| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Canagliflozin (hemihydrate) perturbation in AN3 CA cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Canagliflozin (hemihydrate)_AN3 CA drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MEST | mesoderm specific transcript | 0.247988 |
| PTMA | prothymosin, alpha | 0.0661435 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0614241 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0556937 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.052021 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0450347 |
| HMGB2 | high mobility group box 2 | 0.0448497 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0434803 |
| CALR | calreticulin | 0.0423525 |
| FN1 | fibronectin 1 | 0.0421242 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0416851 |
| RPS2 | ribosomal protein S2 | 0.0377491 |
| HYOU1 | hypoxia up-regulated 1 | 0.0375601 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0369328 |
| ARHGAP21 | Rho GTPase activating protein 21 | 0.0344517 |
| RPS7 | ribosomal protein S7 | 0.034044 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0336929 |
| FBN1 | fibrillin 1 | 0.0305675 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0304649 |
| SPIDR | scaffolding protein involved in DNA repair | 0.0295261 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | 0.0288891 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0288637 |
| UBQLN1 | ubiquilin 1 | 0.0288463 |
| SET | SET nuclear proto-oncogene | 0.0281695 |
| TPX2 | TPX2, microtubule-associated | 0.0261001 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | 0.0260369 |
| NUP58 | nucleoporin 58 | 0.0249752 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0245925 |
| RNASEH2A | ribonuclease H2, subunit A | 0.0239642 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.023728 |
| LMO4 | LIM domain only 4 | 0.023571 |
| RPS3 | ribosomal protein S3 | 0.0231035 |
| COL1A2 | collagen, type I, alpha 2 | 0.0229696 |
| EIF3B | eukaryotic translation initiation factor 3, subunit B | 0.0223284 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0221623 |
| SNX3 | sorting nexin 3 | 0.0221085 |
| SERPINH1 | serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) | 0.0219859 |
| LBR | lamin B receptor | 0.0219622 |
| KIF11 | kinesin family member 11 | 0.0216472 |
| CHMP5 | charged multivesicular body protein 5 | 0.0212777 |
| MATR3 | matrin 3 | 0.021201 |
| SOBP | sine oculis binding protein homolog (Drosophila) | 0.021173 |
| MLEC | malectin | 0.0210667 |
| CEP350 | centrosomal protein 350kDa | 0.0208946 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0206692 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0205326 |
| TXNRD1 | thioredoxin reductase 1 | 0.0205164 |
| RYK | receptor-like tyrosine kinase | 0.020482 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.020402 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0203866 |
| MYO1B | myosin IB | 0.0202994 |
| PAIP1 | poly(A) binding protein interacting protein 1 | 0.0201008 |
| YEATS2 | YEATS domain containing 2 | 0.0200328 |
| RPS12 | ribosomal protein S12 | 0.0199433 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | 0.0197427 |
| CCDC112 | coiled-coil domain containing 112 | 0.0197273 |
| PSMD2 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | 0.0194469 |
| BOC | BOC cell adhesion associated, oncogene regulated | 0.0194097 |
| ITM2B | integral membrane protein 2B | 0.0192112 |
| MORF4L2 | mortality factor 4 like 2 | 0.0191008 |
| GRB2 | growth factor receptor-bound protein 2 | 0.0189427 |
| TTC1 | tetratricopeptide repeat domain 1 | 0.0189166 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.0188936 |
| MAP3K1 | mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase | 0.0188509 |
| CAMLG | calcium modulating ligand | 0.0188463 |
| CENPU | centromere protein U | 0.0186702 |
| KIF23 | kinesin family member 23 | 0.0183636 |
| ZNF266 | zinc finger protein 266 | 0.0183199 |
| LSM14A | LSM14A, SCD6 homolog A (S. cerevisiae) | 0.018169 |
| ARFGEF1 | ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) | 0.0180077 |
| XRN1 | 5'-3' exoribonuclease 1 | 0.0176209 |
| PLD3 | phospholipase D family, member 3 | 0.0175885 |
| SUMO2 | small ubiquitin-like modifier 2 | 0.0175553 |
| EYA1 | EYA transcriptional coactivator and phosphatase 1 | 0.0175359 |
| NRG2 | neuregulin 2 | 0.0175223 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0174577 |
| KDELR1 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 | 0.0174002 |
| NUP54 | nucleoporin 54kDa | 0.017338 |
| SCLT1 | sodium channel and clathrin linker 1 | 0.017201 |
| RPS18 | ribosomal protein S18 | 0.017173 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0171008 |
| XRRA1 | X-ray radiation resistance associated 1 | 0.0170011 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 0.0169651 |
| MKRN1 | makorin ring finger protein 1 | 0.0169321 |
| DNAJB6 | DnaJ (Hsp40) homolog, subfamily B, member 6 | 0.0169084 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0168862 |
| FANCI | Fanconi anemia, complementation group I | 0.0168783 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0166277 |
| TRIP11 | thyroid hormone receptor interactor 11 | 0.0163888 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0163067 |
| ATP6V0E1 | ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1 | 0.0162881 |
| NOTCH2 | notch 2 | 0.0162718 |
| PIK3R1 | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | 0.0161697 |
| SYAP1 | synapse associated protein 1 | 0.0161293 |
| HLTF | helicase-like transcription factor | 0.0161166 |
| FBXO7 | F-box protein 7 | 0.0161166 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0160725 |
| DLX1 | distal-less homeobox 1 | 0.015836 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | 0.0158179 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0157715 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.157645 |
| CADM2 | cell adhesion molecule 2 | -0.147723 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0990513 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.096099 |
| PRKG1 | protein kinase, cGMP-dependent, type I | -0.08877 |
| TSHZ2 | teashirt zinc finger homeobox 2 | -0.0835593 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.07303 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0700028 |
| JMJD1C | jumonji domain containing 1C | -0.0687168 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0646547 |
| FNIP1 | folliculin interacting protein 1 | -0.0644906 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0635783 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0624224 |
| ACTG1 | actin gamma 1 | -0.0613961 |
| RPL34 | ribosomal protein L34 | -0.0600865 |
| RPL35A | ribosomal protein L35a | -0.0584931 |
| CANX | calnexin | -0.0573249 |
| AHNAK | AHNAK nucleoprotein | -0.056683 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | -0.0555378 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0548935 |
| ZFHX3 | zinc finger homeobox 3 | -0.0505482 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0499397 |
| BBX | bobby sox homolog (Drosophila) | -0.0493192 |
| TPK1 | thiamin pyrophosphokinase 1 | -0.0491744 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.048938 |
| NFIB | nuclear factor I/B | -0.0488649 |
| DEK | DEK proto-oncogene | -0.0485531 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0484606 |
| PARD3 | par-3 family cell polarity regulator | -0.0480686 |
| CTBP2 | C-terminal binding protein 2 | -0.0478875 |
| IER3 | immediate early response 3 | -0.0466925 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0464492 |
| TCF12 | transcription factor 12 | -0.045602 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0455509 |
| TULP4 | tubby like protein 4 | -0.0448716 |
| FBXO11 | F-box protein 11 | -0.0447285 |
| USP9X | ubiquitin specific peptidase 9, X-linked | -0.0445487 |
| ANO6 | anoctamin 6 | -0.0434021 |
| RPS19 | ribosomal protein S19 | -0.0418681 |
| MYOF | myoferlin | -0.0417385 |
| RPS24 | ribosomal protein S24 | -0.0416482 |
| B3GALT1 | UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 | -0.0407995 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0402194 |
| NFIA | nuclear factor I/A | -0.0401969 |
| IGF2R | insulin-like growth factor 2 receptor | -0.0399061 |
| FOXO3 | forkhead box O3 | -0.0389413 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0386497 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0383886 |
| ERBIN | erbb2 interacting protein | -0.038336 |
| RPLP2 | ribosomal protein, large, P2 | -0.0381041 |
| CUL1 | cullin 1 | -0.0374882 |
| HMGA1 | high mobility group AT-hook 1 | -0.0374806 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0373186 |
| RAPGEF6 | Rap guanine nucleotide exchange factor (GEF) 6 | -0.0369035 |
| MED13L | mediator complex subunit 13-like | -0.0368811 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0367623 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | -0.0367476 |
| SENP6 | SUMO1/sentrin specific peptidase 6 | -0.0365711 |
| CDK6 | cyclin-dependent kinase 6 | -0.0364506 |
| TUBB | tubulin, beta class I | -0.036355 |
| ARHGAP12 | Rho GTPase activating protein 12 | -0.0361301 |
| SBF2 | SET binding factor 2 | -0.0361272 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0360604 |
| TENT4A | terminal nucleotidyltransferase 4A | -0.0356564 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0355325 |
| GOLGA4 | golgin A4 | -0.0347688 |
| KDM4B | lysine (K)-specific demethylase 4B | -0.0335655 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.033299 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0331877 |
| ATP8A1 | ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 | -0.0330279 |
| RPS23 | ribosomal protein S23 | -0.0330181 |
| APP | amyloid beta (A4) precursor protein | -0.0327799 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0324316 |
| PDE10A | phosphodiesterase 10A | -0.0322672 |
| RHEB | Ras homolog enriched in brain | -0.0318809 |
| SERTAD2 | SERTA domain containing 2 | -0.031816 |
| PKM | pyruvate kinase, muscle | -0.0317864 |
| GALNT11 | polypeptide N-acetylgalactosaminyltransferase 11 | -0.0317589 |
| ENO1 | enolase 1, (alpha) | -0.0316193 |
| PTK2 | protein tyrosine kinase 2 | -0.0314526 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0313563 |
| RPS8 | ribosomal protein S8 | -0.0312361 |
| BRD4 | bromodomain containing 4 | -0.031076 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0310001 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0309159 |
| NRF1 | nuclear respiratory factor 1 | -0.030895 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0307636 |
| STXBP5 | syntaxin binding protein 5 (tomosyn) | -0.0306683 |
| RPL23 | ribosomal protein L23 | -0.0305032 |
| TRPM7 | transient receptor potential cation channel, subfamily M, member 7 | -0.0300082 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0300068 |
| RPS6 | ribosomal protein S6 | -0.0299708 |
| ST13 | suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) | -0.0299578 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | -0.0299013 |
| KIRREL1 | kirre like nephrin family adhesion molecule 1 | -0.0294439 |
| CLIP2 | CAP-GLY domain containing linker protein 2 | -0.0294043 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0293987 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | -0.0293917 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0291141 |
| UBC | ubiquitin C | -0.0291124 |
