| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Cabozantinib (S-malate) perturbation in NCI-H1792 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Cabozantinib (S-malate)_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NAMPT | nicotinamide phosphoribosyltransferase | 0.15486 |
| SMAD3 | SMAD family member 3 | 0.0973398 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.090526 |
| PCBP2 | poly(rC) binding protein 2 | 0.0599051 |
| RBM39 | RNA binding motif protein 39 | 0.0570652 |
| GOLGA4 | golgin A4 | 0.0547343 |
| FAM13A | family with sequence similarity 13, member A | 0.0542061 |
| OGA | O-GlcNAcase | 0.0528104 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0525465 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0500391 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.048927 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0447315 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0429227 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0399335 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0384164 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0383048 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0380154 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0360762 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0349406 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0341584 |
| PARP8 | poly (ADP-ribose) polymerase family, member 8 | 0.0330017 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0327674 |
| DPYSL3 | dihydropyrimidinase-like 3 | 0.0327379 |
| ATP13A3 | ATPase type 13A3 | 0.0324607 |
| ZNF292 | zinc finger protein 292 | 0.0324254 |
| YBX3 | Y box binding protein 3 | 0.0313644 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0312942 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0311885 |
| SBF2 | SET binding factor 2 | 0.0306893 |
| USP3 | ubiquitin specific peptidase 3 | 0.0296109 |
| HELZ | helicase with zinc finger | 0.0290527 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0288308 |
| RNF145 | ring finger protein 145 | 0.0283534 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0283331 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0278835 |
| OS9 | osteosarcoma amplified 9, endoplasmic reticulum lectin | 0.0271474 |
| KYNU | kynureninase | 0.0265776 |
| RUNX1 | runt-related transcription factor 1 | 0.0263443 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0261223 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0259645 |
| SETD5 | SET domain containing 5 | 0.025935 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | 0.0254 |
| FOXO3 | forkhead box O3 | 0.0251603 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0247816 |
| COPA | coatomer protein complex, subunit alpha | 0.0244639 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0242985 |
| SPAG9 | sperm associated antigen 9 | 0.0242624 |
| XPO1 | exportin 1 | 0.0241126 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.023912 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0237354 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0233524 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.0233353 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0233235 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | 0.0229369 |
| SLTM | SAFB-like, transcription modulator | 0.0228619 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0226572 |
| SRP54 | signal recognition particle 54kDa | 0.0225278 |
| CD109 | CD109 molecule | 0.0225078 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0224068 |
| FLNB | filamin B, beta | 0.0223296 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0221304 |
| ZNF638 | zinc finger protein 638 | 0.0221091 |
| AOPEP | aminopeptidase O (putative) | 0.0220947 |
| RNF24 | ring finger protein 24 | 0.0219149 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.0216222 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0215378 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0215051 |
| SIK3 | SIK family kinase 3 | 0.0213406 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0212957 |
| TPR | translocated promoter region, nuclear basket protein | 0.0212521 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | 0.021126 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0210998 |
| MIS18BP1 | MIS18 binding protein 1 | 0.0210449 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | 0.0210026 |
| TGM2 | transglutaminase 2 | 0.0208304 |
| CABIN1 | calcineurin binding protein 1 | 0.0208269 |
| SYAP1 | synapse associated protein 1 | 0.020692 |
| STRN3 | striatin, calmodulin binding protein 3 | 0.0205872 |
| FBXL13 | F-box and leucine-rich repeat protein 13 | 0.0203251 |
| APP | amyloid beta (A4) precursor protein | 0.0202496 |
| PTBP2 | polypyrimidine tract binding protein 2 | 0.0200349 |
| RBM25 | RNA binding motif protein 25 | 0.019979 |
| ADM | adrenomedullin | 0.0199025 |
| ELP2 | elongator acetyltransferase complex subunit 2 | 0.0198287 |
| TTLL10 | tubulin tyrosine ligase-like family member 10 | 0.0197014 |
| CDH2 | cadherin 2, type 1, N-cadherin (neuronal) | 0.019686 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0194051 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0193647 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0192792 |
| NBAS | neuroblastoma amplified sequence | 0.0190283 |
| COG5 | component of oligomeric golgi complex 5 | 0.0189473 |
| YEATS2 | YEATS domain containing 2 | 0.0187974 |
| NAV2 | neuron navigator 2 | 0.0186395 |
| YTHDC1 | YTH domain containing 1 | 0.0186162 |
| RAB8B | RAB8B, member RAS oncogene family | 0.018496 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0184638 |
| KIF5B | kinesin family member 5B | 0.0184508 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.0182809 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | 0.0182286 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0181173 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.146766 |
| VIM | vimentin | -0.129506 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.102594 |
| LOX | lysyl oxidase | -0.10227 |
| CDH13 | cadherin 13 | -0.0979069 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | -0.0972974 |
| HMGA2 | high mobility group AT-hook 2 | -0.0947532 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0877203 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0728487 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0714483 |
| TMSB10 | thymosin beta 10 | -0.0701735 |
| STC1 | stanniocalcin 1 | -0.0671869 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0609987 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0592546 |
| MTSS1 | metastasis suppressor 1 | -0.0572469 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0569304 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0535804 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0534126 |
| NRG1 | neuregulin 1 | -0.0525472 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0485834 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0485675 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0480335 |
| MSRB3 | methionine sulfoxide reductase B3 | -0.0450939 |
| GLCCI1 | glucocorticoid induced 1 | -0.0448529 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0445781 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0442891 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0421693 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0421621 |
| FAM20C | family with sequence similarity 20, member C | -0.0412546 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0410289 |
| ENO1 | enolase 1, (alpha) | -0.0410086 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0397708 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0382592 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0379085 |
| AADAC | arylacetamide deacetylase | -0.0365412 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0362212 |
| RAI14 | retinoic acid induced 14 | -0.0345993 |
| CLMP | CXADR-like membrane protein | -0.0335025 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0318425 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0317312 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0315217 |
| ASPH | aspartate beta-hydroxylase | -0.0309645 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0308159 |
| INTS6 | integrator complex subunit 6 | -0.0302856 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | -0.0299111 |
| ITGB3 | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | -0.0297268 |
| MEF2A | myocyte enhancer factor 2A | -0.0296654 |
| ZNF804A | zinc finger protein 804A | -0.0289913 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.028813 |
| DST | dystonin | -0.0282458 |
| CDK14 | cyclin-dependent kinase 14 | -0.0282245 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0281975 |
| OXR1 | oxidation resistance 1 | -0.0281944 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0281083 |
| CUX1 | cut-like homeobox 1 | -0.027639 |
| FBN1 | fibrillin 1 | -0.0271589 |
| NDRG1 | N-myc downstream regulated 1 | -0.0271157 |
| NAV1 | neuron navigator 1 | -0.0269049 |
| S100A6 | S100 calcium binding protein A6 | -0.0267793 |
| CDCP1 | CUB domain containing protein 1 | -0.0266989 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0261507 |
| SP100 | SP100 nuclear antigen | -0.0258814 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0257041 |
| AHNAK | AHNAK nucleoprotein | -0.0254528 |
| IL1B | interleukin 1, beta | -0.0253992 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0253015 |
| GLIS3 | GLIS family zinc finger 3 | -0.0248701 |
| LDHA | lactate dehydrogenase A | -0.0247387 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0245244 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0241827 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.024175 |
| EFNA5 | ephrin-A5 | -0.0235402 |
| EFCAB13 | EF-hand calcium binding domain 13 | -0.0233685 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0233417 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0232429 |
| IFI44L | interferon-induced protein 44-like | -0.0231456 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0231439 |
| RPL31 | ribosomal protein L31 | -0.0230014 |
| TMTC1 | transmembrane and tetratricopeptide repeat containing 1 | -0.0228636 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | -0.022686 |
| DIAPH2 | diaphanous-related formin 2 | -0.022616 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | -0.0225961 |
| RASAL2 | RAS protein activator like 2 | -0.0225506 |
| ANXA10 | annexin A10 | -0.0225151 |
| PKM | pyruvate kinase, muscle | -0.0222724 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0221554 |
| VCL | vinculin | -0.0220306 |
| HMGA1 | high mobility group AT-hook 1 | -0.0220266 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0219636 |
| NLK | nemo-like kinase | -0.0217027 |
| RPS24 | ribosomal protein S24 | -0.0214177 |
| SYT1 | synaptotagmin I | -0.0207337 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0206804 |
| NUMB | numb homolog (Drosophila) | -0.0205279 |
| NTN4 | netrin 4 | -0.020396 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0203751 |
| FBXO11 | F-box protein 11 | -0.0200389 |
| GALNT18 | polypeptide N-acetylgalactosaminyltransferase 18 | -0.0199012 |
| HM13 | histocompatibility (minor) 13 | -0.0198706 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.01982 |
