| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Cabozantinib (S-malate) perturbation in SK-MEL-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Cabozantinib (S-malate)_SK-MEL-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FMN1 | formin 1 | 0.213162 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.193733 |
| LSAMP | limbic system-associated membrane protein | 0.126355 |
| FRMD4A | FERM domain containing 4A | 0.0697473 |
| FHIT | fragile histidine triad | 0.0576048 |
| CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 | 0.0536473 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0503685 |
| NLGN1 | neuroligin 1 | 0.0501853 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.04978 |
| FLNA | filamin A, alpha | 0.0496515 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0476114 |
| ACTG1 | actin gamma 1 | 0.047604 |
| EXOC4 | exocyst complex component 4 | 0.047472 |
| MACROD2 | MACRO domain containing 2 | 0.0465886 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0457292 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | 0.0450757 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0447337 |
| CNIH3 | cornichon family AMPA receptor auxiliary protein 3 | 0.0417512 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0413586 |
| PLEC | plectin | 0.0406769 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0399635 |
| NRG3 | neuregulin 3 | 0.0397736 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | 0.0395515 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0392168 |
| HSPA8 | heat shock 70kDa protein 8 | 0.039069 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0387666 |
| FMNL2 | formin-like 2 | 0.0376115 |
| SMYD3 | SET and MYND domain containing 3 | 0.0373759 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0370992 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0367107 |
| SQSTM1 | sequestosome 1 | 0.0361611 |
| HDAC9 | histone deacetylase 9 | 0.0349947 |
| RNF213 | ring finger protein 213 | 0.0348853 |
| SMAD3 | SMAD family member 3 | 0.0348471 |
| ARHGEF11 | Rho guanine nucleotide exchange factor (GEF) 11 | 0.0342308 |
| NAV2 | neuron navigator 2 | 0.0335087 |
| ST3GAL6 | ST3 beta-galactoside alpha-2,3-sialyltransferase 6 | 0.0334951 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0333845 |
| KAZN | kazrin, periplakin interacting protein | 0.0328448 |
| MSI2 | musashi RNA-binding protein 2 | 0.0318271 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0315391 |
| LINGO2 | leucine rich repeat and Ig domain containing 2 | 0.0314932 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0313137 |
| CADM1 | cell adhesion molecule 1 | 0.0310868 |
| CTTN | cortactin | 0.0310133 |
| INPP5F | inositol polyphosphate-5-phosphatase F | 0.0305499 |
| ST13 | suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) | 0.0304121 |
| FBXL17 | F-box and leucine-rich repeat protein 17 | 0.0303305 |
| TPM3 | tropomyosin 3 | 0.0294885 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0294834 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0293293 |
| GRIK5 | glutamate receptor, ionotropic, kainate 5 | 0.0290494 |
| BCAS3 | breast carcinoma amplified sequence 3 | 0.0284586 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0283474 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | 0.0282018 |
| HDAC4 | histone deacetylase 4 | 0.0280025 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.027999 |
| SLC39A11 | solute carrier family 39, member 11 | 0.0278285 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0274268 |
| SFTPA2 | surfactant protein A2 | 0.0274147 |
| OSBPL10 | oxysterol binding protein-like 10 | 0.0270055 |
| RAD51B | RAD51 paralog B | 0.026711 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0263768 |
| OGA | O-GlcNAcase | 0.0263449 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.026272 |
| ARB2A | ARB2 cotranscriptional regulator A | 0.0260314 |
| PMEL | premelanosome protein | 0.0254582 |
| SEPTIN9 | septin 9 | 0.0251756 |
| SUMF1 | sulfatase modifying factor 1 | 0.0245433 |
| YEATS2 | YEATS domain containing 2 | 0.0244977 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.0244098 |
| CEP250 | centrosomal protein 250kDa | 0.0242936 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0241688 |
| ARL15 | ADP-ribosylation factor-like 15 | 0.0237818 |
| LDLRAD3 | low density lipoprotein receptor class A domain containing 3 | 0.0236016 |
| PGK1 | phosphoglycerate kinase 1 | 0.0236 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.023224 |
| LEF1 | lymphoid enhancer-binding factor 1 | 0.0231735 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0228368 |
| NBEA | neurobeachin | 0.0225818 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0225015 |
| ANKS1A | ankyrin repeat and sterile alpha motif domain containing 1A | 0.0224602 |
| FNIP1 | folliculin interacting protein 1 | 0.0224134 |
| FOXP1 | forkhead box P1 | 0.0223398 |
| TBC1D5 | TBC1 domain family, member 5 | 0.02226 |
| C10ORF90 | chromosome 10 open reading frame 90 | 0.0222107 |
| TSPAN14 | tetraspanin 14 | 0.022054 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0220441 |
| TUSC3 | tumor suppressor candidate 3 | 0.0218893 |
| CLIP4 | CAP-GLY domain containing linker protein family, member 4 | 0.0218796 |
| CD109 | CD109 molecule | 0.0218224 |
| RBM33 | RNA binding motif protein 33 | 0.0216183 |
| FAM219A | family with sequence similarity 219, member A | 0.0215735 |
| RBM6 | RNA binding motif protein 6 | 0.0215019 |
| AUTS2 | autism susceptibility candidate 2 | 0.0213129 |
| PRKD1 | protein kinase D1 | 0.0212182 |
| KCNIP4 | Kv channel interacting protein 4 | 0.0209776 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0205261 |
| STK10 | serine/threonine kinase 10 | 0.0205126 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0204175 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.301772 |
| FN1 | fibronectin 1 | -0.186716 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.122711 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0784958 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0714926 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0704874 |
| CCND1 | cyclin D1 | -0.0704457 |
| MT2A | metallothionein 2A | -0.0660191 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0659487 |
| LDHA | lactate dehydrogenase A | -0.0608104 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0555297 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0545697 |
| NDRG1 | N-myc downstream regulated 1 | -0.0512449 |
| PTMA | prothymosin, alpha | -0.0495542 |
| PKM | pyruvate kinase, muscle | -0.0479961 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0476004 |
| RPLP1 | ribosomal protein, large, P1 | -0.0429191 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0423118 |
| FTL | ferritin, light polypeptide | -0.0388996 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0380342 |
| ANGPTL4 | angiopoietin-like 4 | -0.035895 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | -0.0342276 |
| TMSB10 | thymosin beta 10 | -0.0338913 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0336979 |
| POTEF | POTE ankyrin domain family, member F | -0.0334325 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0330087 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0316366 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0314496 |
| HMGA1 | high mobility group AT-hook 1 | -0.0304479 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0300603 |
| TENM1 | teneurin transmembrane protein 1 | -0.0297428 |
| ENO1 | enolase 1, (alpha) | -0.0296722 |
| CD44 | CD44 molecule (Indian blood group) | -0.0294298 |
| B2M | beta-2-microglobulin | -0.029144 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0285479 |
| MSN | moesin | -0.0283697 |
| RPS8 | ribosomal protein S8 | -0.0268129 |
| ANLN | anillin, actin binding protein | -0.0265279 |
| RPS6 | ribosomal protein S6 | -0.0256974 |
| RPLP0 | ribosomal protein, large, P0 | -0.0256378 |
| SEPTIN7 | septin 7 | -0.0256123 |
| S100A10 | S100 calcium binding protein A10 | -0.0255309 |
| CBX3 | chromobox homolog 3 | -0.0250324 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0245533 |
| DDX1 | DEAD (Asp-Glu-Ala-Asp) box helicase 1 | -0.024269 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.023794 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0237174 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0233765 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.023304 |
| RPS24 | ribosomal protein S24 | -0.0226945 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0226875 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0225285 |
| MORF4L2 | mortality factor 4 like 2 | -0.0224648 |
| RPL35A | ribosomal protein L35a | -0.0217881 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.021718 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0216852 |
| TXNRD1 | thioredoxin reductase 1 | -0.0216193 |
| IPO7 | importin 7 | -0.0215246 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0212151 |
| RPS13 | ribosomal protein S13 | -0.0211529 |
| RAB7A | RAB7A, member RAS oncogene family | -0.021144 |
| RACK1 | receptor for activated C kinase 1 | -0.0210676 |
| ARF4 | ADP-ribosylation factor 4 | -0.0209332 |
| WDR45B | WD repeat domain 45B | -0.0208076 |
| TPM4 | tropomyosin 4 | -0.0207053 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0206776 |
| TPI1 | triosephosphate isomerase 1 | -0.0201241 |
| TUBA1B | tubulin, alpha 1b | -0.0201053 |
| KLF6 | Kruppel-like factor 6 | -0.0195423 |
| RPLP2 | ribosomal protein, large, P2 | -0.0195295 |
| ANXA2 | annexin A2 | -0.0195271 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0192038 |
| CLIC4 | chloride intracellular channel 4 | -0.0190793 |
| LAMP2 | lysosomal-associated membrane protein 2 | -0.0190036 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.018984 |
| RBM39 | RNA binding motif protein 39 | -0.0189342 |
| RPS21 | ribosomal protein S21 | -0.018836 |
| H3-3B | H3.3 histone B | -0.0184478 |
| PAIP2 | poly(A) binding protein interacting protein 2 | -0.0178929 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0177814 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0176562 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0176376 |
| RPL12 | ribosomal protein L12 | -0.0176196 |
| UBC | ubiquitin C | -0.0173494 |
| TUBB6 | tubulin, beta 6 class V | -0.0169993 |
| CCT6A | chaperonin containing TCP1, subunit 6A (zeta 1) | -0.0166454 |
| RPS14 | ribosomal protein S14 | -0.0165161 |
| MT1X | metallothionein 1X | -0.0164417 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0163583 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | -0.0162823 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0162805 |
| TPX2 | TPX2, microtubule-associated | -0.0161652 |
| RPL32 | ribosomal protein L32 | -0.0161213 |
| PFN1 | profilin 1 | -0.0160506 |
| LITAF | lipopolysaccharide-induced TNF factor | -0.0159362 |
| RPS3 | ribosomal protein S3 | -0.0158981 |
| ZNF207 | zinc finger protein 207 | -0.0157946 |
| RIOK3 | RIO kinase 3 | -0.0156897 |
| RAN | RAN, member RAS oncogene family | -0.0154505 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0154394 |
