Canagliflozin (hemihydrate)_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Canagliflozin (hemihydrate) perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Canagliflozin (hemihydrate)_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0861463
ANXA1 annexin A1 0.0523546
KIF5B kinesin family member 5B 0.0426022
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.0421619
RPS3 ribosomal protein S3 0.0416961
RPS7 ribosomal protein S7 0.0411566
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0361615
PDK4 pyruvate dehydrogenase kinase, isozyme 4 0.0309086
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0306274
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0270231
RPL26 ribosomal protein L26 0.025618
SET SET nuclear proto-oncogene 0.0240903
STARD4 StAR-related lipid transfer (START) domain containing 4 0.0240502
CSNK1A1 casein kinase 1, alpha 1 0.0237525
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0225787
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.0220743
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 0.0212597
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) 0.0211769
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0207607
LARS1 leucyl-tRNA synthetase 1 0.020286
RPS2 ribosomal protein S2 0.0190828
PA2G4 proliferation-associated 2G4, 38kDa 0.01856
HMGB2 high mobility group box 2 0.018501
VMP1 vacuole membrane protein 1 0.018409
CSDE1 cold shock domain containing E1, RNA-binding 0.0178809
MGAT4C MGAT4 family, member C 0.0178744
DHX36 DEAH (Asp-Glu-Ala-His) box polypeptide 36 0.0176637
NFE2L1 nuclear factor, erythroid 2-like 1 0.0176559
ENO1 enolase 1, (alpha) 0.0176409
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0173436
RPS12 ribosomal protein S12 0.0172625
NUP58 nucleoporin 58 0.0171397
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0169595
GPBP1 GC-rich promoter binding protein 1 0.0167842
SERBP1 SERPINE1 mRNA binding protein 1 0.0160185
NAP1L1 nucleosome assembly protein 1-like 1 0.0159475
ERRFI1 ERBB receptor feedback inhibitor 1 0.0155417
NARS1 asparaginyl-tRNA synthetase 1 0.0154902
KPNB1 karyopherin (importin) beta 1 0.0149396
VIM vimentin 0.0147945
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0146248
CAVIN1 caveolae associated protein 1 0.0144161
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10 0.0143443
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.0141136
HDGF hepatoma-derived growth factor 0.0140593
ITSN2 intersectin 2 0.0138983
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.0137275
PLK2 polo-like kinase 2 0.0137272
SERINC1 serine incorporator 1 0.0136164
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.0135089
NR2F1 nuclear receptor subfamily 2, group F, member 1 0.0133982
MIB1 mindbomb E3 ubiquitin protein ligase 1 0.0131679
HLTF helicase-like transcription factor 0.0130837
BRWD3 bromodomain and WD repeat domain containing 3 0.012691
SPATS2 spermatogenesis associated, serine-rich 2 0.0126263
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 0.0125934
CHD1 chromodomain helicase DNA binding protein 1 0.0125088
SRRM1 serine/arginine repetitive matrix 1 0.0125038
VEZT vezatin, adherens junctions transmembrane protein 0.0124906
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 0.012485
TFAM transcription factor A, mitochondrial 0.0124719
BZW1 basic leucine zipper and W2 domains 1 0.0121406
RPL18 ribosomal protein L18 0.0120601
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.012042
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 0.0117869
KLF6 Kruppel-like factor 6 0.0117535
SFXN1 sideroflexin 1 0.0113941
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0113934
BIRC6 baculoviral IAP repeat containing 6 0.0112732
MXI1 MAX interactor 1, dimerization protein 0.011257
EIF4B eukaryotic translation initiation factor 4B 0.0112006
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.0111453
PTMS parathymosin 0.0110859
S100A6 S100 calcium binding protein A6 0.0110517
PNISR PNN-interacting serine/arginine-rich protein 0.0109744
SNX6 sorting nexin 6 0.0109668
GNL2 guanine nucleotide binding protein-like 2 (nucleolar) 0.0109556
HSPA8 heat shock 70kDa protein 8 0.0108523
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0107963
CISD1 CDGSH iron sulfur domain 1 0.0106327
TPM3 tropomyosin 3 0.0105846
KMT2C lysine (K)-specific methyltransferase 2C 0.0105714
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0105465
VPS26A vacuolar protein sorting 26 homolog A (S. pombe) 0.0105
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 0.0104048
TBK1 TANK-binding kinase 1 0.0104002
ITGA6 integrin, alpha 6 0.0103934
PPIG peptidylprolyl isomerase G (cyclophilin G) 0.0103779
IWS1 IWS1 homolog (S. cerevisiae) 0.0103041
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0102978
KDM2A lysine (K)-specific demethylase 2A 0.0100639
CEP170 centrosomal protein 170kDa 0.0100305
NDUFS4 NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) 0.0100257
CHD4 chromodomain helicase DNA binding protein 4 0.0100155
ILF3 interleukin enhancer binding factor 3, 90kDa 0.00996467
SRRM2 serine/arginine repetitive matrix 2 0.00993556
RLF rearranged L-myc fusion 0.0099065
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.00978689
MLF1 myeloid leukemia factor 1 0.00972317
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E 0.0096205

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.387487
PDE4D phosphodiesterase 4D, cAMP-specific -0.112185
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.103847
TMSB10 thymosin beta 10 -0.0955564
ACTG1 actin gamma 1 -0.0880457
RPL35A ribosomal protein L35a -0.0851053
ATP5F1B ATP synthase F1 subunit beta -0.0691888
NLGN1 neuroligin 1 -0.0614187
RPS23 ribosomal protein S23 -0.0601403
YAP1 Yes-associated protein 1 -0.057455
RPS19 ribosomal protein S19 -0.0496243
RPS6 ribosomal protein S6 -0.0484632
SLC38A2 solute carrier family 38, member 2 -0.0479142
HMGA2 high mobility group AT-hook 2 -0.044991
RPL23 ribosomal protein L23 -0.0424136
EIF1 eukaryotic translation initiation factor 1 -0.041619
PCDH7 protocadherin 7 -0.04116
POTEF POTE ankyrin domain family, member F -0.0409212
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0406131
RPS15 ribosomal protein S15 -0.0396078
ANKRD12 ankyrin repeat domain 12 -0.0383801
RPS29 ribosomal protein S29 -0.0353404
RAB7A RAB7A, member RAS oncogene family -0.0336169
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0334747
CELF2 CUGBP, Elav-like family member 2 -0.0322521
UBC ubiquitin C -0.0320599
RTN4 reticulon 4 -0.0315982
TRMT112 tRNA methyltransferase 11-2 homolog (S. cerevisiae) -0.0305111
S100A10 S100 calcium binding protein A10 -0.0296877
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0296379
PCBP2 poly(rC) binding protein 2 -0.0292294
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.028342
EGR1 early growth response 1 -0.0281332
RPL34 ribosomal protein L34 -0.0280787
DEK DEK proto-oncogene -0.0272646
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -0.0270845
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0268549
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa -0.0267041
RPS21 ribosomal protein S21 -0.0266905
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0258004
ANKRD28 ankyrin repeat domain 28 -0.0255787
PDGFC platelet derived growth factor C -0.0251339
RPL19 ribosomal protein L19 -0.0248046
RPS11 ribosomal protein S11 -0.0246966
RPL28 ribosomal protein L28 -0.0246757
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0240352
TM4SF1 transmembrane 4 L six family member 1 -0.0238948
RPL8 ribosomal protein L8 -0.0237599
RPL32 ribosomal protein L32 -0.0233784
LRRTM4 leucine rich repeat transmembrane neuronal 4 -0.0232478
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0232344
RPLP1 ribosomal protein, large, P1 -0.0231972
RPS14 ribosomal protein S14 -0.0230632
HLA-A major histocompatibility complex, class I, A -0.0229923
ZNF804A zinc finger protein 804A -0.0227596
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0225004
CCND1 cyclin D1 -0.0222544
AREG amphiregulin -0.0222262
AHNAK AHNAK nucleoprotein -0.0221867
NHSL1 NHS-like 1 -0.0219106
CCN2 cellular communication network factor 2 -0.021469
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0214542
EDARADD EDAR-associated death domain -0.0213682
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0212655
LDHB lactate dehydrogenase B -0.0206321
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0205279
ADGRG6 adhesion G protein-coupled receptor G6 -0.0203818
RPL9 ribosomal protein L9 -0.0203498
RPS20 ribosomal protein S20 -0.0198499
EIF4A2 eukaryotic translation initiation factor 4A2 -0.019453
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0190189
MAP1B microtubule-associated protein 1B -0.0188307
RPL31 ribosomal protein L31 -0.018731
BPTF bromodomain PHD finger transcription factor -0.0186759
MARCHF4 membrane associated ring-CH-type finger 4 -0.018417
ERBIN erbb2 interacting protein -0.0183871
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0179544
RPS10 ribosomal protein S10 -0.0177574
TUBA1B tubulin, alpha 1b -0.0177115
YBX1 Y box binding protein 1 -0.0176308
DLC1 DLC1 Rho GTPase activating protein -0.0175919
FUS FUS RNA binding protein -0.0173328
VDAC1 voltage-dependent anion channel 1 -0.0173203
FTL ferritin, light polypeptide -0.0172578
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) -0.0171016
CMIP c-Maf inducing protein -0.0168216
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0168163
SYT1 synaptotagmin I -0.0166449
RPS5 ribosomal protein S5 -0.016573
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0164746
RPS4X ribosomal protein S4, X-linked -0.0164288
RPS13 ribosomal protein S13 -0.0163894
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0162356
DST dystonin -0.0162266
RASAL2 RAS protein activator like 2 -0.0160654
TXNRD1 thioredoxin reductase 1 -0.0159197
RBM39 RNA binding motif protein 39 -0.0157025
MSRB3 methionine sulfoxide reductase B3 -0.0156661
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 -0.0156279
ZNF638 zinc finger protein 638 -0.0154974