| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Cabozantinib (S-malate) perturbation in LoVo cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Cabozantinib (S-malate)_LoVo drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| RPS6 | ribosomal protein S6 | 0.172836 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.160455 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.159082 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.125914 |
| LGR5 | leucine-rich repeat containing G protein-coupled receptor 5 | 0.103481 |
| CCSER1 | coiled-coil serine-rich protein 1 | 0.0985536 |
| PRELID2 | PRELI domain containing 2 | 0.0826895 |
| PTPN13 | protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) | 0.0753357 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0722708 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0720871 |
| PTPRR | protein tyrosine phosphatase, receptor type, R | 0.0719525 |
| RAD51B | RAD51 paralog B | 0.0718912 |
| RPL21 | ribosomal protein L21 | 0.0707469 |
| GCNT3 | glucosaminyl (N-acetyl) transferase 3, mucin type | 0.0695922 |
| FAT1 | FAT atypical cadherin 1 | 0.0678462 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0664979 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0662522 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0619229 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0605555 |
| RNF145 | ring finger protein 145 | 0.0571548 |
| EGFR | epidermal growth factor receptor | 0.0568509 |
| RPL3 | ribosomal protein L3 | 0.0565999 |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | 0.0557189 |
| RPS19 | ribosomal protein S19 | 0.0556791 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0556371 |
| SPON1 | spondin 1, extracellular matrix protein | 0.0524621 |
| ETV6 | ets variant 6 | 0.0523865 |
| RPL23 | ribosomal protein L23 | 0.051713 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0513644 |
| PCBP2 | poly(rC) binding protein 2 | 0.0512421 |
| NOS1AP | nitric oxide synthase 1 (neuronal) adaptor protein | 0.0510797 |
| VPS13C | vacuolar protein sorting 13 homolog C (S. cerevisiae) | 0.0490411 |
| HLA-B | major histocompatibility complex, class I, B | 0.0486975 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0482512 |
| FOXO1 | forkhead box O1 | 0.0469869 |
| RPL28 | ribosomal protein L28 | 0.046862 |
| TNRC18 | trinucleotide repeat containing 18 | 0.0456947 |
| ATXN1 | ataxin 1 | 0.0456345 |
| UTRN | utrophin | 0.0455081 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0437322 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0436868 |
| MAP7 | microtubule-associated protein 7 | 0.0429821 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | 0.0423325 |
| RPL13A | ribosomal protein L13a | 0.0421165 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.041758 |
| RPS20 | ribosomal protein S20 | 0.0410839 |
| RPS12 | ribosomal protein S12 | 0.0402218 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0396965 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0389675 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.0386082 |
| RPL4 | ribosomal protein L4 | 0.0384517 |
| KIF16B | kinesin family member 16B | 0.0383818 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0383261 |
| VEGFA | vascular endothelial growth factor A | 0.0380267 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.037495 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | 0.037382 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0372296 |
| ATP8A1 | ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 | 0.0371667 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | 0.0371347 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0368804 |
| FOXP1 | forkhead box P1 | 0.0365995 |
| NEBL | nebulette | 0.0364991 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0363291 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0362487 |
| ACTG1 | actin gamma 1 | 0.0354914 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | 0.0353294 |
| FAM13A | family with sequence similarity 13, member A | 0.0349719 |
| RPS27 | ribosomal protein S27 | 0.0348239 |
| LOC105378220 | macrophage receptor MARCO-like | 0.033977 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0339234 |
| DAPK1 | death-associated protein kinase 1 | 0.0337569 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0336928 |
| IRS2 | insulin receptor substrate 2 | 0.0334417 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | 0.0329778 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0316951 |
| CCPG1 | cell cycle progression 1 | 0.0313269 |
| RFX3 | regulatory factor X, 3 (influences HLA class II expression) | 0.0309559 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0308939 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0308066 |
| UST | uronyl-2-sulfotransferase | 0.0305967 |
| CFTR | cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) | 0.0305717 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0305467 |
| ITGB4 | integrin, beta 4 | 0.0300458 |
| BRD2 | bromodomain containing 2 | 0.029412 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0291584 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.029061 |
| HLA-A | major histocompatibility complex, class I, A | 0.0290468 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | 0.0289331 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0286808 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0285424 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.0284565 |
| DST | dystonin | 0.0283543 |
| RPL8 | ribosomal protein L8 | 0.0282648 |
| KMT2D | lysine (K)-specific methyltransferase 2D | 0.0278124 |
| RPL37 | ribosomal protein L37 | 0.027636 |
| SMAD3 | SMAD family member 3 | 0.0275669 |
| RPS8 | ribosomal protein S8 | 0.0275668 |
| RPL37A | ribosomal protein L37a | 0.0275384 |
| KIZ | kizuna centrosomal protein | 0.0272574 |
| GOLGB1 | golgin B1 | 0.0270115 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.167901 |
| ANXA2 | annexin A2 | -0.120563 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.10691 |
| MYOF | myoferlin | -0.101285 |
| EZR | ezrin | -0.100852 |
| FLNB | filamin B, beta | -0.0925065 |
| SLCO1B3 | solute carrier organic anion transporter family, member 1B3 | -0.092265 |
| TXNRD1 | thioredoxin reductase 1 | -0.091833 |
| MSI2 | musashi RNA-binding protein 2 | -0.0915632 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0872646 |
| RPLP1 | ribosomal protein, large, P1 | -0.0786178 |
| TMSB10 | thymosin beta 10 | -0.0782436 |
| LAMB3 | laminin, beta 3 | -0.0766444 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0598922 |
| PKM | pyruvate kinase, muscle | -0.0572147 |
| ACTN4 | actinin, alpha 4 | -0.0525266 |
| RPS24 | ribosomal protein S24 | -0.051286 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0510694 |
| EREG | epiregulin | -0.0509109 |
| VCL | vinculin | -0.0496801 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0495248 |
| TC2N | tandem C2 domains, nuclear | -0.0481268 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0478759 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0471427 |
| RHPN2 | rhophilin, Rho GTPase binding protein 2 | -0.0463902 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0462131 |
| SERPINB5 | serpin peptidase inhibitor, clade B (ovalbumin), member 5 | -0.0460436 |
| LAMA4 | laminin, alpha 4 | -0.0439334 |
| S100A10 | S100 calcium binding protein A10 | -0.0436083 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | -0.0386226 |
| OXSR1 | oxidative stress responsive 1 | -0.037605 |
| RPLP0 | ribosomal protein, large, P0 | -0.0359022 |
| EPCAM | epithelial cell adhesion molecule | -0.0353725 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.035216 |
| SLCO1B3-SLCO1B7 | SLCO1B3-SLCO1B7 readthrough | -0.0351595 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0349712 |
| RRBP1 | ribosome binding protein 1 | -0.0349247 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0344229 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.034411 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0342802 |
| EMP1 | epithelial membrane protein 1 | -0.034191 |
| DSG3 | desmoglein 3 | -0.034162 |
| IER3 | immediate early response 3 | -0.0331324 |
| CLOCK | clock circadian regulator | -0.0326372 |
| PTMA | prothymosin, alpha | -0.032446 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0323344 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0304291 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0303885 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0301399 |
| SPAG9 | sperm associated antigen 9 | -0.0299178 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0292611 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0292269 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | -0.0291982 |
| C6ORF132 | chromosome 6 open reading frame 132 | -0.0290913 |
| PPARG | peroxisome proliferator-activated receptor gamma | -0.0290728 |
| FERMT1 | fermitin family member 1 | -0.0287733 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0274049 |
| IFRD1 | interferon-related developmental regulator 1 | -0.0270725 |
| LMNA | lamin A/C | -0.027026 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0266862 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0264889 |
| CCND1 | cyclin D1 | -0.026417 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0263764 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0263582 |
| KRT19 | keratin 19, type I | -0.0261316 |
| P3H2 | prolyl 3-hydroxylase 2 | -0.0261293 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0260046 |
| PRSS3 | protease, serine, 3 | -0.025256 |
| MATR3 | matrin 3 | -0.0251334 |
| AHNAK | AHNAK nucleoprotein | -0.0250816 |
| PCDHB16 | protocadherin beta 16 | -0.0246493 |
| MTDH | metadherin | -0.0246143 |
| MORF4L2 | mortality factor 4 like 2 | -0.0245297 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | -0.0245033 |
| ARF1 | ADP-ribosylation factor 1 | -0.0245007 |
| MKI67 | marker of proliferation Ki-67 | -0.0244997 |
| CCNI | cyclin I | -0.0243031 |
| RIGI | RNA sensor RIG-I | -0.0242722 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | -0.0240787 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0238562 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0237699 |
| SERINC5 | serine incorporator 5 | -0.023653 |
| GDF15 | growth differentiation factor 15 | -0.0235568 |
| KRT8 | keratin 8, type II | -0.0234939 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0233707 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.023317 |
| AHCYL2 | adenosylhomocysteinase-like 2 | -0.0230625 |
| SLMAP | sarcolemma associated protein | -0.0229548 |
| COPS2 | COP9 signalosome subunit 2 | -0.0227891 |
| MYO5B | myosin VB | -0.0227138 |
| CALU | calumenin | -0.0225409 |
| RPL6 | ribosomal protein L6 | -0.0224708 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0224475 |
| RTN4 | reticulon 4 | -0.0224299 |
| NPR2 | natriuretic peptide receptor 2 | -0.0224186 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0222905 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0221999 |
| EPB41L1 | erythrocyte membrane protein band 4.1-like 1 | -0.0221981 |
| SKP1 | S-phase kinase-associated protein 1 | -0.0221476 |
| HEPH | hephaestin | -0.0220932 |
