Canagliflozin (hemihydrate)_A498 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Canagliflozin (hemihydrate) perturbation in A498 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Canagliflozin (hemihydrate)_A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DDIT4 DNA-damage-inducible transcript 4 0.0707295
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0689344
PTMA prothymosin, alpha 0.0570597
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0548179
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.049371
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.046406
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0400252
NRP2 neuropilin 2 0.0382304
VCL vinculin 0.0381282
HMGB2 high mobility group box 2 0.0361287
FTH1 ferritin, heavy polypeptide 1 0.0353056
RPS7 ribosomal protein S7 0.0333348
CHMP5 charged multivesicular body protein 5 0.033194
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.033159
PLK2 polo-like kinase 2 0.0329285
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0320879
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0306492
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0303849
ZFP36L1 ZFP36 ring finger protein-like 1 0.0287964
VCAN versican 0.0286915
VMP1 vacuole membrane protein 1 0.0275586
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 0.0269224
MYH9 myosin, heavy chain 9, non-muscle 0.0261865
ASPH aspartate beta-hydroxylase 0.0257097
TBC1D10A TBC1 domain family, member 10A 0.0233794
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0228818
CBX3 chromobox homolog 3 0.0226609
MKI67 marker of proliferation Ki-67 0.0225707
BZW1 basic leucine zipper and W2 domains 1 0.0221539
IGFBP7 insulin-like growth factor binding protein 7 0.0220091
TGFB2 transforming growth factor, beta 2 0.0219541
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.021172
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0206012
NUP58 nucleoporin 58 0.0199438
CSDE1 cold shock domain containing E1, RNA-binding 0.0198298
SKAP2 src kinase associated phosphoprotein 2 0.0194955
ITGAV integrin, alpha V 0.019402
IRS2 insulin receptor substrate 2 0.0192728
SET SET nuclear proto-oncogene 0.0192064
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa 0.0188989
PNISR PNN-interacting serine/arginine-rich protein 0.0185722
VCAM1 vascular cell adhesion molecule 1 0.0182748
SLC31A1 solute carrier family 31 (copper transporter), member 1 0.0181406
WDR43 WD repeat domain 43 0.0178232
UBQLN1 ubiquilin 1 0.0178015
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 0.0177444
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0175272
LITAF lipopolysaccharide-induced TNF factor 0.0174737
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10 0.0173549
TMF1 TATA element modulatory factor 1 0.0172676
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) 0.0171079
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0170473
RINT1 RAD50 interactor 1 0.0169148
CHD1 chromodomain helicase DNA binding protein 1 0.0167753
SPIDR scaffolding protein involved in DNA repair 0.0163629
DIAPH3 diaphanous-related formin 3 0.0161352
CD46 CD46 molecule, complement regulatory protein 0.0160804
ATP13A3 ATPase type 13A3 0.015929
GOLPH3 golgi phosphoprotein 3 (coat-protein) 0.0150928
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0150414
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0149023
FLNA filamin A, alpha 0.0148296
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0147642
VIRMA vir like m6A methyltransferase associated 0.0145832
TM9SF2 transmembrane 9 superfamily member 2 0.0145448
RPL22L1 ribosomal protein L22-like 1 0.0145229
SAA2-SAA4 SAA2-SAA4 readthrough 0.0145155
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 0.0144556
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0143827
DOCK5 dedicator of cytokinesis 5 0.0142305
SINHCAF SIN3-HDAC complex associated factor 0.0142004
CRY1 cryptochrome circadian clock 1 0.0141174
RPS3 ribosomal protein S3 0.0140802
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0139338
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.0138647
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0135949
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0135639
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) 0.0135563
RNASEH2A ribonuclease H2, subunit A 0.0135261
CDK13 cyclin-dependent kinase 13 0.0135224
WEE1 WEE1 G2 checkpoint kinase 0.0132857
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0131473
SMC4 structural maintenance of chromosomes 4 0.0131324
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 0.0129332
SERINC1 serine incorporator 1 0.0128681
YME1L1 YME1-like 1 ATPase 0.0127599
NFE2L1 nuclear factor, erythroid 2-like 1 0.0126951
CA12 carbonic anhydrase XII 0.0125921
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0125639
NUCB2 nucleobindin 2 0.0125575
TMED2 transmembrane emp24 domain trafficking protein 2 0.0124996
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0124794
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0124546
DHRS7 dehydrogenase/reductase (SDR family) member 7 0.0124286
HYOU1 hypoxia up-regulated 1 0.0124093
MKRN1 makorin ring finger protein 1 0.0123843
GCC2 GRIP and coiled-coil domain containing 2 0.012285
SERINC3 serine incorporator 3 0.0122552
EIF3B eukaryotic translation initiation factor 3, subunit B 0.0122155
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0121855

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.317342
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.212739
NDRG1 N-myc downstream regulated 1 -0.110265
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.109624
FRMD4A FERM domain containing 4A -0.107393
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0774492
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) -0.0736882
UBC ubiquitin C -0.0707641
RPS6 ribosomal protein S6 -0.065009
RPL35A ribosomal protein L35a -0.0569032
CXCL8 chemokine (C-X-C motif) ligand 8 -0.054512
TRIO trio Rho guanine nucleotide exchange factor -0.0510774
EIF1 eukaryotic translation initiation factor 1 -0.0485819
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0465934
LOC112694756 uncharaterized LOC112694756 -0.0463204
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0461408
RND3 Rho family GTPase 3 -0.0430626
CD44 CD44 molecule (Indian blood group) -0.0428698
CANX calnexin -0.042199
HLA-B major histocompatibility complex, class I, B -0.0413434
FTL ferritin, light polypeptide -0.0404948
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0394861
S100A10 S100 calcium binding protein A10 -0.0374867
CTSD cathepsin D -0.0367854
MAP1B microtubule-associated protein 1B -0.0364809
RNF213 ring finger protein 213 -0.0363937
CSF1 colony stimulating factor 1 (macrophage) -0.035738
TMSB10 thymosin beta 10 -0.0344744
PFN1 profilin 1 -0.0341079
IARS1 isoleucyl-tRNA synthetase 1 -0.0327508
FMNL2 formin-like 2 -0.032405
GPC6 glypican 6 -0.0322795
PKM pyruvate kinase, muscle -0.0321101
POTEF POTE ankyrin domain family, member F -0.0319058
NAMPT nicotinamide phosphoribosyltransferase -0.0317942
RRBP1 ribosome binding protein 1 -0.0317452
HSPB1 heat shock 27kDa protein 1 -0.0316867
AHNAK AHNAK nucleoprotein -0.0309848
RPL28 ribosomal protein L28 -0.0307981
RAB2A RAB2A, member RAS oncogene family -0.0302607
LMAN1 lectin, mannose-binding, 1 -0.0300198
TSC22D2 TSC22 domain family, member 2 -0.0292664
CADM1 cell adhesion molecule 1 -0.0290446
TXNRD1 thioredoxin reductase 1 -0.0288733
SDCBP syndecan binding protein (syntenin) -0.028253
HLA-C major histocompatibility complex, class I, C -0.0280468
CXXC1 CXXC finger protein 1 -0.0279962
OPTN optineurin -0.0277698
SOD2 superoxide dismutase 2, mitochondrial -0.027714
RPL8 ribosomal protein L8 -0.0272008
HMGA1 high mobility group AT-hook 1 -0.0266076
PRKCA protein kinase C, alpha -0.026538
TFPI2 tissue factor pathway inhibitor 2 -0.0265331
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0264545
ATP5F1B ATP synthase F1 subunit beta -0.0263205
RPS5 ribosomal protein S5 -0.0261961
RPL34 ribosomal protein L34 -0.0257821
RAI14 retinoic acid induced 14 -0.0257019
MX1 MX dynamin-like GTPase 1 -0.0256471
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.025556
RIGI RNA sensor RIG-I -0.0255382
LMNA lamin A/C -0.0255258
HIBADH 3-hydroxyisobutyrate dehydrogenase -0.0251612
PML promyelocytic leukemia -0.0246175
SEC31A SEC31 homolog A (S. cerevisiae) -0.0244686
TRAM1 translocation associated membrane protein 1 -0.0242119
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0239045
RPLP1 ribosomal protein, large, P1 -0.0237954
ARF1 ADP-ribosylation factor 1 -0.0237794
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0237276
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0237249
RPS20 ribosomal protein S20 -0.0236638
ICAM1 intercellular adhesion molecule 1 -0.0233913
ITM2B integral membrane protein 2B -0.0233526
RPL19 ribosomal protein L19 -0.0232457
CP ceruloplasmin (ferroxidase) -0.0232022
INSIG1 insulin induced gene 1 -0.0229174
UFM1 ubiquitin-fold modifier 1 -0.0226274
TFG TRK-fused gene -0.022547
LOXL2 lysyl oxidase-like 2 -0.0224778
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0223924
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0220147
FNDC3B fibronectin type III domain containing 3B -0.021813
FXR1 fragile X mental retardation, autosomal homolog 1 -0.021701
NIBAN1 niban apoptosis regulator 1 -0.0213507
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0210951
SLC39A14 solute carrier family 39 (zinc transporter), member 14 -0.0210001
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0208856
MRPS6 mitochondrial ribosomal protein S6 -0.0208784
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0208677
NAP1L4 nucleosome assembly protein 1-like 4 -0.0208029
FBXO11 F-box protein 11 -0.0207933
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0207636
G0S2 G0/G1 switch 2 -0.0207317
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0207188
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0205586
RPS19 ribosomal protein S19 -0.0203069
ADAR adenosine deaminase, RNA-specific -0.020113
KIRREL1 kirre like nephrin family adhesion molecule 1 -0.0200713
RPS4X ribosomal protein S4, X-linked -0.0199872