| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Cabozantinib (S-malate) perturbation in SW 900 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Cabozantinib (S-malate)_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.101142 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0857494 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0850802 |
| SQSTM1 | sequestosome 1 | 0.0795 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0785212 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0748628 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0711168 |
| RNF145 | ring finger protein 145 | 0.0657786 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0647471 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0575847 |
| AHR | aryl hydrocarbon receptor | 0.0553205 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.052908 |
| OGA | O-GlcNAcase | 0.0498582 |
| SFTPA2 | surfactant protein A2 | 0.0494561 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0493352 |
| HELZ | helicase with zinc finger | 0.0438453 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.041824 |
| DENND5B | DENN/MADD domain containing 5B | 0.0408151 |
| VEGFA | vascular endothelial growth factor A | 0.0407388 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0406616 |
| AOPEP | aminopeptidase O (putative) | 0.0401426 |
| SUCO | SUN domain containing ossification factor | 0.0396423 |
| RPS20 | ribosomal protein S20 | 0.0393715 |
| B2M | beta-2-microglobulin | 0.0389629 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0388425 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0387969 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0385157 |
| NEK7 | NIMA-related kinase 7 | 0.0376604 |
| SON | SON DNA binding protein | 0.0375293 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0374106 |
| TMED9 | transmembrane emp24 protein transport domain containing 9 | 0.0368728 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0366742 |
| RAD21 | RAD21 homolog (S. pombe) | 0.036657 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0359513 |
| DCAF6 | DDB1 and CUL4 associated factor 6 | 0.0358123 |
| TPR | translocated promoter region, nuclear basket protein | 0.0355774 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | 0.0355279 |
| RBM25 | RNA binding motif protein 25 | 0.0353338 |
| SMAD3 | SMAD family member 3 | 0.0349107 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | 0.0337323 |
| STC2 | stanniocalcin 2 | 0.0335225 |
| DHFR | dihydrofolate reductase | 0.0331076 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0325578 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0323244 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.032148 |
| ETNK1 | ethanolamine kinase 1 | 0.0320525 |
| LIFR | leukemia inhibitory factor receptor alpha | 0.0317259 |
| H1-0 | H1.0 linker histone | 0.0315461 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0315417 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0314198 |
| RPL28 | ribosomal protein L28 | 0.03115 |
| PPP1R15B | protein phosphatase 1, regulatory subunit 15B | 0.031088 |
| PCMTD1 | protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 | 0.0310643 |
| CUL3 | cullin 3 | 0.0302824 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0302769 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.0297557 |
| FAM13A | family with sequence similarity 13, member A | 0.0295035 |
| HLA-A | major histocompatibility complex, class I, A | 0.0294589 |
| SETD5 | SET domain containing 5 | 0.0289338 |
| RND3 | Rho family GTPase 3 | 0.028842 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0287718 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.028627 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0286058 |
| SRPK2 | SRSF protein kinase 2 | 0.0285909 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0283293 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | 0.0282545 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | 0.0281227 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.0275377 |
| ZC3H11A | zinc finger CCCH-type containing 11A | 0.0274343 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.027398 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0270588 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | 0.0270336 |
| ATF3 | activating transcription factor 3 | 0.0270182 |
| RBM39 | RNA binding motif protein 39 | 0.0269495 |
| APP | amyloid beta (A4) precursor protein | 0.0269166 |
| MCTP2 | multiple C2 domains, transmembrane 2 | 0.0268979 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0265711 |
| RBM33 | RNA binding motif protein 33 | 0.0265197 |
| NCOA3 | nuclear receptor coactivator 3 | 0.0263336 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0260443 |
| CD109 | CD109 molecule | 0.0257788 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | 0.0257323 |
| EMP1 | epithelial membrane protein 1 | 0.0257177 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0256596 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.025464 |
| MGST1 | microsomal glutathione S-transferase 1 | 0.025318 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0252512 |
| SNX13 | sorting nexin 13 | 0.0252266 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0248629 |
| CDC73 | cell division cycle 73 | 0.0248617 |
| FOXJ3 | forkhead box J3 | 0.0248576 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0246479 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0246047 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0241807 |
| TTLL10 | tubulin tyrosine ligase-like family member 10 | 0.0241766 |
| BRD2 | bromodomain containing 2 | 0.0238819 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0238511 |
| IDS | iduronate 2-sulfatase | 0.0237958 |
| LCORL | ligand dependent nuclear receptor corepressor-like | 0.0236489 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0236092 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.310668 |
| VIM | vimentin | -0.140456 |
| PTMA | prothymosin, alpha | -0.138649 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.100907 |
| FTL | ferritin, light polypeptide | -0.0967481 |
| ASPH | aspartate beta-hydroxylase | -0.0956416 |
| NDRG1 | N-myc downstream regulated 1 | -0.0923906 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0904104 |
| TMSB10 | thymosin beta 10 | -0.0849862 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0832117 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0773253 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0651006 |
| HMGA2 | high mobility group AT-hook 2 | -0.0639062 |
| MT2A | metallothionein 2A | -0.0636177 |
| IER3 | immediate early response 3 | -0.0616751 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0559015 |
| RPS24 | ribosomal protein S24 | -0.0523289 |
| S100A6 | S100 calcium binding protein A6 | -0.0509951 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.045715 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0453203 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0436886 |
| S100A10 | S100 calcium binding protein A10 | -0.0432428 |
| NRG1 | neuregulin 1 | -0.0428954 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0424472 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0424428 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.042362 |
| ACTG1 | actin gamma 1 | -0.0412508 |
| EGR1 | early growth response 1 | -0.0400219 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0398327 |
| PKM | pyruvate kinase, muscle | -0.0396046 |
| HMGA1 | high mobility group AT-hook 1 | -0.0395371 |
| RPLP1 | ribosomal protein, large, P1 | -0.0386463 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0385326 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0349636 |
| TPM4 | tropomyosin 4 | -0.034834 |
| VCL | vinculin | -0.0324834 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0323206 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0321978 |
| RRBP1 | ribosome binding protein 1 | -0.030421 |
| GNAS | GNAS complex locus | -0.0302626 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.02946 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0293942 |
| RPL37A | ribosomal protein L37a | -0.0289213 |
| CAPN2 | calpain 2, (m/II) large subunit | -0.0286026 |
| RPL9 | ribosomal protein L9 | -0.0284076 |
| RPS8 | ribosomal protein S8 | -0.0280996 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0279863 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0278912 |
| CD44 | CD44 molecule (Indian blood group) | -0.0274289 |
| RPL31 | ribosomal protein L31 | -0.0272017 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0271383 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0263712 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0263121 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0257633 |
| RPS25 | ribosomal protein S25 | -0.0255737 |
| IGF2 | insulin-like growth factor 2 | -0.0254707 |
| POTEF | POTE ankyrin domain family, member F | -0.0244097 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0242804 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0242349 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0241637 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0239559 |
| MAP1B | microtubule-associated protein 1B | -0.0239101 |
| ANXA2 | annexin A2 | -0.0235772 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | -0.0231864 |
| FN1 | fibronectin 1 | -0.0230828 |
| EREG | epiregulin | -0.0226576 |
| MORF4L2 | mortality factor 4 like 2 | -0.0224005 |
| TUBA1B | tubulin, alpha 1b | -0.0223066 |
| RPS23 | ribosomal protein S23 | -0.0215876 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.021561 |
| NRP1 | neuropilin 1 | -0.0213445 |
| HMGB1 | high mobility group box 1 | -0.0213348 |
| PFN1 | profilin 1 | -0.0212965 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0212013 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0211927 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0211866 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0211226 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.0209377 |
| AREG | amphiregulin | -0.0209321 |
| STC1 | stanniocalcin 1 | -0.0208574 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0202977 |
| TMEM156 | transmembrane protein 156 | -0.0202676 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0201326 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0200477 |
| TMEM131 | transmembrane protein 131 | -0.0197304 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0196671 |
| RPLP0 | ribosomal protein, large, P0 | -0.0196595 |
| IL6ST | interleukin 6 signal transducer | -0.0195543 |
| ETV1 | ets variant 1 | -0.0194424 |
| ACTN4 | actinin, alpha 4 | -0.0192903 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0191249 |
| SELENOK | selenoprotein K | -0.0187913 |
| ENO1 | enolase 1, (alpha) | -0.0187358 |
| RPS13 | ribosomal protein S13 | -0.0186714 |
| H3-3B | H3.3 histone B | -0.0186108 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0186049 |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | -0.0185783 |
| LDHA | lactate dehydrogenase A | -0.0184972 |
| CDCP1 | CUB domain containing protein 1 | -0.0184284 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | -0.0183137 |
