 | ring finger protein 145 | 0.0274036 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0265227 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0264458 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0262977 |
| RPL18 | ribosomal protein L18 | 0.0261129 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0259232 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | 0.0259093 |
| SBF2 | SET binding factor 2 | 0.0253175 |
| CALR | calreticulin | 0.0247039 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0240089 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0239917 |
| BRD2 | bromodomain containing 2 | 0.0235184 |
| YBX1 | Y box binding protein 1 | 0.0233638 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0231093 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0230461 |
| RBM33 | RNA binding motif protein 33 | 0.0229867 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0227524 |
| TPM3 | tropomyosin 3 | 0.0226502 |
| NUP58 | nucleoporin 58 | 0.0224232 |
| ACTG1 | actin gamma 1 | 0.0224084 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0221438 |
| RPL36 | ribosomal protein L36 | 0.0219107 |
| RPL8 | ribosomal protein L8 | 0.0218971 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0218813 |
| HELZ | helicase with zinc finger | 0.0218442 |
| ITPKC | inositol-trisphosphate 3-kinase C | 0.0210648 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0210201 |
| FBXO32 | F-box protein 32 | 0.0206901 |
| CNBP | CCHC-type zinc finger, nucleic acid binding protein | 0.0206461 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0205691 |
| LSM14A | LSM14A, SCD6 homolog A (S. cerevisiae) | 0.0204566 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0203749 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0203677 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0202873 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.0198632 |
| JMY | junction mediating and regulatory protein, p53 cofactor | 0.0198181 |
| YTHDC1 | YTH domain containing 1 | 0.0197536 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0193337 |
| ZC3H15 | zinc finger CCCH-type containing 15 | 0.0189636 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0189137 |
| DNM2 | dynamin 2 | 0.0188523 |
| OPTN | optineurin | 0.0187651 |
| KMT2A | lysine (K)-specific methyltransferase 2A | 0.0185596 |
| PTEN | phosphatase and tensin homolog | 0.0181473 |
| SRSF11 | serine/arginine-rich splicing factor 11 | 0.0180727 |
| ARID1A | AT rich interactive domain 1A (SWI-like) | 0.0180239 |
| ZNF292 | zinc finger protein 292 | 0.0180099 |
| TXNRD1 | thioredoxin reductase 1 | 0.0178775 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0178514 |
| RPL13A | ribosomal protein L13a | 0.0177861 |
| KIF5B | kinesin family member 5B | 0.0176111 |
| ZNF638 | zinc finger protein 638 | 0.017489 |
| UBE2B | ubiquitin-conjugating enzyme E2B | 0.0172988 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0171999 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0171748 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0170819 |
| RPL35 | ribosomal protein L35 | 0.0169111 |
| SF1 | splicing factor 1 | 0.0168669 |
| MATR3 | matrin 3 | 0.0167933 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.016549 |
| B2M | beta-2-microglobulin | 0.0164789 |
| FNBP4 | formin binding protein 4 | 0.0164295 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0163801 |
| DHFR | dihydrofolate reductase | 0.0162586 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0162321 |
| ATF3 | activating transcription factor 3 | 0.0161329 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0159666 |
| CCNL1 | cyclin L1 | 0.0156652 |
| RNMT | RNA (guanine-7-) methyltransferase | 0.0156606 |
| CNOT12 | CCR4-NOT transcription complex subunit 12 | 0.0156522 |
| SRSF4 | serine/arginine-rich splicing factor 4 | 0.0155571 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0155562 |
| GOLGA2 | golgin A2 | 0.015535 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0155295 |
| ZNF148 | zinc finger protein 148 | 0.0155189 |
| AP1AR | adaptor-related protein complex 1 associated regulatory protein | 0.0154055 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MYH14 | myosin, heavy chain 14, non-muscle | -0.152711 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | -0.124631 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | -0.113964 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.108567 |
| LAMA4 | laminin, alpha 4 | -0.104061 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0999786 |
| KRT20 | keratin 20, type I | -0.099362 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0978906 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0928102 |
| LMO7 | LIM domain 7 | -0.0890731 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0848432 |
| PTMA | prothymosin, alpha | -0.0786893 |
| SMAD3 | SMAD family member 3 | -0.0776001 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0741659 |
| GCNT3 | glucosaminyl (N-acetyl) transferase 3, mucin type | -0.0733023 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0721467 |
| AHNAK | AHNAK nucleoprotein | -0.0720468 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.0714302 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.071416 |
| ANXA2 | annexin A2 | -0.0701431 |
| MMP7 | matrix metallopeptidase 7 | -0.0680308 |
| SLC45A4 | solute carrier family 45, member 4 | -0.0676897 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0664258 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0650514 |
| TMEM123 | transmembrane protein 123 | -0.061043 |
| TJP1 | tight junction protein 1 | -0.0609261 |
| ACTN4 | actinin, alpha 4 | -0.0578765 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0569798 |
| POF1B | premature ovarian failure, 1B | -0.0554487 |
| TRIB1 | tribbles pseudokinase 1 | -0.0554296 |
| ASPH | aspartate beta-hydroxylase | -0.0553769 |
| INTS6 | integrator complex subunit 6 | -0.0550164 |
| MYO1E | myosin IE | -0.0528782 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | -0.0520105 |
| RPS24 | ribosomal protein S24 | -0.0516297 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0515761 |
| ARHGAP32 | Rho GTPase activating protein 32 | -0.0502523 |
| DIAPH2 | diaphanous-related formin 2 | -0.0488216 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0484444 |
| VCL | vinculin | -0.0473947 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | -0.04723 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | -0.0466781 |
| FRY | furry homolog (Drosophila) | -0.0455454 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0447468 |
| CTBP2 | C-terminal binding protein 2 | -0.0431068 |
| TMEM65 | transmembrane protein 65 | -0.0426106 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0400666 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0398536 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0393365 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0390298 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | -0.0383939 |
| KRT19 | keratin 19, type I | -0.0381674 |
| S100A10 | S100 calcium binding protein A10 | -0.0376289 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0375728 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0370687 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0370483 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0369031 |
| EGR1 | early growth response 1 | -0.0366726 |
| KLF5 | Kruppel-like factor 5 (intestinal) | -0.0364509 |
| GAREM1 | GRB2 associated regulator of MAPK1 subtype 1 | -0.0362621 |
| AGR2 | anterior gradient 2 | -0.0351441 |
| ETV6 | ets variant 6 | -0.0350575 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.0350289 |
| WNT2B | wingless-type MMTV integration site family, member 2B | -0.0345185 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0341247 |
| PRELID2 | PRELI domain containing 2 | -0.0332792 |
| CAPN8 | calpain 8 | -0.0332506 |
| MCL1 | myeloid cell leukemia 1 | -0.0332204 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0331565 |
| HIVEP1 | human immunodeficiency virus type I enhancer binding protein 1 | -0.0327422 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0327181 |
| SLC38A2 | solute carrier family 38, member 2 | -0.032686 |
| PPARD | peroxisome proliferator-activated receptor delta | -0.0321763 |
| TMSB10 | thymosin beta 10 | -0.0318365 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0317752 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0316395 |
| JUN | jun proto-oncogene | -0.031453 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0313873 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | -0.0313607 |
| EPB41L5 | erythrocyte membrane protein band 4.1 like 5 | -0.0303709 |
| NTN4 | netrin 4 | -0.0297216 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0296888 |
| LYZ | lysozyme | -0.0290979 |
| SDC4 | syndecan 4 | -0.0288442 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0288222 |
| ATXN1 | ataxin 1 | -0.0287516 |
| PYGB | phosphorylase, glycogen; brain | -0.0285224 |
| FAT1 | FAT atypical cadherin 1 | -0.0283177 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0278687 |
| PRR5L | proline rich 5 like | -0.0274145 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | -0.0267634 |
| LDHA | lactate dehydrogenase A | -0.0264566 |
| CCSER1 | coiled-coil serine-rich protein 1 | -0.0263295 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | -0.0260658 |
| DGKH | diacylglycerol kinase, eta | -0.0260037 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.02599 |
| RNF213 | ring finger protein 213 | -0.0256248 |
| CBL | Cbl proto-oncogene, E3 ubiquitin protein ligase | -0.0254759 |
| PLK2 | polo-like kinase 2 | -0.0253934 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0251633 |
