Cabozantinib (S-malate)_PANC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cabozantinib (S-malate) perturbation in PANC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cabozantinib (S-malate)_PANC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RPS16 ribosomal protein S16 0.243775
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.112571
ACTG1 actin gamma 1 0.109498
SRRM2 serine/arginine repetitive matrix 2 0.0921046
SMAD3 SMAD family member 3 0.0892771
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0851326
EIF1 eukaryotic translation initiation factor 1 0.0742874
SEPTIN9 septin 9 0.0731624
RPL35A ribosomal protein L35a 0.0695879
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0641303
SFTPA2 surfactant protein A2 0.0619021
TNS3 tensin 3 0.0572502
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 0.0549396
RPL11 ribosomal protein L11 0.0544145
SDK1 sidekick cell adhesion molecule 1 0.051885
AKT2 v-akt murine thymoma viral oncogene homolog 2 0.0514844
PTMA prothymosin, alpha 0.049144
COL18A1 collagen, type XVIII, alpha 1 0.0485079
NCOR2 nuclear receptor corepressor 2 0.0452731
RPS6 ribosomal protein S6 0.0426552
AFAP1 actin filament associated protein 1 0.0414967
KMT2A lysine (K)-specific methyltransferase 2A 0.0409013
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0400072
RPL28 ribosomal protein L28 0.0381517
FTL ferritin, light polypeptide 0.0377952
IGF1R insulin-like growth factor 1 receptor 0.0376287
RNF213 ring finger protein 213 0.0373705
RPL23 ribosomal protein L23 0.0365993
NACA nascent polypeptide-associated complex alpha subunit 0.0364053
CDK19 cyclin-dependent kinase 19 0.0363566
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0348858
TRERF1 transcriptional regulating factor 1 0.0341233
PLEC plectin 0.0336883
HOXB3 homeobox B3 0.0319198
RPS20 ribosomal protein S20 0.0312259
FLNB filamin B, beta 0.0309146
ADM adrenomedullin 0.0294417
RPL21 ribosomal protein L21 0.0291512
HSPA8 heat shock 70kDa protein 8 0.0291411
S100A6 S100 calcium binding protein A6 0.0290422
OGA O-GlcNAcase 0.0289995
RPLP2 ribosomal protein, large, P2 0.0287328
RPS3 ribosomal protein S3 0.028597
RPS8 ribosomal protein S8 0.0285069
GOLGA4 golgin A4 0.0284059
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0282051
ECH1 enoyl CoA hydratase 1, peroxisomal 0.0278704
MYH9 myosin, heavy chain 9, non-muscle 0.0276092
RNASE12 ribonuclease, RNase A family, 12 (non-active) 0.0274571
RPS19 ribosomal protein S19 0.0272972
B2M beta-2-microglobulin 0.0271075
SQSTM1 sequestosome 1 0.0270769
RPL4 ribosomal protein L4 0.0265555
ZMIZ1 zinc finger, MIZ-type containing 1 0.026486
TPT1 tumor protein, translationally-controlled 1 0.0264845
MED13L mediator complex subunit 13-like 0.0263475
TNRC6A trinucleotide repeat containing 6A 0.0262803
ZCCHC7 zinc finger, CCHC domain containing 7 0.0261308
HSPG2 heparan sulfate proteoglycan 2 0.0261088
HPCAL1 hippocalcin-like 1 0.0261081
LOC112694756 uncharaterized LOC112694756 0.0260573
RNF145 ring finger protein 145 0.0257835
GSE1 Gse1 coiled-coil protein 0.0257488
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0257034
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 0.0256457
ATXN1 ataxin 1 0.0253011
PHF21A PHD finger protein 21A 0.0251979
CTSD cathepsin D 0.0251618
STEAP3 STEAP family member 3, metalloreductase 0.025039
IFITM3 interferon induced transmembrane protein 3 0.0248416
MYOF myoferlin 0.024616
PGK1 phosphoglycerate kinase 1 0.0245369
RPL12 ribosomal protein L12 0.024263
EIF4B eukaryotic translation initiation factor 4B 0.0242412
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0240774
VEGFA vascular endothelial growth factor A 0.0240346
ECE1 endothelin converting enzyme 1 0.0238134
MBNL2 muscleblind-like splicing regulator 2 0.0236238
L1CAM L1 cell adhesion molecule 0.0235238
CNBP CCHC-type zinc finger, nucleic acid binding protein 0.023139
TRIO trio Rho guanine nucleotide exchange factor 0.0229431
ZNF292 zinc finger protein 292 0.0229172
FBXO17 F-box protein 17 0.0228559
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0227092
NUMA1 nuclear mitotic apparatus protein 1 0.022269
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0222017
LARP1 La ribonucleoprotein domain family, member 1 0.0220017
RPS12 ribosomal protein S12 0.0219543
CTBP2 C-terminal binding protein 2 0.021717
RPL37A ribosomal protein L37a 0.0216491
RAD51B RAD51 paralog B 0.0214548
RPL13A ribosomal protein L13a 0.0213485
RPL37 ribosomal protein L37 0.0212371
PHF3 PHD finger protein 3 0.021176
ZNF638 zinc finger protein 638 0.0211426
HLA-A major histocompatibility complex, class I, A 0.0209472
RPL34 ribosomal protein L34 0.020751
TTC3 tetratricopeptide repeat domain 3 0.0206424
PRRC2C proline-rich coiled-coil 2C 0.0206119
PRELID2 PRELI domain containing 2 0.020583

decreased expression

Symbol Name Standardized Value
VCL vinculin -0.307745
VIM vimentin -0.255321
ERRFI1 ERBB receptor feedback inhibitor 1 -0.16196
TM4SF1 transmembrane 4 L six family member 1 -0.132384
AKAP12 A kinase (PRKA) anchor protein 12 -0.0824292
MCL1 myeloid cell leukemia 1 -0.0727116
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.071743
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0711402
UBC ubiquitin C -0.0693609
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0687174
RTN4 reticulon 4 -0.0682794
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0621739
VMP1 vacuole membrane protein 1 -0.0609968
ELL2 elongation factor, RNA polymerase II, 2 -0.0572758
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.057147
EGR1 early growth response 1 -0.0562877
CD44 CD44 molecule (Indian blood group) -0.0557678
BMAL2 basic helix-loop-helix ARNT like 2 -0.049975
CSNK1A1 casein kinase 1, alpha 1 -0.0498502
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0492897
NT5E 5'-nucleotidase, ecto (CD73) -0.0484489
JMJD1C jumonji domain containing 1C -0.0479317
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0472218
TPM1 tropomyosin 1 (alpha) -0.04528
EXT1 exostosin glycosyltransferase 1 -0.0450372
ASPH aspartate beta-hydroxylase -0.0450088
NCEH1 neutral cholesterol ester hydrolase 1 -0.0444862
RAP1B RAP1B, member of RAS oncogene family -0.0434034
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.04242
SLC35F3 solute carrier family 35, member F3 -0.042063
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0407842
BIRC3 baculoviral IAP repeat containing 3 -0.0406842
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0395161
RASAL2 RAS protein activator like 2 -0.0392902
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) -0.0380854
AHNAK AHNAK nucleoprotein -0.0378088
UBASH3B ubiquitin associated and SH3 domain containing B -0.0371631
ACTN4 actinin, alpha 4 -0.037107
ZFAND3 zinc finger, AN1-type domain 3 -0.0362776
IPO7 importin 7 -0.0359314
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.0351289
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0344303
TXNRD1 thioredoxin reductase 1 -0.0344125
KLF6 Kruppel-like factor 6 -0.0342891
OSMR oncostatin M receptor -0.033975
RAB7A RAB7A, member RAS oncogene family -0.0334863
DDAH1 dimethylarginine dimethylaminohydrolase 1 -0.0328809
ARHGAP29 Rho GTPase activating protein 29 -0.0322533
DGKD diacylglycerol kinase, delta 130kDa -0.0321982
LOC102724023 ES1 protein homolog, mitochondrial -0.0321022
LDHA lactate dehydrogenase A -0.0317227
JUN jun proto-oncogene -0.0316319
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0313371
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.0310929
HMGA2 high mobility group AT-hook 2 -0.0303662
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0302522
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) -0.0298358
MSRB3 methionine sulfoxide reductase B3 -0.0294876
TMEM41B transmembrane protein 41B -0.0292118
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0278325
THSD4 thrombospondin, type I, domain containing 4 -0.0276072
NUP98 nucleoporin 98kDa -0.026945
BIRC2 baculoviral IAP repeat containing 2 -0.0267959
SLC38A2 solute carrier family 38, member 2 -0.0265278
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0263102
WWTR1 WW domain containing transcription regulator 1 -0.0259651
CDCP1 CUB domain containing protein 1 -0.0258416
TRIP12 thyroid hormone receptor interactor 12 -0.0257717
FOSL1 FOS-like antigen 1 -0.0254214
ATP13A3 ATPase type 13A3 -0.0253622
ANGPTL4 angiopoietin-like 4 -0.0247036
CD59 CD59 molecule, complement regulatory protein -0.0244958
MORF4L2 mortality factor 4 like 2 -0.0244685
IER3 immediate early response 3 -0.0243377
ZNF644 zinc finger protein 644 -0.0239494
FNDC3B fibronectin type III domain containing 3B -0.0239162
MYO10 myosin X -0.0236734
ITGAV integrin, alpha V -0.0236104
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0235729
MYO1E myosin IE -0.023459
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0230646
SEC14L1 SEC14-like 1 (S. cerevisiae) -0.0230373
IL6ST interleukin 6 signal transducer -0.022817
NABP1 nucleic acid binding protein 1 -0.0228006
FHL2 four and a half LIM domains 2 -0.022521
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0222293
F2RL1 coagulation factor II (thrombin) receptor-like 1 -0.0219725
HDAC9 histone deacetylase 9 -0.0217403
LUZP1 leucine zipper protein 1 -0.0216941
PDLIM5 PDZ and LIM domain 5 -0.0215733
TM9SF3 transmembrane 9 superfamily member 3 -0.0215192
SPAG9 sperm associated antigen 9 -0.0213821
RSU1 Ras suppressor protein 1 -0.0211832
MT2A metallothionein 2A -0.0210658
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0210637
ACTR3 ARP3 actin-related protein 3 homolog (yeast) -0.0208692
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0208455
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.020501
CARD18 caspase recruitment domain family, member 18 -0.0201119
STK17A serine/threonine kinase 17a -0.0199173