Cabozantinib (S-malate)_LOX-IMVI Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cabozantinib (S-malate) perturbation in LOX-IMVI cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cabozantinib (S-malate)_LOX-IMVI drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ACTG1 actin gamma 1 0.161769
EIF1 eukaryotic translation initiation factor 1 0.136343
SRRM2 serine/arginine repetitive matrix 2 0.118622
RPS6 ribosomal protein S6 0.108908
TMSB10 thymosin beta 10 0.0904633
HSPA8 heat shock 70kDa protein 8 0.0850996
RNF145 ring finger protein 145 0.074981
CD109 CD109 molecule 0.0742872
RPL23 ribosomal protein L23 0.0662298
PTPRG protein tyrosine phosphatase, receptor type, G 0.0638729
SMAD3 SMAD family member 3 0.0618086
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0610124
WDR43 WD repeat domain 43 0.059746
MMP12 matrix metallopeptidase 12 0.0596546
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0591722
NCOR2 nuclear receptor corepressor 2 0.0577262
RPL13A ribosomal protein L13a 0.0572646
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0566166
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0563501
LOC112694756 uncharaterized LOC112694756 0.0562382
ANKRD11 ankyrin repeat domain 11 0.0558815
EIF4B eukaryotic translation initiation factor 4B 0.0542052
OGA O-GlcNAcase 0.0541609
RPS20 ribosomal protein S20 0.0532795
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0531204
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0506241
NTM neurotrimin 0.0503441
PTK2 protein tyrosine kinase 2 0.0487589
NACA nascent polypeptide-associated complex alpha subunit 0.0484996
MPRIP myosin phosphatase Rho interacting protein 0.048114
PLEC plectin 0.0480841
ADAM9 ADAM metallopeptidase domain 9 0.0474754
SETD5 SET domain containing 5 0.0457534
MYH9 myosin, heavy chain 9, non-muscle 0.0448421
NRP2 neuropilin 2 0.0447452
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0423448
WSB1 WD repeat and SOCS box containing 1 0.0420197
PRRC2A proline-rich coiled-coil 2A 0.0414541
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0411396
RBM33 RNA binding motif protein 33 0.0411138
EEF2 eukaryotic translation elongation factor 2 0.0411089
FMNL2 formin-like 2 0.0408943
GNPDA1 glucosamine-6-phosphate deaminase 1 0.040577
RPL11 ribosomal protein L11 0.0404426
ADM adrenomedullin 0.0401587
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0395817
RPL21 ribosomal protein L21 0.0394962
COL6A2 collagen, type VI, alpha 2 0.0389159
FLNA filamin A, alpha 0.0388516
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 0.0386547
MIDEAS mitotic deacetylase associated SANT domain protein 0.038201
MED13L mediator complex subunit 13-like 0.0377538
NUP58 nucleoporin 58 0.0377529
WAC WW domain containing adaptor with coiled-coil 0.0370426
ENO2 enolase 2 (gamma, neuronal) 0.036945
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0368299
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0366791
BRD2 bromodomain containing 2 0.0366671
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0355719
YBX3 Y box binding protein 3 0.0348012
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0344309
PTMA prothymosin, alpha 0.0343698
CSTB cystatin B (stefin B) 0.0341535
PACS1 phosphofurin acidic cluster sorting protein 1 0.033969
USP3 ubiquitin specific peptidase 3 0.0337372
EIF3E eukaryotic translation initiation factor 3, subunit E 0.0336768
PRRC2C proline-rich coiled-coil 2C 0.0336625
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.033356
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0327768
PRKCE protein kinase C, epsilon 0.032743
PTCHD4 patched domain containing 4 0.0326221
RPL4 ribosomal protein L4 0.0323857
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0322084
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0321473
ARID1A AT rich interactive domain 1A (SWI-like) 0.0319429
PDE4D phosphodiesterase 4D, cAMP-specific 0.0316336
HELZ helicase with zinc finger 0.0313496
APP amyloid beta (A4) precursor protein 0.0311394
ZFAND3 zinc finger, AN1-type domain 3 0.0310508
CCNY cyclin Y 0.0303078
H1-0 H1.0 linker histone 0.0302298
RPS19 ribosomal protein S19 0.0299683
UGCG UDP-glucose ceramide glucosyltransferase 0.0298435
SCAF4 SR-related CTD-associated factor 4 0.0298347
ARHGAP21 Rho GTPase activating protein 21 0.029685
RPL19 ribosomal protein L19 0.0296194
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0294568
SAMD4A sterile alpha motif domain containing 4A 0.0288862
TRIO trio Rho guanine nucleotide exchange factor 0.0287333
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.0286053
TPM3 tropomyosin 3 0.028286
FOXJ3 forkhead box J3 0.0282218
SBF2 SET binding factor 2 0.0281364
CREBBP CREB binding protein 0.027914
HP1BP3 heterochromatin protein 1, binding protein 3 0.0275525
ELL elongation factor RNA polymerase II 0.0272619
CELF1 CUGBP, Elav-like family member 1 0.0272314
ASTN2 astrotactin 2 0.0271694
RPL28 ribosomal protein L28 0.0271586
AHNAK AHNAK nucleoprotein 0.0270741

decreased expression

Symbol Name Standardized Value
EXT1 exostosin glycosyltransferase 1 -0.148723
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.13318
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.126338
LDHA lactate dehydrogenase A -0.104503
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0889012
TXNRD1 thioredoxin reductase 1 -0.0780795
CALD1 caldesmon 1 -0.0757471
STC1 stanniocalcin 1 -0.0673318
SAMD3 sterile alpha motif domain containing 3 -0.0668304
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0655093
VIM vimentin -0.0634569
CFAP251 cilia and flagella associated protein 251 -0.0631023
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0613806
EFNA5 ephrin-A5 -0.0604704
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.059713
LIMA1 LIM domain and actin binding 1 -0.0586752
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0579002
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0571914
PRKG1 protein kinase, cGMP-dependent, type I -0.0560579
DDAH1 dimethylarginine dimethylaminohydrolase 1 -0.0559364
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.053766
RPS2 ribosomal protein S2 -0.0535167
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0528885
ALCAM activated leukocyte cell adhesion molecule -0.0502951
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0498272
NDRG1 N-myc downstream regulated 1 -0.0497973
ASPH aspartate beta-hydroxylase -0.0479733
DTNA dystrobrevin, alpha -0.0477902
USP34 ubiquitin specific peptidase 34 -0.0458372
ENO1 enolase 1, (alpha) -0.0456882
RPS24 ribosomal protein S24 -0.044831
ELL2 elongation factor, RNA polymerase II, 2 -0.0417708
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0407573
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0404757
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0384661
TM4SF1 transmembrane 4 L six family member 1 -0.0382937
TMPRSS15 transmembrane protease, serine 15 -0.0382765
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0371288
IPO7 importin 7 -0.0368346
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0357715
GLIPR1 GLI pathogenesis-related 1 -0.0349791
VGLL3 vestigial-like family member 3 -0.0346465
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0338589
NABP1 nucleic acid binding protein 1 -0.0331876
CD44 CD44 molecule (Indian blood group) -0.0330237
OSMR oncostatin M receptor -0.0329777
VDAC1 voltage-dependent anion channel 1 -0.0327563
ENKUR enkurin, TRPC channel interacting protein -0.0312717
BLZF1 basic leucine zipper nuclear factor 1 -0.030886
LIMCH1 LIM and calponin homology domains 1 -0.0304451
ERBIN erbb2 interacting protein -0.0300522
TPM4 tropomyosin 4 -0.029409
RTN4 reticulon 4 -0.0293194
KISS1 KiSS-1 metastasis-suppressor -0.0290102
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0284436
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0283432
IL6ST interleukin 6 signal transducer -0.0282548
BMAL2 basic helix-loop-helix ARNT like 2 -0.0281272
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.027047
PTPRD protein tyrosine phosphatase, receptor type, D -0.0267081
SMAP1 small ArfGAP 1 -0.0267007
POTEF POTE ankyrin domain family, member F -0.0266194
KLF6 Kruppel-like factor 6 -0.0260586
YES1 YES proto-oncogene 1, Src family tyrosine kinase -0.0258907
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0256541
TUBB6 tubulin, beta 6 class V -0.0255891
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.0254901
SERINC1 serine incorporator 1 -0.0253662
MAP1B microtubule-associated protein 1B -0.0253482
CD163L1 CD163 molecule-like 1 -0.025244
NRIP1 nuclear receptor interacting protein 1 -0.0252259
TNNC1 troponin C type 1 (slow) -0.0252104
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0250759
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0246661
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0244763
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0239225
VEPH1 ventricular zone expressed PH domain-containing 1 -0.0239218
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0236484
KDM7A lysine (K)-specific demethylase 7A -0.0227626
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.022468
ZNF207 zinc finger protein 207 -0.0219121
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0218356
PKM pyruvate kinase, muscle -0.0217173
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -0.0215571
STARD13 StAR-related lipid transfer (START) domain containing 13 -0.0215233
NT5E 5'-nucleotidase, ecto (CD73) -0.0214865
LMAN1 lectin, mannose-binding, 1 -0.0211815
FTL ferritin, light polypeptide -0.0207988
FAM162A family with sequence similarity 162, member A -0.0206767
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0206009
ITGA6 integrin, alpha 6 -0.0204864
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0204421
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0203436
SKP1 S-phase kinase-associated protein 1 -0.020282
JARID2 jumonji, AT rich interactive domain 2 -0.0197482
SAMD9 sterile alpha motif domain containing 9 -0.0195157
PTPN11 protein tyrosine phosphatase, non-receptor type 11 -0.0193744
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3 -0.0193561
TM9SF3 transmembrane 9 superfamily member 3 -0.0192496
SPATS2 spermatogenesis associated, serine-rich 2 -0.0192458