Cabozantinib (S-malate)_RKO Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cabozantinib (S-malate) perturbation in RKO cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cabozantinib (S-malate)_RKO drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SRRM2 serine/arginine repetitive matrix 2 0.166552
DLC1 DLC1 Rho GTPase activating protein 0.118757
SAMD4A sterile alpha motif domain containing 4A 0.115202
TRIO trio Rho guanine nucleotide exchange factor 0.0962221
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0956456
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0909398
CALD1 caldesmon 1 0.0865771
LPP LIM domain containing preferred translocation partner in lipoma 0.0863146
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0735712
EIF1 eukaryotic translation initiation factor 1 0.0695235
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 0.0649582
EEF2 eukaryotic translation elongation factor 2 0.0634821
RPS6 ribosomal protein S6 0.0626425
HLA-A major histocompatibility complex, class I, A 0.0615052
RPL35A ribosomal protein L35a 0.0587064
LAMB3 laminin, beta 3 0.0585602
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0573654
RPL13A ribosomal protein L13a 0.0567925
CALR calreticulin 0.056425
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0544232
RPL7A ribosomal protein L7a 0.0541226
HMGA2 high mobility group AT-hook 2 0.0500466
OGA O-GlcNAcase 0.048335
NACA nascent polypeptide-associated complex alpha subunit 0.0470088
RPL23 ribosomal protein L23 0.0469769
TTR transthyretin 0.0466513
RPS20 ribosomal protein S20 0.0466488
RPL8 ribosomal protein L8 0.0458186
RUNX1 runt-related transcription factor 1 0.0457016
FOXO3 forkhead box O3 0.045446
ENO2 enolase 2 (gamma, neuronal) 0.042474
RBM33 RNA binding motif protein 33 0.0419365
PRRC2C proline-rich coiled-coil 2C 0.0417136
FRMD6 FERM domain containing 6 0.0413784
NAV2 neuron navigator 2 0.0406576
PHC2 polyhomeotic homolog 2 (Drosophila) 0.0402003
RPL11 ribosomal protein L11 0.0395495
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0395248
EIF4B eukaryotic translation initiation factor 4B 0.0380611
ZCCHC7 zinc finger, CCHC domain containing 7 0.0379127
SBF2 SET binding factor 2 0.0376775
EXOC4 exocyst complex component 4 0.0373224
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0364768
RPS19 ribosomal protein S19 0.0354047
SMTN smoothelin 0.0351921
CAMK2D calcium/calmodulin-dependent protein kinase II delta 0.0348261
CEP250 centrosomal protein 250kDa 0.0348194
TPT1 tumor protein, translationally-controlled 1 0.0342574
FHL2 four and a half LIM domains 2 0.0339795
CREB5 cAMP responsive element binding protein 5 0.0338161
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0331935
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0327992
RPS8 ribosomal protein S8 0.0326644
RB1CC1 RB1-inducible coiled-coil 1 0.032481
LOC112694756 uncharaterized LOC112694756 0.0324128
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0322255
ACTG1 actin gamma 1 0.0321228
ANKRD11 ankyrin repeat domain 11 0.0320096
RPS3 ribosomal protein S3 0.031913
PDIA3 protein disulfide isomerase family A, member 3 0.0311836
AKAP9 A kinase (PRKA) anchor protein 9 0.0310632
FTL ferritin, light polypeptide 0.0306845
RNF145 ring finger protein 145 0.0306247
POU2F1 POU class 2 homeobox 1 0.0302302
RPL26 ribosomal protein L26 0.0297712
PDIA6 protein disulfide isomerase family A, member 6 0.0296344
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.0293724
FNDC3B fibronectin type III domain containing 3B 0.0289324
SRPK2 SRSF protein kinase 2 0.0286706
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.028152
B2M beta-2-microglobulin 0.0278967
ZBTB20 zinc finger and BTB domain containing 20 0.0276116
SMAD3 SMAD family member 3 0.0275456
RPL4 ribosomal protein L4 0.0274986
RAD51B RAD51 paralog B 0.0274658
HLA-B major histocompatibility complex, class I, B 0.0273455
FMNL2 formin-like 2 0.0270779
RGMB repulsive guidance molecule family member b 0.0270375
CTIF CBP80/20-dependent translation initiation factor 0.0270304
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0267295
AKAP13 A kinase (PRKA) anchor protein 13 0.0265543
TMED9 transmembrane emp24 protein transport domain containing 9 0.0264728
HMGA1 high mobility group AT-hook 1 0.0264707
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0263754
BAZ2A bromodomain adjacent to zinc finger domain, 2A 0.0263384
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0261951
CANX calnexin 0.0260162
RPL19 ribosomal protein L19 0.0258718
MPRIP myosin phosphatase Rho interacting protein 0.025757
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0257001
RPL21 ribosomal protein L21 0.0256389
HSPA8 heat shock 70kDa protein 8 0.0254781
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0254546
GOLGA2 golgin A2 0.0254031
FNBP4 formin binding protein 4 0.0252478
DHFR dihydrofolate reductase 0.0251028
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0249225
ZNF292 zinc finger protein 292 0.0248898
RPL28 ribosomal protein L28 0.0248819
SETD5 SET domain containing 5 0.024846

decreased expression

Symbol Name Standardized Value
NAV3 neuron navigator 3 -0.151956
ZEB1 zinc finger E-box binding homeobox 1 -0.121487
TXNRD1 thioredoxin reductase 1 -0.120128
STC1 stanniocalcin 1 -0.0907814
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0736285
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0720415
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0706426
MAPKAP1 mitogen-activated protein kinase associated protein 1 -0.0659521
ZNF438 zinc finger protein 438 -0.0639783
ARHGAP22 Rho GTPase activating protein 22 -0.0615992
C2CD2 C2 calcium-dependent domain containing 2 -0.0598945
ELL2 elongation factor, RNA polymerase II, 2 -0.059584
EXT1 exostosin glycosyltransferase 1 -0.0536579
SGMS2 sphingomyelin synthase 2 -0.0536366
RPS2 ribosomal protein S2 -0.0534797
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0504462
LDHA lactate dehydrogenase A -0.0488023
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0479127
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0471494
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0468667
USP34 ubiquitin specific peptidase 34 -0.0465471
AGO2 argonaute RISC catalytic component 2 -0.0453193
PTPN1 protein tyrosine phosphatase, non-receptor type 1 -0.0441202
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0426322
STK4 serine/threonine kinase 4 -0.0422597
SP100 SP100 nuclear antigen -0.0410241
UPP1 uridine phosphorylase 1 -0.0406404
ATAD2 ATPase family, AAA domain containing 2 -0.0400793
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.039653
IFI16 interferon, gamma-inducible protein 16 -0.039649
MKI67 marker of proliferation Ki-67 -0.039483
POTEF POTE ankyrin domain family, member F -0.0393204
AHNAK AHNAK nucleoprotein -0.038995
TMEM156 transmembrane protein 156 -0.0385317
TM4SF1 transmembrane 4 L six family member 1 -0.0383791
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0380523
RBM39 RNA binding motif protein 39 -0.0379521
CLTC clathrin, heavy chain (Hc) -0.0379005
DGKI diacylglycerol kinase, iota -0.0368266
IL6ST interleukin 6 signal transducer -0.0367079
FRMD4A FERM domain containing 4A -0.0365492
GLRX glutaredoxin (thioltransferase) -0.0361282
RASA2 RAS p21 protein activator 2 -0.0357618
RAB7A RAB7A, member RAS oncogene family -0.0355227
CDK17 cyclin-dependent kinase 17 -0.0354372
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 -0.0354033
GFPT2 glutamine-fructose-6-phosphate transaminase 2 -0.0353245
SPRY4 sprouty homolog 4 (Drosophila) -0.0347564
MAPK8 mitogen-activated protein kinase 8 -0.0342726
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.0340731
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0339757
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -0.032742
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.030666
SETX senataxin -0.0290278
ENO1 enolase 1, (alpha) -0.0285906
RECQL RecQ helicase-like -0.0283498
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0278795
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0270142
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0269855
CAPN2 calpain 2, (m/II) large subunit -0.0268724
PBX3 pre-B-cell leukemia homeobox 3 -0.0266862
PDS5A PDS5 cohesin associated factor A -0.0266412
DDX50 DEAD (Asp-Glu-Ala-Asp) box polypeptide 50 -0.0263809
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0261292
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0260052
BLZF1 basic leucine zipper nuclear factor 1 -0.0259076
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0255505
PAPOLA poly(A) polymerase alpha -0.025543
SAMD9 sterile alpha motif domain containing 9 -0.0254134
CTTNBP2NL CTTNBP2 N-terminal like -0.0250802
CSNK1A1 casein kinase 1, alpha 1 -0.0250178
TASOR2 transcription activation suppressor family member 2 -0.0244799
TRIP12 thyroid hormone receptor interactor 12 -0.0243563
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 -0.0241167
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.024032
PKM pyruvate kinase, muscle -0.0239502
RPS24 ribosomal protein S24 -0.0238881
TUBB4B tubulin, beta 4B class IVb -0.0236836
BIRC2 baculoviral IAP repeat containing 2 -0.0236654
ANXA5 annexin A5 -0.023648
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0235903
RCOR1 REST corepressor 1 -0.0232832
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0232497
WNT2B wingless-type MMTV integration site family, member 2B -0.0230427
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked -0.0230404
ASPH aspartate beta-hydroxylase -0.0227338
TOMM34 translocase of outer mitochondrial membrane 34 -0.02272
GPHN gephyrin -0.0225386
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0225193
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0223589
RNF168 ring finger protein 168, E3 ubiquitin protein ligase -0.0217666
ARHGAP31 Rho GTPase activating protein 31 -0.0216679
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.0213867
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0213184
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -0.0212949
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0212519
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0211938
TCF12 transcription factor 12 -0.0211683
CCND2 cyclin D2 -0.0211673
STARD4 StAR-related lipid transfer (START) domain containing 4 -0.0210609