| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Cabozantinib (S-malate) perturbation in KATO III cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Cabozantinib (S-malate)_KATO III drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FGFR2 | fibroblast growth factor receptor 2 | 0.243953 |
| NUPR1 | nuclear protein, transcriptional regulator, 1 | 0.0823986 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0783017 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.075432 |
| DSPP | dentin sialophosphoprotein | 0.0734779 |
| VEGFA | vascular endothelial growth factor A | 0.0730188 |
| RAD51B | RAD51 paralog B | 0.0692158 |
| TMC5 | transmembrane channel-like 5 | 0.0658336 |
| PRELID2 | PRELI domain containing 2 | 0.0526683 |
| RNF213 | ring finger protein 213 | 0.0523408 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.051936 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0490952 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | 0.0466725 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.0466102 |
| TNS3 | tensin 3 | 0.0458821 |
| B2M | beta-2-microglobulin | 0.0453382 |
| ATF7IP2 | activating transcription factor 7 interacting protein 2 | 0.0425672 |
| TMEM45B | transmembrane protein 45B | 0.0424936 |
| FAAH2 | fatty acid amide hydrolase 2 | 0.0411147 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.0405086 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.037964 |
| HLA-B | major histocompatibility complex, class I, B | 0.0358431 |
| MACROD2 | MACRO domain containing 2 | 0.0342897 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0338759 |
| HLA-A | major histocompatibility complex, class I, A | 0.0326226 |
| CDK19 | cyclin-dependent kinase 19 | 0.0316292 |
| ARHGAP32 | Rho GTPase activating protein 32 | 0.0315803 |
| CAPN5 | calpain 5 | 0.0313071 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0312542 |
| ZNF292 | zinc finger protein 292 | 0.0311603 |
| EXOC4 | exocyst complex component 4 | 0.0307318 |
| FOXP1 | forkhead box P1 | 0.0306806 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | 0.0305375 |
| RUNX1 | runt-related transcription factor 1 | 0.0305002 |
| HKDC1 | hexokinase domain containing 1 | 0.0302588 |
| BCAS3 | breast carcinoma amplified sequence 3 | 0.029366 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0288501 |
| FRY | furry homolog (Drosophila) | 0.0285349 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0283347 |
| DNM2 | dynamin 2 | 0.0280331 |
| RAB40B | RAB40B, member RAS oncogene family | 0.0277434 |
| TXNIP | thioredoxin interacting protein | 0.027517 |
| TNRC6B | trinucleotide repeat containing 6B | 0.0273406 |
| BBS9 | Bardet-Biedl syndrome 9 | 0.0273008 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.026919 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | 0.0268571 |
| ZKSCAN1 | zinc finger with KRAB and SCAN domains 1 | 0.0268383 |
| PRSS3 | protease, serine, 3 | 0.0258223 |
| FOSL2 | FOS-like antigen 2 | 0.0252546 |
| ATXN1 | ataxin 1 | 0.0251368 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0250903 |
| CLDN4 | claudin 4 | 0.0246435 |
| CNKSR3 | CNKSR family member 3 | 0.0245773 |
| KLHL29 | kelch-like family member 29 | 0.0240637 |
| SORBS2 | sorbin and SH3 domain containing 2 | 0.0238723 |
| PHF3 | PHD finger protein 3 | 0.0236165 |
| AUH | AU RNA binding protein/enoyl-CoA hydratase | 0.0236118 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0234148 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0232221 |
| RBM47 | RNA binding motif protein 47 | 0.0231207 |
| ALPK1 | alpha-kinase 1 | 0.0229478 |
| MUC1 | mucin 1, cell surface associated | 0.0225533 |
| ATF5 | activating transcription factor 5 | 0.0224641 |
| RNF145 | ring finger protein 145 | 0.0223272 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0223198 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | 0.0221898 |
| PCBP2 | poly(rC) binding protein 2 | 0.0221229 |
| LURAP1L | leucine rich adaptor protein 1-like | 0.0214405 |
| CAMK2D | calcium/calmodulin-dependent protein kinase II delta | 0.0214154 |
| TRIM2 | tripartite motif containing 2 | 0.0213438 |
| SETD5 | SET domain containing 5 | 0.0212865 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0211377 |
| EPB41 | erythrocyte membrane protein band 4.1 | 0.0209029 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | 0.020594 |
| NBR1 | neighbor of BRCA1 gene 1 | 0.0205302 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0204366 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0203109 |
| TBC1D5 | TBC1 domain family, member 5 | 0.020268 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0202075 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.0199657 |
| LCN2 | lipocalin 2 | 0.0198968 |
| ATP9A | ATPase, class II, type 9A | 0.0198559 |
| SCAPER | S-phase cyclin A-associated protein in the ER | 0.0197657 |
| EEIG1 | estrogen-induced osteoclastogenesis regulator 1 | 0.0196808 |
| SSH2 | slingshot protein phosphatase 2 | 0.019607 |
| ATM | ATM serine/threonine kinase | 0.0196047 |
| KLF3 | Kruppel-like factor 3 (basic) | 0.0195758 |
| GNGT1 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | 0.0194914 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0193575 |
| ERBB3 | erb-b2 receptor tyrosine kinase 3 | 0.0190265 |
| PCM1 | pericentriolar material 1 | 0.018878 |
| MYO9A | myosin IXA | 0.018851 |
| NDRG1 | N-myc downstream regulated 1 | 0.018806 |
| KIF16B | kinesin family member 16B | 0.018779 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.0181569 |
| KLHL24 | kelch-like family member 24 | 0.0181453 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | 0.0181288 |
| FOXN3 | forkhead box N3 | 0.0180886 |
| LDLRAD4 | low density lipoprotein receptor class A domain containing 4 | 0.017985 |
| MECOM | MDS1 and EVI1 complex locus | 0.0179249 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.270488 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.181646 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.165322 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.154474 |
| EMP1 | epithelial membrane protein 1 | -0.113506 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.105431 |
| ANXA2 | annexin A2 | -0.0971223 |
| LMO7 | LIM domain 7 | -0.0863122 |
| AGR2 | anterior gradient 2 | -0.0779681 |
| KRT18 | keratin 18, type I | -0.0778163 |
| HSD17B12 | hydroxysteroid (17-beta) dehydrogenase 12 | -0.0717636 |
| EZR | ezrin | -0.070909 |
| FLNB | filamin B, beta | -0.0705364 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.0675909 |
| EHBP1 | EH domain binding protein 1 | -0.0602807 |
| FAT1 | FAT atypical cadherin 1 | -0.0584504 |
| KRT8 | keratin 8, type II | -0.0573172 |
| TXNRD1 | thioredoxin reductase 1 | -0.0552054 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0524857 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.051721 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0506974 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0479299 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0461728 |
| ASPH | aspartate beta-hydroxylase | -0.0455163 |
| ACTN4 | actinin, alpha 4 | -0.044514 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0441098 |
| S100A6 | S100 calcium binding protein A6 | -0.0440458 |
| ANLN | anillin, actin binding protein | -0.0430585 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0429445 |
| BCL2L1 | BCL2-like 1 | -0.040824 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0396805 |
| MYOF | myoferlin | -0.0387074 |
| RRBP1 | ribosome binding protein 1 | -0.0386166 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | -0.0374913 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0371657 |
| CAPN8 | calpain 8 | -0.0369032 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0367403 |
| ECT2 | epithelial cell transforming 2 | -0.036712 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0360339 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0358421 |
| CLTC | clathrin, heavy chain (Hc) | -0.0358307 |
| S100A10 | S100 calcium binding protein A10 | -0.0347 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0346079 |
| RAB1A | RAB1A, member RAS oncogene family | -0.034596 |
| RBM39 | RNA binding motif protein 39 | -0.0343528 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.033898 |
| MORF4L2 | mortality factor 4 like 2 | -0.0336499 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0334869 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0334345 |
| TPM4 | tropomyosin 4 | -0.0331974 |
| CANX | calnexin | -0.0325688 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0325581 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | -0.032214 |
| MYO6 | myosin VI | -0.0321134 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | -0.0319582 |
| GOLGA4 | golgin A4 | -0.0314649 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0310158 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0307575 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0303653 |
| TOP1 | topoisomerase (DNA) I | -0.0296824 |
| TES | testin LIM domain protein | -0.0286688 |
| SLCO1B3 | solute carrier organic anion transporter family, member 1B3 | -0.0272482 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0270653 |
| ITGA6 | integrin, alpha 6 | -0.0267859 |
| SNX9 | sorting nexin 9 | -0.0266789 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0266737 |
| ACACA | acetyl-CoA carboxylase alpha | -0.0265318 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.026318 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0260412 |
| WWC1 | WW and C2 domain containing 1 | -0.0260242 |
| HM13 | histocompatibility (minor) 13 | -0.0256202 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0253339 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | -0.0252115 |
| ACTG1 | actin gamma 1 | -0.0250241 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0249757 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.024864 |
| CALU | calumenin | -0.0247845 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0244041 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0242958 |
| H1-0 | H1.0 linker histone | -0.0242362 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.024233 |
| PRKCA | protein kinase C, alpha | -0.0240251 |
| CDK6 | cyclin-dependent kinase 6 | -0.0240178 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0236247 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0236078 |
| TMSB10 | thymosin beta 10 | -0.0235087 |
| KRT19 | keratin 19, type I | -0.0234825 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | -0.0232689 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.023197 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | -0.0231961 |
| KIF5B | kinesin family member 5B | -0.0226718 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0225255 |
| CCDC47 | coiled-coil domain containing 47 | -0.0224556 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | -0.0223679 |
| ANXA1 | annexin A1 | -0.0223515 |
| RAB2A | RAB2A, member RAS oncogene family | -0.0217574 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0215525 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0212838 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.0212794 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.021218 |
