| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Cabozantinib (S-malate) perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Cabozantinib (S-malate)_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ACTG1 | actin gamma 1 | 0.137979 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.127721 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.119402 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0939857 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0914179 |
| HLA-B | major histocompatibility complex, class I, B | 0.0906869 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0904928 |
| ZDHHC14 | zinc finger, DHHC-type containing 14 | 0.0859776 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.083359 |
| LOC112694756 | uncharaterized LOC112694756 | 0.079753 |
| TMSB4X | thymosin beta 4, X-linked | 0.0782316 |
| TMSB10 | thymosin beta 10 | 0.076702 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0723036 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0712003 |
| PGK1 | phosphoglycerate kinase 1 | 0.0699163 |
| TSC22D1 | TSC22 domain family, member 1 | 0.0695981 |
| EXOC4 | exocyst complex component 4 | 0.068735 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | 0.0673036 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0672661 |
| TNS3 | tensin 3 | 0.067155 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0659739 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0650846 |
| EHBP1 | EH domain binding protein 1 | 0.0642226 |
| RAD51B | RAD51 paralog B | 0.0630502 |
| RPL35A | ribosomal protein L35a | 0.0613083 |
| RNF213 | ring finger protein 213 | 0.0602913 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0596541 |
| RPL23 | ribosomal protein L23 | 0.0571845 |
| CADM2 | cell adhesion molecule 2 | 0.055052 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0548172 |
| DPYD | dihydropyrimidine dehydrogenase | 0.0541021 |
| PLEKHA4 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 | 0.0519651 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0507567 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | 0.0502356 |
| PODXL | podocalyxin-like | 0.0498715 |
| RUNX1 | runt-related transcription factor 1 | 0.0497145 |
| SMYD3 | SET and MYND domain containing 3 | 0.0494773 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | 0.0492755 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0490826 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0486499 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | 0.0473068 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 0.0470107 |
| SQSTM1 | sequestosome 1 | 0.0469677 |
| EFNA5 | ephrin-A5 | 0.0463833 |
| ZNF638 | zinc finger protein 638 | 0.045285 |
| GNGT1 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | 0.0445804 |
| EPHA4 | EPH receptor A4 | 0.0444782 |
| ITGB4 | integrin, beta 4 | 0.0434119 |
| CALR | calreticulin | 0.0424317 |
| BCAS3 | breast carcinoma amplified sequence 3 | 0.0420949 |
| TP63 | tumor protein p63 | 0.0415641 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0408832 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | 0.0404301 |
| PLEC | plectin | 0.0402797 |
| CSMD3 | CUB and Sushi multiple domains 3 | 0.0401406 |
| PRG2 | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) | 0.0396553 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0396316 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0392336 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | 0.0385594 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.0383345 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0378117 |
| BPTF | bromodomain PHD finger transcription factor | 0.0377309 |
| WDR27 | WD repeat domain 27 | 0.0376695 |
| PATJ | PATJ crumbs cell polarity complex component | 0.0371591 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.036325 |
| HLA-A | major histocompatibility complex, class I, A | 0.0362236 |
| RPL28 | ribosomal protein L28 | 0.0353598 |
| MIDEAS | mitotic deacetylase associated SANT domain protein | 0.0353481 |
| PTMA | prothymosin, alpha | 0.0349399 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0348932 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0348502 |
| PRRC2A | proline-rich coiled-coil 2A | 0.0346126 |
| PRRC2B | proline-rich coiled-coil 2B | 0.0345484 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.0343403 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0342914 |
| FLNB | filamin B, beta | 0.0340938 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0337711 |
| CEP250 | centrosomal protein 250kDa | 0.033736 |
| KIRREL1 | kirre like nephrin family adhesion molecule 1 | 0.0335247 |
| EGR1 | early growth response 1 | 0.0334321 |
| DOCK11 | dedicator of cytokinesis 11 | 0.0332749 |
| SMAD3 | SMAD family member 3 | 0.0332374 |
| CNIH3 | cornichon family AMPA receptor auxiliary protein 3 | 0.0331514 |
| C6ORF62 | chromosome 6 open reading frame 62 | 0.0331507 |
| LOXL2 | lysyl oxidase-like 2 | 0.0330699 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0327558 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0327401 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0317888 |
| NR2F1 | nuclear receptor subfamily 2, group F, member 1 | 0.0316158 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0315527 |
| SON | SON DNA binding protein | 0.0315036 |
| RPS6 | ribosomal protein S6 | 0.0314995 |
| ECE1 | endothelin converting enzyme 1 | 0.0313823 |
| TTC28 | tetratricopeptide repeat domain 28 | 0.031162 |
| FNIP1 | folliculin interacting protein 1 | 0.0309721 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | 0.0305725 |
| YEATS2 | YEATS domain containing 2 | 0.0302976 |
| TRERF1 | transcriptional regulating factor 1 | 0.0298523 |
| GOLGA4 | golgin A4 | 0.0298365 |
| RPL19 | ribosomal protein L19 | 0.0296719 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.208962 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.199571 |
| TXNRD1 | thioredoxin reductase 1 | -0.109143 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.108572 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0849051 |
| VIM | vimentin | -0.0838295 |
| SPAG9 | sperm associated antigen 9 | -0.0836354 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0688528 |
| RPS2 | ribosomal protein S2 | -0.0611698 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0599325 |
| KLF6 | Kruppel-like factor 6 | -0.0570913 |
| RAI1 | retinoic acid induced 1 | -0.056405 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0490264 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0469805 |
| EREG | epiregulin | -0.0468252 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0456343 |
| ZNF217 | zinc finger protein 217 | -0.0450908 |
| RTN4 | reticulon 4 | -0.0448479 |
| EZR | ezrin | -0.0437132 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0422744 |
| IPO7 | importin 7 | -0.0418724 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0412912 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0410053 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0393937 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0384479 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0383596 |
| MT2A | metallothionein 2A | -0.0380923 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0367371 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | -0.0359811 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0349042 |
| USP34 | ubiquitin specific peptidase 34 | -0.0348619 |
| CDCP1 | CUB domain containing protein 1 | -0.0337103 |
| POTEF | POTE ankyrin domain family, member F | -0.0336166 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.033039 |
| BIRC2 | baculoviral IAP repeat containing 2 | -0.0328525 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0324608 |
| USP12 | ubiquitin specific peptidase 12 | -0.0317417 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0310473 |
| TSC22D2 | TSC22 domain family, member 2 | -0.03087 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | -0.0307893 |
| ADAM17 | ADAM metallopeptidase domain 17 | -0.0306524 |
| ANLN | anillin, actin binding protein | -0.030087 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0296304 |
| RASAL2 | RAS protein activator like 2 | -0.0295334 |
| EMP1 | epithelial membrane protein 1 | -0.0286451 |
| TRIP12 | thyroid hormone receptor interactor 12 | -0.028637 |
| DNM1L | dynamin 1-like | -0.0281631 |
| CLTC | clathrin, heavy chain (Hc) | -0.0279709 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0265668 |
| ZNF207 | zinc finger protein 207 | -0.0261916 |
| RYBP | RING1 and YY1 binding protein | -0.0253175 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | -0.0248713 |
| GOLT1B | golgi transport 1B | -0.0248593 |
| CCT8 | chaperonin containing TCP1, subunit 8 (theta) | -0.024514 |
| ANXA1 | annexin A1 | -0.0240388 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0239593 |
| ECT2 | epithelial cell transforming 2 | -0.023897 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0238763 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0236024 |
| HOOK2 | hook microtubule-tethering protein 2 | -0.0234567 |
| FERMT1 | fermitin family member 1 | -0.0234448 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | -0.0233308 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0232511 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0229187 |
| NCKAP1 | NCK-associated protein 1 | -0.0228424 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0227387 |
| PAPOLA | poly(A) polymerase alpha | -0.022665 |
| HNRNPK | heterogeneous nuclear ribonucleoprotein K | -0.0225731 |
| NUP58 | nucleoporin 58 | -0.02255 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0222221 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0220952 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0220731 |
| RIOK3 | RIO kinase 3 | -0.0218606 |
| SEPTIN7 | septin 7 | -0.0216114 |
| ARL5B | ADP-ribosylation factor-like 5B | -0.0215969 |
| TFRC | transferrin receptor | -0.0214759 |
| SKP1 | S-phase kinase-associated protein 1 | -0.0214693 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | -0.0213729 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0213463 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | -0.0211909 |
| CSE1L | CSE1 chromosome segregation 1-like (yeast) | -0.0211393 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0210971 |
| CCT6A | chaperonin containing TCP1, subunit 6A (zeta 1) | -0.0210748 |
| RBM39 | RNA binding motif protein 39 | -0.0208428 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0207615 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0207519 |
| ANGPTL4 | angiopoietin-like 4 | -0.0207022 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0206985 |
| IL6ST | interleukin 6 signal transducer | -0.0206763 |
| WDR45B | WD repeat domain 45B | -0.0205387 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | -0.0204201 |
| OLA1 | Obg-like ATPase 1 | -0.0204147 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0204103 |
| RECQL | RecQ helicase-like | -0.0203309 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | -0.0202832 |
| SRGN | serglycin | -0.0202522 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0202003 |
| DDX50 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 50 | -0.0201429 |
| CHD1 | chromodomain helicase DNA binding protein 1 | -0.0200989 |
| RPS24 | ribosomal protein S24 | -0.0200091 |
