| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Cabozantinib (S-malate) perturbation in RPMI-7951 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Cabozantinib (S-malate)_RPMI-7951 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ZNF292 | zinc finger protein 292 | 0.0857923 |
| PGK1 | phosphoglycerate kinase 1 | 0.0802596 |
| CD109 | CD109 molecule | 0.0772672 |
| GOLGA4 | golgin A4 | 0.0717375 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 0.0695404 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0681408 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0635286 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0617661 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0609651 |
| NAV2 | neuron navigator 2 | 0.0556945 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0516298 |
| RBM39 | RNA binding motif protein 39 | 0.0453444 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0452806 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0441334 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0437778 |
| XPO1 | exportin 1 | 0.0413524 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0397325 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.0394206 |
| YEATS2 | YEATS domain containing 2 | 0.0383726 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0368343 |
| DPYSL3 | dihydropyrimidinase-like 3 | 0.0367659 |
| MMP2 | matrix metallopeptidase 2 | 0.0364197 |
| CALD1 | caldesmon 1 | 0.0362165 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.0361528 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.035921 |
| OGA | O-GlcNAcase | 0.0357686 |
| FBXO32 | F-box protein 32 | 0.0351229 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0348393 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0338256 |
| TFG | TRK-fused gene | 0.0332397 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0321044 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0314706 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0314673 |
| FNIP1 | folliculin interacting protein 1 | 0.0313199 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0311468 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0309506 |
| ZNF148 | zinc finger protein 148 | 0.0304965 |
| RNF145 | ring finger protein 145 | 0.0303465 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0303465 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | 0.0300898 |
| FAM13A | family with sequence similarity 13, member A | 0.0298995 |
| HELZ | helicase with zinc finger | 0.0297765 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0296629 |
| TNRC6A | trinucleotide repeat containing 6A | 0.0290501 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0290376 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0289336 |
| PHF3 | PHD finger protein 3 | 0.0289116 |
| INSIG2 | insulin induced gene 2 | 0.0283829 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0280802 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0279517 |
| YTHDC1 | YTH domain containing 1 | 0.0277519 |
| NUP58 | nucleoporin 58 | 0.0275929 |
| EYA1 | EYA transcriptional coactivator and phosphatase 1 | 0.0275721 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0274856 |
| PHF21A | PHD finger protein 21A | 0.0274768 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.0274299 |
| AHR | aryl hydrocarbon receptor | 0.0273544 |
| DPYD | dihydropyrimidine dehydrogenase | 0.027278 |
| SETD5 | SET domain containing 5 | 0.0272777 |
| CENPF | centromere protein F, 350/400kDa | 0.0271053 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0269023 |
| PRKCSH | protein kinase C substrate 80K-H | 0.026765 |
| ELP2 | elongator acetyltransferase complex subunit 2 | 0.026692 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0266754 |
| DYNC2H1 | dynein, cytoplasmic 2, heavy chain 1 | 0.0265715 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0263432 |
| RPS6 | ribosomal protein S6 | 0.0262847 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0261873 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0260699 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0260629 |
| HMGB2 | high mobility group box 2 | 0.0259325 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0258388 |
| NCAM1 | neural cell adhesion molecule 1 | 0.0257701 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0257497 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0257015 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0256875 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.025626 |
| PCBP2 | poly(rC) binding protein 2 | 0.025561 |
| CDK19 | cyclin-dependent kinase 19 | 0.0253791 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0248776 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.024675 |
| ATOSA | atos homolog A | 0.0246549 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0246268 |
| TP53BP1 | tumor protein p53 binding protein 1 | 0.0246193 |
| NPTN | neuroplastin | 0.024496 |
| DENND4C | DENN/MADD domain containing 4C | 0.0241791 |
| CLIP4 | CAP-GLY domain containing linker protein family, member 4 | 0.0239125 |
| RLIM | ring finger protein, LIM domain interacting | 0.0238929 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0237912 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0230736 |
| MCTP2 | multiple C2 domains, transmembrane 2 | 0.0230476 |
| PPME1 | protein phosphatase methylesterase 1 | 0.0230152 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.0230029 |
| PDPK1 | 3-phosphoinositide dependent protein kinase 1 | 0.0229909 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0229578 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0228825 |
| MATR3 | matrin 3 | 0.0228339 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0228202 |
| AVL9 | AVL9 homolog (S. cerevisiase) | 0.0227654 |
| RPL13A | ribosomal protein L13a | 0.0227266 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.244467 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.134204 |
| COL1A2 | collagen, type I, alpha 2 | -0.131118 |
| VIM | vimentin | -0.128576 |
| COL1A1 | collagen, type I, alpha 1 | -0.104543 |
| STC1 | stanniocalcin 1 | -0.0994334 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0949795 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0803341 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0752599 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0676076 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0673043 |
| NDRG1 | N-myc downstream regulated 1 | -0.0651893 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0651808 |
| NAV1 | neuron navigator 1 | -0.0632896 |
| FTL | ferritin, light polypeptide | -0.0607918 |
| HLA-B | major histocompatibility complex, class I, B | -0.0603207 |
| ASPH | aspartate beta-hydroxylase | -0.0588085 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0561325 |
| COL5A1 | collagen, type V, alpha 1 | -0.0557425 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0556823 |
| IER3 | immediate early response 3 | -0.0526504 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0519908 |
| CD44 | CD44 molecule (Indian blood group) | -0.0518505 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0514101 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0511313 |
| APCDD1L | adenomatosis polyposis coli down-regulated 1-like | -0.0511159 |
| FRMD4A | FERM domain containing 4A | -0.0506825 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0495972 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0477872 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0464318 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0459264 |
| CDH13 | cadherin 13 | -0.0456237 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0454697 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0451151 |
| GLIS3 | GLIS family zinc finger 3 | -0.0441821 |
| INHBA | inhibin, beta A | -0.0425785 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0419786 |
| MTSS1 | metastasis suppressor 1 | -0.0395124 |
| SLIT2 | slit homolog 2 (Drosophila) | -0.0382483 |
| IL1B | interleukin 1, beta | -0.0378549 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0372408 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0364214 |
| HPCAL1 | hippocalcin-like 1 | -0.0359502 |
| LOXL2 | lysyl oxidase-like 2 | -0.0354343 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | -0.0351312 |
| ANGPTL4 | angiopoietin-like 4 | -0.0351188 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0346218 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0337748 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0335158 |
| PTMA | prothymosin, alpha | -0.032852 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0326273 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.032399 |
| COL5A3 | collagen, type V, alpha 3 | -0.0323243 |
| RRBP1 | ribosome binding protein 1 | -0.0312041 |
| FAM20C | family with sequence similarity 20, member C | -0.0305897 |
| EGR1 | early growth response 1 | -0.0305105 |
| COL6A2 | collagen, type VI, alpha 2 | -0.030377 |
| HMGA2 | high mobility group AT-hook 2 | -0.0301276 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.0296316 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0286448 |
| EML5 | echinoderm microtubule associated protein like 5 | -0.0285429 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0281344 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0279045 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0275851 |
| VCL | vinculin | -0.0275842 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.027114 |
| PLOD1 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 | -0.0270373 |
| SERPINH1 | serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) | -0.0268861 |
| TMSB10 | thymosin beta 10 | -0.0267812 |
| MAP1B | microtubule-associated protein 1B | -0.0266856 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0263922 |
| TPM4 | tropomyosin 4 | -0.0263828 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0263211 |
| HM13 | histocompatibility (minor) 13 | -0.0261483 |
| TMEM178B | transmembrane protein 178B | -0.0259572 |
| ENO1 | enolase 1, (alpha) | -0.0253851 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0253537 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0250092 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.0249456 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0249441 |
| PPIB | peptidylprolyl isomerase B (cyclophilin B) | -0.0243786 |
| CAVIN1 | caveolae associated protein 1 | -0.0238167 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0233906 |
| S100A10 | S100 calcium binding protein A10 | -0.0229533 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0228108 |
| CLMP | CXADR-like membrane protein | -0.0225444 |
| SP100 | SP100 nuclear antigen | -0.0224951 |
| JARID2 | jumonji, AT rich interactive domain 2 | -0.0223852 |
| TGFB1 | transforming growth factor, beta 1 | -0.0220176 |
| PCBP3 | poly(rC) binding protein 3 | -0.0219182 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0214819 |
| CCND1 | cyclin D1 | -0.0214717 |
| ZHX2 | zinc fingers and homeoboxes 2 | -0.0210892 |
| RAI14 | retinoic acid induced 14 | -0.0210637 |
| S100A6 | S100 calcium binding protein A6 | -0.0207081 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0206599 |
| ECE1 | endothelin converting enzyme 1 | -0.0204339 |
| INTS6 | integrator complex subunit 6 | -0.0203594 |
| NT5E | 5'-nucleotidase, ecto (CD73) | -0.0202507 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0201993 |
