| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Cabozantinib (S-malate) perturbation in hTERT-HPNE cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Cabozantinib (S-malate)_hTERT-HPNE drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| COL6A3 | collagen, type VI, alpha 3 | 0.245796 |
| COL6A2 | collagen, type VI, alpha 2 | 0.174481 |
| HLA-B | major histocompatibility complex, class I, B | 0.163079 |
| FN1 | fibronectin 1 | 0.127551 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.125161 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | 0.123008 |
| HMGA2 | high mobility group AT-hook 2 | 0.117334 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.110132 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | 0.100525 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0989387 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0978733 |
| COL1A1 | collagen, type I, alpha 1 | 0.0975811 |
| COL6A1 | collagen, type VI, alpha 1 | 0.0899317 |
| ADM | adrenomedullin | 0.0826952 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | 0.0767961 |
| PDGFRB | platelet-derived growth factor receptor, beta polypeptide | 0.0744129 |
| GREM1 | gremlin 1, DAN family BMP antagonist | 0.0722293 |
| NPTX1 | neuronal pentraxin I | 0.0714696 |
| TMSB10 | thymosin beta 10 | 0.0683517 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0673426 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0629433 |
| HLA-A | major histocompatibility complex, class I, A | 0.0622394 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0609347 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.0605524 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0597295 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0583311 |
| ACTG1 | actin gamma 1 | 0.0582981 |
| ARHGAP21 | Rho GTPase activating protein 21 | 0.0574473 |
| B2M | beta-2-microglobulin | 0.0519946 |
| SMAD3 | SMAD family member 3 | 0.0519533 |
| HDLBP | high density lipoprotein binding protein | 0.0483936 |
| COL5A2 | collagen, type V, alpha 2 | 0.0476207 |
| HLA-C | major histocompatibility complex, class I, C | 0.0472216 |
| NAV1 | neuron navigator 1 | 0.0465612 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0440477 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0431827 |
| TNS1 | tensin 1 | 0.0430365 |
| COL4A2 | collagen, type IV, alpha 2 | 0.041794 |
| MMP12 | matrix metallopeptidase 12 | 0.0406452 |
| NAV2 | neuron navigator 2 | 0.0405461 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0393524 |
| SGIP1 | SH3-domain GRB2-like (endophilin) interacting protein 1 | 0.0386236 |
| INHBA | inhibin, beta A | 0.038561 |
| SMTN | smoothelin | 0.0384052 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0383397 |
| COL4A1 | collagen, type IV, alpha 1 | 0.0382555 |
| COL8A1 | collagen, type VIII, alpha 1 | 0.0381061 |
| DHFR | dihydrofolate reductase | 0.0376693 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0376307 |
| FMNL2 | formin-like 2 | 0.0373799 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0371889 |
| RPL35A | ribosomal protein L35a | 0.0371447 |
| HLA-E | major histocompatibility complex, class I, E | 0.0363094 |
| TMED9 | transmembrane emp24 protein transport domain containing 9 | 0.0358358 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0357542 |
| GRIK5 | glutamate receptor, ionotropic, kainate 5 | 0.0355828 |
| CAVIN1 | caveolae associated protein 1 | 0.0353537 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0350337 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0346391 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0345889 |
| SH3PXD2A | SH3 and PX domains 2A | 0.034185 |
| GOLGA2 | golgin A2 | 0.0334405 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0333026 |
| GANAB | glucosidase, alpha; neutral AB | 0.0326124 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | 0.0325047 |
| STC2 | stanniocalcin 2 | 0.032353 |
| FTL | ferritin, light polypeptide | 0.0322431 |
| MGST1 | microsomal glutathione S-transferase 1 | 0.0315046 |
| COL1A2 | collagen, type I, alpha 2 | 0.0312716 |
| IGFBP4 | insulin-like growth factor binding protein 4 | 0.0312147 |
| BBS9 | Bardet-Biedl syndrome 9 | 0.0305695 |
| ADGRB3 | adhesion G protein-coupled receptor B3 | 0.0304578 |
| PRRX1 | paired related homeobox 1 | 0.0302592 |
| DNER | delta/notch-like EGF repeat containing | 0.0300803 |
| AXL | AXL receptor tyrosine kinase | 0.029905 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0297478 |
| VEGFA | vascular endothelial growth factor A | 0.0290568 |
| ABL1 | ABL proto-oncogene 1, non-receptor tyrosine kinase | 0.0290454 |
| DST | dystonin | 0.0284837 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0281036 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0279357 |
| MRPS6 | mitochondrial ribosomal protein S6 | 0.027517 |
| TGFB1 | transforming growth factor, beta 1 | 0.0274744 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0274162 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0273125 |
| NLRP1 | NLR family, pyrin domain containing 1 | 0.0273068 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0268954 |
| APOLD1 | apolipoprotein L domain containing 1 | 0.0268205 |
| TMSB4X | thymosin beta 4, X-linked | 0.026796 |
| CALD1 | caldesmon 1 | 0.0266923 |
| ATXN1 | ataxin 1 | 0.026469 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 0.0263548 |
| FRMPD4 | FERM and PDZ domain containing 4 | 0.0261778 |
| RNF213 | ring finger protein 213 | 0.026034 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0257134 |
| OXR1 | oxidation resistance 1 | 0.0256099 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.0253844 |
| SEPTIN9 | septin 9 | 0.0251961 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0251804 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | 0.0249459 |
| Symbol | Name | Standardized Value |
|---|---|---|
| STC1 | stanniocalcin 1 | -0.321341 |
| MYO10 | myosin X | -0.132148 |
| NDRG1 | N-myc downstream regulated 1 | -0.127284 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.099804 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0935549 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0920091 |
| CD44 | CD44 molecule (Indian blood group) | -0.0872985 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0831348 |
| ASPH | aspartate beta-hydroxylase | -0.0793065 |
| SPAG9 | sperm associated antigen 9 | -0.0763171 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0760119 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0719701 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0706636 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0683002 |
| MT2A | metallothionein 2A | -0.066132 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0649368 |
| VIM | vimentin | -0.0646083 |
| LDHA | lactate dehydrogenase A | -0.0618248 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0577937 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0567369 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0562054 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0561357 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0539968 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0539943 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0529752 |
| RPS2 | ribosomal protein S2 | -0.0524972 |
| CLTC | clathrin, heavy chain (Hc) | -0.0496376 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0491655 |
| MMP1 | matrix metallopeptidase 1 | -0.0489502 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0461347 |
| CCND1 | cyclin D1 | -0.0455733 |
| PKM | pyruvate kinase, muscle | -0.044227 |
| FRMD4A | FERM domain containing 4A | -0.0429605 |
| MSN | moesin | -0.0428955 |
| EMP1 | epithelial membrane protein 1 | -0.0418564 |
| RTN4 | reticulon 4 | -0.0414772 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.04112 |
| POTEF | POTE ankyrin domain family, member F | -0.0399086 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | -0.0385534 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0368562 |
| MYO1B | myosin IB | -0.036417 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0358429 |
| RAI14 | retinoic acid induced 14 | -0.0348005 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | -0.0342523 |
| ZNF292 | zinc finger protein 292 | -0.0326925 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0325461 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0323115 |
| WNT5A | wingless-type MMTV integration site family, member 5A | -0.0319459 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0318685 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | -0.0315718 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0306388 |
| NUMB | numb homolog (Drosophila) | -0.0302583 |
| MAP4 | microtubule-associated protein 4 | -0.0301254 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0299839 |
| IL6ST | interleukin 6 signal transducer | -0.0298802 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0296912 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0295185 |
| CD59 | CD59 molecule, complement regulatory protein | -0.0295127 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0288846 |
| ENO1 | enolase 1, (alpha) | -0.0279182 |
| IER3 | immediate early response 3 | -0.0278959 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | -0.0278771 |
| SPRY4 | sprouty homolog 4 (Drosophila) | -0.0277072 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0270778 |
| SEPTIN7 | septin 7 | -0.0265787 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | -0.0262978 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0260754 |
| DSPP | dentin sialophosphoprotein | -0.0258185 |
| BPNT2 | 3'(2'), 5'-bisphosphate nucleotidase 2 | -0.0257362 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0255105 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0253555 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0246312 |
| MED13L | mediator complex subunit 13-like | -0.0243592 |
| HAS2 | hyaluronan synthase 2 | -0.0242185 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0240695 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0238951 |
| QKI | QKI, KH domain containing, RNA binding | -0.0235844 |
| ANXA5 | annexin A5 | -0.0235596 |
| IPO7 | importin 7 | -0.0234736 |
| USP34 | ubiquitin specific peptidase 34 | -0.0234572 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0234463 |
| YME1L1 | YME1-like 1 ATPase | -0.0233472 |
| MORF4L2 | mortality factor 4 like 2 | -0.0233165 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0232538 |
| ITGAV | integrin, alpha V | -0.0231898 |
| MAP1B | microtubule-associated protein 1B | -0.0231774 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0230882 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0223569 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0222922 |
| VPS13A | vacuolar protein sorting 13 homolog A (S. cerevisiae) | -0.0221994 |
| PFN1 | profilin 1 | -0.0219972 |
| SRGN | serglycin | -0.0218495 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.0217107 |
| GLIS3 | GLIS family zinc finger 3 | -0.021708 |
| TRAM1 | translocation associated membrane protein 1 | -0.0216886 |
| SEPTIN11 | septin 11 | -0.0215506 |
| ZNF207 | zinc finger protein 207 | -0.021462 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0213675 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0211462 |
| MXI1 | MAX interactor 1, dimerization protein | -0.0208598 |
