| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Cabozantinib (S-malate) perturbation in LS 180 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Cabozantinib (S-malate)_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.117894 |
| GPHN | gephyrin | 0.10624 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.101019 |
| RPS6 | ribosomal protein S6 | 0.100718 |
| GOLGA4 | golgin A4 | 0.0947868 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0943373 |
| RNF145 | ring finger protein 145 | 0.0921683 |
| MUC6 | mucin 6, oligomeric mucus/gel-forming | 0.089743 |
| VEGFA | vascular endothelial growth factor A | 0.0825435 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.076375 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0702016 |
| RNF43 | ring finger protein 43 | 0.0700245 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0662319 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0654574 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0641559 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0629495 |
| FAM13A | family with sequence similarity 13, member A | 0.0563381 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0556163 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0543879 |
| PTEN | phosphatase and tensin homolog | 0.053219 |
| CALR | calreticulin | 0.0525785 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0525588 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.0492126 |
| MLEC | malectin | 0.0489299 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0473444 |
| SETD5 | SET domain containing 5 | 0.0472412 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0465803 |
| MED13L | mediator complex subunit 13-like | 0.0460327 |
| RPS19 | ribosomal protein S19 | 0.0446031 |
| OGA | O-GlcNAcase | 0.0444223 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0440671 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0432323 |
| TXNIP | thioredoxin interacting protein | 0.041608 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0397589 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0397186 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0395256 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0393774 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0392401 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0389257 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.038822 |
| NEBL | nebulette | 0.0384651 |
| TRIM2 | tripartite motif containing 2 | 0.0383726 |
| CD46 | CD46 molecule, complement regulatory protein | 0.038244 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0380008 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0379395 |
| ESRP1 | epithelial splicing regulatory protein 1 | 0.037758 |
| NCOR1 | nuclear receptor corepressor 1 | 0.0376154 |
| DNM2 | dynamin 2 | 0.0373322 |
| MYO10 | myosin X | 0.0371538 |
| MON2 | MON2 homolog (S. cerevisiae) | 0.0368567 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | 0.036695 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0364828 |
| RPL23 | ribosomal protein L23 | 0.0360866 |
| ZNF292 | zinc finger protein 292 | 0.035774 |
| PTMA | prothymosin, alpha | 0.0355433 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0355431 |
| RBM39 | RNA binding motif protein 39 | 0.0352971 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | 0.0351324 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0350386 |
| PCM1 | pericentriolar material 1 | 0.0345931 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0342146 |
| PCBP2 | poly(rC) binding protein 2 | 0.0337272 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.033565 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | 0.0335041 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0334589 |
| LGR4 | leucine-rich repeat containing G protein-coupled receptor 4 | 0.0332156 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0327008 |
| FNBP1L | formin binding protein 1-like | 0.0319064 |
| PIGR | polymeric immunoglobulin receptor | 0.0315391 |
| IARS1 | isoleucyl-tRNA synthetase 1 | 0.0315176 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0313014 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0308932 |
| ETS2 | v-ets avian erythroblastosis virus E26 oncogene homolog 2 | 0.0307727 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0307475 |
| PCDHB16 | protocadherin beta 16 | 0.030576 |
| BTBD9 | BTB (POZ) domain containing 9 | 0.0305325 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | 0.0305307 |
| ITGA6 | integrin, alpha 6 | 0.0305179 |
| RAB3GAP1 | RAB3 GTPase activating protein subunit 1 (catalytic) | 0.0304938 |
| EPHB2 | EPH receptor B2 | 0.0304608 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0303055 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0301019 |
| COPA | coatomer protein complex, subunit alpha | 0.0296174 |
| USP3 | ubiquitin specific peptidase 3 | 0.0295502 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | 0.0293323 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | 0.0292229 |
| HELZ | helicase with zinc finger | 0.0292198 |
| S100P | S100 calcium binding protein P | 0.0291845 |
| CTBP2 | C-terminal binding protein 2 | 0.02918 |
| FOXJ3 | forkhead box J3 | 0.0291037 |
| RPLP2 | ribosomal protein, large, P2 | 0.0288581 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.0287915 |
| RPL36 | ribosomal protein L36 | 0.0287548 |
| RBCK1 | RanBP-type and C3HC4-type zinc finger containing 1 | 0.0287344 |
| RPL11 | ribosomal protein L11 | 0.0287136 |
| DERA | deoxyribose-phosphate aldolase (putative) | 0.028665 |
| MATR3 | matrin 3 | 0.0285834 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0285455 |
| SEL1L | sel-1 suppressor of lin-12-like (C. elegans) | 0.0284086 |
| COG5 | component of oligomeric golgi complex 5 | 0.0283496 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.165799 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.163351 |
| NPSR1 | neuropeptide S receptor 1 | -0.15006 |
| VCL | vinculin | -0.139555 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0892745 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0886896 |
| ANXA2 | annexin A2 | -0.0850819 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0797835 |
| MYO1E | myosin IE | -0.0788018 |
| LAMA4 | laminin, alpha 4 | -0.077937 |
| ONECUT3 | one cut homeobox 3 | -0.0778486 |
| TPM4 | tropomyosin 4 | -0.0753364 |
| GRIN2B | glutamate receptor, ionotropic, N-methyl D-aspartate 2B | -0.0741872 |
| GREB1L | growth regulation by estrogen in breast cancer-like | -0.0728966 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0697109 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0690312 |
| ASPH | aspartate beta-hydroxylase | -0.0683286 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0631931 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0589099 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0585902 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0539561 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0526375 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0522497 |
| FLNB | filamin B, beta | -0.051266 |
| AHNAK | AHNAK nucleoprotein | -0.0494196 |
| KRT18 | keratin 18, type I | -0.0486699 |
| IER3 | immediate early response 3 | -0.0464386 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0429301 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0422852 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | -0.0421165 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0417879 |
| KLF6 | Kruppel-like factor 6 | -0.041243 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0396843 |
| LDHA | lactate dehydrogenase A | -0.0389433 |
| USP53 | ubiquitin specific peptidase 53 | -0.03704 |
| KRT19 | keratin 19, type I | -0.0370207 |
| SLCO1B3-SLCO1B7 | SLCO1B3-SLCO1B7 readthrough | -0.0357006 |
| NAB1 | NGFI-A binding protein 1 (EGR1 binding protein 1) | -0.0355946 |
| EGFR | epidermal growth factor receptor | -0.0349028 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0343674 |
| PTPRB | protein tyrosine phosphatase, receptor type, B | -0.0342929 |
| ACTG1 | actin gamma 1 | -0.0341999 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0337464 |
| FERMT1 | fermitin family member 1 | -0.0336971 |
| EZR | ezrin | -0.0329656 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | -0.0329506 |
| RNF217 | ring finger protein 217 | -0.0327283 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0326358 |
| EMP1 | epithelial membrane protein 1 | -0.0325375 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.032441 |
| S100A6 | S100 calcium binding protein A6 | -0.0321443 |
| CCND1 | cyclin D1 | -0.0318903 |
| B4GALNT3 | beta-1,4-N-acetyl-galactosaminyl transferase 3 | -0.0307593 |
| PALLD | palladin, cytoskeletal associated protein | -0.0306898 |
| KLF5 | Kruppel-like factor 5 (intestinal) | -0.0304857 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.030435 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0293207 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0281222 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0272839 |
| RCOR1 | REST corepressor 1 | -0.0270738 |
| TFF1 | trefoil factor 1 | -0.0270558 |
| PCDH9 | protocadherin 9 | -0.0266722 |
| RPS24 | ribosomal protein S24 | -0.0266521 |
| ANXA3 | annexin A3 | -0.0262494 |
| LMO7 | LIM domain 7 | -0.026124 |
| MYOF | myoferlin | -0.0259739 |
| LAMC2 | laminin, gamma 2 | -0.0259366 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0256703 |
| S100A10 | S100 calcium binding protein A10 | -0.0253902 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0253638 |
| MUC17 | mucin 17, cell surface associated | -0.0253512 |
| MYH14 | myosin, heavy chain 14, non-muscle | -0.0250911 |
| SLC20A2 | solute carrier family 20 (phosphate transporter), member 2 | -0.02502 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0249529 |
| LRCH1 | leucine-rich repeats and calponin homology (CH) domain containing 1 | -0.0248342 |
| SH3D19 | SH3 domain containing 19 | -0.0244392 |
| ACTN4 | actinin, alpha 4 | -0.024405 |
| MARCHF3 | membrane associated ring-CH-type finger 3 | -0.0242029 |
| LAMB3 | laminin, beta 3 | -0.0241464 |
| CADPS | Ca++-dependent secretion activator | -0.0237354 |
| POF1B | premature ovarian failure, 1B | -0.0236289 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0236012 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0231628 |
| EHBP1 | EH domain binding protein 1 | -0.0231418 |
| ITPRID2 | ITPR interacting domain containing 2 | -0.0230687 |
| FRMD5 | FERM domain containing 5 | -0.0230612 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0225846 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | -0.0224676 |
| IGFL2 | IGF-like family member 2 | -0.0224498 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0223364 |
| CLOCK | clock circadian regulator | -0.0221158 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0219618 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0219344 |
| EGR1 | early growth response 1 | -0.021889 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | -0.0218022 |
| RIGI | RNA sensor RIG-I | -0.0216302 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0215321 |
| EFNB2 | ephrin-B2 | -0.0215047 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | -0.0213959 |
| IFRD1 | interferon-related developmental regulator 1 | -0.0211024 |
