Cabozantinib (S-malate)_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cabozantinib (S-malate) perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cabozantinib (S-malate)_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.165541
MYH9 myosin, heavy chain 9, non-muscle 0.146481
HLA-B major histocompatibility complex, class I, B 0.124915
ZMIZ1 zinc finger, MIZ-type containing 1 0.103734
UGCG UDP-glucose ceramide glucosyltransferase 0.0686762
MYOF myoferlin 0.0568601
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.054808
TNS3 tensin 3 0.054695
BICC1 BicC family RNA binding protein 1 0.0540717
ACTG1 actin gamma 1 0.051174
SRRM2 serine/arginine repetitive matrix 2 0.0510004
HLA-A major histocompatibility complex, class I, A 0.0494773
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0491767
OPTN optineurin 0.0479352
KYNU kynureninase 0.047836
CADM1 cell adhesion molecule 1 0.0470701
SMAD3 SMAD family member 3 0.0446544
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0436958
DST dystonin 0.0430788
IGFBP7 insulin-like growth factor binding protein 7 0.0429739
EIF1 eukaryotic translation initiation factor 1 0.0409881
PTMA prothymosin, alpha 0.0396031
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0383551
FRMD4A FERM domain containing 4A 0.0382895
PTPRK protein tyrosine phosphatase, receptor type, K 0.0374279
FLNA filamin A, alpha 0.0372799
INSIG1 insulin induced gene 1 0.0366256
FNDC3B fibronectin type III domain containing 3B 0.0361656
NAV2 neuron navigator 2 0.0356559
TGFBI transforming growth factor, beta-induced, 68kDa 0.0348257
PHF21A PHD finger protein 21A 0.0344414
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0341517
DSCAM Down syndrome cell adhesion molecule 0.0336273
RPS6 ribosomal protein S6 0.0330445
CDK19 cyclin-dependent kinase 19 0.0330349
OGA O-GlcNAcase 0.0329983
TIMP2 TIMP metallopeptidase inhibitor 2 0.0328717
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0326968
ANKRD28 ankyrin repeat domain 28 0.0316709
SREBF2 sterol regulatory element binding transcription factor 2 0.0315192
CENPF centromere protein F, 350/400kDa 0.0312264
N4BP2L2 NEDD4 binding protein 2-like 2 0.0311325
CEP250 centrosomal protein 250kDa 0.0304454
TBC1D5 TBC1 domain family, member 5 0.0303064
MKI67 marker of proliferation Ki-67 0.0300763
SOD2 superoxide dismutase 2, mitochondrial 0.0299416
RAD51B RAD51 paralog B 0.0294436
SFTPA2 surfactant protein A2 0.0291198
MBNL2 muscleblind-like splicing regulator 2 0.0289163
ZNF608 zinc finger protein 608 0.0287968
ZNF292 zinc finger protein 292 0.028635
SMYD3 SET and MYND domain containing 3 0.0281924
FOXP1 forkhead box P1 0.0281864
MYLK myosin light chain kinase 0.0280361
VEGFA vascular endothelial growth factor A 0.0280291
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0277182
TNIP1 TNFAIP3 interacting protein 1 0.0273569
EXOC4 exocyst complex component 4 0.0270988
PDE4D phosphodiesterase 4D, cAMP-specific 0.0267298
NUMA1 nuclear mitotic apparatus protein 1 0.0266368
STARD4 StAR-related lipid transfer (START) domain containing 4 0.0263332
TNRC6B trinucleotide repeat containing 6B 0.0263133
DPYSL3 dihydropyrimidinase-like 3 0.0263101
RPL23 ribosomal protein L23 0.0262862
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0260876
EEF2 eukaryotic translation elongation factor 2 0.0258108
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0256643
RPL37A ribosomal protein L37a 0.0255974
BRD2 bromodomain containing 2 0.0255325
AOPEP aminopeptidase O (putative) 0.0252479
RBM33 RNA binding motif protein 33 0.0252165
ZBTB20 zinc finger and BTB domain containing 20 0.0250454
LDLR low density lipoprotein receptor 0.0250098
RNF213 ring finger protein 213 0.0247992
HLA-C major histocompatibility complex, class I, C 0.0247726
LRRC7 leucine rich repeat containing 7 0.0247673
ADM adrenomedullin 0.0247063
CACNB2 calcium channel, voltage-dependent, beta 2 subunit 0.0245641
FBXO32 F-box protein 32 0.0242494
GOLGA4 golgin A4 0.0241462
PRKCSH protein kinase C substrate 80K-H 0.0240849
B2M beta-2-microglobulin 0.0240097
RALA v-ral simian leukemia viral oncogene homolog A (ras related) 0.0239634
PRKN parkin RBR E3 ubiquitin protein ligase 0.023941
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0238135
UTRN utrophin 0.0237659
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0236673
CKAP5 cytoskeleton associated protein 5 0.0233742
HSPA8 heat shock 70kDa protein 8 0.0233405
RUNX2 runt-related transcription factor 2 0.0233237
ACACA acetyl-CoA carboxylase alpha 0.0230075
AUH AU RNA binding protein/enoyl-CoA hydratase 0.0230016
SETD5 SET domain containing 5 0.0229701
ELOVL5 ELOVL fatty acid elongase 5 0.0229119
KIF4A kinesin family member 4A 0.0228667
STAT2 signal transducer and activator of transcription 2, 113kDa 0.0225689
ACSS2 acyl-CoA synthetase short-chain family member 2 0.0225561
KLHL24 kelch-like family member 24 0.0224943
FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial 0.0223811
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0223534

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.205049
CD44 CD44 molecule (Indian blood group) -0.160755
GLIS3 GLIS family zinc finger 3 -0.155747
AKAP12 A kinase (PRKA) anchor protein 12 -0.152473
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.141353
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.129728
MT2A metallothionein 2A -0.104792
VIM vimentin -0.102551
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.101779
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0981424
HMGA2 high mobility group AT-hook 2 -0.0936666
VCAN versican -0.0909201
VCL vinculin -0.08876
NDRG1 N-myc downstream regulated 1 -0.0858103
LDHA lactate dehydrogenase A -0.0844886
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0786168
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0733767
EGR1 early growth response 1 -0.0717233
STC1 stanniocalcin 1 -0.0680522
IER3 immediate early response 3 -0.0673847
TMSB10 thymosin beta 10 -0.0670608
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0637841
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0615121
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0596989
CDH13 cadherin 13 -0.0574087
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0537751
MORF4L2 mortality factor 4 like 2 -0.0515751
KLF6 Kruppel-like factor 6 -0.0503639
NAV1 neuron navigator 1 -0.0503395
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0491246
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0489568
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0488256
NABP1 nucleic acid binding protein 1 -0.0486228
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0461448
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0457334
SFRP1 secreted frizzled-related protein 1 -0.0453648
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0452328
RAB7A RAB7A, member RAS oncogene family -0.045169
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0448817
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0445213
VMP1 vacuole membrane protein 1 -0.0435656
CDCP1 CUB domain containing protein 1 -0.0434309
FTH1 ferritin, heavy polypeptide 1 -0.0424192
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0412654
MT1X metallothionein 1X -0.0408665
HDAC9 histone deacetylase 9 -0.0404446
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.040064
INHBA inhibin, beta A -0.0396001
ZBTB38 zinc finger and BTB domain containing 38 -0.0386686
FN1 fibronectin 1 -0.0380998
GLIPR1 GLI pathogenesis-related 1 -0.0380708
SLC38A1 solute carrier family 38, member 1 -0.0379173
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0378123
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0377384
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0377321
GNAS GNAS complex locus -0.0371426
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.036019
LOX lysyl oxidase -0.0348741
JUN jun proto-oncogene -0.0347479
PPARD peroxisome proliferator-activated receptor delta -0.0344362
MAP1B microtubule-associated protein 1B -0.0343056
RAI14 retinoic acid induced 14 -0.0341663
THBS1 thrombospondin 1 -0.0340117
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0337429
ABTB3 ankyrin repeat and BTB domain containing 3 -0.0337406
DIAPH2 diaphanous-related formin 2 -0.0334981
RND3 Rho family GTPase 3 -0.0317977
UBA6 ubiquitin-like modifier activating enzyme 6 -0.031643
ELL2 elongation factor, RNA polymerase II, 2 -0.0315687
RRBP1 ribosome binding protein 1 -0.0306203
NT5E 5'-nucleotidase, ecto (CD73) -0.0303703
SEC24A SEC24 family member A -0.0303699
ARHGAP5 Rho GTPase activating protein 5 -0.0302004
EFNA5 ephrin-A5 -0.0300378
GFPT2 glutamine-fructose-6-phosphate transaminase 2 -0.0299021
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0298768
ENO1 enolase 1, (alpha) -0.0296755
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) -0.0296113
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0293578
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0291736
AFF3 AF4/FMR2 family, member 3 -0.0290148
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0288152
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0287639
PDE10A phosphodiesterase 10A -0.0280407
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0278838
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0277803
GREM1 gremlin 1, DAN family BMP antagonist -0.0276168
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0273779
SAMD3 sterile alpha motif domain containing 3 -0.0273332
ASPH aspartate beta-hydroxylase -0.0273046
IL6ST interleukin 6 signal transducer -0.0271564
FTL ferritin, light polypeptide -0.0262883
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0261264
VDAC1 voltage-dependent anion channel 1 -0.0259329
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0257606
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0256994
IFI16 interferon, gamma-inducible protein 16 -0.0254867
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0249373
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 -0.0248812
TNNC1 troponin C type 1 (slow) -0.0247963