| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Canagliflozin (hemihydrate) perturbation in A-172 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Canagliflozin (hemihydrate)_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.213793 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.123342 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.116269 |
| VIM | vimentin | 0.114435 |
| COL3A1 | collagen, type III, alpha 1 | 0.0963179 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0836752 |
| FBN1 | fibrillin 1 | 0.0709484 |
| LOXL2 | lysyl oxidase-like 2 | 0.0676074 |
| COL1A2 | collagen, type I, alpha 2 | 0.0601699 |
| STC1 | stanniocalcin 1 | 0.0583498 |
| PTMA | prothymosin, alpha | 0.0492844 |
| THBS2 | thrombospondin 2 | 0.0492744 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.048716 |
| FRMD5 | FERM domain containing 5 | 0.0460386 |
| LOX | lysyl oxidase | 0.0455861 |
| SBF2 | SET binding factor 2 | 0.0436544 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0422931 |
| PLAT | plasminogen activator, tissue | 0.0411332 |
| MYADM | myeloid-associated differentiation marker | 0.0379346 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.037812 |
| ATP13A3 | ATPase type 13A3 | 0.0361414 |
| FLNB | filamin B, beta | 0.0355972 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0351435 |
| HLA-E | major histocompatibility complex, class I, E | 0.0335479 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0335175 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0327449 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0323187 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0322658 |
| S100A6 | S100 calcium binding protein A6 | 0.0321848 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0307233 |
| CAVIN1 | caveolae associated protein 1 | 0.030521 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0300891 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.0294148 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0265504 |
| RNF145 | ring finger protein 145 | 0.0264675 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0260456 |
| ADAM19 | ADAM metallopeptidase domain 19 | 0.0258346 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0251334 |
| PDXK | pyridoxal (pyridoxine, vitamin B6) kinase | 0.0248131 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0244074 |
| RIPK1 | receptor (TNFRSF)-interacting serine-threonine kinase 1 | 0.0241765 |
| B2M | beta-2-microglobulin | 0.0241237 |
| SRSF11 | serine/arginine-rich splicing factor 11 | 0.0237524 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0234806 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0231349 |
| FNBP1 | formin binding protein 1 | 0.0224917 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0224681 |
| OGA | O-GlcNAcase | 0.0222734 |
| SECISBP2L | SECIS binding protein 2-like | 0.0219848 |
| RAI14 | retinoic acid induced 14 | 0.0215512 |
| CLIP2 | CAP-GLY domain containing linker protein 2 | 0.0211763 |
| RBM25 | RNA binding motif protein 25 | 0.0210028 |
| GOLGA2 | golgin A2 | 0.0205824 |
| TMOD1 | tropomodulin 1 | 0.0202825 |
| HMGB2 | high mobility group box 2 | 0.0200709 |
| FAM193B | family with sequence similarity 193, member B | 0.0200307 |
| UBAP1 | ubiquitin associated protein 1 | 0.0197533 |
| NPC1 | Niemann-Pick disease, type C1 | 0.0197266 |
| ZBTB7A | zinc finger and BTB domain containing 7A | 0.0195111 |
| SERINC1 | serine incorporator 1 | 0.0192501 |
| KIF5B | kinesin family member 5B | 0.0192498 |
| ARL15 | ADP-ribosylation factor-like 15 | 0.0191786 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0190902 |
| COL6A2 | collagen, type VI, alpha 2 | 0.0190178 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0190106 |
| ZFC3H1 | zinc finger, C3H1-type containing | 0.0187101 |
| SP3 | Sp3 transcription factor | 0.0185627 |
| MRC2 | mannose receptor, C type 2 | 0.0185521 |
| PLAUR | plasminogen activator, urokinase receptor | 0.018166 |
| DOCK5 | dedicator of cytokinesis 5 | 0.018069 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | 0.0179813 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0178531 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0178252 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0175991 |
| SH3BP5 | SH3-domain binding protein 5 (BTK-associated) | 0.017574 |
| APP | amyloid beta (A4) precursor protein | 0.0174133 |
| DPYSL2 | dihydropyrimidinase-like 2 | 0.0173906 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | 0.0173752 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0172673 |
| RPS3 | ribosomal protein S3 | 0.0171967 |
| CSTB | cystatin B (stefin B) | 0.0171704 |
| NDST1 | N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 | 0.0171214 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | 0.0171181 |
| MYO9A | myosin IXA | 0.0170427 |
| TUT4 | terminal uridylyl transferase 4 | 0.0170128 |
| TOP6BL | TOP6B like initiator of meiotic double strand breaks | 0.0169732 |
| CLU | clusterin | 0.0169331 |
| MT2A | metallothionein 2A | 0.0165131 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0164253 |
| MTSS1 | metastasis suppressor 1 | 0.0163696 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | 0.0162283 |
| CDC42EP3 | CDC42 effector protein (Rho GTPase binding) 3 | 0.0160765 |
| SQLE | squalene epoxidase | 0.0160739 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0160736 |
| MAP4K3 | mitogen-activated protein kinase kinase kinase kinase 3 | 0.0158514 |
| CD46 | CD46 molecule, complement regulatory protein | 0.0157135 |
| AVL9 | AVL9 homolog (S. cerevisiase) | 0.0153576 |
| RHOBTB3 | Rho-related BTB domain containing 3 | 0.01534 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | 0.0152872 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0152768 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.302569 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.222375 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.153423 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.126158 |
| POTEF | POTE ankyrin domain family, member F | -0.108728 |
| CDH13 | cadherin 13 | -0.104023 |
| MAP1B | microtubule-associated protein 1B | -0.103357 |
| AHNAK | AHNAK nucleoprotein | -0.101772 |
| NDRG1 | N-myc downstream regulated 1 | -0.100784 |
| UBC | ubiquitin C | -0.0894805 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0824247 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0744142 |
| S100A10 | S100 calcium binding protein A10 | -0.0742423 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0738708 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0736065 |
| PODXL | podocalyxin-like | -0.0711277 |
| RIGI | RNA sensor RIG-I | -0.0704698 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0671134 |
| NAV1 | neuron navigator 1 | -0.0636525 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0601495 |
| CANX | calnexin | -0.0543232 |
| FN1 | fibronectin 1 | -0.0529886 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0527869 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0519272 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0518356 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.051191 |
| COL5A1 | collagen, type V, alpha 1 | -0.0510386 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0503095 |
| PKM | pyruvate kinase, muscle | -0.0499508 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0495489 |
| PBX3 | pre-B-cell leukemia homeobox 3 | -0.0467524 |
| EGFR | epidermal growth factor receptor | -0.046693 |
| TMSB10 | thymosin beta 10 | -0.0463997 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0446667 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0441417 |
| GNB4 | guanine nucleotide binding protein (G protein), beta polypeptide 4 | -0.0428137 |
| LDHA | lactate dehydrogenase A | -0.0419033 |
| CENPF | centromere protein F, 350/400kDa | -0.0409622 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0401806 |
| FSTL1 | follistatin-like 1 | -0.040159 |
| RPS6KA2 | ribosomal protein S6 kinase, 90kDa, polypeptide 2 | -0.0398641 |
| MX2 | MX dynamin-like GTPase 2 | -0.0397092 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | -0.0394318 |
| ACTG1 | actin gamma 1 | -0.0389308 |
| NAV2 | neuron navigator 2 | -0.0388374 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0385673 |
| SP100 | SP100 nuclear antigen | -0.0385525 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0382199 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0381233 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0370497 |
| SEPTIN7 | septin 7 | -0.0363138 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0357469 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.0357281 |
| MEIS2 | Meis homeobox 2 | -0.0350625 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | -0.0339379 |
| RUNX1 | runt-related transcription factor 1 | -0.0338341 |
| IL7R | interleukin 7 receptor | -0.0335852 |
| CCND1 | cyclin D1 | -0.033446 |
| PLXNA2 | plexin A2 | -0.0332392 |
| MSI2 | musashi RNA-binding protein 2 | -0.0330484 |
| OASL | 2'-5'-oligoadenylate synthetase-like | -0.0326337 |
| CYTH3 | cytohesin 3 | -0.0323736 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0318211 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0314869 |
| SAMD9L | sterile alpha motif domain containing 9-like | -0.0314649 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0309743 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0308714 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0302189 |
| LMNA | lamin A/C | -0.0299263 |
| NEK7 | NIMA-related kinase 7 | -0.0298902 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0294834 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0294526 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | -0.029396 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0288586 |
| RPL28 | ribosomal protein L28 | -0.0287107 |
| CDH2 | cadherin 2, type 1, N-cadherin (neuronal) | -0.0287052 |
| TPM1 | tropomyosin 1 (alpha) | -0.0285014 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0282365 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.0280971 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | -0.02799 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0275427 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0274568 |
| PFN1 | profilin 1 | -0.0271391 |
| DENND1A | DENN/MADD domain containing 1A | -0.0270076 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0268946 |
| ARHGEF10 | Rho guanine nucleotide exchange factor (GEF) 10 | -0.0267417 |
| FNDC3B | fibronectin type III domain containing 3B | -0.026709 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0263368 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0261255 |
| HELZ | helicase with zinc finger | -0.0260688 |
| RPL35A | ribosomal protein L35a | -0.0259086 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0257883 |
| PRKAG2 | protein kinase, AMP-activated, gamma 2 non-catalytic subunit | -0.0257454 |
| NCOR2 | nuclear receptor corepressor 2 | -0.0256167 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0255654 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0255499 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.025512 |
| ZC3H11A | zinc finger CCCH-type containing 11A | -0.025511 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | -0.025472 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0252848 |
