| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Canagliflozin (hemihydrate) perturbation in C32 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Canagliflozin (hemihydrate)_C32 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | 0.127414 |
| ENO1 | enolase 1, (alpha) | 0.0989536 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0678541 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0591572 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.051217 |
| VCL | vinculin | 0.0497421 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | 0.0469847 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.045103 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0443077 |
| EGR1 | early growth response 1 | 0.0434784 |
| CENPF | centromere protein F, 350/400kDa | 0.0429101 |
| VMP1 | vacuole membrane protein 1 | 0.0420797 |
| TPR | translocated promoter region, nuclear basket protein | 0.0415603 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0412724 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0405305 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0402283 |
| MYO1E | myosin IE | 0.03983 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0395898 |
| IGFBP7 | insulin-like growth factor binding protein 7 | 0.037779 |
| CLIC4 | chloride intracellular channel 4 | 0.0365402 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.036122 |
| GDF15 | growth differentiation factor 15 | 0.0355324 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0352494 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0346589 |
| PLIN2 | perilipin 2 | 0.0343248 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.033197 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | 0.0319089 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0318136 |
| RNF145 | ring finger protein 145 | 0.0312749 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.030843 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0304921 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0299782 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0299753 |
| S100A6 | S100 calcium binding protein A6 | 0.0295201 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0291304 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.028152 |
| ASPH | aspartate beta-hydroxylase | 0.0280754 |
| RNASEH2A | ribonuclease H2, subunit A | 0.027421 |
| PLOD3 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 | 0.0267781 |
| RPS12 | ribosomal protein S12 | 0.0266703 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0266131 |
| LDHA | lactate dehydrogenase A | 0.026341 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.0261154 |
| KDM2B | lysine (K)-specific demethylase 2B | 0.0258821 |
| PPP1R12B | protein phosphatase 1, regulatory subunit 12B | 0.0257254 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | 0.0256042 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.0255153 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0254189 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0251608 |
| HIP1 | huntingtin interacting protein 1 | 0.0250599 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | 0.0248684 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0248291 |
| SEM1 | SEM1 26S proteasome subunit | 0.0242843 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0241532 |
| PUS7 | pseudouridylate synthase 7 (putative) | 0.0238114 |
| B2M | beta-2-microglobulin | 0.0234112 |
| IGF2 | insulin-like growth factor 2 | 0.0232867 |
| SET | SET nuclear proto-oncogene | 0.0231565 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0230343 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0230097 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 0.0229989 |
| AHCYL2 | adenosylhomocysteinase-like 2 | 0.0229692 |
| IER2 | immediate early response 2 | 0.0229443 |
| RNF24 | ring finger protein 24 | 0.0228707 |
| MKRN1 | makorin ring finger protein 1 | 0.0227551 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0226838 |
| JUN | jun proto-oncogene | 0.0225131 |
| USP34 | ubiquitin specific peptidase 34 | 0.022372 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0222009 |
| ZNF654 | zinc finger protein 654 | 0.0221687 |
| CALU | calumenin | 0.0220052 |
| DSTN | destrin (actin depolymerizing factor) | 0.0216842 |
| HNRNPH3 | heterogeneous nuclear ribonucleoprotein H3 (2H9) | 0.0215335 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0214773 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0211189 |
| PTCHD4 | patched domain containing 4 | 0.0210475 |
| HLA-A | major histocompatibility complex, class I, A | 0.0209672 |
| PPIG | peptidylprolyl isomerase G (cyclophilin G) | 0.0209448 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0206266 |
| MSN | moesin | 0.0205747 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0205614 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0203376 |
| EHBP1 | EH domain binding protein 1 | 0.0202854 |
| SQSTM1 | sequestosome 1 | 0.0202259 |
| HMGB2 | high mobility group box 2 | 0.0202215 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0200519 |
| ZFYVE16 | zinc finger, FYVE domain containing 16 | 0.0200419 |
| MFGE8 | milk fat globule-EGF factor 8 protein | 0.0199762 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0194395 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0194322 |
| POM121C | POM121 transmembrane nucleoporin C | 0.0193531 |
| TMEM255B | transmembrane protein 255B | 0.0190162 |
| LRCH3 | leucine-rich repeats and calponin homology (CH) domain containing 3 | 0.018998 |
| RAB11FIP3 | RAB11 family interacting protein 3 (class II) | 0.0189497 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0189051 |
| FERMT2 | fermitin family member 2 | 0.0188143 |
| CCDC91 | coiled-coil domain containing 91 | 0.0187771 |
| SPAG9 | sperm associated antigen 9 | 0.0187551 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | 0.0187272 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0186883 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.172926 |
| FN1 | fibronectin 1 | -0.166798 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.139217 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.123619 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | -0.111888 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.105866 |
| LEF1 | lymphoid enhancer-binding factor 1 | -0.105455 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.092266 |
| NDRG1 | N-myc downstream regulated 1 | -0.0844279 |
| TNNC1 | troponin C type 1 (slow) | -0.0787544 |
| TNFRSF19 | tumor necrosis factor receptor superfamily, member 19 | -0.0754666 |
| VGF | VGF nerve growth factor inducible | -0.0740107 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0722885 |
| FMNL2 | formin-like 2 | -0.069162 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0622143 |
| FYN | FYN proto-oncogene, Src family tyrosine kinase | -0.0620479 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0610914 |
| NLGN1 | neuroligin 1 | -0.060427 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0593502 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0569045 |
| GPC6 | glypican 6 | -0.0568973 |
| PDE10A | phosphodiesterase 10A | -0.0564375 |
| CHSY1 | chondroitin sulfate synthase 1 | -0.0559601 |
| IER3 | immediate early response 3 | -0.0536695 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0510218 |
| PPFIA4 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 | -0.0509994 |
| PCDH7 | protocadherin 7 | -0.0506633 |
| MACROD2 | MACRO domain containing 2 | -0.049538 |
| CDC73 | cell division cycle 73 | -0.048991 |
| TMEM178B | transmembrane protein 178B | -0.0477248 |
| HMCN1 | hemicentin 1 | -0.0459696 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0452969 |
| NAV3 | neuron navigator 3 | -0.0424006 |
| SDC2 | syndecan 2 | -0.041681 |
| SMAD3 | SMAD family member 3 | -0.0411957 |
| CDK14 | cyclin-dependent kinase 14 | -0.0410763 |
| NPR2 | natriuretic peptide receptor 2 | -0.0405854 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0398333 |
| COG5 | component of oligomeric golgi complex 5 | -0.0382944 |
| VGLL4 | vestigial-like family member 4 | -0.0375722 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0374113 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0371029 |
| RUNX1 | runt-related transcription factor 1 | -0.0365483 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0361251 |
| DST | dystonin | -0.0359119 |
| GSN | gelsolin | -0.0358643 |
| FBXO32 | F-box protein 32 | -0.0350803 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0349949 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | -0.034576 |
| AHNAK | AHNAK nucleoprotein | -0.0338588 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.033674 |
| OGA | O-GlcNAcase | -0.0334376 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0332014 |
| EYA1 | EYA transcriptional coactivator and phosphatase 1 | -0.0308842 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.03077 |
| TMSB10 | thymosin beta 10 | -0.0303707 |
| MITF | microphthalmia-associated transcription factor | -0.0302523 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0301609 |
| ITGB3 | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | -0.0292264 |
| RRBP1 | ribosome binding protein 1 | -0.0291021 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0288698 |
| ST6GALNAC3 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 | -0.0288286 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0287954 |
| KIRREL1 | kirre like nephrin family adhesion molecule 1 | -0.0285506 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.0284396 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | -0.0282629 |
| ZC3H11A | zinc finger CCCH-type containing 11A | -0.0282235 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0279715 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0273768 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0269853 |
| OSMR | oncostatin M receptor | -0.026649 |
| USP3 | ubiquitin specific peptidase 3 | -0.0265948 |
| MT2A | metallothionein 2A | -0.0265468 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0264613 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.0263844 |
| LINGO2 | leucine rich repeat and Ig domain containing 2 | -0.0262343 |
| TENT4A | terminal nucleotidyltransferase 4A | -0.0261856 |
| PTK2 | protein tyrosine kinase 2 | -0.0260643 |
| FHIT | fragile histidine triad | -0.0254949 |
| TAC4 | tachykinin 4 (hemokinin) | -0.0251797 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | -0.0250229 |
| EWSR1 | EWS RNA-binding protein 1 | -0.0249816 |
| HELZ | helicase with zinc finger | -0.0248441 |
| RBM33 | RNA binding motif protein 33 | -0.0246724 |
| LAMB1 | laminin, beta 1 | -0.0246136 |
| CPEB2 | cytoplasmic polyadenylation element binding protein 2 | -0.0244606 |
| EXOC4 | exocyst complex component 4 | -0.0243448 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0241988 |
| TSPAN14 | tetraspanin 14 | -0.0239698 |
| ATF6 | activating transcription factor 6 | -0.0238654 |
| C10ORF90 | chromosome 10 open reading frame 90 | -0.0236504 |
| BBX | bobby sox homolog (Drosophila) | -0.0235788 |
| FRMD4A | FERM domain containing 4A | -0.0234376 |
| FOXJ3 | forkhead box J3 | -0.0233735 |
| NOS1AP | nitric oxide synthase 1 (neuronal) adaptor protein | -0.0231503 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.02294 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0228601 |
| INPP5F | inositol polyphosphate-5-phosphatase F | -0.0226034 |
| RASA3 | RAS p21 protein activator 3 | -0.0225593 |
| MT1X | metallothionein 1X | -0.0223665 |
