| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Canagliflozin (hemihydrate) perturbation in CHP-212 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Canagliflozin (hemihydrate)_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| DDX1 | DEAD (Asp-Glu-Ala-Asp) box helicase 1 | 0.183869 |
| MYCN | v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog | 0.060142 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0508722 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.046477 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0460287 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0400516 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0398632 |
| VEGFA | vascular endothelial growth factor A | 0.0373832 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0368044 |
| LPIN1 | lipin 1 | 0.036458 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.035777 |
| XPO1 | exportin 1 | 0.0357188 |
| VIM | vimentin | 0.0354185 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0303206 |
| PTMA | prothymosin, alpha | 0.0299171 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0277403 |
| MATR3 | matrin 3 | 0.0275042 |
| RPS12 | ribosomal protein S12 | 0.0274911 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0261325 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | 0.025938 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0259312 |
| SET | SET nuclear proto-oncogene | 0.0257095 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0256748 |
| RPL23 | ribosomal protein L23 | 0.0256336 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0255054 |
| HMGB2 | high mobility group box 2 | 0.0250278 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0241773 |
| B2M | beta-2-microglobulin | 0.023979 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | 0.0239179 |
| PPM1D | protein phosphatase, Mg2+/Mn2+ dependent, 1D | 0.0237689 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0234648 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.023342 |
| ZNF148 | zinc finger protein 148 | 0.0229432 |
| RPL7 | ribosomal protein L7 | 0.0227592 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.02252 |
| MMP2 | matrix metallopeptidase 2 | 0.0223904 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0221837 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0221675 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0221471 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0220869 |
| ITSN2 | intersectin 2 | 0.0219974 |
| KLHL24 | kelch-like family member 24 | 0.0217301 |
| WDR26 | WD repeat domain 26 | 0.0214223 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0211526 |
| SETD2 | SET domain containing 2 | 0.0210748 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0209916 |
| RPS16 | ribosomal protein S16 | 0.0208205 |
| LSM14A | LSM14A, SCD6 homolog A (S. cerevisiae) | 0.0206085 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0205993 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0205168 |
| PSMD11 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 | 0.0203466 |
| VGF | VGF nerve growth factor inducible | 0.0203446 |
| RNASEH2A | ribonuclease H2, subunit A | 0.0202896 |
| SYAP1 | synapse associated protein 1 | 0.0200134 |
| TPM3 | tropomyosin 3 | 0.019794 |
| VEZT | vezatin, adherens junctions transmembrane protein | 0.0197771 |
| CERT1 | ceramide transporter 1 | 0.0196799 |
| STRN3 | striatin, calmodulin binding protein 3 | 0.0196383 |
| MED13L | mediator complex subunit 13-like | 0.0196221 |
| AP1G1 | adaptor-related protein complex 1, gamma 1 subunit | 0.0195947 |
| POTEF | POTE ankyrin domain family, member F | 0.0194834 |
| PHIP | pleckstrin homology domain interacting protein | 0.0193493 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0191865 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0191484 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | 0.0188986 |
| ZBTB11 | zinc finger and BTB domain containing 11 | 0.0186701 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0186019 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.0184796 |
| QKI | QKI, KH domain containing, RNA binding | 0.0184404 |
| FAT1 | FAT atypical cadherin 1 | 0.018198 |
| FAM107B | family with sequence similarity 107, member B | 0.0180043 |
| RPL30 | ribosomal protein L30 | 0.0178187 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0178061 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0177511 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0176676 |
| TAF3 | TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa | 0.0174093 |
| YY1AP1 | YY1 associated protein 1 | 0.0173223 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0172752 |
| SRP54 | signal recognition particle 54kDa | 0.0172479 |
| RPS23 | ribosomal protein S23 | 0.0172446 |
| UBE2K | ubiquitin-conjugating enzyme E2K | 0.0172124 |
| MYO10 | myosin X | 0.0171687 |
| RBM6 | RNA binding motif protein 6 | 0.0171686 |
| DISP1 | dispatched homolog 1 (Drosophila) | 0.0171577 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0170802 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0170373 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0168469 |
| BRD2 | bromodomain containing 2 | 0.0167982 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0166628 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0166568 |
| PSMD7 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 | 0.0166404 |
| TAF7 | TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa | 0.0165939 |
| NSUN6 | NOP2/Sun domain family, member 6 | 0.0165689 |
| RAB14 | RAB14, member RAS oncogene family | 0.0165361 |
| COPS2 | COP9 signalosome subunit 2 | 0.016514 |
| SLC16A3 | solute carrier family 16 (monocarboxylate transporter), member 3 | 0.0164165 |
| RSRC1 | arginine/serine-rich coiled-coil 1 | 0.0163982 |
| PRKAR2A | protein kinase, cAMP-dependent, regulatory, type II, alpha | 0.0163639 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0162443 |
| RPL27 | ribosomal protein L27 | 0.016219 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NRG1 | neuregulin 1 | -0.265498 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.150578 |
| EXT1 | exostosin glycosyltransferase 1 | -0.14108 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.113872 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.109537 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | -0.0939579 |
| LSAMP | limbic system-associated membrane protein | -0.0903973 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0891906 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.086531 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0850323 |
| SYT1 | synaptotagmin I | -0.0808283 |
| NCAM2 | neural cell adhesion molecule 2 | -0.080549 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0786213 |
| CPED1 | cadherin-like and PC-esterase domain containing 1 | -0.0751875 |
| ZNF804A | zinc finger protein 804A | -0.0733519 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0703898 |
| NREP | neuronal regeneration related protein | -0.0699835 |
| LINGO2 | leucine rich repeat and Ig domain containing 2 | -0.0695444 |
| MEIS2 | Meis homeobox 2 | -0.0641598 |
| IGF2 | insulin-like growth factor 2 | -0.0630999 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0616134 |
| LRFN5 | leucine rich repeat and fibronectin type III domain containing 5 | -0.0611575 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0594416 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0593852 |
| BPTF | bromodomain PHD finger transcription factor | -0.0592784 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0590465 |
| GPC5 | glypican 5 | -0.055651 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0548943 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | -0.0548185 |
| CADM2 | cell adhesion molecule 2 | -0.0529358 |
| AFF3 | AF4/FMR2 family, member 3 | -0.0510453 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0506854 |
| SCN9A | sodium channel, voltage gated, type IX alpha subunit | -0.0505698 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0504174 |
| ATRNL1 | attractin-like 1 | -0.0502531 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.0484433 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0482861 |
| COL4A5 | collagen, type IV, alpha 5 | -0.0482082 |
| FRMD4A | FERM domain containing 4A | -0.0481355 |
| TENT5A | terminal nucleotidyltransferase 5A | -0.0479635 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0470313 |
| MEF2A | myocyte enhancer factor 2A | -0.0466529 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.046166 |
| DENND1A | DENN/MADD domain containing 1A | -0.045146 |
| ANTXR1 | anthrax toxin receptor 1 | -0.04512 |
| ST6GALNAC3 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 | -0.0444921 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0424763 |
| UNC5C | unc-5 homolog C (C. elegans) | -0.0422914 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.0420923 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.0420428 |
| KLHL13 | kelch-like family member 13 | -0.0419535 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0410763 |
| PTPRE | protein tyrosine phosphatase, receptor type, E | -0.0407075 |
| MAP1B | microtubule-associated protein 1B | -0.040655 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0404834 |
| MAPK10 | mitogen-activated protein kinase 10 | -0.0401841 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0399212 |
| NBEA | neurobeachin | -0.0385381 |
| KCNT2 | potassium channel, sodium activated subfamily T, member 2 | -0.0381066 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0379743 |
| PCDH9 | protocadherin 9 | -0.0377149 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0367786 |
| CENPF | centromere protein F, 350/400kDa | -0.0367477 |
| CACNA2D1 | calcium channel, voltage-dependent, alpha 2/delta subunit 1 | -0.0365082 |
| FMN1 | formin 1 | -0.0363155 |
| DNM3 | dynamin 3 | -0.0361124 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | -0.0359263 |
| MCL1 | myeloid cell leukemia 1 | -0.0358607 |
| TRMT11 | tRNA methyltransferase 11 homolog (S. cerevisiae) | -0.0356704 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0355315 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.035467 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0353593 |
| DIAPH2 | diaphanous-related formin 2 | -0.0351765 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0350453 |
| HELZ | helicase with zinc finger | -0.0350325 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0347894 |
| NDRG1 | N-myc downstream regulated 1 | -0.0345973 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0340351 |
| CUX1 | cut-like homeobox 1 | -0.0338991 |
| VCL | vinculin | -0.0327496 |
| PCBP3 | poly(rC) binding protein 3 | -0.0326056 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0325952 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0325776 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0321287 |
| PLPP1 | phospholipid phosphatase 1 | -0.0321246 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0321207 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | -0.0318839 |
| SCG2 | secretogranin II | -0.0316927 |
| PACS1 | phosphofurin acidic cluster sorting protein 1 | -0.0315317 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0315237 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0314175 |
| EDEM3 | ER degradation enhancer, mannosidase alpha-like 3 | -0.0310198 |
| CANX | calnexin | -0.0310136 |
| PTPN13 | protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) | -0.0309068 |
| KCNIP4 | Kv channel interacting protein 4 | -0.0308934 |
| ITGA1 | integrin, alpha 1 | -0.0308225 |
| GOLGB1 | golgin B1 | -0.0307858 |
| CCND1 | cyclin D1 | -0.0307617 |
| PRKCA | protein kinase C, alpha | -0.0307552 |
| C1ORF21 | chromosome 1 open reading frame 21 | -0.030714 |
