Cabozantinib (S-malate)_J82 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cabozantinib (S-malate) perturbation in J82 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cabozantinib (S-malate)_J82 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HLA-B major histocompatibility complex, class I, B 0.118503
SLC12A8 solute carrier family 12, member 8 0.111357
SRRM2 serine/arginine repetitive matrix 2 0.0656608
HLA-A major histocompatibility complex, class I, A 0.0607989
SMAD3 SMAD family member 3 0.0556484
PLIN2 perilipin 2 0.0552051
SQSTM1 sequestosome 1 0.0540661
N4BP2L2 NEDD4 binding protein 2-like 2 0.0490366
LRMDA leucine rich melanocyte differentiation associated 0.0485847
ZBTB20 zinc finger and BTB domain containing 20 0.0483645
ADM adrenomedullin 0.0463834
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0457261
OPTN optineurin 0.0442148
EIF1 eukaryotic translation initiation factor 1 0.043943
NCOR2 nuclear receptor corepressor 2 0.0435982
MYH9 myosin, heavy chain 9, non-muscle 0.0432646
FNIP1 folliculin interacting protein 1 0.0427089
MBNL2 muscleblind-like splicing regulator 2 0.0421294
FTL ferritin, light polypeptide 0.0407542
KTN1 kinectin 1 (kinesin receptor) 0.0387368
DPYD dihydropyrimidine dehydrogenase 0.0386468
SMYD3 SET and MYND domain containing 3 0.0378474
KLHL24 kelch-like family member 24 0.0372528
B2M beta-2-microglobulin 0.0362409
C6ORF62 chromosome 6 open reading frame 62 0.0360819
DSCAM Down syndrome cell adhesion molecule 0.0359421
RNF213 ring finger protein 213 0.0352968
NR6A1 nuclear receptor subfamily 6, group A, member 1 0.0348085
MBNL1 muscleblind-like splicing regulator 1 0.0345477
SETD5 SET domain containing 5 0.0343453
TNS3 tensin 3 0.0340615
RPS6 ribosomal protein S6 0.0330969
ACTG1 actin gamma 1 0.0330334
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0327499
MECOM MDS1 and EVI1 complex locus 0.0326251
FLNB filamin B, beta 0.0321445
PODXL podocalyxin-like 0.0317557
RAD51B RAD51 paralog B 0.0312896
PDE4D phosphodiesterase 4D, cAMP-specific 0.0311328
PHF21A PHD finger protein 21A 0.0308457
GATA2 GATA binding protein 2 0.0308349
LPP LIM domain containing preferred translocation partner in lipoma 0.030697
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0303746
GNPDA1 glucosamine-6-phosphate deaminase 1 0.030333
ZNF841 zinc finger protein 841 0.0299823
ATXN1 ataxin 1 0.029755
PGK1 phosphoglycerate kinase 1 0.0297401
SULF1 sulfatase 1 0.0289084
AOPEP aminopeptidase O (putative) 0.028733
NUMA1 nuclear mitotic apparatus protein 1 0.0283489
TIMP2 TIMP metallopeptidase inhibitor 2 0.0282183
PHF3 PHD finger protein 3 0.0282105
COL5A2 collagen, type V, alpha 2 0.0277504
KRT18 keratin 18, type I 0.0275947
ASPH aspartate beta-hydroxylase 0.0275684
CEP250 centrosomal protein 250kDa 0.0267467
ZNF148 zinc finger protein 148 0.0267094
AFAP1 actin filament associated protein 1 0.0264709
IGF1R insulin-like growth factor 1 receptor 0.0263427
BRD4 bromodomain containing 4 0.0261925
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0261772
NCOA3 nuclear receptor coactivator 3 0.0261225
PACS1 phosphofurin acidic cluster sorting protein 1 0.0259595
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0257706
NBEA neurobeachin 0.0257371
AUH AU RNA binding protein/enoyl-CoA hydratase 0.0257057
PLEC plectin 0.0256717
IFITM3 interferon induced transmembrane protein 3 0.0256668
SBF2 SET binding factor 2 0.0254297
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) 0.0253935
EXOC4 exocyst complex component 4 0.0253279
MIDEAS mitotic deacetylase associated SANT domain protein 0.0250873
ENO2 enolase 2 (gamma, neuronal) 0.0250688
ABI3BP ABI family, member 3 (NESH) binding protein 0.0249817
BRD2 bromodomain containing 2 0.024931
HLA-C major histocompatibility complex, class I, C 0.0248745
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.024823
DEK DEK proto-oncogene 0.0247136
ANKRD10 ankyrin repeat domain 10 0.0244427
HLA-E major histocompatibility complex, class I, E 0.024373
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0243609
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0243079
PRRC2A proline-rich coiled-coil 2A 0.0242591
MPRIP myosin phosphatase Rho interacting protein 0.0239212
ZNF638 zinc finger protein 638 0.0238404
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0237771
YEATS2 YEATS domain containing 2 0.0237537
RPL23 ribosomal protein L23 0.0236871
CTSD cathepsin D 0.0236315
MARCKS myristoylated alanine-rich protein kinase C substrate 0.0233753
HPS3 Hermansky-Pudlak syndrome 3 0.0233585
RICTOR RPTOR independent companion of MTOR, complex 2 0.0232675
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0231469
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0229748
AFF1 AF4/FMR2 family, member 1 0.022919
RPL21 ribosomal protein L21 0.0228136
BCAS3 breast carcinoma amplified sequence 3 0.0226773
SRSF4 serine/arginine-rich splicing factor 4 0.022446
MBD5 methyl-CpG binding domain protein 5 0.0223264
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0220801

decreased expression

Symbol Name Standardized Value
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.268773
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.22687
EXT1 exostosin glycosyltransferase 1 -0.191185
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.162577
NALF1 NALCN channel auxiliary factor 1 -0.136249
CD44 CD44 molecule (Indian blood group) -0.116268
ERBIN erbb2 interacting protein -0.108867
TRIO trio Rho guanine nucleotide exchange factor -0.0918502
F3 coagulation factor III (thromboplastin, tissue factor) -0.0851452
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0790956
TXNRD1 thioredoxin reductase 1 -0.0768659
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0672721
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0664421
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0600297
AKAP12 A kinase (PRKA) anchor protein 12 -0.0589529
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.0582698
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0577172
ELL2 elongation factor, RNA polymerase II, 2 -0.0577042
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0544889
MT2A metallothionein 2A -0.0480293
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.048023
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0477249
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 -0.0455268
PLCB4 phospholipase C, beta 4 -0.0442746
ARF4 ADP-ribosylation factor 4 -0.0401715
ANXA2 annexin A2 -0.0377464
WNT5B wingless-type MMTV integration site family, member 5B -0.037004
IL6ST interleukin 6 signal transducer -0.0368363
MORF4L2 mortality factor 4 like 2 -0.0365278
CCBE1 collagen and calcium binding EGF domains 1 -0.035414
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0353703
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0348406
CCND1 cyclin D1 -0.0334451
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.0334333
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0327287
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0326086
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0321319
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0319761
DIAPH3 diaphanous-related formin 3 -0.0316758
CANX calnexin -0.0308234
IGFBP3 insulin-like growth factor binding protein 3 -0.0293251
THBS1 thrombospondin 1 -0.029031
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0287105
MB21D2 Mab-21 domain containing 2 -0.0282988
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0273285
DDAH1 dimethylarginine dimethylaminohydrolase 1 -0.0270459
IPO7 importin 7 -0.0269587
PPME1 protein phosphatase methylesterase 1 -0.0267174
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.026578
STARD13 StAR-related lipid transfer (START) domain containing 13 -0.0265102
DTNA dystrobrevin, alpha -0.0264341
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene) -0.0263078
TSC22D2 TSC22 domain family, member 2 -0.0262335
CALU calumenin -0.0261226
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0257301
VGLL3 vestigial-like family member 3 -0.0254243
SENP5 SUMO1/sentrin specific peptidase 5 -0.0248834
HEG1 heart development protein with EGF-like domains 1 -0.0246209
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0241293
NPPB natriuretic peptide B -0.0239596
MAPK8 mitogen-activated protein kinase 8 -0.0239521
CDK17 cyclin-dependent kinase 17 -0.0238828
LDHA lactate dehydrogenase A -0.0237833
TUBB tubulin, beta class I -0.0232958
IER3 immediate early response 3 -0.0228062
SAMD4A sterile alpha motif domain containing 4A -0.0223591
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0223041
CAVIN1 caveolae associated protein 1 -0.0222848
LATS2 large tumor suppressor kinase 2 -0.0222687
FOSL1 FOS-like antigen 1 -0.0220233
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0216226
SH3RF1 SH3 domain containing ring finger 1 -0.0213407
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0212557
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.0212271
NUP153 nucleoporin 153kDa -0.0211798
LAMP1 lysosomal-associated membrane protein 1 -0.0211593
NOP58 NOP58 ribonucleoprotein -0.0211322
MYL12B myosin, light chain 12B, regulatory -0.0210384
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0208193
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0204188
HMGB1 high mobility group box 1 -0.0203827
TUBA1B tubulin, alpha 1b -0.0203374
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0202382
RRBP1 ribosome binding protein 1 -0.0200967
GNAS GNAS complex locus -0.0200557
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0199594
KLF6 Kruppel-like factor 6 -0.0199003
IPO5 importin 5 -0.0198323
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0195442
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0194067
SCFD2 sec1 family domain containing 2 -0.019342
CSE1L CSE1 chromosome segregation 1-like (yeast) -0.0192533
ATP13A3 ATPase type 13A3 -0.0190736
DIS3 DIS3 exosome endoribonuclease and 3'-5' exoribonuclease -0.0189371
RBM39 RNA binding motif protein 39 -0.0189103
VEGFC vascular endothelial growth factor C -0.0188972
OXTR oxytocin receptor -0.0188417
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 -0.0188017
LIMA1 LIM domain and actin binding 1 -0.0187764
SEC31A SEC31 homolog A (S. cerevisiae) -0.0183622