Cabozantinib (S-malate)_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cabozantinib (S-malate) perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cabozantinib (S-malate)_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
C3 complement component 3 0.218018
GPC6 glypican 6 0.14667
LRMDA leucine rich melanocyte differentiation associated 0.100754
IGFBP1 insulin-like growth factor binding protein 1 0.0948474
RPL11 ribosomal protein L11 0.0882011
RPS6 ribosomal protein S6 0.0788008
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0735264
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0733602
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0663304
RPL23 ribosomal protein L23 0.0644469
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0641748
TPT1 tumor protein, translationally-controlled 1 0.0634482
TNS3 tensin 3 0.0625382
MYH9 myosin, heavy chain 9, non-muscle 0.0615389
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0602854
RPL37A ribosomal protein L37a 0.0595589
EEF2 eukaryotic translation elongation factor 2 0.0594243
RPS12 ribosomal protein S12 0.0570468
RPS8 ribosomal protein S8 0.0557151
ECE1 endothelin converting enzyme 1 0.0536611
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0534055
IGF1R insulin-like growth factor 1 receptor 0.0530158
GPAM glycerol-3-phosphate acyltransferase, mitochondrial 0.0519661
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0511907
ZMIZ1 zinc finger, MIZ-type containing 1 0.0511058
NACA nascent polypeptide-associated complex alpha subunit 0.0504328
RPL13A ribosomal protein L13a 0.0493005
RPL4 ribosomal protein L4 0.0465557
SRRM2 serine/arginine repetitive matrix 2 0.0445069
USP3 ubiquitin specific peptidase 3 0.0438796
RPL26 ribosomal protein L26 0.041911
ACTG1 actin gamma 1 0.0417255
RPL9 ribosomal protein L9 0.0411107
DOCK4 dedicator of cytokinesis 4 0.0404911
EIF4B eukaryotic translation initiation factor 4B 0.0399496
ENAH enabled homolog (Drosophila) 0.0391723
TTC3 tetratricopeptide repeat domain 3 0.038807
CHD6 chromodomain helicase DNA binding protein 6 0.0382667
RPL34 ribosomal protein L34 0.0380262
RPL35A ribosomal protein L35a 0.0370538
RPLP1 ribosomal protein, large, P1 0.0362375
KRT8 keratin 8, type II 0.0359979
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0356888
RPS20 ribosomal protein S20 0.0355781
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.035188
HSPA8 heat shock 70kDa protein 8 0.0348097
BCL2L1 BCL2-like 1 0.0345318
RPS17 ribosomal protein S17 0.0340765
OLA1 Obg-like ATPase 1 0.0339988
MSI2 musashi RNA-binding protein 2 0.0338533
ICAM1 intercellular adhesion molecule 1 0.0334465
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0327718
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0325691
PCBP2 poly(rC) binding protein 2 0.0324245
RPL37 ribosomal protein L37 0.0318089
IGF2R insulin-like growth factor 2 receptor 0.0314273
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 0.0310021
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0309487
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0308752
RPL3 ribosomal protein L3 0.0308593
ARL15 ADP-ribosylation factor-like 15 0.0307829
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.0307398
EIF1 eukaryotic translation initiation factor 1 0.0305295
RPS16 ribosomal protein S16 0.0301396
RPL5 ribosomal protein L5 0.0297009
FAT1 FAT atypical cadherin 1 0.0296549
KRT18 keratin 18, type I 0.0294985
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0291839
CCN2 cellular communication network factor 2 0.0291476
RPS3 ribosomal protein S3 0.0290328
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0287844
ANKRD11 ankyrin repeat domain 11 0.0285492
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0285065
TPM1 tropomyosin 1 (alpha) 0.0283781
MACF1 microtubule-actin crosslinking factor 1 0.028246
ACTN1 actinin, alpha 1 0.0282284
SMYD3 SET and MYND domain containing 3 0.0281399
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 0.0277172
LMCD1 LIM and cysteine-rich domains 1 0.027483
PTPRM protein tyrosine phosphatase, receptor type, M 0.0274578
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0273488
NAP1L1 nucleosome assembly protein 1-like 1 0.0273484
QKI QKI, KH domain containing, RNA binding 0.0273121
RPS15A ribosomal protein S15a 0.0272334
RPS25 ribosomal protein S25 0.027181
RPS14 ribosomal protein S14 0.0271013
AGFG1 ArfGAP with FG repeats 1 0.0269277
EXOC6B exocyst complex component 6B 0.026809
PTPRK protein tyrosine phosphatase, receptor type, K 0.0264443
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.0264172
MED13L mediator complex subunit 13-like 0.0263767
PTBP3 polypyrimidine tract binding protein 3 0.0262707
SLC23A1 solute carrier family 23 (ascorbic acid transporter), member 1 0.0260748
GOLGA4 golgin A4 0.0259684
MTMR3 myotubularin related protein 3 0.0259312
CCNY cyclin Y 0.0258903
PEBP1 phosphatidylethanolamine binding protein 1 0.0258402
RSU1 Ras suppressor protein 1 0.0256581
RPL7A ribosomal protein L7a 0.0254995
RPLP0 ribosomal protein, large, P0 0.0252409

decreased expression

Symbol Name Standardized Value
SLC38A2 solute carrier family 38, member 2 -0.190678
IGF2 insulin-like growth factor 2 -0.151929
ERRFI1 ERBB receptor feedback inhibitor 1 -0.14422
AKAP12 A kinase (PRKA) anchor protein 12 -0.132515
EHBP1 EH domain binding protein 1 -0.128475
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.10493
FRMD5 FERM domain containing 5 -0.0908493
MAML2 mastermind-like 2 (Drosophila) -0.0902669
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0853036
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0785185
ENO1 enolase 1, (alpha) -0.0736245
ELL2 elongation factor, RNA polymerase II, 2 -0.0735486
SAMD4A sterile alpha motif domain containing 4A -0.0701793
TM4SF1 transmembrane 4 L six family member 1 -0.0687492
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0656852
TRIM26 tripartite motif containing 26 -0.0656643
MT2A metallothionein 2A -0.0652196
FN1 fibronectin 1 -0.0638288
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0616451
TMEM123 transmembrane protein 123 -0.0592105
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0548311
APOB apolipoprotein B -0.0543
DSPP dentin sialophosphoprotein -0.0535078
NDRG1 N-myc downstream regulated 1 -0.053217
EML4 echinoderm microtubule associated protein like 4 -0.0519239
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0504634
GMDS GDP-mannose 4,6-dehydratase -0.050117
KDM3A lysine (K)-specific demethylase 3A -0.0471917
GPC3 glypican 3 -0.0470723
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0465079
NPAS2 neuronal PAS domain protein 2 -0.045553
PDGFB platelet-derived growth factor beta polypeptide -0.0454344
DST dystonin -0.0446559
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 -0.0444417
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0439046
FNDC3B fibronectin type III domain containing 3B -0.0439044
PEG3 paternally expressed 3 -0.0429689
ZBTB20 zinc finger and BTB domain containing 20 -0.0425771
DSCAM Down syndrome cell adhesion molecule -0.0402147
LDHA lactate dehydrogenase A -0.0397515
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) -0.0393966
ARHGAP5 Rho GTPase activating protein 5 -0.0393866
STAU1 staufen double-stranded RNA binding protein 1 -0.0389875
PTTG1IP pituitary tumor-transforming 1 interacting protein -0.0389647
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0388145
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) -0.0380846
H1-0 H1.0 linker histone -0.0371446
TXNRD1 thioredoxin reductase 1 -0.037137
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0365497
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0355231
MALT1 MALT1 paracaspase -0.0349459
GCC2 GRIP and coiled-coil domain containing 2 -0.0348361
ASPH aspartate beta-hydroxylase -0.0343579
FILIP1L filamin A interacting protein 1-like -0.0342936
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 -0.0334885
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0334862
FAM135A family with sequence similarity 135, member A -0.0333539
GK glycerol kinase -0.0328706
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 -0.0327908
LRRTM4 leucine rich repeat transmembrane neuronal 4 -0.0325939
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.0325668
SLC38A1 solute carrier family 38, member 1 -0.0323182
STK17A serine/threonine kinase 17a -0.032018
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0319983
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0317237
FNDC3A fibronectin type III domain containing 3A -0.0317225
WDR45B WD repeat domain 45B -0.0315927
DENND4A DENN/MADD domain containing 4A -0.0315649
RUNX1 runt-related transcription factor 1 -0.0315082
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0310758
EPAS1 endothelial PAS domain protein 1 -0.031069
ARHGAP18 Rho GTPase activating protein 18 -0.0310032
DLC1 DLC1 Rho GTPase activating protein -0.0305594
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0301216
FBF1 Fas (TNFRSF6) binding factor 1 -0.0298127
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0295241
VCL vinculin -0.0294559
CCDC146 coiled-coil domain containing 146 -0.0291627
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -0.0289558
NPR2 natriuretic peptide receptor 2 -0.0287691
PATJ PATJ crumbs cell polarity complex component -0.0284908
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0283146
MBNL2 muscleblind-like splicing regulator 2 -0.0277708
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0276762
TXNIP thioredoxin interacting protein -0.0275105
LYZ lysozyme -0.0270108
USP34 ubiquitin specific peptidase 34 -0.0270053
UBXN4 UBX domain protein 4 -0.0268971
TFRC transferrin receptor -0.0266583
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0264838
RNF128 ring finger protein 128, E3 ubiquitin protein ligase -0.0264808
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0264354
ZMYND8 zinc finger, MYND-type containing 8 -0.0261333
MAN1A1 mannosidase, alpha, class 1A, member 1 -0.0255321
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0254953
FTL ferritin, light polypeptide -0.0241891
LAMA4 laminin, alpha 4 -0.0239798
DUSP6 dual specificity phosphatase 6 -0.0239153
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0237867
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0236166