| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Cabozantinib (S-malate) perturbation in SNU-1 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Cabozantinib (S-malate)_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.145001 |
| HDAC9 | histone deacetylase 9 | 0.127309 |
| ENOX1 | ecto-NOX disulfide-thiol exchanger 1 | 0.116534 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.111239 |
| B3GALT1 | UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 | 0.0989902 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0926802 |
| PDGFC | platelet derived growth factor C | 0.0905257 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.0888871 |
| NBEA | neurobeachin | 0.0763389 |
| EFNA5 | ephrin-A5 | 0.0760164 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0759241 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 0.0741554 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0729943 |
| NFIA | nuclear factor I/A | 0.0723566 |
| PYGB | phosphorylase, glycogen; brain | 0.0682175 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0676476 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0631389 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.0628601 |
| ACTG1 | actin gamma 1 | 0.0586889 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0567242 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0561979 |
| FOXP1 | forkhead box P1 | 0.0545256 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0540132 |
| SMYD3 | SET and MYND domain containing 3 | 0.0518986 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0516438 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0511679 |
| RBM39 | RNA binding motif protein 39 | 0.0510936 |
| ZNF292 | zinc finger protein 292 | 0.0503837 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0481391 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0477771 |
| ANK2 | ankyrin 2, neuronal | 0.0476519 |
| TMSB4X | thymosin beta 4, X-linked | 0.0475157 |
| EML4 | echinoderm microtubule associated protein like 4 | 0.0464933 |
| EGFR | epidermal growth factor receptor | 0.0464213 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0455816 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0445029 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0438733 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | 0.0436363 |
| RNF145 | ring finger protein 145 | 0.0422915 |
| MSI2 | musashi RNA-binding protein 2 | 0.0416298 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0415835 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0413026 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.041268 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0406722 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0404267 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.039957 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0398643 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.039434 |
| RPL4 | ribosomal protein L4 | 0.0393118 |
| ZNF608 | zinc finger protein 608 | 0.0381349 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0368093 |
| RTN4 | reticulon 4 | 0.0362121 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0359629 |
| CREB5 | cAMP responsive element binding protein 5 | 0.0359487 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0350456 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0339022 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0337591 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0335115 |
| PER1 | period circadian clock 1 | 0.0334534 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0326746 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0317917 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0317136 |
| JMJD1C | jumonji domain containing 1C | 0.0315521 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0314797 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0314211 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0313932 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0312057 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0305185 |
| PDE10A | phosphodiesterase 10A | 0.0304435 |
| COG5 | component of oligomeric golgi complex 5 | 0.0300146 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | 0.0298284 |
| NCKAP1 | NCK-associated protein 1 | 0.0296617 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | 0.0296553 |
| PRPF38B | pre-mRNA processing factor 38B | 0.0292505 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | 0.0282129 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | 0.0280915 |
| RAB27B | RAB27B, member RAS oncogene family | 0.0280552 |
| GPHN | gephyrin | 0.0280488 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0279558 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0278184 |
| GSE1 | Gse1 coiled-coil protein | 0.0273074 |
| TRERF1 | transcriptional regulating factor 1 | 0.0272772 |
| PLCE1 | phospholipase C, epsilon 1 | 0.0271682 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0267414 |
| PPM1L | protein phosphatase, Mg2+/Mn2+ dependent, 1L | 0.0267143 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0265637 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0264824 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | 0.0262609 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | 0.0262252 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0262229 |
| PGK1 | phosphoglycerate kinase 1 | 0.0261114 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0257962 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0257382 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | 0.0254325 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0251398 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.0247491 |
| MED13L | mediator complex subunit 13-like | 0.024615 |
| ARID1A | AT rich interactive domain 1A (SWI-like) | 0.0244037 |
| FNBP4 | formin binding protein 4 | 0.0242867 |
| CCNL1 | cyclin L1 | 0.0242689 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.113887 |
| PTMA | prothymosin, alpha | -0.113293 |
| PKM | pyruvate kinase, muscle | -0.110626 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0588618 |
| BMP10 | bone morphogenetic protein 10 | -0.0477865 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0442922 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0431468 |
| S100A6 | S100 calcium binding protein A6 | -0.0337326 |
| POTEF | POTE ankyrin domain family, member F | -0.0327314 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0302499 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0298456 |
| RHOA | ras homolog family member A | -0.0293179 |
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | -0.0280609 |
| MYO5C | myosin VC | -0.0270925 |
| CCND1 | cyclin D1 | -0.0269934 |
| ALDH3A2 | aldehyde dehydrogenase 3 family, member A2 | -0.0256407 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0252489 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | -0.0244006 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0241981 |
| PFN1 | profilin 1 | -0.0238691 |
| MKI67 | marker of proliferation Ki-67 | -0.0228529 |
| EMP3 | epithelial membrane protein 3 | -0.0219926 |
| S100A4 | S100 calcium binding protein A4 | -0.02113 |
| TPM4 | tropomyosin 4 | -0.0211143 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | -0.0210236 |
| GLI3 | GLI family zinc finger 3 | -0.0203764 |
| LOXL3 | lysyl oxidase-like 3 | -0.0200994 |
| ALDH1A2 | aldehyde dehydrogenase 1 family, member A2 | -0.0194576 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0188422 |
| ENO1 | enolase 1, (alpha) | -0.0185844 |
| TOB1 | transducer of ERBB2, 1 | -0.0179324 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0174983 |
| FTL | ferritin, light polypeptide | -0.0172338 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0171529 |
| TUBA1B | tubulin, alpha 1b | -0.0167984 |
| MYO5A | myosin VA (heavy chain 12, myoxin) | -0.0162566 |
| SMC4 | structural maintenance of chromosomes 4 | -0.015993 |
| PRDX2 | peroxiredoxin 2 | -0.0157518 |
| MYL12B | myosin, light chain 12B, regulatory | -0.015267 |
| DIAPH3 | diaphanous-related formin 3 | -0.015252 |
| HJURP | Holliday junction recognition protein | -0.0152429 |
| MAP3K14 | mitogen-activated protein kinase kinase kinase 14 | -0.0151389 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0150217 |
| ARL2BP | ADP-ribosylation factor-like 2 binding protein | -0.0145938 |
| PRDX1 | peroxiredoxin 1 | -0.0144216 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0144155 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | -0.0143381 |
| RRM2 | ribonucleotide reductase M2 | -0.0141813 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0141346 |
| TUBB4B | tubulin, beta 4B class IVb | -0.0136013 |
| SUZ12 | SUZ12 polycomb repressive complex 2 subunit | -0.013542 |
| THBD | thrombomodulin | -0.0135065 |
| FER1L6 | fer-1-like family member 6 | -0.0134236 |
| CENPE | centromere protein E, 312kDa | -0.0132551 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0132052 |
| NAV2 | neuron navigator 2 | -0.0131097 |
| CKAP2 | cytoskeleton associated protein 2 | -0.0128765 |
| RSPRY1 | ring finger and SPRY domain containing 1 | -0.0128604 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0128349 |
| PLXNA2 | plexin A2 | -0.0126333 |
| PTMS | parathymosin | -0.0123012 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0122815 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0122683 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0122366 |
| PNPT1 | polyribonucleotide nucleotidyltransferase 1 | -0.0121427 |
| KNL1 | kinetochore scaffold 1 | -0.01125 |
| ARF4 | ADP-ribosylation factor 4 | -0.0112119 |
| KIF18B | kinesin family member 18B | -0.0109106 |
| TPX2 | TPX2, microtubule-associated | -0.010795 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0107323 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0105976 |
| LDHA | lactate dehydrogenase A | -0.0105009 |
| DUSP6 | dual specificity phosphatase 6 | -0.0104631 |
| TMPO | thymopoietin | -0.0102629 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0101062 |
| TPI1 | triosephosphate isomerase 1 | -0.0100873 |
| CYB5B | cytochrome b5 type B (outer mitochondrial membrane) | -0.0100721 |
| LATS2 | large tumor suppressor kinase 2 | -0.010044 |
| AHNAK | AHNAK nucleoprotein | -0.010025 |
| IFITM2 | interferon induced transmembrane protein 2 | -0.00996691 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.00989384 |
| COX7A2 | cytochrome c oxidase subunit VIIa polypeptide 2 (liver) | -0.00982165 |
| SPRY4 | sprouty homolog 4 (Drosophila) | -0.00980714 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.00977441 |
| RACK1 | receptor for activated C kinase 1 | -0.0097054 |
| RHOB | ras homolog family member B | -0.00968814 |
| SMIM44 | small integral membrane protein 44 | -0.00962612 |
| KLF2 | Kruppel-like factor 2 | -0.00959637 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0094772 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0094454 |
| TACC3 | transforming, acidic coiled-coil containing protein 3 | -0.00944438 |
| CBX3 | chromobox homolog 3 | -0.00939618 |
| CBL | Cbl proto-oncogene, E3 ubiquitin protein ligase | -0.00938281 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.00937926 |
| TRIOBP | TRIO and F-actin binding protein | -0.00930797 |
| KIAA0232 | KIAA0232 | -0.00929327 |
| CDC25C | cell division cycle 25C | -0.0092361 |
| YWHAH | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta | -0.00916804 |
| SLC9A1 | solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 | -0.00906411 |
| RAB10 | RAB10, member RAS oncogene family | -0.00903447 |
