Cabozantinib (S-malate)_SW1417 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cabozantinib (S-malate) perturbation in SW1417 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Cabozantinib (S-malate)_SW1417 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SRRM2 serine/arginine repetitive matrix 2 0.103682
EIF1 eukaryotic translation initiation factor 1 0.0900191
KRT8 keratin 8, type II 0.0866121
ZNRF3 zinc and ring finger 3 0.0777087
RPS6 ribosomal protein S6 0.0733962
H1-0 H1.0 linker histone 0.0698699
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.0682568
CADPS Ca++-dependent secretion activator 0.0674297
NEBL nebulette 0.0624947
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0623253
PTMA prothymosin, alpha 0.0622938
KMT2E lysine (K)-specific methyltransferase 2E 0.0622558
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0610572
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0600208
NCOA3 nuclear receptor coactivator 3 0.0600107
HLA-A major histocompatibility complex, class I, A 0.0579798
B2M beta-2-microglobulin 0.0577081
TMSB10 thymosin beta 10 0.0562914
RNF43 ring finger protein 43 0.0558161
FTL ferritin, light polypeptide 0.0548245
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.053794
PLEC plectin 0.0530852
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) 0.05282
RPL23 ribosomal protein L23 0.050948
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.050241
UBE2H ubiquitin-conjugating enzyme E2H 0.0501182
ARHGAP32 Rho GTPase activating protein 32 0.0496094
KRT18 keratin 18, type I 0.0487693
RBM33 RNA binding motif protein 33 0.0487676
HSPA8 heat shock 70kDa protein 8 0.0486681
HOXA3 homeobox A3 0.0482032
CEMIP cell migration inducing protein, hyaluronan binding 0.0479851
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0479067
RPL13A ribosomal protein L13a 0.0475895
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0474545
SERINC5 serine incorporator 5 0.0463383
RPL28 ribosomal protein L28 0.045679
LMTK2 lemur tyrosine kinase 2 0.0450662
SETD5 SET domain containing 5 0.0448742
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0445402
PRELID2 PRELI domain containing 2 0.0443091
FTH1 ferritin, heavy polypeptide 1 0.0439217
EPCAM epithelial cell adhesion molecule 0.0436339
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0435434
ZNF292 zinc finger protein 292 0.0432413
USP3 ubiquitin specific peptidase 3 0.042192
ACTG1 actin gamma 1 0.0411641
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0408363
TRIM2 tripartite motif containing 2 0.0398937
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0396901
FMR1 fragile X mental retardation 1 0.0396709
CHD6 chromodomain helicase DNA binding protein 6 0.038813
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0383489
DEK DEK proto-oncogene 0.0381539
ARHGAP42 Rho GTPase activating protein 42 0.0378186
RICTOR RPTOR independent companion of MTOR, complex 2 0.0377722
RNF13 ring finger protein 13 0.0368621
DIDO1 death inducer-obliterator 1 0.0368135
PRRC2C proline-rich coiled-coil 2C 0.0365996
RPS13 ribosomal protein S13 0.0363641
RNF145 ring finger protein 145 0.0362098
ZNF148 zinc finger protein 148 0.0361755
ANKRD11 ankyrin repeat domain 11 0.0349172
OSBPL10 oxysterol binding protein-like 10 0.0343178
ERBB3 erb-b2 receptor tyrosine kinase 3 0.0342689
LOC112694756 uncharaterized LOC112694756 0.0340317
MATR3 matrin 3 0.0338894
PDE4D phosphodiesterase 4D, cAMP-specific 0.0338219
PGK1 phosphoglycerate kinase 1 0.0334065
AOPEP aminopeptidase O (putative) 0.0333842
CD9 CD9 molecule 0.033145
ARHGAP12 Rho GTPase activating protein 12 0.0326963
MYO10 myosin X 0.0326517
OXR1 oxidation resistance 1 0.0323195
CALR calreticulin 0.0323143
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0322686
RAD21 RAD21 homolog (S. pombe) 0.0319386
DSCAM Down syndrome cell adhesion molecule 0.0315471
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0311538
EPS8 epidermal growth factor receptor pathway substrate 8 0.0308987
CTNND1 catenin (cadherin-associated protein), delta 1 0.0307779
PNISR PNN-interacting serine/arginine-rich protein 0.0307432
YAP1 Yes-associated protein 1 0.0304981
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain 0.030331
VSNL1 visinin-like 1 0.0302303
TNRC6A trinucleotide repeat containing 6A 0.0301794
TXNIP thioredoxin interacting protein 0.0301198
FMN1 formin 1 0.0300121
NACA nascent polypeptide-associated complex alpha subunit 0.0299652
ERGIC3 ERGIC and golgi 3 0.0299576
KMT2C lysine (K)-specific methyltransferase 2C 0.0299209
HOXB3 homeobox B3 0.0297898
PRELID3B PRELI domain containing 3B 0.0297497
TNRC6B trinucleotide repeat containing 6B 0.0296823
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0294989
RPS16 ribosomal protein S16 0.0293456
SF1 splicing factor 1 0.029181
MTMR3 myotubularin related protein 3 0.0290482
BCLAF1 BCL2-associated transcription factor 1 0.0289086
NCKAP1 NCK-associated protein 1 0.0289082

decreased expression

Symbol Name Standardized Value
EZR ezrin -0.143542
VCL vinculin -0.123982
NCEH1 neutral cholesterol ester hydrolase 1 -0.119287
MACC1 metastasis associated in colon cancer 1 -0.0897728
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0863342
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0788462
EGR1 early growth response 1 -0.0781513
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0701478
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 -0.0649652
MAML2 mastermind-like 2 (Drosophila) -0.0608279
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.059784
TGFA transforming growth factor, alpha -0.056684
MYOF myoferlin -0.0545594
SDK1 sidekick cell adhesion molecule 1 -0.0544126
BCL2L1 BCL2-like 1 -0.053983
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0526735
TJP1 tight junction protein 1 -0.0510728
FRMD5 FERM domain containing 5 -0.0500864
LOC102724023 ES1 protein homolog, mitochondrial -0.0499096
WWC1 WW and C2 domain containing 1 -0.0492898
IER3 immediate early response 3 -0.0477894
FOSL1 FOS-like antigen 1 -0.0477453
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0463326
CALU calumenin -0.0444607
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0438726
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 -0.0436664
ANXA2 annexin A2 -0.0411529
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0409949
STAU1 staufen double-stranded RNA binding protein 1 -0.0408322
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.0404501
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.040398
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0403609
TFRC transferrin receptor -0.0401002
PCSK5 proprotein convertase subtilisin/kexin type 5 -0.0398553
CCND1 cyclin D1 -0.0395067
IFRD1 interferon-related developmental regulator 1 -0.0384216
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0380542
EHBP1 EH domain binding protein 1 -0.0379535
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0374615
EDN1 endothelin 1 -0.0371247
MALT1 MALT1 paracaspase -0.0366179
PICALM phosphatidylinositol binding clathrin assembly protein -0.0365807
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0361298
AZIN1 antizyme inhibitor 1 -0.0360776
LDHA lactate dehydrogenase A -0.0358847
GNAS GNAS complex locus -0.0357017
DLG1 discs, large homolog 1 (Drosophila) -0.0350484
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0348989
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0340805
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0339653
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.033619
TXNRD1 thioredoxin reductase 1 -0.0333969
HM13 histocompatibility (minor) 13 -0.0330852
BZW2 basic leucine zipper and W2 domains 2 -0.0324392
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0323105
RAB7A RAB7A, member RAS oncogene family -0.0319562
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0317391
GMDS GDP-mannose 4,6-dehydratase -0.0315577
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0313857
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0307109
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0304633
ZNF217 zinc finger protein 217 -0.0303893
NUP98 nucleoporin 98kDa -0.0302914
HDAC9 histone deacetylase 9 -0.0302364
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0300362
MORF4L2 mortality factor 4 like 2 -0.029203
BMP6 bone morphogenetic protein 6 -0.029141
INTS6 integrator complex subunit 6 -0.0289477
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0286708
TOP1 topoisomerase (DNA) I -0.0281993
TES testin LIM domain protein -0.0280683
TNS4 tensin 4 -0.0276292
PCSK6 proprotein convertase subtilisin/kexin type 6 -0.0275387
CHKA choline kinase alpha -0.027238
ARF4 ADP-ribosylation factor 4 -0.0269556
SPTLC2 serine palmitoyltransferase, long chain base subunit 2 -0.0267954
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0267611
IPO7 importin 7 -0.0266893
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0262477
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0262386
RTN4 reticulon 4 -0.0261463
TPM4 tropomyosin 4 -0.026059
KIAA0040 KIAA0040 -0.0260148
RASAL2 RAS protein activator like 2 -0.0259296
UBAP2 ubiquitin associated protein 2 -0.0255143
KCMF1 potassium channel modulatory factor 1 -0.0254812
EGFR epidermal growth factor receptor -0.025349
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0252003
ATXN2 ataxin 2 -0.0246662
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0245838
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56 -0.0245609
SAV1 salvador family WW domain containing protein 1 -0.024236
KCNH8 potassium channel, voltage gated eag related subfamily H, member 8 -0.0241794
TMEM41B transmembrane protein 41B -0.024145
EXT1 exostosin glycosyltransferase 1 -0.0240125
THBS1 thrombospondin 1 -0.0236373
CYTH3 cytohesin 3 -0.0236329
XRN2 5'-3' exoribonuclease 2 -0.0236018
LSR lipolysis stimulated lipoprotein receptor -0.0234705
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0234214