Cabozantinib (S-malate)_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cabozantinib (S-malate) perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cabozantinib (S-malate)_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 0.240719
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.169946
PGK1 phosphoglycerate kinase 1 0.127342
TPT1 tumor protein, translationally-controlled 1 0.10791
FNDC3B fibronectin type III domain containing 3B 0.106856
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0977181
HMGA2 high mobility group AT-hook 2 0.0933803
FMN1 formin 1 0.087302
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0872838
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0861705
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0857323
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0836725
TMSB10 thymosin beta 10 0.0830082
RAB7A RAB7A, member RAS oncogene family 0.0809002
FAM13A family with sequence similarity 13, member A 0.0774934
STC1 stanniocalcin 1 0.0764283
MYOF myoferlin 0.0719913
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0715695
RICTOR RPTOR independent companion of MTOR, complex 2 0.0709781
FAM162A family with sequence similarity 162, member A 0.0699144
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.069208
LOC112694756 uncharaterized LOC112694756 0.0683943
PRELID2 PRELI domain containing 2 0.0683736
SEC31A SEC31 homolog A (S. cerevisiae) 0.0683244
WDR45B WD repeat domain 45B 0.0679688
TTC3 tetratricopeptide repeat domain 3 0.0672547
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0652951
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.065146
MYH9 myosin, heavy chain 9, non-muscle 0.0636664
TPD52 tumor protein D52 0.0625305
ATXN1 ataxin 1 0.0617625
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0594395
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0585664
TRIO trio Rho guanine nucleotide exchange factor 0.0582091
KIAA1217 KIAA1217 0.0573151
HOOK2 hook microtubule-tethering protein 2 0.0568804
FLNB filamin B, beta 0.0568121
TBC1D22A TBC1 domain family, member 22A 0.0562117
COG5 component of oligomeric golgi complex 5 0.055965
TXNRD1 thioredoxin reductase 1 0.052966
MT2A metallothionein 2A 0.0525162
PNISR PNN-interacting serine/arginine-rich protein 0.0521657
VCL vinculin 0.0519864
ANXA2 annexin A2 0.0518261
CCNI cyclin I 0.0517006
SRRM2 serine/arginine repetitive matrix 2 0.0510664
KYNU kynureninase 0.0510346
PRKCA protein kinase C, alpha 0.0505669
AKAP9 A kinase (PRKA) anchor protein 9 0.0490486
CALU calumenin 0.0490351
ACTG1 actin gamma 1 0.0489052
NAV2 neuron navigator 2 0.0486867
TMEM165 transmembrane protein 165 0.0484889
MON2 MON2 homolog (S. cerevisiae) 0.0478456
OGA O-GlcNAcase 0.0477737
ZMYND8 zinc finger, MYND-type containing 8 0.0454517
ELL2 elongation factor, RNA polymerase II, 2 0.0453072
KMT2E lysine (K)-specific methyltransferase 2E 0.0447632
TMF1 TATA element modulatory factor 1 0.044426
SOS1 son of sevenless homolog 1 (Drosophila) 0.0441933
RORA RAR-related orphan receptor A 0.0435795
KDM4B lysine (K)-specific demethylase 4B 0.0434555
SETD5 SET domain containing 5 0.043321
BRWD3 bromodomain and WD repeat domain containing 3 0.0433203
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0432507
BACE2 beta-site APP-cleaving enzyme 2 0.0427489
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0422163
SPTBN1 spectrin, beta, non-erythrocytic 1 0.042144
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0419694
RPL28 ribosomal protein L28 0.0417332
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0412115
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0412031
YEATS2 YEATS domain containing 2 0.0411789
BBX bobby sox homolog (Drosophila) 0.040746
KDM5B lysine (K)-specific demethylase 5B 0.0407443
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0396124
TPR translocated promoter region, nuclear basket protein 0.0395459
SEPTIN9 septin 9 0.039279
GPHN gephyrin 0.0392624
VEGFA vascular endothelial growth factor A 0.0390803
EZR ezrin 0.0387366
DARS1 aspartyl-tRNA synthetase 1 0.0386675
RBM33 RNA binding motif protein 33 0.0381844
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0379891
RPS8 ribosomal protein S8 0.0376939
RAD51B RAD51 paralog B 0.03758
IGF1R insulin-like growth factor 1 receptor 0.0373704
CADM1 cell adhesion molecule 1 0.0369359
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0367431
B2M beta-2-microglobulin 0.0367197
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.036392
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0360576
IGFBP3 insulin-like growth factor binding protein 3 0.0360175
SMAD3 SMAD family member 3 0.0352831
BIRC6 baculoviral IAP repeat containing 6 0.0349585
ENO1 enolase 1, (alpha) 0.0344769
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0342861
FOXO3 forkhead box O3 0.0342531
NCOR2 nuclear receptor corepressor 2 0.0342287
FTH1 ferritin, heavy polypeptide 1 0.0336417

decreased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific -0.142598
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.109443
MCTP1 multiple C2 domains, transmembrane 1 -0.107641
SAMD4A sterile alpha motif domain containing 4A -0.101253
NKD1 naked cuticle homolog 1 (Drosophila) -0.0985714
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 -0.0972205
CEMIP cell migration inducing protein, hyaluronan binding -0.0943324
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0879524
PDE10A phosphodiesterase 10A -0.0877876
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0867607
NAMPT nicotinamide phosphoribosyltransferase -0.0847323
USP33 ubiquitin specific peptidase 33 -0.0832731
GLS2 glutaminase 2 (liver, mitochondrial) -0.0830321
CYRIB CYFIP related Rac1 interactor B -0.0805668
AGO3 argonaute RISC catalytic component 3 -0.0803824
DDIT4 DNA-damage-inducible transcript 4 -0.0803667
PEAK1 pseudopodium-enriched atypical kinase 1 -0.0776265
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0760355
VIM vimentin -0.0708268
ZNF292 zinc finger protein 292 -0.070616
TUSC3 tumor suppressor candidate 3 -0.0705072
COPB1 coatomer protein complex, subunit beta 1 -0.0683821
KIF5B kinesin family member 5B -0.0680302
NUP98 nucleoporin 98kDa -0.0657533
ZEB1 zinc finger E-box binding homeobox 1 -0.0645208
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0644793
CUL4A cullin 4A -0.0640838
AK1 adenylate kinase 1 -0.0637967
GNAQ guanine nucleotide binding protein (G protein), q polypeptide -0.0630917
NCOR1 nuclear receptor corepressor 1 -0.0617746
SPATS2 spermatogenesis associated, serine-rich 2 -0.0611941
EEF2 eukaryotic translation elongation factor 2 -0.0611782
WAPL WAPL cohesin release factor -0.0593301
ILRUN inflammation and lipid regulator with UBA-like and NBR1-like domains -0.059111
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0589837
SCFD1 sec1 family domain containing 1 -0.0583833
GOLGB1 golgin B1 -0.058142
BRWD1 bromodomain and WD repeat domain containing 1 -0.0574883
CDK19 cyclin-dependent kinase 19 -0.0569992
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0568465
VGF VGF nerve growth factor inducible -0.056844
SRSF11 serine/arginine-rich splicing factor 11 -0.0565533
ZNF207 zinc finger protein 207 -0.0562619
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.056237
STAU2 staufen double-stranded RNA binding protein 2 -0.0559632
RPL8 ribosomal protein L8 -0.0558412
PALM2AKAP2 PALM2 and AKAP2 fusion -0.055724
COL6A3 collagen, type VI, alpha 3 -0.0555786
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0554514
STAU1 staufen double-stranded RNA binding protein 1 -0.0553884
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0548675
ZFAND3 zinc finger, AN1-type domain 3 -0.0544851
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 -0.0544562
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0544092
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0540322
RTN4 reticulon 4 -0.0537859
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0537509
XPR1 xenotropic and polytropic retrovirus receptor 1 -0.0536884
PPP1R2 protein phosphatase 1, regulatory (inhibitor) subunit 2 -0.0536224
SRPK2 SRSF protein kinase 2 -0.0531581
CARD16 caspase recruitment domain family, member 16 -0.0530231
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 -0.0528251
ADGRB3 adhesion G protein-coupled receptor B3 -0.0509295
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0496863
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha -0.049414
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0494063
RPS4X ribosomal protein S4, X-linked -0.049017
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) -0.0487738
MAST4 microtubule associated serine/threonine kinase family member 4 -0.0487343
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0486065
MAML2 mastermind-like 2 (Drosophila) -0.0466018
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0465036
SRP72 signal recognition particle 72kDa -0.0465
CEMIP2 cell migration inducing hyaluronidase 2 -0.0457744
CNKSR3 CNKSR family member 3 -0.0453587
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0444129
TAS2R14 taste receptor, type 2, member 14 -0.044305
KLF6 Kruppel-like factor 6 -0.0443023
MMP1 matrix metallopeptidase 1 -0.0437556
CD44 CD44 molecule (Indian blood group) -0.0434453
UBE2H ubiquitin-conjugating enzyme E2H -0.0426477
MBNL1 muscleblind-like splicing regulator 1 -0.042178
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0419468
ZNF638 zinc finger protein 638 -0.0417512
SEPTIN7 septin 7 -0.0416186
EFNA5 ephrin-A5 -0.0415663
ABI3BP ABI family, member 3 (NESH) binding protein -0.0415203
ARHGAP32 Rho GTPase activating protein 32 -0.0412791
ZBTB20 zinc finger and BTB domain containing 20 -0.0403559
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0398082
PLAUR plasminogen activator, urokinase receptor -0.039688
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0391432
RBM47 RNA binding motif protein 47 -0.0390105
DIAPH2 diaphanous-related formin 2 -0.038785
MCL1 myeloid cell leukemia 1 -0.0387804
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0381598
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0374917
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0372959
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0371864
PTK2 protein tyrosine kinase 2 -0.0369314