| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Canagliflozin (hemihydrate) perturbation in A549 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Canagliflozin (hemihydrate)_A549 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FTH1 | ferritin, heavy polypeptide 1 | 0.0955308 |
| FTL | ferritin, light polypeptide | 0.0373746 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0282939 |
| GOLGA4 | golgin A4 | 0.0171058 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0169051 |
| RPS7 | ribosomal protein S7 | 0.0151942 |
| S100A6 | S100 calcium binding protein A6 | 0.0127109 |
| SRP54 | signal recognition particle 54kDa | 0.0121175 |
| MORF4L2 | mortality factor 4 like 2 | 0.0113615 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0111763 |
| DHRS7 | dehydrogenase/reductase (SDR family) member 7 | 0.010788 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0105823 |
| ACBD3 | acyl-CoA binding domain containing 3 | 0.0101985 |
| PDGFA | platelet-derived growth factor alpha polypeptide | 0.00994589 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.00992985 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.00969235 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | 0.00937426 |
| MON2 | MON2 homolog (S. cerevisiae) | 0.00925377 |
| KDELR1 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 | 0.0092353 |
| C1D | C1D nuclear receptor corepressor | 0.00913713 |
| VEZT | vezatin, adherens junctions transmembrane protein | 0.00897923 |
| RPL13A | ribosomal protein L13a | 0.00889793 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.00867015 |
| RPS27L | ribosomal protein S27-like | 0.00866661 |
| RPS27 | ribosomal protein S27 | 0.00851974 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0084273 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | 0.00816799 |
| HM13 | histocompatibility (minor) 13 | 0.00815384 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.00803965 |
| CD68 | CD68 molecule | 0.0079707 |
| NOP58 | NOP58 ribonucleoprotein | 0.00784803 |
| GOLGA2 | golgin A2 | 0.00777689 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.00772716 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.00745856 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.00741838 |
| SEC62 | SEC62 homolog (S. cerevisiae) | 0.00739477 |
| SEPTIN2 | septin 2 | 0.00738723 |
| RNASEH2A | ribonuclease H2, subunit A | 0.00738351 |
| CEBPB | CCAAT/enhancer binding protein (C/EBP), beta | 0.00726879 |
| WDR43 | WD repeat domain 43 | 0.00711428 |
| ZBTB43 | zinc finger and BTB domain containing 43 | 0.00702361 |
| RPL36 | ribosomal protein L36 | 0.00701583 |
| RPL18 | ribosomal protein L18 | 0.00696495 |
| BDP1 | B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB | 0.00695443 |
| DDX18 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 | 0.00695438 |
| LAMB3 | laminin, beta 3 | 0.00676761 |
| RAB6A | RAB6A, member RAS oncogene family | 0.00675022 |
| PGM3 | phosphoglucomutase 3 | 0.00674623 |
| RNMT | RNA (guanine-7-) methyltransferase | 0.00667365 |
| SURF4 | surfeit 4 | 0.00664871 |
| ATXN2L | ataxin 2-like | 0.0066195 |
| SNX3 | sorting nexin 3 | 0.0065538 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.00648323 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | 0.00637976 |
| TMEM41B | transmembrane protein 41B | 0.00615802 |
| MPHOSPH10 | M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein) | 0.0061274 |
| SUCO | SUN domain containing ossification factor | 0.00610392 |
| DNAJC25 | DnaJ (Hsp40) homolog, subfamily C , member 25 | 0.00608496 |
| LAMA5 | laminin, alpha 5 | 0.00593839 |
| ERLEC1 | endoplasmic reticulum lectin 1 | 0.00593108 |
| ITSN2 | intersectin 2 | 0.00590051 |
| FA2H | fatty acid 2-hydroxylase | 0.00587423 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.00586701 |
| SEC22A | SEC22 vesicle trafficking protein homolog A (S. cerevisiae) | 0.00582447 |
| SEC24A | SEC24 family member A | 0.0057752 |
| RPLP0 | ribosomal protein, large, P0 | 0.00577363 |
| TBC1D10A | TBC1 domain family, member 10A | 0.00576942 |
| WDR45B | WD repeat domain 45B | 0.00569972 |
| RRP12 | ribosomal RNA processing 12 homolog (S. cerevisiae) | 0.00566848 |
| ANGPTL4 | angiopoietin-like 4 | 0.00566168 |
| GNL2 | guanine nucleotide binding protein-like 2 (nucleolar) | 0.00561789 |
| EIF5B | eukaryotic translation initiation factor 5B | 0.00560218 |
| GRB2 | growth factor receptor-bound protein 2 | 0.00557879 |
| SIRT2 | sirtuin 2 | 0.00556079 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.00555617 |
| ENTPD7 | ectonucleoside triphosphate diphosphohydrolase 7 | 0.00555435 |
| PDXDC1 | pyridoxal-dependent decarboxylase domain containing 1 | 0.00553001 |
| DNAJC10 | DnaJ (Hsp40) homolog, subfamily C, member 10 | 0.00551212 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.00540111 |
| CCDC174 | coiled-coil domain containing 174 | 0.00539521 |
| DAPK3 | death-associated protein kinase 3 | 0.00536041 |
| CHMP5 | charged multivesicular body protein 5 | 0.00535175 |
| DHX36 | DEAH (Asp-Glu-Ala-His) box polypeptide 36 | 0.00532401 |
| PFN1 | profilin 1 | 0.00532169 |
| USP37 | ubiquitin specific peptidase 37 | 0.00529774 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0052916 |
| SPTY2D1 | SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae) | 0.00520026 |
| POLR3D | polymerase (RNA) III (DNA directed) polypeptide D, 44kDa | 0.00517649 |
| PRRC1 | proline-rich coiled-coil 1 | 0.00513795 |
| TNPO3 | transportin 3 | 0.00512872 |
| COQ10B | coenzyme Q10 homolog B (S. cerevisiae) | 0.00510423 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.00509719 |
| CIRSR | corepressor of RBPJ and splicing regulator | 0.00509155 |
| CLPTM1 | cleft lip and palate associated transmembrane protein 1 | 0.00508704 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | 0.00504127 |
| RAB18 | RAB18, member RAS oncogene family | 0.00500247 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | 0.00496743 |
| RPL21 | ribosomal protein L21 | 0.00494242 |
| NUP54 | nucleoporin 54kDa | 0.00493555 |
| CAVIN1 | caveolae associated protein 1 | 0.00490591 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.228454 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.194784 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.135517 |
| UBC | ubiquitin C | -0.123356 |
| PDE10A | phosphodiesterase 10A | -0.108655 |
| SMAD3 | SMAD family member 3 | -0.105459 |
| ACTG1 | actin gamma 1 | -0.105184 |
| ASPH | aspartate beta-hydroxylase | -0.0975875 |
| KYNU | kynureninase | -0.0918368 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0911596 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0892294 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0829215 |
| AHNAK | AHNAK nucleoprotein | -0.0757045 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0627071 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0625331 |
| TXNRD1 | thioredoxin reductase 1 | -0.0622199 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0608407 |
| ANXA2 | annexin A2 | -0.0600643 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0573251 |
| EFNA5 | ephrin-A5 | -0.054689 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.053025 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0515307 |
| FAM107B | family with sequence similarity 107, member B | -0.0511706 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.049381 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0481936 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0469752 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0465913 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0462417 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0446153 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0439726 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.043572 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0434751 |
| RPS27A | ribosomal protein S27a | -0.0432251 |
| MCL1 | myeloid cell leukemia 1 | -0.0429962 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0418914 |
| POTEF | POTE ankyrin domain family, member F | -0.0417096 |
| STC1 | stanniocalcin 1 | -0.0414827 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0411774 |
| FLNB | filamin B, beta | -0.0410402 |
| PKM | pyruvate kinase, muscle | -0.0403823 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0392829 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0391752 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.0389121 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0387035 |
| TNIP1 | TNFAIP3 interacting protein 1 | -0.0378551 |
| EGFR | epidermal growth factor receptor | -0.037456 |
| VCL | vinculin | -0.0372848 |
| OSMR | oncostatin M receptor | -0.0368798 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0367083 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0361812 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.0361484 |
| PARD3 | par-3 family cell polarity regulator | -0.0356983 |
| CD44 | CD44 molecule (Indian blood group) | -0.0353951 |
| SLC35F3 | solute carrier family 35, member F3 | -0.034653 |
| LDHA | lactate dehydrogenase A | -0.0345637 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0341594 |
| VIM | vimentin | -0.0330905 |
| ENO1 | enolase 1, (alpha) | -0.0329507 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | -0.0327839 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0327539 |
| KRT7 | keratin 7, type II | -0.0325783 |
| ACTN4 | actinin, alpha 4 | -0.0321679 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0321255 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0320699 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0317045 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0313011 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0307318 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.0305739 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0300729 |
| MT1X | metallothionein 1X | -0.0297092 |
| NAV2 | neuron navigator 2 | -0.0294989 |
| AUTS2 | autism susceptibility candidate 2 | -0.0292674 |
| RPL4 | ribosomal protein L4 | -0.029201 |
| FMNL2 | formin-like 2 | -0.0291373 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.028833 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0288194 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0287847 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0284109 |
| PCBP2 | poly(rC) binding protein 2 | -0.0279405 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0279195 |
| MYO10 | myosin X | -0.0278714 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0274556 |
| CMIP | c-Maf inducing protein | -0.0272142 |
| APP | amyloid beta (A4) precursor protein | -0.0271751 |
| CANX | calnexin | -0.0269807 |
| PDE8A | phosphodiesterase 8A | -0.0268726 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0267139 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0261431 |
| GRAMD1B | GRAM domain containing 1B | -0.0260836 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0255787 |
| PTK2 | protein tyrosine kinase 2 | -0.0252899 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0251889 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0250466 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0249268 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0247775 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0247021 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0245429 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0245127 |
| AXL | AXL receptor tyrosine kinase | -0.0243928 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0240672 |
