| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Cabozantinib (S-malate) perturbation in Panc 03.27 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Cabozantinib (S-malate)_Panc 03.27 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HLA-B | major histocompatibility complex, class I, B | 0.16201 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.152429 |
| KRT18 | keratin 18, type I | 0.121516 |
| ACTG1 | actin gamma 1 | 0.109382 |
| MUC4 | mucin 4, cell surface associated | 0.0968575 |
| SMAD3 | SMAD family member 3 | 0.0958589 |
| RPS6 | ribosomal protein S6 | 0.0890541 |
| HLA-A | major histocompatibility complex, class I, A | 0.0832 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0804548 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.079042 |
| RPL35A | ribosomal protein L35a | 0.0772242 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0723626 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0676497 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0660103 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0649484 |
| EFNA5 | ephrin-A5 | 0.0643788 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0619926 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0619112 |
| RUNX1 | runt-related transcription factor 1 | 0.060671 |
| TMSB4X | thymosin beta 4, X-linked | 0.0595656 |
| VEGFA | vascular endothelial growth factor A | 0.0563588 |
| RAD51B | RAD51 paralog B | 0.056212 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.0556152 |
| HLA-C | major histocompatibility complex, class I, C | 0.0541215 |
| LMO7 | LIM domain 7 | 0.05231 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | 0.0522126 |
| CLIP4 | CAP-GLY domain containing linker protein family, member 4 | 0.0518515 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0491549 |
| TGM2 | transglutaminase 2 | 0.0486378 |
| FAM107B | family with sequence similarity 107, member B | 0.0476631 |
| RPL13A | ribosomal protein L13a | 0.0474079 |
| RPL28 | ribosomal protein L28 | 0.0467 |
| FN1 | fibronectin 1 | 0.0461441 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0458127 |
| RPL19 | ribosomal protein L19 | 0.0454201 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.0453451 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0443081 |
| MUC16 | mucin 16, cell surface associated | 0.0438216 |
| SEPTIN9 | septin 9 | 0.0434892 |
| LY6E | lymphocyte antigen 6 complex, locus E | 0.0434848 |
| YBX3 | Y box binding protein 3 | 0.0422304 |
| KRT8 | keratin 8, type II | 0.0420728 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0415435 |
| KRT7 | keratin 7, type II | 0.0411044 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0408163 |
| SVIL | supervillin | 0.0407798 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0407354 |
| SAMD12 | sterile alpha motif domain containing 12 | 0.040688 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.0396913 |
| SCNN1A | sodium channel, non voltage gated 1 alpha subunit | 0.0396386 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0389472 |
| RPL11 | ribosomal protein L11 | 0.0388369 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0386211 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0384807 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0384264 |
| BAZ2A | bromodomain adjacent to zinc finger domain, 2A | 0.0384038 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0381828 |
| C6ORF62 | chromosome 6 open reading frame 62 | 0.038024 |
| RPS20 | ribosomal protein S20 | 0.0378382 |
| OGA | O-GlcNAcase | 0.0375367 |
| BRD2 | bromodomain containing 2 | 0.0373726 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0369492 |
| H1-0 | H1.0 linker histone | 0.0369013 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0346127 |
| RPL34 | ribosomal protein L34 | 0.0345705 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0343881 |
| EGFR | epidermal growth factor receptor | 0.0342994 |
| PLEC | plectin | 0.0340119 |
| STAT2 | signal transducer and activator of transcription 2, 113kDa | 0.0325076 |
| C3 | complement component 3 | 0.0324679 |
| GAREM1 | GRB2 associated regulator of MAPK1 subtype 1 | 0.0323142 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0322212 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0318273 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0317313 |
| ETV6 | ets variant 6 | 0.031509 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0312928 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0311685 |
| RNF213 | ring finger protein 213 | 0.0310941 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0310766 |
| TTC17 | tetratricopeptide repeat domain 17 | 0.0310463 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0307199 |
| RBM33 | RNA binding motif protein 33 | 0.0303762 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0301557 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0300548 |
| MAP3K13 | mitogen-activated protein kinase kinase kinase 13 | 0.0300414 |
| SKAP2 | src kinase associated phosphoprotein 2 | 0.0300335 |
| CNKSR3 | CNKSR family member 3 | 0.0298448 |
| RPL36 | ribosomal protein L36 | 0.0296914 |
| ZC3H13 | zinc finger CCCH-type containing 13 | 0.0296785 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0295929 |
| GOLGB1 | golgin B1 | 0.0294414 |
| PTMA | prothymosin, alpha | 0.0292091 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.0291081 |
| LASP1 | LIM and SH3 protein 1 | 0.028955 |
| RPS29 | ribosomal protein S29 | 0.0286439 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0286115 |
| ATP11A | ATPase, class VI, type 11A | 0.0285108 |
| DAPK1 | death-associated protein kinase 1 | 0.0284261 |
| RPS19 | ribosomal protein S19 | 0.0280614 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0279998 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.204801 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.131016 |
| POTEF | POTE ankyrin domain family, member F | -0.0787283 |
| NDRG1 | N-myc downstream regulated 1 | -0.0764065 |
| LAMA4 | laminin, alpha 4 | -0.0754199 |
| FOSL1 | FOS-like antigen 1 | -0.0728943 |
| UBC | ubiquitin C | -0.0725385 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0684104 |
| LDHA | lactate dehydrogenase A | -0.0654458 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0647556 |
| EZR | ezrin | -0.0639651 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0633388 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0588664 |
| CD44 | CD44 molecule (Indian blood group) | -0.0583785 |
| EHF | ets homologous factor | -0.057527 |
| CANX | calnexin | -0.054392 |
| TPM4 | tropomyosin 4 | -0.0541484 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0540047 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0533458 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0516928 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0492986 |
| RTN4 | reticulon 4 | -0.0490234 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0487553 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0482421 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0478952 |
| ENO1 | enolase 1, (alpha) | -0.047706 |
| PKM | pyruvate kinase, muscle | -0.0473429 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0471009 |
| FAM3C | family with sequence similarity 3, member C | -0.0467599 |
| AHNAK | AHNAK nucleoprotein | -0.0466971 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | -0.0464062 |
| PCLO | piccolo presynaptic cytomatrix protein | -0.044833 |
| EGR1 | early growth response 1 | -0.0446134 |
| ANXA2 | annexin A2 | -0.043552 |
| HMGA1 | high mobility group AT-hook 1 | -0.0416239 |
| THBS1 | thrombospondin 1 | -0.0409564 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0398977 |
| TMEM123 | transmembrane protein 123 | -0.0398542 |
| ITGA6 | integrin, alpha 6 | -0.038106 |
| VCL | vinculin | -0.0376676 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.037373 |
| ZNF207 | zinc finger protein 207 | -0.0370187 |
| RIOK3 | RIO kinase 3 | -0.0369706 |
| EMP1 | epithelial membrane protein 1 | -0.0367349 |
| SMC4 | structural maintenance of chromosomes 4 | -0.03655 |
| LAMC2 | laminin, gamma 2 | -0.0365211 |
| TMSB10 | thymosin beta 10 | -0.0360379 |
| RPS24 | ribosomal protein S24 | -0.0356876 |
| VIM | vimentin | -0.0354218 |
| IL6ST | interleukin 6 signal transducer | -0.0353639 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0340043 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0338116 |
| CCNL1 | cyclin L1 | -0.0331324 |
| RYBP | RING1 and YY1 binding protein | -0.0329795 |
| ANLN | anillin, actin binding protein | -0.0327414 |
| RPS27A | ribosomal protein S27a | -0.0323897 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0321541 |
| CDCP1 | CUB domain containing protein 1 | -0.0320347 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0319664 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0318216 |
| JUN | jun proto-oncogene | -0.0312437 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0311484 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0305583 |
| VMP1 | vacuole membrane protein 1 | -0.0304739 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0298494 |
| ACTN4 | actinin, alpha 4 | -0.0295813 |
| TUBA1B | tubulin, alpha 1b | -0.0295132 |
| SDC4 | syndecan 4 | -0.0293905 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.029198 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | -0.0289239 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0284892 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0284603 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0277661 |
| TJP1 | tight junction protein 1 | -0.0277533 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0277532 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.0276244 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0275501 |
| DIAPH3 | diaphanous-related formin 3 | -0.0275151 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | -0.0274334 |
| ATP11B | ATPase, class VI, type 11B | -0.0272466 |
| TXNRD1 | thioredoxin reductase 1 | -0.0271407 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0267381 |
| CLIC4 | chloride intracellular channel 4 | -0.0263958 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0263159 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0263 |
| AZIN1 | antizyme inhibitor 1 | -0.0261355 |
| ASPH | aspartate beta-hydroxylase | -0.0259014 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | -0.0256098 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0253415 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0252961 |
| SEPTIN7 | septin 7 | -0.0252126 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0252113 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0252045 |
| CENPF | centromere protein F, 350/400kDa | -0.0251495 |
| PCBP2 | poly(rC) binding protein 2 | -0.0250304 |
| KLF6 | Kruppel-like factor 6 | -0.0248507 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0247981 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0247168 |
| RACK1 | receptor for activated C kinase 1 | -0.0246349 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0244922 |
