| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Canagliflozin (hemihydrate) perturbation in AsPC-1 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Canagliflozin (hemihydrate)_AsPC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| VCAN | versican | 0.149949 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.132239 |
| VIM | vimentin | 0.104765 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0881371 |
| LAMA4 | laminin, alpha 4 | 0.0861906 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0842641 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | 0.0727669 |
| PTPRR | protein tyrosine phosphatase, receptor type, R | 0.0704078 |
| ARHGAP42 | Rho GTPase activating protein 42 | 0.0681399 |
| PTMA | prothymosin, alpha | 0.0656817 |
| KLF6 | Kruppel-like factor 6 | 0.0646019 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0627531 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0602941 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.057642 |
| LDHA | lactate dehydrogenase A | 0.0542077 |
| NPSR1 | neuropeptide S receptor 1 | 0.0537655 |
| ITGA6 | integrin, alpha 6 | 0.0517971 |
| MUC17 | mucin 17, cell surface associated | 0.0494647 |
| ITGB4 | integrin, beta 4 | 0.0491281 |
| S100A4 | S100 calcium binding protein A4 | 0.0468197 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0458261 |
| RNASEH2A | ribonuclease H2, subunit A | 0.0450427 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0391926 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0390139 |
| EHBP1 | EH domain binding protein 1 | 0.0378379 |
| CD9 | CD9 molecule | 0.0375141 |
| MYOF | myoferlin | 0.0374496 |
| EGFR | epidermal growth factor receptor | 0.0372619 |
| HMGB2 | high mobility group box 2 | 0.0362015 |
| S100A6 | S100 calcium binding protein A6 | 0.0350874 |
| LMO7 | LIM domain 7 | 0.0344383 |
| PERP | PERP, TP53 apoptosis effector | 0.0343183 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0340637 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | 0.0326799 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0324302 |
| KIAA0040 | KIAA0040 | 0.0321164 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0318952 |
| EMP1 | epithelial membrane protein 1 | 0.0315314 |
| PRELID2 | PRELI domain containing 2 | 0.0305207 |
| CDH17 | cadherin 17, LI cadherin (liver-intestine) | 0.0301582 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0294676 |
| PLEKHA1 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 | 0.029213 |
| SKAP2 | src kinase associated phosphoprotein 2 | 0.0288624 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0286773 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0285164 |
| PPARG | peroxisome proliferator-activated receptor gamma | 0.027968 |
| FAT1 | FAT atypical cadherin 1 | 0.02786 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | 0.0272448 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0270597 |
| UBE2R2 | ubiquitin-conjugating enzyme E2R 2 | 0.0268281 |
| CAMK2D | calcium/calmodulin-dependent protein kinase II delta | 0.0260839 |
| CDKN2A | cyclin-dependent kinase inhibitor 2A | 0.0260109 |
| EEPD1 | endonuclease/exonuclease/phosphatase family domain containing 1 | 0.0258854 |
| CD46 | CD46 molecule, complement regulatory protein | 0.0255476 |
| PARP8 | poly (ADP-ribose) polymerase family, member 8 | 0.0254192 |
| RPS3 | ribosomal protein S3 | 0.0249017 |
| MKI67 | marker of proliferation Ki-67 | 0.024639 |
| ITGB8 | integrin, beta 8 | 0.0245284 |
| REL | v-rel avian reticuloendotheliosis viral oncogene homolog | 0.0245245 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0243074 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0241817 |
| HP1BP3 | heterochromatin protein 1, binding protein 3 | 0.0236917 |
| RPS7 | ribosomal protein S7 | 0.0236267 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0235283 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | 0.0235282 |
| CLIP2 | CAP-GLY domain containing linker protein 2 | 0.0234612 |
| OXR1 | oxidation resistance 1 | 0.0234404 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0234284 |
| TOP1 | topoisomerase (DNA) I | 0.0233041 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0232079 |
| PLAC8 | placenta-specific 8 | 0.0228662 |
| NBEAL1 | neurobeachin-like 1 | 0.0227067 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0225587 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0224151 |
| KIF16B | kinesin family member 16B | 0.0223102 |
| SULF2 | sulfatase 2 | 0.0221807 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0220028 |
| CD47 | CD47 molecule | 0.0219675 |
| ANXA2 | annexin A2 | 0.0218689 |
| CSTB | cystatin B (stefin B) | 0.0218201 |
| CYP51A1 | cytochrome P450, family 51, subfamily A, polypeptide 1 | 0.0216522 |
| TMSB10 | thymosin beta 10 | 0.0213782 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0213744 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0212893 |
| CLIC1 | chloride intracellular channel 1 | 0.0212755 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0211048 |
| ADD3 | adducin 3 (gamma) | 0.0210387 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | 0.0208171 |
| ANLN | anillin, actin binding protein | 0.0206688 |
| RHPN2 | rhophilin, Rho GTPase binding protein 2 | 0.0201636 |
| FHL2 | four and a half LIM domains 2 | 0.020021 |
| TNFRSF6B | tumor necrosis factor receptor superfamily, member 6b, decoy | 0.020011 |
| RALB | v-ral simian leukemia viral oncogene homolog B | 0.0199616 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.019562 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.019555 |
| CLMN | calmin (calponin-like, transmembrane) | 0.0195275 |
| SLTM | SAFB-like, transcription modulator | 0.0193429 |
| PON2 | paraoxonase 2 | 0.0193326 |
| APAF1 | apoptotic peptidase activating factor 1 | 0.0192039 |
| NEK7 | NIMA-related kinase 7 | 0.0190415 |
| Symbol | Name | Standardized Value |
|---|---|---|
| LAMB3 | laminin, beta 3 | -0.198672 |
| NDRG1 | N-myc downstream regulated 1 | -0.159222 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.144988 |
| DHRS9 | dehydrogenase/reductase (SDR family) member 9 | -0.1382 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.136247 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.119202 |
| UBC | ubiquitin C | -0.113675 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0976169 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0972206 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0954095 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0947069 |
| POTEF | POTE ankyrin domain family, member F | -0.0910839 |
| FTL | ferritin, light polypeptide | -0.0784324 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0782892 |
| LAMC2 | laminin, gamma 2 | -0.0728583 |
| KLK10 | kallikrein-related peptidase 10 | -0.0707325 |
| ACTG1 | actin gamma 1 | -0.0695201 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0678428 |
| RPL35A | ribosomal protein L35a | -0.0677932 |
| TPM4 | tropomyosin 4 | -0.0667273 |
| SACK1A | scaffolding CK1 anchoring protein A | -0.0633899 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0633317 |
| CLMP | CXADR-like membrane protein | -0.0623861 |
| MCL1 | myeloid cell leukemia 1 | -0.0599664 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0598763 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0588723 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0586968 |
| FLNB | filamin B, beta | -0.0579383 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0565363 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.056202 |
| AHNAK | AHNAK nucleoprotein | -0.0550111 |
| PPARD | peroxisome proliferator-activated receptor delta | -0.0549704 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0538592 |
| UPP1 | uridine phosphorylase 1 | -0.0533616 |
| FMNL2 | formin-like 2 | -0.0524539 |
| MXD1 | MAX dimerization protein 1 | -0.0519324 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0515627 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | -0.0504681 |
| RIOK3 | RIO kinase 3 | -0.0485383 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0483888 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.048009 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0473969 |
| ABTB3 | ankyrin repeat and BTB domain containing 3 | -0.0471104 |
| PARD3 | par-3 family cell polarity regulator | -0.0467061 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0442836 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0439878 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | -0.043153 |
| CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | -0.0428286 |
| PMM2 | phosphomannomutase 2 | -0.0398111 |
| ARPC1A | actin related protein 2/3 complex, subunit 1A, 41kDa | -0.0396638 |
| CDCP1 | CUB domain containing protein 1 | -0.0393572 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0393258 |
| SNX9 | sorting nexin 9 | -0.0390064 |
| ANTXR2 | anthrax toxin receptor 2 | -0.038953 |
| SDC4 | syndecan 4 | -0.0370681 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0369462 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | -0.0368696 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.036722 |
| DSG2 | desmoglein 2 | -0.0365852 |
| B2M | beta-2-microglobulin | -0.0360963 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0358607 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0353997 |
| ASPH | aspartate beta-hydroxylase | -0.0347671 |
| FUS | FUS RNA binding protein | -0.0342289 |
| PLEC | plectin | -0.034189 |
| SEPTIN10 | septin 10 | -0.0341539 |
| RBM39 | RNA binding motif protein 39 | -0.0339175 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0337825 |
| RRBP1 | ribosome binding protein 1 | -0.0336999 |
| MSN | moesin | -0.0336269 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0335772 |
| RPS2 | ribosomal protein S2 | -0.0334579 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0334461 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0334392 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | -0.0328558 |
| CORO1C | coronin, actin binding protein, 1C | -0.0326006 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0325982 |
| S100A10 | S100 calcium binding protein A10 | -0.032486 |
| RPS21 | ribosomal protein S21 | -0.0323567 |
| PARD6B | par-6 family cell polarity regulator beta | -0.0323474 |
| SETX | senataxin | -0.0323382 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.031968 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.0319053 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | -0.0318703 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | -0.0311684 |
| RPS29 | ribosomal protein S29 | -0.0311124 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0310255 |
| RPL34 | ribosomal protein L34 | -0.0309681 |
| NUP98 | nucleoporin 98kDa | -0.0309342 |
| OPTN | optineurin | -0.030572 |
| FGD6 | FYVE, RhoGEF and PH domain containing 6 | -0.0304604 |
| RPS15 | ribosomal protein S15 | -0.0303762 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | -0.0302651 |
| HSPA8 | heat shock 70kDa protein 8 | -0.030237 |
| TPM3 | tropomyosin 3 | -0.0302237 |
| RPL8 | ribosomal protein L8 | -0.0301148 |
| USP53 | ubiquitin specific peptidase 53 | -0.029893 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | -0.0297586 |
| ARF4 | ADP-ribosylation factor 4 | -0.0297329 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0293012 |
