| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Cabozantinib (S-malate) perturbation in NCI-H661 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Cabozantinib (S-malate)_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0821936 |
| TSC22D2 | TSC22 domain family, member 2 | 0.07365 |
| ZNF292 | zinc finger protein 292 | 0.0612695 |
| ADGRV1 | adhesion G protein-coupled receptor V1 | 0.0595069 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0591278 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0582803 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0581534 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0568471 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0559834 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0545469 |
| CENPF | centromere protein F, 350/400kDa | 0.0530173 |
| G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | 0.0508589 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0504551 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0499966 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0478469 |
| APP | amyloid beta (A4) precursor protein | 0.0441625 |
| PGAP1 | post-GPI attachment to proteins 1 | 0.0433864 |
| PTMA | prothymosin, alpha | 0.0430611 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0427726 |
| ENAH | enabled homolog (Drosophila) | 0.0423301 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0419433 |
| FBXO11 | F-box protein 11 | 0.0410145 |
| TPM3 | tropomyosin 3 | 0.0408419 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0408305 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0401956 |
| TRERF1 | transcriptional regulating factor 1 | 0.0393956 |
| CRY1 | cryptochrome circadian clock 1 | 0.039371 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0391059 |
| CXADR | coxsackie virus and adenovirus receptor | 0.0382784 |
| ACTG1 | actin gamma 1 | 0.0371722 |
| HP1BP3 | heterochromatin protein 1, binding protein 3 | 0.0371667 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0370245 |
| SETD5 | SET domain containing 5 | 0.0365055 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0362686 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0356991 |
| RASAL2 | RAS protein activator like 2 | 0.0348749 |
| SRPK2 | SRSF protein kinase 2 | 0.0343667 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.034281 |
| YAP1 | Yes-associated protein 1 | 0.0337503 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0336048 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0332818 |
| RUNX1T1 | runt-related transcription factor 1; translocated to, 1 (cyclin D-related) | 0.0332477 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0329777 |
| MKI67 | marker of proliferation Ki-67 | 0.0319189 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0313548 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0309807 |
| NOP58 | NOP58 ribonucleoprotein | 0.0308298 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0303106 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0300997 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.030064 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0297737 |
| CLASP2 | cytoplasmic linker associated protein 2 | 0.0296571 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0295335 |
| PRTG | protogenin | 0.0293857 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | 0.0278622 |
| PCBP2 | poly(rC) binding protein 2 | 0.0274843 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0273403 |
| ATXN2 | ataxin 2 | 0.0273277 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0270639 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0266687 |
| H1-0 | H1.0 linker histone | 0.0266286 |
| RPS12 | ribosomal protein S12 | 0.026497 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0263418 |
| POLR2B | polymerase (RNA) II (DNA directed) polypeptide B, 140kDa | 0.026108 |
| YBX1 | Y box binding protein 1 | 0.0260823 |
| PAK4 | p21 protein (Cdc42/Rac)-activated kinase 4 | 0.0257169 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | 0.0256469 |
| SBNO1 | strawberry notch homolog 1 (Drosophila) | 0.0256012 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 0.0255429 |
| ATP5F1B | ATP synthase F1 subunit beta | 0.0255135 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | 0.0253609 |
| EWSR1 | EWS RNA-binding protein 1 | 0.0251651 |
| HNRNPM | heterogeneous nuclear ribonucleoprotein M | 0.024966 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0249611 |
| ZFPM2 | zinc finger protein, FOG family member 2 | 0.0249507 |
| MTMR3 | myotubularin related protein 3 | 0.0247378 |
| RAB30 | RAB30, member RAS oncogene family | 0.0246636 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0244809 |
| GPC4 | glypican 4 | 0.0243537 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0243315 |
| CRISPLD1 | cysteine-rich secretory protein LCCL domain containing 1 | 0.0240786 |
| KDM5B | lysine (K)-specific demethylase 5B | 0.0238739 |
| CCNA2 | cyclin A2 | 0.0237434 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0236967 |
| MEF2A | myocyte enhancer factor 2A | 0.023688 |
| ARL5B | ADP-ribosylation factor-like 5B | 0.0236601 |
| RPL23 | ribosomal protein L23 | 0.0234871 |
| RHEB | Ras homolog enriched in brain | 0.0233744 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.02334 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0233053 |
| EP300 | E1A binding protein p300 | 0.0232808 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.02315 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0230874 |
| NCKAP1 | NCK-associated protein 1 | 0.0230732 |
| DENND4A | DENN/MADD domain containing 4A | 0.0230416 |
| FNBP4 | formin binding protein 4 | 0.0229979 |
| UBE2G1 | ubiquitin-conjugating enzyme E2G 1 | 0.0229812 |
| PGK1 | phosphoglycerate kinase 1 | 0.0228542 |
| PRRC2A | proline-rich coiled-coil 2A | 0.0226931 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0226086 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.097036 |
| COL11A1 | collagen, type XI, alpha 1 | -0.0686647 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | -0.0509423 |
| PEG10 | paternally expressed 10 | -0.0501394 |
| VIM | vimentin | -0.0500913 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0459115 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | -0.0437356 |
| ITGAV | integrin, alpha V | -0.0423456 |
| COL5A2 | collagen, type V, alpha 2 | -0.0407392 |
| CDH6 | cadherin 6, type 2, K-cadherin (fetal kidney) | -0.0353022 |
| MED13L | mediator complex subunit 13-like | -0.0342899 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0336973 |
| SEMA3D | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D | -0.0335516 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | -0.0334724 |
| ZEB2 | zinc finger E-box binding homeobox 2 | -0.0326108 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0317914 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0306482 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0292882 |
| TENM3 | teneurin transmembrane protein 3 | -0.0292722 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.0268161 |
| CBX3 | chromobox homolog 3 | -0.0240321 |
| RAI1 | retinoic acid induced 1 | -0.0234336 |
| COL3A1 | collagen, type III, alpha 1 | -0.0233903 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0233537 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | -0.0225679 |
| PCLO | piccolo presynaptic cytomatrix protein | -0.0206098 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | -0.020273 |
| DDIT4 | DNA-damage-inducible transcript 4 | -0.0202028 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0198175 |
| LYST | lysosomal trafficking regulator | -0.0198072 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | -0.019415 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0188748 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0186435 |
| NF1 | neurofibromin 1 | -0.018549 |
| FER | fer (fps/fes related) tyrosine kinase | -0.0183881 |
| PARD3B | par-3 family cell polarity regulator beta | -0.0183122 |
| MAP4K3 | mitogen-activated protein kinase kinase kinase kinase 3 | -0.0182275 |
| HS3ST5 | heparan sulfate (glucosamine) 3-O-sulfotransferase 5 | -0.0181515 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0180446 |
| ZNF644 | zinc finger protein 644 | -0.0177402 |
| TFRC | transferrin receptor | -0.0177095 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0177085 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0176189 |
| PALLD | palladin, cytoskeletal associated protein | -0.0173519 |
| PROS1 | protein S (alpha) | -0.0170731 |
| NEMF | nuclear export mediator factor | -0.0170229 |
| NRG1 | neuregulin 1 | -0.0169686 |
| IBTK | inhibitor of Bruton agammaglobulinemia tyrosine kinase | -0.0166361 |
| SEMA3E | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E | -0.0165314 |
| ENO1 | enolase 1, (alpha) | -0.0164701 |
| SYTL2 | synaptotagmin-like 2 | -0.0164267 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0164266 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0164131 |
| SORBS2 | sorbin and SH3 domain containing 2 | -0.0162083 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0161073 |
| POMP | proteasome maturation protein | -0.0159047 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0157289 |
| BAZ2B | bromodomain adjacent to zinc finger domain, 2B | -0.0157285 |
| RPS8 | ribosomal protein S8 | -0.0156792 |
| SHROOM3 | shroom family member 3 | -0.0155928 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0155812 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.015404 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0152287 |
| TRRAP | transformation/transcription domain-associated protein | -0.0152261 |
| CDKAL1 | CDK5 regulatory subunit associated protein 1-like 1 | -0.015129 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0150681 |
| CCT8 | chaperonin containing TCP1, subunit 8 (theta) | -0.0150667 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | -0.0149575 |
| FBL | fibrillarin | -0.0149186 |
| MSI2 | musashi RNA-binding protein 2 | -0.0148257 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0145351 |
| C1ORF21 | chromosome 1 open reading frame 21 | -0.0145036 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0144357 |
| ZZZ3 | zinc finger, ZZ-type containing 3 | -0.014306 |
| SQSTM1 | sequestosome 1 | -0.0142687 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0141104 |
| VMP1 | vacuole membrane protein 1 | -0.014057 |
| RTF2 | replication termination factor 2 | -0.0138827 |
| SENP7 | SUMO1/sentrin specific peptidase 7 | -0.0138441 |
| RIGI | RNA sensor RIG-I | -0.0137738 |
| TXNDC12 | thioredoxin domain containing 12 (endoplasmic reticulum) | -0.0137524 |
| DDIT3 | DNA-damage-inducible transcript 3 | -0.0137499 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | -0.0136728 |
| NCOA6 | nuclear receptor coactivator 6 | -0.0136045 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.01352 |
| LDHA | lactate dehydrogenase A | -0.0135078 |
| PLCXD1 | phosphatidylinositol-specific phospholipase C, X domain containing 1 | -0.0134915 |
| PHF21A | PHD finger protein 21A | -0.0134648 |
| SNRNP70 | small nuclear ribonucleoprotein 70kDa (U1) | -0.0134159 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0133299 |
| DNAJC8 | DnaJ (Hsp40) homolog, subfamily C, member 8 | -0.0132949 |
| FN1 | fibronectin 1 | -0.0132744 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0132607 |
| EIF3D | eukaryotic translation initiation factor 3, subunit D | -0.0132382 |
| GOLGB1 | golgin B1 | -0.0132097 |
| CTPS1 | CTP synthase 1 | -0.0131675 |
| CEP350 | centrosomal protein 350kDa | -0.0131091 |
| CABLES1 | Cdk5 and Abl enzyme substrate 1 | -0.0129476 |
| KIDINS220 | kinase D-interacting substrate, 220kDa | -0.012842 |
| RPS13 | ribosomal protein S13 | -0.0127952 |
