| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Canagliflozin (hemihydrate) perturbation in BT-474 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Canagliflozin (hemihydrate)_BT-474 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FTH1 | ferritin, heavy polypeptide 1 | 0.0971033 |
| ERBB2 | erb-b2 receptor tyrosine kinase 2 | 0.0761941 |
| ACSS2 | acyl-CoA synthetase short-chain family member 2 | 0.0458554 |
| MUC6 | mucin 6, oligomeric mucus/gel-forming | 0.0386405 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0320127 |
| TMEM165 | transmembrane protein 165 | 0.0313782 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.0291277 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0285931 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0264789 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0240427 |
| S100A8 | S100 calcium binding protein A8 | 0.0235924 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0233829 |
| TOP6BL | TOP6B like initiator of meiotic double strand breaks | 0.0220815 |
| MSMO1 | methylsterol monooxygenase 1 | 0.0212419 |
| ELOVL5 | ELOVL fatty acid elongase 5 | 0.0211183 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.019257 |
| MT2A | metallothionein 2A | 0.0191072 |
| FAM13A | family with sequence similarity 13, member A | 0.0179119 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0178717 |
| RNF24 | ring finger protein 24 | 0.0173336 |
| YPEL2 | yippee-like 2 (Drosophila) | 0.0171616 |
| BCAS1 | breast carcinoma amplified sequence 1 | 0.0167561 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0160377 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.0159338 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0152244 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0150901 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 0.0148597 |
| TMED2 | transmembrane emp24 domain trafficking protein 2 | 0.0148264 |
| HMGB2 | high mobility group box 2 | 0.0147071 |
| KLF6 | Kruppel-like factor 6 | 0.0146957 |
| TP53INP2 | tumor protein p53 inducible nuclear protein 2 | 0.0143296 |
| SERPINB4 | serpin peptidase inhibitor, clade B (ovalbumin), member 4 | 0.0142946 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0142296 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.01398 |
| FBXO32 | F-box protein 32 | 0.0139369 |
| MUC19 | mucin 19, oligomeric | 0.0136868 |
| SQLE | squalene epoxidase | 0.0136299 |
| ZSWIM4 | zinc finger, SWIM-type containing 4 | 0.0134961 |
| TMEM45B | transmembrane protein 45B | 0.0134839 |
| CFB | complement factor B | 0.0132872 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0132704 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0129722 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | 0.0128875 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | 0.0126057 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | 0.0125775 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0125775 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0123125 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0122241 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0122005 |
| FAM174B | family with sequence similarity 174, member B | 0.0121512 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | 0.0117674 |
| ABHD17C | abhydrolase domain containing 17C | 0.0117533 |
| DAPK3 | death-associated protein kinase 3 | 0.011683 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0114657 |
| HYOU1 | hypoxia up-regulated 1 | 0.011357 |
| IDI1 | isopentenyl-diphosphate delta isomerase 1 | 0.0112915 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0111776 |
| CYP51A1 | cytochrome P450, family 51, subfamily A, polypeptide 1 | 0.0111019 |
| KAZN | kazrin, periplakin interacting protein | 0.0110437 |
| SERINC1 | serine incorporator 1 | 0.0108966 |
| GBP2 | guanylate binding protein 2, interferon-inducible | 0.0107955 |
| NUP58 | nucleoporin 58 | 0.0107764 |
| ADM | adrenomedullin | 0.0106633 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0106249 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | 0.0104474 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0104242 |
| PGR | progesterone receptor | 0.0103698 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0102434 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0102096 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0100913 |
| ZNRF2 | zinc and ring finger 2, E3 ubiquitin protein ligase | 0.0100028 |
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) | 0.00989299 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.00973567 |
| TNFAIP2 | tumor necrosis factor, alpha-induced protein 2 | 0.0097353 |
| RPS6KA5 | ribosomal protein S6 kinase, 90kDa, polypeptide 5 | 0.00971656 |
| WWOX | WW domain containing oxidoreductase | 0.00968143 |
| CREBRF | CREB3 regulatory factor | 0.0096626 |
| GCC2 | GRIP and coiled-coil domain containing 2 | 0.00966037 |
| NIBAN2 | niban apoptosis regulator 2 | 0.00963549 |
| ANKRD30A | ankyrin repeat domain 30A | 0.0095726 |
| GOLPH3 | golgi phosphoprotein 3 (coat-protein) | 0.00957134 |
| SLMAP | sarcolemma associated protein | 0.00957103 |
| MXI1 | MAX interactor 1, dimerization protein | 0.00956721 |
| ABI1 | abl-interactor 1 | 0.00954727 |
| NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 | 0.0095207 |
| CLDN12 | claudin 12 | 0.00950099 |
| EIF2AK3 | eukaryotic translation initiation factor 2-alpha kinase 3 | 0.00944691 |
| PDCD4 | programmed cell death 4 (neoplastic transformation inhibitor) | 0.00932021 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.00922478 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.00918792 |
| DUSP6 | dual specificity phosphatase 6 | 0.00915299 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.00906802 |
| SARAF | store-operated calcium entry-associated regulatory factor | 0.00882462 |
| CALR | calreticulin | 0.00881469 |
| RNASEH2A | ribonuclease H2, subunit A | 0.0087972 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.00874923 |
| SERPINB3 | serpin peptidase inhibitor, clade B (ovalbumin), member 3 | 0.00867944 |
| LYN | LYN proto-oncogene, Src family tyrosine kinase | 0.00865592 |
| ATP11B | ATPase, class VI, type 11B | 0.00853477 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.00853469 |
| Symbol | Name | Standardized Value |
|---|---|---|
| RPL19 | ribosomal protein L19 | -0.283101 |
| RPL23 | ribosomal protein L23 | -0.273471 |
| CDK12 | cyclin-dependent kinase 12 | -0.169133 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.148875 |
| CATSPERB | catsper channel auxiliary subunit beta | -0.0988994 |
| ACTG1 | actin gamma 1 | -0.0850669 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0809064 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0758361 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0745638 |
| ACACA | acetyl-CoA carboxylase alpha | -0.065124 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0639044 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0636497 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0632219 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0627413 |
| ASPH | aspartate beta-hydroxylase | -0.0600095 |
| PTK2 | protein tyrosine kinase 2 | -0.0584694 |
| RPL35A | ribosomal protein L35a | -0.0579383 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0579378 |
| SP100 | SP100 nuclear antigen | -0.0558631 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0547837 |
| CLTC | clathrin, heavy chain (Hc) | -0.0542108 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0540571 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0519182 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.050397 |
| CEP250 | centrosomal protein 250kDa | -0.050178 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0494755 |
| VMP1 | vacuole membrane protein 1 | -0.0473291 |
| RARRES1 | retinoic acid receptor responder (tazarotene induced) 1 | -0.0472285 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0464426 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.0463096 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0450863 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0437588 |
| PRRC2B | proline-rich coiled-coil 2B | -0.0434359 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0428526 |
| RAB22A | RAB22A, member RAS oncogene family | -0.0421629 |
| CCND1 | cyclin D1 | -0.0421347 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0414532 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0412705 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0408015 |
| SBF2 | SET binding factor 2 | -0.0403887 |
| ENAH | enabled homolog (Drosophila) | -0.0403024 |
| INTS6 | integrator complex subunit 6 | -0.0402174 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0395851 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.0385279 |
| SRCIN1 | SRC kinase signaling inhibitor 1 | -0.038459 |
| MLLT6 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 | -0.0383802 |
| POTEF | POTE ankyrin domain family, member F | -0.0382271 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0381592 |
| LARGE1 | LARGE xylosyl- and glucuronyltransferase 1 | -0.0372265 |
| DENND1A | DENN/MADD domain containing 1A | -0.0371592 |
| NDRG1 | N-myc downstream regulated 1 | -0.0368287 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0366453 |
| SAMD12 | sterile alpha motif domain containing 12 | -0.0363616 |
| ATXN1 | ataxin 1 | -0.0362481 |
| VCP | valosin containing protein | -0.0359717 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0358459 |
| DTNA | dystrobrevin, alpha | -0.0357777 |
| NF1 | neurofibromin 1 | -0.035729 |
| HLA-C | major histocompatibility complex, class I, C | -0.0355182 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0351937 |
| IL1RAPL2 | interleukin 1 receptor accessory protein-like 2 | -0.0351886 |
| RAD51B | RAD51 paralog B | -0.0350477 |
| SMYD3 | SET and MYND domain containing 3 | -0.0343915 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0343241 |
| VAPB | VAMP (vesicle-associated membrane protein)-associated protein B and C | -0.034099 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0335468 |
| PARD3 | par-3 family cell polarity regulator | -0.0332692 |
| NCOA6 | nuclear receptor coactivator 6 | -0.0330159 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0329345 |
| PLSCR1 | phospholipid scramblase 1 | -0.0326858 |
| MIPOL1 | mirror-image polydactyly 1 | -0.0325469 |
| EXOC4 | exocyst complex component 4 | -0.0325112 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0321361 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0321106 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0315686 |
| EFNA5 | ephrin-A5 | -0.0313805 |
| UBC | ubiquitin C | -0.0311748 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0310824 |
| MCL1 | myeloid cell leukemia 1 | -0.031069 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0310539 |
| KRT7 | keratin 7, type II | -0.0309917 |
| UQCC1 | ubiquinol-cytochrome c reductase complex assembly factor 1 | -0.0301884 |
| LARP4B | La ribonucleoprotein domain family, member 4B | -0.0301137 |
| KRT8 | keratin 8, type II | -0.0300179 |
| RBM47 | RNA binding motif protein 47 | -0.0298991 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0297486 |
| LDHA | lactate dehydrogenase A | -0.0294686 |
| PACS1 | phosphofurin acidic cluster sorting protein 1 | -0.0289661 |
| RPL8 | ribosomal protein L8 | -0.0288537 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0286466 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0285758 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | -0.0284132 |
| HLA-B | major histocompatibility complex, class I, B | -0.0283306 |
| RNF213 | ring finger protein 213 | -0.0281464 |
| RPS19 | ribosomal protein S19 | -0.0276855 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0271949 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.027132 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0271029 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0270452 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.026888 |
