| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Cabozantinib (S-malate) perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Cabozantinib (S-malate)_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GRAMD1B | GRAM domain containing 1B | 0.209905 |
| SMAD3 | SMAD family member 3 | 0.0897122 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0799191 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0778674 |
| TPM3 | tropomyosin 3 | 0.0754054 |
| ADAR | adenosine deaminase, RNA-specific | 0.0666729 |
| PLEC | plectin | 0.0648693 |
| TXNRD1 | thioredoxin reductase 1 | 0.063582 |
| RAD51B | RAD51 paralog B | 0.0620775 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.059406 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0549287 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | 0.0539578 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0539525 |
| RNF145 | ring finger protein 145 | 0.0526896 |
| EXOC6B | exocyst complex component 6B | 0.0522465 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0517896 |
| MAP3K14 | mitogen-activated protein kinase kinase kinase 14 | 0.051755 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0496435 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0492538 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.045649 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0445383 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0428931 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0428495 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.0424231 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0422477 |
| KMT2D | lysine (K)-specific methyltransferase 2D | 0.0415701 |
| CEP250 | centrosomal protein 250kDa | 0.0414567 |
| BCAS3 | breast carcinoma amplified sequence 3 | 0.0406049 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0401286 |
| MED13L | mediator complex subunit 13-like | 0.0397039 |
| PCBP2 | poly(rC) binding protein 2 | 0.0394944 |
| ARHGEF11 | Rho guanine nucleotide exchange factor (GEF) 11 | 0.0394869 |
| GATAD2B | GATA zinc finger domain containing 2B | 0.0386282 |
| RBM33 | RNA binding motif protein 33 | 0.0384547 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0382665 |
| ZNF638 | zinc finger protein 638 | 0.0376175 |
| ATP11A | ATPase, class VI, type 11A | 0.0376023 |
| DOCK3 | dedicator of cytokinesis 3 | 0.0358717 |
| NOTCH2 | notch 2 | 0.0357243 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0355959 |
| MSH6 | mutS homolog 6 | 0.0352996 |
| XPO1 | exportin 1 | 0.0351785 |
| PIP5K1A | phosphatidylinositol-4-phosphate 5-kinase, type I, alpha | 0.0349795 |
| KRT18 | keratin 18, type I | 0.0349467 |
| YAP1 | Yes-associated protein 1 | 0.0343482 |
| TAB2 | TGF-beta activated kinase 1/MAP3K7 binding protein 2 | 0.0342905 |
| RUSC2 | RUN and SH3 domain containing 2 | 0.0339531 |
| SRBD1 | S1 RNA binding domain 1 | 0.0332918 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0332294 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0332002 |
| CTTN | cortactin | 0.0330807 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0330433 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0324191 |
| SPIDR | scaffolding protein involved in DNA repair | 0.0322764 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0314516 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0312527 |
| IQGAP3 | IQ motif containing GTPase activating protein 3 | 0.031024 |
| RPRD2 | regulation of nuclear pre-mRNA domain containing 2 | 0.0310221 |
| TRAPPC9 | trafficking protein particle complex 9 | 0.0308255 |
| OGA | O-GlcNAcase | 0.0307911 |
| DIDO1 | death inducer-obliterator 1 | 0.0307024 |
| SMYD3 | SET and MYND domain containing 3 | 0.0305878 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0304849 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | 0.0304168 |
| PGK1 | phosphoglycerate kinase 1 | 0.0300993 |
| DCAF8 | DDB1 and CUL4 associated factor 8 | 0.0300082 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | 0.0299626 |
| ARID1A | AT rich interactive domain 1A (SWI-like) | 0.0298821 |
| PRRC2A | proline-rich coiled-coil 2A | 0.0298255 |
| THADA | thyroid adenoma associated | 0.0297277 |
| STAT2 | signal transducer and activator of transcription 2, 113kDa | 0.029696 |
| CENPF | centromere protein F, 350/400kDa | 0.02966 |
| ANKRD36C | ankyrin repeat domain 36C | 0.0293034 |
| ZBTB1 | zinc finger and BTB domain containing 1 | 0.0291128 |
| MKI67 | marker of proliferation Ki-67 | 0.0288215 |
| ZNF148 | zinc finger protein 148 | 0.0285852 |
| ZBTB25 | zinc finger and BTB domain containing 25 | 0.0283759 |
| EXOC4 | exocyst complex component 4 | 0.0283337 |
| DENND5B | DENN/MADD domain containing 5B | 0.0283219 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0283043 |
| ANO6 | anoctamin 6 | 0.0278583 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.0274782 |
| SETD5 | SET domain containing 5 | 0.0270512 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0270239 |
| SRSF11 | serine/arginine-rich splicing factor 11 | 0.0269242 |
| TMEM41B | transmembrane protein 41B | 0.0267592 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | 0.0266889 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0265667 |
| PPP1R21 | protein phosphatase 1, regulatory subunit 21 | 0.0263485 |
| KCTD20 | potassium channel tetramerization domain containing 20 | 0.0260677 |
| GSE1 | Gse1 coiled-coil protein | 0.0260002 |
| MEF2D | myocyte enhancer factor 2D | 0.0256778 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0256563 |
| KIRREL1 | kirre like nephrin family adhesion molecule 1 | 0.0255926 |
| PHF3 | PHD finger protein 3 | 0.0255357 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0253759 |
| SQSTM1 | sequestosome 1 | 0.0253687 |
| BPTF | bromodomain PHD finger transcription factor | 0.0250384 |
| SNRNP200 | small nuclear ribonucleoprotein 200kDa (U5) | 0.0248283 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0246184 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.252819 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.185969 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.100744 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0908113 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0755642 |
| VIM | vimentin | -0.0751123 |
| PTMA | prothymosin, alpha | -0.073656 |
| TMSB10 | thymosin beta 10 | -0.0700654 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.06547 |
| EGR1 | early growth response 1 | -0.0575748 |
| MCL1 | myeloid cell leukemia 1 | -0.0555844 |
| ACTG1 | actin gamma 1 | -0.0549811 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0532745 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0518063 |
| PRELID2 | PRELI domain containing 2 | -0.049902 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0484414 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0482373 |
| RYR3 | ryanodine receptor 3 | -0.0462179 |
| OSMR | oncostatin M receptor | -0.0450332 |
| POTEF | POTE ankyrin domain family, member F | -0.0445471 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.042548 |
| MORF4L2 | mortality factor 4 like 2 | -0.0409048 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0404564 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0402684 |
| HMGA2 | high mobility group AT-hook 2 | -0.0401497 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0397681 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.039371 |
| CANX | calnexin | -0.0388148 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0381541 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0380542 |
| FMNL2 | formin-like 2 | -0.0379839 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | -0.0378236 |
| TPM4 | tropomyosin 4 | -0.0376481 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0369929 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0364206 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0362865 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0359033 |
| RPS21 | ribosomal protein S21 | -0.0345265 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0344873 |
| JUN | jun proto-oncogene | -0.0341185 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0335084 |
| YBX3 | Y box binding protein 3 | -0.0328052 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0327905 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0326578 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0320562 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | -0.0315819 |
| VCL | vinculin | -0.0312484 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0310481 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | -0.0309598 |
| IER3 | immediate early response 3 | -0.030365 |
| SRP72 | signal recognition particle 72kDa | -0.0302947 |
| GNAS | GNAS complex locus | -0.0300366 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0299964 |
| STC1 | stanniocalcin 1 | -0.0293965 |
| S100A10 | S100 calcium binding protein A10 | -0.0292669 |
| RBM39 | RNA binding motif protein 39 | -0.0289475 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0286293 |
| INTS6 | integrator complex subunit 6 | -0.0284413 |
| AFF3 | AF4/FMR2 family, member 3 | -0.0280667 |
| MT2A | metallothionein 2A | -0.028055 |
| DIAPH2 | diaphanous-related formin 2 | -0.0278323 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0274044 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.027368 |
| AEBP2 | AE binding protein 2 | -0.0268888 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0268498 |
| ATXN1 | ataxin 1 | -0.0265583 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.026333 |
| KLF6 | Kruppel-like factor 6 | -0.0263084 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0261773 |
| S100A11 | S100 calcium binding protein A11 | -0.0257846 |
| NEK10 | NIMA-related kinase 10 | -0.0257086 |
| CCNL1 | cyclin L1 | -0.0255108 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | -0.02545 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0241418 |
| CDK17 | cyclin-dependent kinase 17 | -0.0239176 |
| RPS24 | ribosomal protein S24 | -0.0238972 |
| CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | -0.0238564 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0237275 |
| CALD1 | caldesmon 1 | -0.0235282 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0233921 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0230589 |
| WNT2B | wingless-type MMTV integration site family, member 2B | -0.0225755 |
| RPS8 | ribosomal protein S8 | -0.0225592 |
| ZNF207 | zinc finger protein 207 | -0.0223274 |
| RPL35A | ribosomal protein L35a | -0.0220088 |
| ATP2A2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | -0.0217196 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0216507 |
| RPL38 | ribosomal protein L38 | -0.0213146 |
| RPL32 | ribosomal protein L32 | -0.0211257 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0210793 |
| NF1 | neurofibromin 1 | -0.0210577 |
| RPS29 | ribosomal protein S29 | -0.0209306 |
| SEPTIN7 | septin 7 | -0.0208401 |
| FSCN1 | fascin actin-bundling protein 1 | -0.0208316 |
| CRY1 | cryptochrome circadian clock 1 | -0.020523 |
| ARF4 | ADP-ribosylation factor 4 | -0.0203376 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | -0.0203014 |
| RPS19 | ribosomal protein S19 | -0.0202972 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | -0.0202494 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0200461 |
