Cabozantinib (S-malate)_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cabozantinib (S-malate) perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

121 genes differentially expressed following the Cabozantinib (S-malate)_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE10A phosphodiesterase 10A 0.270516
ACYP2 acylphosphatase 2, muscle type 0.150258
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.145666
FNDC3B fibronectin type III domain containing 3B 0.136136
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.124674
MT2A metallothionein 2A 0.106743
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0964181
AREG amphiregulin 0.0956085
ACTG1 actin gamma 1 0.0942843
FRMD4A FERM domain containing 4A 0.0917631
TRIO trio Rho guanine nucleotide exchange factor 0.0901562
TXNRD1 thioredoxin reductase 1 0.085707
B2M beta-2-microglobulin 0.0825511
PGK1 phosphoglycerate kinase 1 0.0800321
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0784796
FN1 fibronectin 1 0.076191
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.06776
FHIT fragile histidine triad 0.0670763
NAV2 neuron navigator 2 0.0587757
FNDC3A fibronectin type III domain containing 3A 0.0543756
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0501711
NDRG1 N-myc downstream regulated 1 0.0500341
LDHA lactate dehydrogenase A 0.0491678
PRELID2 PRELI domain containing 2 0.0472612
ATXN1 ataxin 1 0.0464949
DST dystonin 0.0462016
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0451168
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0442589
SRPK2 SRSF protein kinase 2 0.0418996
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0394304
RPS6 ribosomal protein S6 0.038081
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0360007
VMP1 vacuole membrane protein 1 0.034873
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0312663
MYOF myoferlin 0.0294301
PRRC2C proline-rich coiled-coil 2C 0.0285883
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0272087
OGA O-GlcNAcase 0.0268407
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0266397
TMSB10 thymosin beta 10 0.0236976
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0188968
ZFAND3 zinc finger, AN1-type domain 3 0.0188595
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.0165768
GOLGA4 golgin A4 0.0150678
RBM25 RNA binding motif protein 25 0.0141919
SMYD3 SET and MYND domain containing 3 0.0110143
BPTF bromodomain PHD finger transcription factor 0.00935729
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.00931345
DSCAM Down syndrome cell adhesion molecule 0.0088046
COL19A1 collagen, type XIX, alpha 1 0.00745729
MON2 MON2 homolog (S. cerevisiae) 0.00571832
SPAG9 sperm associated antigen 9 0.00563077
LMO7 LIM domain 7 0.00364633
PDE4D phosphodiesterase 4D, cAMP-specific 0.00236921
ASPH aspartate beta-hydroxylase 1.80211E-4

decreased expression

Symbol Name Standardized Value
GPC6 glypican 6 -0.122546
TPT1 tumor protein, translationally-controlled 1 -0.11924
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.11043
HDLBP high density lipoprotein binding protein -0.110262
VIM vimentin -0.109844
KMT2E lysine (K)-specific methyltransferase 2E -0.109798
VCL vinculin -0.10148
PTPRM protein tyrosine phosphatase, receptor type, M -0.0948075
CDH13 cadherin 13 -0.0936909
ZNF292 zinc finger protein 292 -0.092602
PTMA prothymosin, alpha -0.092498
SBF2 SET binding factor 2 -0.089248
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0783862
NKD1 naked cuticle homolog 1 (Drosophila) -0.0778656
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0759549
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0741975
MEF2A myocyte enhancer factor 2A -0.0736503
EXT1 exostosin glycosyltransferase 1 -0.0700459
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0674609
IER3 immediate early response 3 -0.0624766
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0620689
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0609733
MYO1E myosin IE -0.0605367
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0583487
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0583229
NPAS2 neuronal PAS domain protein 2 -0.0582811
PRKCA protein kinase C, alpha -0.0572256
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0558276
MAML3 mastermind-like 3 (Drosophila) -0.0537872
PDLIM5 PDZ and LIM domain 5 -0.0519295
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0484044
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0448903
EFNA5 ephrin-A5 -0.0435994
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0433972
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0407777
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0401486
PUM2 pumilio RNA-binding family member 2 -0.0381679
TBC1D22A TBC1 domain family, member 22A -0.0361313
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0360141
PARD3 par-3 family cell polarity regulator -0.0337042
RORA RAR-related orphan receptor A -0.03176
CHD9 chromodomain helicase DNA binding protein 9 -0.0304501
MAML2 mastermind-like 2 (Drosophila) -0.0284518
EGFR epidermal growth factor receptor -0.0276706
IGFBP5 insulin-like growth factor binding protein 5 -0.0257804
RASA3 RAS p21 protein activator 3 -0.0238384
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0224206
SEC31A SEC31 homolog A (S. cerevisiae) -0.0199247
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0179047
NHSL1 NHS-like 1 -0.0172606
GRIK1 glutamate receptor, ionotropic, kainate 1 -0.0166693
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0144738
SND1 staphylococcal nuclease and tudor domain containing 1 -0.0117179
FTL ferritin, light polypeptide -0.0105674
PSD3 pleckstrin and Sec7 domain containing 3 -0.00999514
MED13L mediator complex subunit 13-like -0.00974055
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.00882418
SETD5 SET domain containing 5 -0.00761336
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.00711025
KDM5B lysine (K)-specific demethylase 5B -0.0063072
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) -0.00527089
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.00490763
RPL26 ribosomal protein L26 -0.00351653
RAD51B RAD51 paralog B -0.0027971
IGFBP3 insulin-like growth factor binding protein 3 -0.00158451
CALR calreticulin -6.07224E-4