| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Cabozantinib (S-malate) perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Cabozantinib (S-malate)_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NAMPT | nicotinamide phosphoribosyltransferase | 0.176116 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | 0.169961 |
| GDA | guanine deaminase | 0.126196 |
| GRAMD1B | GRAM domain containing 1B | 0.11643 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.114877 |
| EFNA5 | ephrin-A5 | 0.111875 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0971895 |
| EPB41L3 | erythrocyte membrane protein band 4.1-like 3 | 0.093791 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0900977 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0826609 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.081399 |
| TXNRD1 | thioredoxin reductase 1 | 0.0771398 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.071727 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0708492 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | 0.0705629 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0697194 |
| RTN4 | reticulon 4 | 0.0692782 |
| OGA | O-GlcNAcase | 0.0652609 |
| SLC39A8 | solute carrier family 39 (zinc transporter), member 8 | 0.0623545 |
| ASPH | aspartate beta-hydroxylase | 0.0622033 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0616136 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.060974 |
| NEK7 | NIMA-related kinase 7 | 0.0580827 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0576304 |
| FLNB | filamin B, beta | 0.0571459 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.0564641 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.05628 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0548941 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0543822 |
| FN1 | fibronectin 1 | 0.0522677 |
| PGK1 | phosphoglycerate kinase 1 | 0.0520304 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0516458 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.051534 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0514632 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0511521 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0499482 |
| NPAS2 | neuronal PAS domain protein 2 | 0.04939 |
| TBXT | T-box transcription factor T | 0.0491532 |
| FAM13A | family with sequence similarity 13, member A | 0.0472582 |
| EZR | ezrin | 0.0469626 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.045587 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0439392 |
| SMYD3 | SET and MYND domain containing 3 | 0.043534 |
| TPM3 | tropomyosin 3 | 0.0428878 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0427644 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0425609 |
| MATR3 | matrin 3 | 0.0422417 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.042211 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | 0.0416705 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0410673 |
| CENPF | centromere protein F, 350/400kDa | 0.0403997 |
| CD109 | CD109 molecule | 0.0401519 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0400351 |
| ENAH | enabled homolog (Drosophila) | 0.039882 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0398212 |
| MYOF | myoferlin | 0.0395049 |
| RNF145 | ring finger protein 145 | 0.0391555 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0388899 |
| PDGFA | platelet-derived growth factor alpha polypeptide | 0.038842 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0385282 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0382083 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0380278 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.0378874 |
| CARD16 | caspase recruitment domain family, member 16 | 0.0376063 |
| B2M | beta-2-microglobulin | 0.0368816 |
| GOLGA4 | golgin A4 | 0.0365357 |
| LAMB1 | laminin, beta 1 | 0.036424 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0363033 |
| WDR43 | WD repeat domain 43 | 0.0361234 |
| PHF20 | PHD finger protein 20 | 0.0360985 |
| LAMA1 | laminin, alpha 1 | 0.0357334 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0353434 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0351131 |
| MAP1B | microtubule-associated protein 1B | 0.0351059 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0350438 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0348892 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0346094 |
| JMJD1C | jumonji domain containing 1C | 0.0343699 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.034367 |
| MFF | mitochondrial fission factor | 0.0342933 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0341565 |
| ATP13A3 | ATPase type 13A3 | 0.0340747 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0340573 |
| SRPK2 | SRSF protein kinase 2 | 0.0338726 |
| CANX | calnexin | 0.0338464 |
| TMX4 | thioredoxin-related transmembrane protein 4 | 0.0337802 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0334635 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0333939 |
| TNPO1 | transportin 1 | 0.0333804 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0332594 |
| AVL9 | AVL9 homolog (S. cerevisiase) | 0.033028 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0327028 |
| PBX1 | pre-B-cell leukemia homeobox 1 | 0.0324372 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0319803 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0317501 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0316943 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.031116 |
| AGFG1 | ArfGAP with FG repeats 1 | 0.0310706 |
| DDX3Y | DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked | 0.0310558 |
| NUP58 | nucleoporin 58 | 0.0307203 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.223131 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0897211 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0817214 |
| DPP10 | dipeptidyl-peptidase 10 (non-functional) | -0.0711433 |
| VCL | vinculin | -0.064217 |
| RPL31 | ribosomal protein L31 | -0.0571751 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0564476 |
| VIM | vimentin | -0.0553368 |
| INTS6 | integrator complex subunit 6 | -0.0538424 |
| CDH13 | cadherin 13 | -0.0489714 |
| RAD51B | RAD51 paralog B | -0.0423779 |
| RPS24 | ribosomal protein S24 | -0.0419779 |
| P3H2 | prolyl 3-hydroxylase 2 | -0.0392655 |
| RPL37A | ribosomal protein L37a | -0.0378364 |
| PM20D1 | peptidase M20 domain containing 1 | -0.0368765 |
| PRELID2 | PRELI domain containing 2 | -0.0359448 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | -0.0353965 |
| LSAMP | limbic system-associated membrane protein | -0.0353947 |
| RPL9 | ribosomal protein L9 | -0.0339876 |
| AEBP2 | AE binding protein 2 | -0.0335996 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0309255 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0295825 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0281403 |
| RPLP1 | ribosomal protein, large, P1 | -0.0279036 |
| PCDH15 | protocadherin-related 15 | -0.0253956 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0250896 |
| NCKAP5 | NCK-associated protein 5 | -0.0248065 |
| RPL38 | ribosomal protein L38 | -0.024469 |
| DENND1A | DENN/MADD domain containing 1A | -0.0241011 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0238529 |
| FTL | ferritin, light polypeptide | -0.0236398 |
| TENM2 | teneurin transmembrane protein 2 | -0.0235939 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0235469 |
| XYLT1 | xylosyltransferase I | -0.0229358 |
| OGDH | oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) | -0.0226642 |
| RPS29 | ribosomal protein S29 | -0.0226321 |
| PKM | pyruvate kinase, muscle | -0.0223948 |
| SCFD1 | sec1 family domain containing 1 | -0.0213614 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0212712 |
| RPS23 | ribosomal protein S23 | -0.0210936 |
| RPL35A | ribosomal protein L35a | -0.0210366 |
| AUTS2 | autism susceptibility candidate 2 | -0.0209225 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | -0.020828 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0204627 |
| RPS27A | ribosomal protein S27a | -0.0204304 |
| RCOR1 | REST corepressor 1 | -0.0203988 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0202807 |
| RPS25 | ribosomal protein S25 | -0.0202726 |
| SLCO1C1 | solute carrier organic anion transporter family, member 1C1 | -0.0198865 |
| OASL | 2'-5'-oligoadenylate synthetase-like | -0.0198043 |
| AADAC | arylacetamide deacetylase | -0.0192707 |
| NBEAL1 | neurobeachin-like 1 | -0.018842 |
| RHOB | ras homolog family member B | -0.0187312 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | -0.0184819 |
| RPS12 | ribosomal protein S12 | -0.0183947 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0182347 |
| COL5A2 | collagen, type V, alpha 2 | -0.0180885 |
| RPS17 | ribosomal protein S17 | -0.0180558 |
| RPS8 | ribosomal protein S8 | -0.0180301 |
| C9ORF153 | chromosome 9 open reading frame 153 | -0.0178043 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0176077 |
| RPS10 | ribosomal protein S10 | -0.0175801 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0173494 |
| SOX6 | SRY (sex determining region Y)-box 6 | -0.017189 |
| LAMB4 | laminin, beta 4 | -0.0171316 |
| HMGA2 | high mobility group AT-hook 2 | -0.0169497 |
| RPS13 | ribosomal protein S13 | -0.0168082 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.016586 |
| SQSTM1 | sequestosome 1 | -0.0165445 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0165336 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -0.0164711 |
| ARMH4 | armadillo like helical domain containing 4 | -0.016243 |
| MAP7 | microtubule-associated protein 7 | -0.0161405 |
| GNAS | GNAS complex locus | -0.0160728 |
| AGTPBP1 | ATP/GTP binding protein 1 | -0.0158686 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0155467 |
| ICE2 | interactor of little elongation complex ELL subunit 2 | -0.0154063 |
| LMNA | lamin A/C | -0.0151522 |
| IGF2 | insulin-like growth factor 2 | -0.0151265 |
| SMAD2 | SMAD family member 2 | -0.0151038 |
| EPC2 | enhancer of polycomb homolog 2 (Drosophila) | -0.0150611 |
| LINGO2 | leucine rich repeat and Ig domain containing 2 | -0.0147682 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0146627 |
| AGR2 | anterior gradient 2 | -0.0143532 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0142507 |
| RBFOX1 | RNA binding protein, fox-1 homolog (C. elegans) 1 | -0.0139342 |
| SMOC1 | SPARC related modular calcium binding 1 | -0.0138937 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0135944 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | -0.0135157 |
| ITPK1 | inositol-tetrakisphosphate 1-kinase | -0.0134356 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0133722 |
| LDHA | lactate dehydrogenase A | -0.0133448 |
| TENM3 | teneurin transmembrane protein 3 | -0.0133097 |
| RHOH | ras homolog family member H | -0.0132684 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0130789 |
| WNT2B | wingless-type MMTV integration site family, member 2B | -0.0130444 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | -0.0129346 |
| RPL5 | ribosomal protein L5 | -0.0127431 |
| GLRX | glutaredoxin (thioltransferase) | -0.0126849 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0125625 |
