| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Canagliflozin (hemihydrate) perturbation in CFPAC-1 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Canagliflozin (hemihydrate)_CFPAC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NAMPT | nicotinamide phosphoribosyltransferase | 0.188284 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.119349 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0994683 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0846095 |
| PTMA | prothymosin, alpha | 0.07846 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0760849 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0748132 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0711817 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0644736 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0627244 |
| VIM | vimentin | 0.0597852 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.058597 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0560808 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0544926 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0542674 |
| RTN4 | reticulon 4 | 0.0534771 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0521715 |
| CCNL1 | cyclin L1 | 0.0483786 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0461985 |
| CD46 | CD46 molecule, complement regulatory protein | 0.0455518 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0452767 |
| TGM2 | transglutaminase 2 | 0.0452163 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0445712 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0426412 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0421566 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.0419274 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0410132 |
| FAM13A | family with sequence similarity 13, member A | 0.0399107 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.0398748 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0394707 |
| ARL5B | ADP-ribosylation factor-like 5B | 0.0389756 |
| TXNIP | thioredoxin interacting protein | 0.0389156 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | 0.0387432 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0387236 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0386053 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0384191 |
| MKI67 | marker of proliferation Ki-67 | 0.0380306 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.036458 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0358496 |
| HMGB2 | high mobility group box 2 | 0.0352104 |
| ABI1 | abl-interactor 1 | 0.0347691 |
| MATR3 | matrin 3 | 0.0343487 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.0343021 |
| LAMA4 | laminin, alpha 4 | 0.0332603 |
| EZR | ezrin | 0.0331932 |
| PCBP2 | poly(rC) binding protein 2 | 0.0329794 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0329383 |
| TXNRD1 | thioredoxin reductase 1 | 0.0328297 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0325676 |
| RLF | rearranged L-myc fusion | 0.0323779 |
| YTHDC1 | YTH domain containing 1 | 0.0322997 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.032249 |
| FAM162A | family with sequence similarity 162, member A | 0.0319847 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.0319086 |
| NUP58 | nucleoporin 58 | 0.031742 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0315797 |
| RBM39 | RNA binding motif protein 39 | 0.0313076 |
| STRN3 | striatin, calmodulin binding protein 3 | 0.0312015 |
| ZNF292 | zinc finger protein 292 | 0.0306026 |
| RNF149 | ring finger protein 149 | 0.0304269 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0302978 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.0300929 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0300101 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0300059 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0295029 |
| PEG10 | paternally expressed 10 | 0.0290837 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0289825 |
| CD47 | CD47 molecule | 0.0287159 |
| VCAN | versican | 0.0287074 |
| SNAPC1 | small nuclear RNA activating complex, polypeptide 1, 43kDa | 0.02852 |
| GBP2 | guanylate binding protein 2, interferon-inducible | 0.0282327 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0277106 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0274603 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.027169 |
| TPM3 | tropomyosin 3 | 0.0270796 |
| NRP1 | neuropilin 1 | 0.027043 |
| TOP1 | topoisomerase (DNA) I | 0.0267643 |
| MAP3K8 | mitogen-activated protein kinase kinase kinase 8 | 0.0266285 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0265024 |
| AREG | amphiregulin | 0.0261261 |
| EFNA5 | ephrin-A5 | 0.0256521 |
| MAL2 | mal, T-cell differentiation protein 2 (gene/pseudogene) | 0.0254347 |
| SPAG9 | sperm associated antigen 9 | 0.0253954 |
| MIS18BP1 | MIS18 binding protein 1 | 0.0253527 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.025219 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0250765 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0250394 |
| RAB8B | RAB8B, member RAS oncogene family | 0.0248907 |
| DDX52 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 52 | 0.0248877 |
| PPP1CB | protein phosphatase 1, catalytic subunit, beta isozyme | 0.0247972 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0246755 |
| YBX1 | Y box binding protein 1 | 0.0246123 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0245039 |
| ZNF148 | zinc finger protein 148 | 0.0243282 |
| EHBP1 | EH domain binding protein 1 | 0.0241306 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0240569 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0240408 |
| LAMB1 | laminin, beta 1 | 0.0238348 |
| SRSF11 | serine/arginine-rich splicing factor 11 | 0.0236855 |
| BICC1 | BicC family RNA binding protein 1 | 0.0236654 |
| Symbol | Name | Standardized Value |
|---|---|---|
| DTNA | dystrobrevin, alpha | -0.172139 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.16205 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.125603 |
| HLA-B | major histocompatibility complex, class I, B | -0.121289 |
| CP | ceruloplasmin (ferroxidase) | -0.111759 |
| LAMB3 | laminin, beta 3 | -0.103714 |
| TMSB10 | thymosin beta 10 | -0.0999825 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0851101 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0848583 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0799074 |
| MMP7 | matrix metallopeptidase 7 | -0.0764157 |
| AHNAK | AHNAK nucleoprotein | -0.0761913 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.0755641 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0682893 |
| APOL1 | apolipoprotein L, 1 | -0.0668237 |
| LAMC2 | laminin, gamma 2 | -0.0655432 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0632021 |
| MCU | mitochondrial calcium uniporter | -0.0631033 |
| KRT19 | keratin 19, type I | -0.0602717 |
| NDRG1 | N-myc downstream regulated 1 | -0.0600291 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0584205 |
| INTS6 | integrator complex subunit 6 | -0.0583807 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0583475 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0567971 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.056438 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0548841 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0533537 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.053249 |
| PARD3 | par-3 family cell polarity regulator | -0.0527205 |
| LCN2 | lipocalin 2 | -0.0518519 |
| NABP1 | nucleic acid binding protein 1 | -0.0514427 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | -0.050962 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0505664 |
| PPARD | peroxisome proliferator-activated receptor delta | -0.049224 |
| SP100 | SP100 nuclear antigen | -0.0479708 |
| AHNAK2 | AHNAK nucleoprotein 2 | -0.0454898 |
| VCL | vinculin | -0.0450192 |
| LMO7 | LIM domain 7 | -0.044751 |
| RCOR1 | REST corepressor 1 | -0.0445105 |
| KLF5 | Kruppel-like factor 5 (intestinal) | -0.0442458 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0436084 |
| TJP1 | tight junction protein 1 | -0.0435912 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0424533 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0417478 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0412679 |
| RPL35A | ribosomal protein L35a | -0.041044 |
| NUMB | numb homolog (Drosophila) | -0.0408095 |
| TBC1D22A | TBC1 domain family, member 22A | -0.039489 |
| CMIP | c-Maf inducing protein | -0.0387997 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | -0.0387124 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0383761 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0381096 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0375985 |
| FAM107B | family with sequence similarity 107, member B | -0.0371761 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0370281 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0368999 |
| PPP1R13B | protein phosphatase 1, regulatory subunit 13B | -0.0367968 |
| SLC6A14 | solute carrier family 6 (amino acid transporter), member 14 | -0.0363669 |
| ACTG1 | actin gamma 1 | -0.0363575 |
| FBXO11 | F-box protein 11 | -0.0362924 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0355641 |
| EXT1 | exostosin glycosyltransferase 1 | -0.03505 |
| CATSPERB | catsper channel auxiliary subunit beta | -0.0349922 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0349122 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0344359 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | -0.0341781 |
| NRG3 | neuregulin 3 | -0.0336298 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0334676 |
| IGF1R | insulin-like growth factor 1 receptor | -0.033079 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | -0.0330198 |
| PRKCA | protein kinase C, alpha | -0.0330084 |
| MYO1E | myosin IE | -0.0329591 |
| LARP4B | La ribonucleoprotein domain family, member 4B | -0.0326681 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0325202 |
| SESTD1 | SEC14 and spectrin domains 1 | -0.0321686 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0320138 |
| PLAT | plasminogen activator, tissue | -0.0319976 |
| RPL34 | ribosomal protein L34 | -0.0319363 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | -0.0318616 |
| PCNX4 | pecanex 4 | -0.0318601 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | -0.0309812 |
| FOXO3 | forkhead box O3 | -0.0309287 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0309187 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0309041 |
| EGR1 | early growth response 1 | -0.030529 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0304516 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0303945 |
| GNAS | GNAS complex locus | -0.030147 |
| TRAF3 | TNF receptor-associated factor 3 | -0.0299954 |
| HDAC9 | histone deacetylase 9 | -0.0291556 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0289502 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0286779 |
| GPATCH2L | G patch domain containing 2-like | -0.0284789 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | -0.0283381 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0279371 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.027794 |
| RUNX1 | runt-related transcription factor 1 | -0.0277057 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0277049 |
| RAI14 | retinoic acid induced 14 | -0.0276177 |
| ST8SIA6 | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 | -0.0274368 |
