| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Cabozantinib (S-malate) perturbation in Hs 766T cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Cabozantinib (S-malate)_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CLU | clusterin | 0.227844 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.121404 |
| FOXP1 | forkhead box P1 | 0.114434 |
| SMAD3 | SMAD family member 3 | 0.0950179 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0865671 |
| AOPEP | aminopeptidase O (putative) | 0.084269 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0832007 |
| KIAA1217 | KIAA1217 | 0.0777452 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0765608 |
| OGA | O-GlcNAcase | 0.0764359 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0752432 |
| PRELID2 | PRELI domain containing 2 | 0.0730583 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0720704 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0710092 |
| ARHGAP29 | Rho GTPase activating protein 29 | 0.0695675 |
| NCOA3 | nuclear receptor coactivator 3 | 0.0638853 |
| BLCAP | bladder cancer associated protein | 0.0628928 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0612751 |
| MYOF | myoferlin | 0.0588923 |
| CAMK2D | calcium/calmodulin-dependent protein kinase II delta | 0.0577846 |
| NAV2 | neuron navigator 2 | 0.0549217 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0531632 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.052867 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0509966 |
| OSBPL6 | oxysterol binding protein-like 6 | 0.0502329 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0469313 |
| DST | dystonin | 0.0456656 |
| RNF19B | ring finger protein 19B | 0.0442721 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0433177 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | 0.0420339 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0415824 |
| H1-0 | H1.0 linker histone | 0.0415513 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0392495 |
| AHNAK | AHNAK nucleoprotein | 0.0385975 |
| MEF2A | myocyte enhancer factor 2A | 0.0385691 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0379393 |
| B2M | beta-2-microglobulin | 0.0369112 |
| ANKRD10 | ankyrin repeat domain 10 | 0.0368658 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0367121 |
| PTPN13 | protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) | 0.0365152 |
| LGR4 | leucine-rich repeat containing G protein-coupled receptor 4 | 0.0362553 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.0357265 |
| CDKN2A | cyclin-dependent kinase inhibitor 2A | 0.0356094 |
| DIDO1 | death inducer-obliterator 1 | 0.0349683 |
| ANKRD33B | ankyrin repeat domain 33B | 0.0345081 |
| RNF145 | ring finger protein 145 | 0.0338949 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0335813 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0333373 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0332995 |
| MRPS6 | mitochondrial ribosomal protein S6 | 0.0325819 |
| NEK7 | NIMA-related kinase 7 | 0.0325122 |
| SBF2 | SET binding factor 2 | 0.0324261 |
| HELZ | helicase with zinc finger | 0.0315569 |
| HYCC2 | hyccin PI4KA lipid kinase complex subunit 2 | 0.0314707 |
| DSTN | destrin (actin depolymerizing factor) | 0.0314702 |
| SLC45A4 | solute carrier family 45, member 4 | 0.0312613 |
| PHF21A | PHD finger protein 21A | 0.0311858 |
| HP1BP3 | heterochromatin protein 1, binding protein 3 | 0.0310502 |
| NRG1 | neuregulin 1 | 0.0310483 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0310248 |
| CUL4B | cullin 4B | 0.0303323 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0302739 |
| PODXL | podocalyxin-like | 0.0301438 |
| SH3PXD2A | SH3 and PX domains 2A | 0.0299429 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0299035 |
| FLNA | filamin A, alpha | 0.0297086 |
| CLDN1 | claudin 1 | 0.0292697 |
| YBX3 | Y box binding protein 3 | 0.028774 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0287177 |
| ZNF292 | zinc finger protein 292 | 0.0284565 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.0283652 |
| ITGB8 | integrin, beta 8 | 0.0283199 |
| NAB1 | NGFI-A binding protein 1 (EGR1 binding protein 1) | 0.028263 |
| JAK1 | Janus kinase 1 | 0.0281112 |
| EFNA5 | ephrin-A5 | 0.0280808 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0275766 |
| HLA-E | major histocompatibility complex, class I, E | 0.0275427 |
| CD9 | CD9 molecule | 0.0274634 |
| ITM2B | integral membrane protein 2B | 0.0274083 |
| FAM3C | family with sequence similarity 3, member C | 0.027107 |
| PRSS23 | protease, serine, 23 | 0.0268355 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0266211 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0265252 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0264856 |
| RIN2 | Ras and Rab interactor 2 | 0.0264277 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0261487 |
| SETBP1 | SET binding protein 1 | 0.0259563 |
| ACSS2 | acyl-CoA synthetase short-chain family member 2 | 0.0259556 |
| CD44 | CD44 molecule (Indian blood group) | 0.0255263 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0252564 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | 0.0252358 |
| ARHGAP12 | Rho GTPase activating protein 12 | 0.0250992 |
| CLEC1B | C-type lectin domain family 1, member B | 0.025023 |
| DENND4C | DENN/MADD domain containing 4C | 0.0249847 |
| ARHGAP21 | Rho GTPase activating protein 21 | 0.0248489 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | 0.0248141 |
| GBP2 | guanylate binding protein 2, interferon-inducible | 0.0246816 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0246199 |
| PLEKHA1 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 | 0.0244235 |
| LIFR | leukemia inhibitory factor receptor alpha | 0.024198 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.219358 |
| SLC35F3 | solute carrier family 35, member F3 | -0.116356 |
| NDRG1 | N-myc downstream regulated 1 | -0.110613 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.105778 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0893753 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0835977 |
| FLNB | filamin B, beta | -0.0742032 |
| POTEF | POTE ankyrin domain family, member F | -0.0721012 |
| ANO1 | anoctamin 1, calcium activated chloride channel | -0.0685533 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | -0.0673496 |
| MTSS1 | metastasis suppressor 1 | -0.0650736 |
| RASAL2 | RAS protein activator like 2 | -0.0645232 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0609814 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0588197 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.056823 |
| LAMC2 | laminin, gamma 2 | -0.0566858 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.0551637 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0510576 |
| CDK6 | cyclin-dependent kinase 6 | -0.0498495 |
| EMP1 | epithelial membrane protein 1 | -0.0497197 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0496061 |
| STC1 | stanniocalcin 1 | -0.0476405 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0475455 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0466754 |
| EZR | ezrin | -0.0463273 |
| CALU | calumenin | -0.0442352 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0434245 |
| LDHA | lactate dehydrogenase A | -0.0432237 |
| TSC22D1 | TSC22 domain family, member 1 | -0.0418307 |
| EGR1 | early growth response 1 | -0.0416275 |
| FOSL1 | FOS-like antigen 1 | -0.040855 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0403326 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.04017 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0398334 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.0397367 |
| CALB1 | calbindin 1, 28kDa | -0.0385851 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0383877 |
| HM13 | histocompatibility (minor) 13 | -0.0373779 |
| ADAMTS16 | ADAM metallopeptidase with thrombospondin type 1 motif, 16 | -0.0369137 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | -0.0361385 |
| S100A10 | S100 calcium binding protein A10 | -0.0359946 |
| MMP14 | matrix metallopeptidase 14 (membrane-inserted) | -0.0357758 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | -0.0350493 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0347269 |
| S100A11 | S100 calcium binding protein A11 | -0.0342244 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | -0.0338088 |
| TPM4 | tropomyosin 4 | -0.0330957 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0326946 |
| CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | -0.0323462 |
| RRBP1 | ribosome binding protein 1 | -0.0319257 |
| LMO7 | LIM domain 7 | -0.0319203 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0314544 |
| FTL | ferritin, light polypeptide | -0.0311141 |
| LUZP1 | leucine zipper protein 1 | -0.0310414 |
| NRCAM | neuronal cell adhesion molecule | -0.0306449 |
| RCOR1 | REST corepressor 1 | -0.030629 |
| ST3GAL6 | ST3 beta-galactoside alpha-2,3-sialyltransferase 6 | -0.0302332 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0299188 |
| THBD | thrombomodulin | -0.0297613 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0296625 |
| AMOTL1 | angiomotin like 1 | -0.0296077 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0286107 |
| CSMD2 | CUB and Sushi multiple domains 2 | -0.0285615 |
| TXNRD1 | thioredoxin reductase 1 | -0.0285193 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0285052 |
| ANGPTL4 | angiopoietin-like 4 | -0.0284244 |
| ACTN4 | actinin, alpha 4 | -0.0281296 |
| LAMB3 | laminin, beta 3 | -0.0279601 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0278771 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.027724 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | -0.0272349 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0270398 |
| ANXA5 | annexin A5 | -0.0263975 |
| EHF | ets homologous factor | -0.0262545 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0256004 |
| CSNK1E | casein kinase 1, epsilon | -0.0255971 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | -0.0253122 |
| HMGA2 | high mobility group AT-hook 2 | -0.0253099 |
| FBXO11 | F-box protein 11 | -0.0253047 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0249239 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0247663 |
| SPINK5 | serine peptidase inhibitor, Kazal type 5 | -0.0247608 |
| CDCP1 | CUB domain containing protein 1 | -0.0246409 |
| FRMD5 | FERM domain containing 5 | -0.0243678 |
| MPRIP | myosin phosphatase Rho interacting protein | -0.0243224 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | -0.0243087 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0242984 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0242682 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0240931 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0240287 |
| IFI44L | interferon-induced protein 44-like | -0.023914 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0238354 |
| TPM3 | tropomyosin 3 | -0.023809 |
| ABLIM3 | actin binding LIM protein family, member 3 | -0.0236181 |
| CYSTM1 | cysteine-rich transmembrane module containing 1 | -0.0233923 |
| SEC24A | SEC24 family member A | -0.0231623 |
| MYO10 | myosin X | -0.0230366 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0230267 |
| CSTB | cystatin B (stefin B) | -0.0230119 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | -0.0227766 |
