Calcipotriol Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
Description A seco-cholestane that has formula C27H40O3. (Chemical Entities of Biological Interest Ontology, CHEBI_50749)
External Link https://pubchem.ncbi.nlm.nih.gov/compound/5288783
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Genes

197 proteins with high or low expression in Calcipotriol relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 3.92
GEM GTP binding protein overexpressed in skeletal muscle 1.57
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 1.53
CRYBG2 crystallin beta-gamma domain containing 2 1.42
KLK6 kallikrein-related peptidase 6 1.31
KLK7 kallikrein-related peptidase 7 1.0
EFL1 elongation factor like GTPase 1 0.85
RPL31 ribosomal protein L31 0.85
DNAH12 dynein, axonemal, heavy chain 12 0.83
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.79
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 0.77
CALB2 calbindin 2 0.74
FOSL2 FOS-like antigen 2 0.73
UPP1 uridine phosphorylase 1 0.66
GDF15 growth differentiation factor 15 0.63
FBLIM1 filamin binding LIM protein 1 0.63
SPTA1 spectrin, alpha, erythrocytic 1 0.63
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast) 0.62
C5ORF30 chromosome 5 open reading frame 30 0.62
ZFP36 ZFP36 ring finger protein 0.6
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase 0.59
ZMYM5 zinc finger, MYM-type 5 0.59
CRLF1 cytokine receptor-like factor 1 0.59
PIP prolactin-induced protein 0.59
DOCK11 dedicator of cytokinesis 11 0.57
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.54
CEBPB CCAAT/enhancer binding protein (C/EBP), beta 0.53
RBX1 ring-box 1, E3 ubiquitin protein ligase 0.51
GEMIN7 gem (nuclear organelle) associated protein 7 0.5
TM7SF3 transmembrane 7 superfamily member 3 0.49
ALYREF Aly/REF export factor 0.49
CLTA clathrin, light chain A 0.49
TIMP2 TIMP metallopeptidase inhibitor 2 0.48
PLEKHG1 pleckstrin homology domain containing, family G (with RhoGef domain) member 1 0.48
SLC30A6 solute carrier family 30 (zinc transporter), member 6 0.48
ADIRF adipogenesis regulatory factor 0.47
JPT1 Jupiter microtubule associated homolog 1 0.47
PGPEP1 pyroglutamyl-peptidase I 0.47
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.46
NUDC nudC nuclear distribution protein 0.46
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.46
JUNB jun B proto-oncogene 0.45
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.44
STMN1 stathmin 1 0.44
NHSL1 NHS-like 1 0.44
RPE ribulose-5-phosphate-3-epimerase 0.44
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 0.43
BRD8 bromodomain containing 8 0.43
CREB3L2 cAMP responsive element binding protein 3-like 2 0.42
USP33 ubiquitin specific peptidase 33 0.42
SP140 SP140 nuclear body protein 0.42
PROSER3 proline and serine rich 3 0.42
C6ORF62 chromosome 6 open reading frame 62 0.42
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 0.41
PKHD1 polycystic kidney and hepatic disease 1 (autosomal recessive) 0.41
RPLP1 ribosomal protein, large, P1 0.4
POLR2M polymerase (RNA) II (DNA directed) polypeptide M 0.4
FDX1 ferredoxin 1 0.4
FAT2 FAT atypical cadherin 2 0.4
LYPD3 LY6/PLAUR domain containing 3 0.4
DCTPP1 dCTP pyrophosphatase 1 0.4
HES1 hes family bHLH transcription factor 1 0.39
AKAP12 A kinase (PRKA) anchor protein 12 0.39
PRKCE protein kinase C, epsilon 0.38
HOXB9 homeobox B9 0.38
SDC1 syndecan 1 0.38
TPM4 tropomyosin 4 0.37
CREBZF CREB/ATF bZIP transcription factor 0.37
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) 0.37
ALG10B ALG10B, alpha-1,2-glucosyltransferase 0.37
RGN regucalcin 0.37
AAMDC adipogenesis associated, Mth938 domain containing 0.37
TM2D3 TM2 domain containing 3 0.37
KIF1B kinesin family member 1B 0.36
ZNF503 zinc finger protein 503 0.36
HINT2 histidine triad nucleotide binding protein 2 0.36
MELTF melanotransferrin 0.35
HAPLN3 hyaluronan and proteoglycan link protein 3 0.35
FGFRL1 fibroblast growth factor receptor-like 1 0.35
TINAGL1 tubulointerstitial nephritis antigen-like 1 0.35
HHEX hematopoietically expressed homeobox 0.35
DNPEP aspartyl aminopeptidase 0.34
GTSF1 gametocyte specific factor 1 0.34
ZNF485 zinc finger protein 485 0.34
CCDC84 coiled-coil domain containing 84 0.34
C2CD4C C2 calcium-dependent domain containing 4C 0.34
ACTG1 actin gamma 1 0.34
ARSG arylsulfatase G 0.34
GRK5 G protein-coupled receptor kinase 5 0.34
DOLPP1 dolichyldiphosphatase 1 0.34
ENO1 enolase 1, (alpha) 0.33
CUEDC2 CUE domain containing 2 0.33
ERH enhancer of rudimentary homolog (Drosophila) 0.33
C16ORF72 chromosome 16 open reading frame 72 0.33
CSTF2 cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa 0.33
C18ORF32 chromosome 18 open reading frame 32 0.33
JDP2 Jun dimerization protein 2 0.33

low expression

Symbol Name Standardized Value
TRIM29 tripartite motif containing 29 -3.17
DNAH5 dynein, axonemal, heavy chain 5 -2.61
ABCA13 ATP-binding cassette, sub-family A (ABC1), member 13 -2.57
WWC3 WWC family member 3 -2.37
KMT2B lysine (K)-specific methyltransferase 2B -2.0
FBN3 fibrillin 3 -1.66
PIGH phosphatidylinositol glycan anchor biosynthesis, class H -1.15
TTLL4 tubulin tyrosine ligase-like family member 4 -1.1
VAV1 vav 1 guanine nucleotide exchange factor -1.0
TMUB2 transmembrane and ubiquitin-like domain containing 2 -0.83
ZNF414 zinc finger protein 414 -0.8
NR1D2 nuclear receptor subfamily 1, group D, member 2 -0.76
DAD1 defender against cell death 1 -0.74
TRIM62 tripartite motif containing 62 -0.69
FGFBP1 fibroblast growth factor binding protein 1 -0.66
TRMT2B tRNA methyltransferase 2 homolog B (S. cerevisiae) -0.66
HPS4 Hermansky-Pudlak syndrome 4 -0.66
COQ10B coenzyme Q10 homolog B (S. cerevisiae) -0.62
DDTL D-dopachrome tautomerase-like -0.62
ZNF431 zinc finger protein 431 -0.61
LIN7A lin-7 homolog A (C. elegans) -0.6
APOBEC3F apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F -0.58
CLN3 ceroid-lipofuscinosis, neuronal 3 -0.58
FBXW4 F-box and WD repeat domain containing 4 -0.56
ADCY5 adenylate cyclase 5 -0.54
NR1H2 nuclear receptor subfamily 1, group H, member 2 -0.52
STK17B serine/threonine kinase 17b -0.52
PPTC7 PTC7 protein phosphatase homolog (S. cerevisiae) -0.51
NEDD8 neural precursor cell expressed, developmentally down-regulated 8 -0.51
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase -0.51
GNG5 guanine nucleotide binding protein (G protein), gamma 5 -0.49
KMT2C lysine (K)-specific methyltransferase 2C -0.49
ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif, 14 -0.46
CHCHD6 coiled-coil-helix-coiled-coil-helix domain containing 6 -0.45
HLA-B major histocompatibility complex, class I, B -0.45
ING2 inhibitor of growth family, member 2 -0.44
MYH7 myosin, heavy chain 7, cardiac muscle, beta -0.44
KRT8 keratin 8, type II -0.43
RNF141 ring finger protein 141 -0.43
PKM pyruvate kinase, muscle -0.42
CILP2 cartilage intermediate layer protein 2 -0.42
AREL1 apoptosis resistant E3 ubiquitin protein ligase 1 -0.41
TCP11L1 t-complex 11, testis-specific-like 1 -0.41
METTL7A methyltransferase like 7A -0.41
POMP proteasome maturation protein -0.41
PBX3 pre-B-cell leukemia homeobox 3 -0.41
RARG retinoic acid receptor, gamma -0.41
MARK4 MAP/microtubule affinity-regulating kinase 4 -0.41
CBR3 carbonyl reductase 3 -0.4
MICOS10 mitochondrial contact site and cristae organizing system subunit 10 -0.4
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 -0.4
GVINP1 GTPase, very large interferon inducible pseudogene 1 -0.4
GAB1 GRB2-associated binding protein 1 -0.39
UBTD1 ubiquitin domain containing 1 -0.39
KLHDC8B kelch domain containing 8B -0.39
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.38
DGKE diacylglycerol kinase, epsilon 64kDa -0.38
PRKD3 protein kinase D3 -0.38
HMGN4 high mobility group nucleosomal binding domain 4 -0.36
MAP3K12 mitogen-activated protein kinase kinase kinase 12 -0.36
SPEG SPEG complex locus -0.36
ADAM19 ADAM metallopeptidase domain 19 -0.36
ANKS6 ankyrin repeat and sterile alpha motif domain containing 6 -0.34
KCNK5 potassium channel, two pore domain subfamily K, member 5 -0.34
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.34
EPB41L4B erythrocyte membrane protein band 4.1 like 4B -0.33
MSX1 msh homeobox 1 -0.33
MYT1 myelin transcription factor 1 -0.33
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) -0.33
ATXN1L ataxin 1-like -0.33
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 -0.33
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 -0.33
TBC1D32 TBC1 domain family, member 32 -0.32
CXXC5 CXXC finger protein 5 -0.32
SPPL2A signal peptide peptidase like 2A -0.32
JAG1 jagged 1 -0.32
SUSD2 sushi domain containing 2 -0.31
ASXL2 additional sex combs like transcriptional regulator 2 -0.31
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -0.31
PRXL2C peroxiredoxin like 2C -0.31
AEBP2 AE binding protein 2 -0.31
YIF1B Yip1 interacting factor homolog B (S. cerevisiae) -0.31
HIST2H2AB histone cluster 2, H2ab -0.31
MFAP3L microfibrillar-associated protein 3-like -0.31
ZNF587 zinc finger protein 587 -0.31
PET100 PET100 homolog (S. cerevisiae) -0.31
MCRIP2 MAPK regulated corepressor interacting protein 2 -0.3
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma -0.3
ZNF729 zinc finger protein 729 -0.3
NECTIN3 nectin cell adhesion molecule 3 -0.3
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 -0.3
TMEM183B transmembrane protein 183B -0.3
FBXO33 F-box protein 33 -0.3
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.3
FKBP1A FK506 binding protein 1A, 12kDa -0.29
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 -0.29
GLUL glutamate-ammonia ligase -0.29
FAM171A1 family with sequence similarity 171, member A1 -0.29
MFAP3 microfibrillar-associated protein 3 -0.29
FHL1 four and a half LIM domains 1 -0.29