Cabozantinib (S-malate)_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cabozantinib (S-malate) perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Cabozantinib (S-malate)_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GRAMD1B GRAM domain containing 1B 0.122554
ANKRD11 ankyrin repeat domain 11 0.103727
EIF1 eukaryotic translation initiation factor 1 0.0989075
TPM3 tropomyosin 3 0.0946246
HSPA8 heat shock 70kDa protein 8 0.0878496
PDE4D phosphodiesterase 4D, cAMP-specific 0.083877
WDR43 WD repeat domain 43 0.0833938
DSCAM Down syndrome cell adhesion molecule 0.0777566
RPS12 ribosomal protein S12 0.0777153
ACTG1 actin gamma 1 0.0747651
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0727373
RPS4Y1 ribosomal protein S4, Y-linked 1 0.0692263
MACF1 microtubule-actin crosslinking factor 1 0.0676075
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0654222
PM20D1 peptidase M20 domain containing 1 0.064884
ZFAND3 zinc finger, AN1-type domain 3 0.0630503
RPL13A ribosomal protein L13a 0.0627882
SMOC1 SPARC related modular calcium binding 1 0.0601842
RTN4 reticulon 4 0.0596963
SRRM2 serine/arginine repetitive matrix 2 0.0592592
THSD4 thrombospondin, type I, domain containing 4 0.0578806
EEF2 eukaryotic translation elongation factor 2 0.0575952
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.05733
RNF145 ring finger protein 145 0.056176
APP amyloid beta (A4) precursor protein 0.0561445
YBX3 Y box binding protein 3 0.0557185
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0538488
SMAD3 SMAD family member 3 0.0530876
RPL4 ribosomal protein L4 0.0529319
AKAP13 A kinase (PRKA) anchor protein 13 0.0526955
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0523961
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0496807
FAM168A family with sequence similarity 168, member A 0.0494554
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0489112
RPL23 ribosomal protein L23 0.0485565
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0479395
TMSB10 thymosin beta 10 0.0474874
FAM107B family with sequence similarity 107, member B 0.0470937
MYH9 myosin, heavy chain 9, non-muscle 0.0463295
ZNF292 zinc finger protein 292 0.0458364
KMT2E lysine (K)-specific methyltransferase 2E 0.0453073
RPL37A ribosomal protein L37a 0.0450763
CYRIB CYFIP related Rac1 interactor B 0.0450466
UTRN utrophin 0.044876
NACA nascent polypeptide-associated complex alpha subunit 0.0446249
JAK1 Janus kinase 1 0.0442926
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.043736
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.04352
SAMD4A sterile alpha motif domain containing 4A 0.0425142
RBM33 RNA binding motif protein 33 0.042512
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0420855
PDE8A phosphodiesterase 8A 0.0418367
PCMTD1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 0.0418173
RPS3 ribosomal protein S3 0.0416747
HDGF hepatoma-derived growth factor 0.0414394
CMIP c-Maf inducing protein 0.041293
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0408808
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0404891
FNDC3B fibronectin type III domain containing 3B 0.0404117
PTK2 protein tyrosine kinase 2 0.0394895
BCLAF1 BCL2-associated transcription factor 1 0.0391799
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0391408
RPL11 ribosomal protein L11 0.0387751
ZFHX3 zinc finger homeobox 3 0.0385411
PARD3 par-3 family cell polarity regulator 0.0384823
TNRC6B trinucleotide repeat containing 6B 0.0384231
PRRC2C proline-rich coiled-coil 2C 0.0381354
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0375926
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0372295
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0371906
HLA-A major histocompatibility complex, class I, A 0.0371452
SPRED2 sprouty-related, EVH1 domain containing 2 0.0370822
RORA RAR-related orphan receptor A 0.036803
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0367995
CCNL1 cyclin L1 0.0364816
SF1 splicing factor 1 0.0363174
SVIL supervillin 0.0361959
RPS20 ribosomal protein S20 0.036083
YAP1 Yes-associated protein 1 0.0357844
DOCK5 dedicator of cytokinesis 5 0.0356227
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0353817
USP3 ubiquitin specific peptidase 3 0.0353241
NTN4 netrin 4 0.0352451
MEF2D myocyte enhancer factor 2D 0.0352342
TPD52 tumor protein D52 0.0349668
HLA-B major histocompatibility complex, class I, B 0.0341694
RICTOR RPTOR independent companion of MTOR, complex 2 0.0339734
RPL36 ribosomal protein L36 0.0334688
ACACA acetyl-CoA carboxylase alpha 0.0333392
UBASH3B ubiquitin associated and SH3 domain containing B 0.033244
PUM1 pumilio RNA-binding family member 1 0.0330449
PLEC plectin 0.033033
IGF1R insulin-like growth factor 1 receptor 0.0328608
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0327608
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.032734
ITGB5 integrin, beta 5 0.0325591
GLG1 golgi glycoprotein 1 0.0325199
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0324986
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0324725
PABPN1 poly(A) binding protein, nuclear 1 0.0321412

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.221795
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.196654
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.172461
MT2A metallothionein 2A -0.111777
TXNRD1 thioredoxin reductase 1 -0.111071
FTL ferritin, light polypeptide -0.108146
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.091746
TFPI2 tissue factor pathway inhibitor 2 -0.0884377
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0812394
TM4SF1 transmembrane 4 L six family member 1 -0.0720802
IER3 immediate early response 3 -0.0715189
C15ORF48 chromosome 15 open reading frame 48 -0.060663
FTH1 ferritin, heavy polypeptide 1 -0.0561326
NQO1 NAD(P)H dehydrogenase, quinone 1 -0.0509261
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0462138
S100A10 S100 calcium binding protein A10 -0.0461585
NRG1 neuregulin 1 -0.0441817
STC1 stanniocalcin 1 -0.0436504
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0409111
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0403521
IGF2 insulin-like growth factor 2 -0.0339474
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0322228
ECT2 epithelial cell transforming 2 -0.0311691
LDHA lactate dehydrogenase A -0.0306384
NAV3 neuron navigator 3 -0.0304696
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0272481
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0268896
HMGA1 high mobility group AT-hook 1 -0.02685
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.026384
S100A6 S100 calcium binding protein A6 -0.0261042
VIM vimentin -0.0252283
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0248764
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0246532
AK1 adenylate kinase 1 -0.0246132
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0237593
TUBA1B tubulin, alpha 1b -0.0233977
MCL1 myeloid cell leukemia 1 -0.0233761
VDAC1 voltage-dependent anion channel 1 -0.0231592
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0230104
PFN1 profilin 1 -0.0226243
GNAS GNAS complex locus -0.0221985
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0215165
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.0210307
ARF4 ADP-ribosylation factor 4 -0.0203598
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0201057
MORF4L2 mortality factor 4 like 2 -0.0200247
HMGB1 high mobility group box 1 -0.0198092
S100A11 S100 calcium binding protein A11 -0.01945
NPEPPS aminopeptidase puromycin sensitive -0.0191239
SEC31A SEC31 homolog A (S. cerevisiae) -0.0188896
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0184868
ANXA1 annexin A1 -0.0184211
ANXA2 annexin A2 -0.0183032
TUBB tubulin, beta class I -0.0180489
PRDX1 peroxiredoxin 1 -0.0179885
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0179002
RAB7A RAB7A, member RAS oncogene family -0.0176009
NCEH1 neutral cholesterol ester hydrolase 1 -0.0167723
H1-0 H1.0 linker histone -0.0166531
IFRD1 interferon-related developmental regulator 1 -0.0163515
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa -0.0163114
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0160068
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 -0.0154877
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.0151661
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) -0.015115
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0150854
RPS24 ribosomal protein S24 -0.0150596
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.0149485
PARK7 parkinson protein 7 -0.0148241
RPLP0 ribosomal protein, large, P0 -0.0147617
CCL2 chemokine (C-C motif) ligand 2 -0.0145412
WDR45B WD repeat domain 45B -0.014298
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0142475
TIPARP TCDD-inducible poly(ADP-ribose) polymerase -0.0141082
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0140947
POTEF POTE ankyrin domain family, member F -0.0140876
GSTP1 glutathione S-transferase pi 1 -0.0140325
RAI1 retinoic acid induced 1 -0.0140007
FOSL1 FOS-like antigen 1 -0.0139418
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0138288
THOC2 THO complex 2 -0.0138009
ATAD2 ATPase family, AAA domain containing 2 -0.0134413
SOD2 superoxide dismutase 2, mitochondrial -0.0132414
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0131379
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 -0.0131304
NABP1 nucleic acid binding protein 1 -0.0130911
DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2 -0.0130517
TMEM87A transmembrane protein 87A -0.0130053
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0129467
CLTC clathrin, heavy chain (Hc) -0.0127592
ENO1 enolase 1, (alpha) -0.0126394
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) -0.012423
BLZF1 basic leucine zipper nuclear factor 1 -0.0123197
CD44 CD44 molecule (Indian blood group) -0.0121508
ERRFI1 ERBB receptor feedback inhibitor 1 -0.012148
TASOR2 transcription activation suppressor family member 2 -0.0121398
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0120613
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.012048
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0120015
AHNAK AHNAK nucleoprotein -0.0119633