| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Cabozantinib (S-malate) perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Cabozantinib (S-malate)_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EGFR | epidermal growth factor receptor | 0.363794 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.128316 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.103909 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.102645 |
| FAM13A | family with sequence similarity 13, member A | 0.0989945 |
| SMAD3 | SMAD family member 3 | 0.0868292 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0802062 |
| ASPH | aspartate beta-hydroxylase | 0.0792497 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0711937 |
| PLEC | plectin | 0.0699526 |
| TMSB10 | thymosin beta 10 | 0.0676454 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0657068 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0636427 |
| PKM | pyruvate kinase, muscle | 0.0630969 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.0604752 |
| VOPP1 | vesicular, overexpressed in cancer, prosurvival protein 1 | 0.0596931 |
| RNF213 | ring finger protein 213 | 0.0588969 |
| ZNF638 | zinc finger protein 638 | 0.0583836 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0577167 |
| CPE | carboxypeptidase E | 0.0568735 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0565452 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.056299 |
| CES1 | carboxylesterase 1 | 0.0560267 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0553897 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0547235 |
| LRP1B | low density lipoprotein receptor-related protein 1B | 0.0542109 |
| RNF145 | ring finger protein 145 | 0.0535249 |
| RPS3 | ribosomal protein S3 | 0.0521257 |
| AFF1 | AF4/FMR2 family, member 1 | 0.051623 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | 0.0513803 |
| KRT18 | keratin 18, type I | 0.0512382 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | 0.0509821 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0508343 |
| B2M | beta-2-microglobulin | 0.0507924 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0504141 |
| KRT7 | keratin 7, type II | 0.0480833 |
| PTEN | phosphatase and tensin homolog | 0.0467316 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.046039 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0453667 |
| RAD51B | RAD51 paralog B | 0.0453528 |
| IRS2 | insulin receptor substrate 2 | 0.0452177 |
| PGK1 | phosphoglycerate kinase 1 | 0.0452132 |
| TNRC6B | trinucleotide repeat containing 6B | 0.0448364 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0439906 |
| ARHGAP32 | Rho GTPase activating protein 32 | 0.0437845 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0432963 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0425178 |
| TMCO3 | transmembrane and coiled-coil domains 3 | 0.0418481 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0415315 |
| PCBP2 | poly(rC) binding protein 2 | 0.0413178 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0407143 |
| HYOU1 | hypoxia up-regulated 1 | 0.040672 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | 0.0406189 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0402951 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0401235 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | 0.0396976 |
| RPS6 | ribosomal protein S6 | 0.0392529 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0376504 |
| ENO1 | enolase 1, (alpha) | 0.0370922 |
| KRT8 | keratin 8, type II | 0.0368744 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.036826 |
| CST3 | cystatin C | 0.0365465 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | 0.0364759 |
| LGALS12 | lectin, galactoside-binding, soluble, 12 | 0.0362662 |
| OGA | O-GlcNAcase | 0.0361262 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0358603 |
| PER2 | period circadian clock 2 | 0.0345295 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0344302 |
| MYOF | myoferlin | 0.0336246 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.033623 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0335348 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0335346 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0332127 |
| GPC6 | glypican 6 | 0.0330396 |
| TNRC6A | trinucleotide repeat containing 6A | 0.0327986 |
| HLA-A | major histocompatibility complex, class I, A | 0.0327208 |
| GRB10 | growth factor receptor-bound protein 10 | 0.032683 |
| SETD5 | SET domain containing 5 | 0.0326468 |
| RPL11 | ribosomal protein L11 | 0.0324137 |
| NCOA3 | nuclear receptor coactivator 3 | 0.03186 |
| TPD52 | tumor protein D52 | 0.0317402 |
| APP | amyloid beta (A4) precursor protein | 0.0316006 |
| TMEM165 | transmembrane protein 165 | 0.0313902 |
| RPL37A | ribosomal protein L37a | 0.0313738 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0313428 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | 0.0313095 |
| KMT2D | lysine (K)-specific methyltransferase 2D | 0.0305966 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.030566 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0303922 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.0300027 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0299783 |
| PHF21A | PHD finger protein 21A | 0.0298103 |
| FOXP1 | forkhead box P1 | 0.0297328 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0297261 |
| PRKCA | protein kinase C, alpha | 0.029613 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0295759 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0294571 |
| HLA-B | major histocompatibility complex, class I, B | 0.0294475 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0292014 |
| VEGFA | vascular endothelial growth factor A | 0.0288756 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TXNRD1 | thioredoxin reductase 1 | -0.128562 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.097373 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0839662 |
| NABP1 | nucleic acid binding protein 1 | -0.0761813 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0697341 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0654531 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0623311 |
| SPAG9 | sperm associated antigen 9 | -0.0600743 |
| OSMR | oncostatin M receptor | -0.0588449 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0569825 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0537286 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0516882 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0453226 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0445962 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0414752 |
| LAMC2 | laminin, gamma 2 | -0.0403423 |
| CDCP1 | CUB domain containing protein 1 | -0.0402947 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | -0.037167 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0371255 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0361779 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0358367 |
| TES | testin LIM domain protein | -0.035516 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | -0.035385 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0332488 |
| IER3 | immediate early response 3 | -0.031877 |
| RTN4 | reticulon 4 | -0.0318303 |
| SLTM | SAFB-like, transcription modulator | -0.0315822 |
| STC1 | stanniocalcin 1 | -0.0310572 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0309343 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0301635 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0297409 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0297373 |
| MORF4L2 | mortality factor 4 like 2 | -0.0272202 |
| LAMA4 | laminin, alpha 4 | -0.0271496 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.027134 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0267493 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0265107 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0265084 |
| ARL5B | ADP-ribosylation factor-like 5B | -0.0257752 |
| GM2A | GM2 ganglioside activator | -0.0253501 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.02501 |
| ECD | ecdysoneless homolog (Drosophila) | -0.0238372 |
| NGLY1 | N-glycanase 1 | -0.0230934 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0230569 |
| GPATCH2L | G patch domain containing 2-like | -0.0227975 |
| RASA2 | RAS p21 protein activator 2 | -0.0225375 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0224021 |
| FAM110C | family with sequence similarity 110, member C | -0.0223939 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0221136 |
| USP34 | ubiquitin specific peptidase 34 | -0.021993 |
| DTNA | dystrobrevin, alpha | -0.0217168 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.0212584 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0206416 |
| VCL | vinculin | -0.0206174 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0204407 |
| RPS24 | ribosomal protein S24 | -0.0203764 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | -0.0201864 |
| FOSL1 | FOS-like antigen 1 | -0.0197804 |
| KDM7A | lysine (K)-specific demethylase 7A | -0.0195982 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.0195129 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0193856 |
| SEPTIN10 | septin 10 | -0.0193043 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0190872 |
| SENP5 | SUMO1/sentrin specific peptidase 5 | -0.0190449 |
| ATG7 | autophagy related 7 | -0.0190413 |
| HOOK2 | hook microtubule-tethering protein 2 | -0.0190107 |
| ATP13A3 | ATPase type 13A3 | -0.0187357 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0186256 |
| ABLIM1 | actin binding LIM protein 1 | -0.0186055 |
| USP53 | ubiquitin specific peptidase 53 | -0.0185642 |
| NSUN6 | NOP2/Sun domain family, member 6 | -0.0184805 |
| TPTEP2-CSNK1E | TPTEP2-CSNK1E readthrough | -0.0184347 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0183969 |
| SYAP1 | synapse associated protein 1 | -0.0182922 |
| ZFAND6 | zinc finger, AN1-type domain 6 | -0.0179864 |
| OXSR1 | oxidative stress responsive 1 | -0.0179739 |
| ZC3H11A | zinc finger CCCH-type containing 11A | -0.0178875 |
| FBXO11 | F-box protein 11 | -0.0175301 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0171238 |
| ANKLE2 | ankyrin repeat and LEM domain containing 2 | -0.0170379 |
| ZNF217 | zinc finger protein 217 | -0.0169121 |
| VEZT | vezatin, adherens junctions transmembrane protein | -0.0166477 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0164493 |
| CCNL1 | cyclin L1 | -0.0162903 |
| ARF1 | ADP-ribosylation factor 1 | -0.0159864 |
| SLC20A2 | solute carrier family 20 (phosphate transporter), member 2 | -0.0159831 |
| FGD6 | FYVE, RhoGEF and PH domain containing 6 | -0.0158555 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0156641 |
| NF1 | neurofibromin 1 | -0.0156321 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0155632 |
| DAPP1 | dual adaptor of phosphotyrosine and 3-phosphoinositides | -0.0154148 |
| SP100 | SP100 nuclear antigen | -0.0153278 |
| TJP1 | tight junction protein 1 | -0.0152423 |
| HMGA2 | high mobility group AT-hook 2 | -0.0151855 |
| MYO1B | myosin IB | -0.0148244 |
| RYBP | RING1 and YY1 binding protein | -0.0146151 |
| JMJD1C | jumonji domain containing 1C | -0.0143459 |
| HBP1 | HMG-box transcription factor 1 | -0.0140487 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0139922 |
| SRP72 | signal recognition particle 72kDa | -0.0138948 |
