| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Canagliflozin (hemihydrate) perturbation in H4 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Canagliflozin (hemihydrate)_H4 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.162161 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.124324 |
| STC1 | stanniocalcin 1 | 0.0954797 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0837786 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0628947 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0590244 |
| MKI67 | marker of proliferation Ki-67 | 0.0558615 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0537117 |
| RTN4 | reticulon 4 | 0.0532326 |
| TXNRD1 | thioredoxin reductase 1 | 0.0480475 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0480257 |
| SBF2 | SET binding factor 2 | 0.0462923 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0462423 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0431336 |
| INHBA | inhibin, beta A | 0.0429094 |
| ATP13A3 | ATPase type 13A3 | 0.0405707 |
| ANKRD17 | ankyrin repeat domain 17 | 0.039883 |
| GOLGA4 | golgin A4 | 0.0384842 |
| VMP1 | vacuole membrane protein 1 | 0.0381949 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0376433 |
| MSN | moesin | 0.0368896 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0360482 |
| SMAD3 | SMAD family member 3 | 0.0358136 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0350371 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0347188 |
| NPC1 | Niemann-Pick disease, type C1 | 0.0343299 |
| WDR26 | WD repeat domain 26 | 0.0341766 |
| AVL9 | AVL9 homolog (S. cerevisiase) | 0.0340228 |
| OGA | O-GlcNAcase | 0.0330113 |
| CENPF | centromere protein F, 350/400kDa | 0.0329537 |
| TXNIP | thioredoxin interacting protein | 0.0327996 |
| ACBD3 | acyl-CoA binding domain containing 3 | 0.0324643 |
| COG5 | component of oligomeric golgi complex 5 | 0.0319668 |
| MAP1B | microtubule-associated protein 1B | 0.0319611 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0317279 |
| RARS1 | arginyl-tRNA synthetase 1 | 0.0315616 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0312395 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0311347 |
| CLTC | clathrin, heavy chain (Hc) | 0.0309428 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.02984 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.029733 |
| GPR107 | G protein-coupled receptor 107 | 0.0294768 |
| GOLGA2 | golgin A2 | 0.0293622 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0293277 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0292511 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.028475 |
| NDRG1 | N-myc downstream regulated 1 | 0.0280221 |
| EIF2AK1 | eukaryotic translation initiation factor 2-alpha kinase 1 | 0.0279772 |
| VIM | vimentin | 0.0276649 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.0276508 |
| ZNF148 | zinc finger protein 148 | 0.0276029 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.027092 |
| SCFD2 | sec1 family domain containing 2 | 0.0270791 |
| ANLN | anillin, actin binding protein | 0.0269757 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0268455 |
| TPM4 | tropomyosin 4 | 0.026769 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0265867 |
| CALR | calreticulin | 0.0264652 |
| UBR2 | ubiquitin protein ligase E3 component n-recognin 2 | 0.0264536 |
| CANX | calnexin | 0.0262357 |
| TNNC1 | troponin C type 1 (slow) | 0.0261102 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | 0.0259092 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0256473 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0252017 |
| COPB1 | coatomer protein complex, subunit beta 1 | 0.0251916 |
| RBM39 | RNA binding motif protein 39 | 0.0250997 |
| SKIC3 | SKI3 subunit of superkiller complex | 0.0250883 |
| TM9SF3 | transmembrane 9 superfamily member 3 | 0.0250184 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0249538 |
| ANXA5 | annexin A5 | 0.0248757 |
| SUCO | SUN domain containing ossification factor | 0.0246715 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0245759 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0245558 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.023984 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0235506 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0234231 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0232045 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0232007 |
| CKAP5 | cytoskeleton associated protein 5 | 0.023195 |
| SETD5 | SET domain containing 5 | 0.0230122 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0227751 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0227737 |
| TMEM39A | transmembrane protein 39A | 0.0227696 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | 0.0227439 |
| USP36 | ubiquitin specific peptidase 36 | 0.0226122 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.022579 |
| YTHDC1 | YTH domain containing 1 | 0.0224557 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0223486 |
| MORF4L2 | mortality factor 4 like 2 | 0.022323 |
| CDC27 | cell division cycle 27 | 0.0221673 |
| ITGAV | integrin, alpha V | 0.022093 |
| TPX2 | TPX2, microtubule-associated | 0.0219078 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0218786 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | 0.0217622 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | 0.0217099 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0216199 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | 0.0215187 |
| CSNK1E | casein kinase 1, epsilon | 0.0213259 |
| RNF216 | ring finger protein 216 | 0.0211499 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0209237 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.310605 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.194266 |
| ASPH | aspartate beta-hydroxylase | -0.129659 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.116078 |
| COL6A3 | collagen, type VI, alpha 3 | -0.110801 |
| GRB10 | growth factor receptor-bound protein 10 | -0.107588 |
| FN1 | fibronectin 1 | -0.105811 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0975967 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0943565 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0759926 |
| TMSB10 | thymosin beta 10 | -0.0739183 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0704516 |
| DTNA | dystrobrevin, alpha | -0.0690099 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0666402 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0622271 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0587636 |
| HLA-B | major histocompatibility complex, class I, B | -0.0566267 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0560378 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.051026 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0481984 |
| NLGN1 | neuroligin 1 | -0.0472532 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0438836 |
| INTS6 | integrator complex subunit 6 | -0.0420737 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.041958 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | -0.039638 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0393047 |
| NRXN3 | neurexin 3 | -0.0392455 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | -0.0380096 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0374386 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | -0.0371961 |
| NAV1 | neuron navigator 1 | -0.0368223 |
| MT2A | metallothionein 2A | -0.0355618 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0355169 |
| ZNF804A | zinc finger protein 804A | -0.0340888 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0336822 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0319305 |
| RPL35A | ribosomal protein L35a | -0.0317378 |
| RIGI | RNA sensor RIG-I | -0.0312748 |
| ITGB3BP | integrin beta 3 binding protein (beta3-endonexin) | -0.0308609 |
| COL5A1 | collagen, type V, alpha 1 | -0.0307583 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0300785 |
| DGKI | diacylglycerol kinase, iota | -0.0295752 |
| OXR1 | oxidation resistance 1 | -0.0295068 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0293191 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0291956 |
| KCTD16 | potassium channel tetramerization domain containing 16 | -0.0288106 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0281787 |
| EGFR | epidermal growth factor receptor | -0.0281335 |
| DST | dystonin | -0.0281311 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | -0.0279682 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0279497 |
| AUTS2 | autism susceptibility candidate 2 | -0.0272972 |
| VCL | vinculin | -0.0269975 |
| POTEF | POTE ankyrin domain family, member F | -0.0268426 |
| IGF2 | insulin-like growth factor 2 | -0.0267522 |
| FBXO11 | F-box protein 11 | -0.0266993 |
| CDK14 | cyclin-dependent kinase 14 | -0.026554 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0257796 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0256087 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0256002 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | -0.0248506 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0248429 |
| PRSS23 | protease, serine, 23 | -0.0247006 |
| HS6ST3 | heparan sulfate 6-O-sulfotransferase 3 | -0.0244184 |
| ZFYVE28 | zinc finger, FYVE domain containing 28 | -0.0243902 |
| PRELID2 | PRELI domain containing 2 | -0.0238081 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0235859 |
| STXBP1 | syntaxin binding protein 1 | -0.023478 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0233968 |
| DENND1A | DENN/MADD domain containing 1A | -0.0233875 |
| TMEM132B | transmembrane protein 132B | -0.0230097 |
| CALD1 | caldesmon 1 | -0.0228917 |
| TNS3 | tensin 3 | -0.0228197 |
| MMP12 | matrix metallopeptidase 12 | -0.0227546 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0226472 |
| PIAS2 | protein inhibitor of activated STAT, 2 | -0.0226463 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.022204 |
| RUNX1 | runt-related transcription factor 1 | -0.022191 |
| RPS6 | ribosomal protein S6 | -0.0221606 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | -0.0221583 |
| CLMP | CXADR-like membrane protein | -0.0221443 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | -0.0221275 |
| HIP1 | huntingtin interacting protein 1 | -0.0220335 |
| ATXN1 | ataxin 1 | -0.021871 |
| PRKCA | protein kinase C, alpha | -0.0217063 |
| HLCS | holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) | -0.0216734 |
| GLRX | glutaredoxin (thioltransferase) | -0.0215692 |
| CCND1 | cyclin D1 | -0.021565 |
| FGF13 | fibroblast growth factor 13 | -0.0214672 |
| CLIC4 | chloride intracellular channel 4 | -0.0213828 |
| PRR16 | proline rich 16 | -0.0212783 |
| LOX | lysyl oxidase | -0.0211208 |
| DPYD | dihydropyrimidine dehydrogenase | -0.020987 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0205074 |
| HLA-A | major histocompatibility complex, class I, A | -0.0204968 |
| FUT11 | fucosyltransferase 11 (alpha (1,3) fucosyltransferase) | -0.0201591 |
| SHISA5 | shisa family member 5 | -0.0200853 |
| ARHGAP22 | Rho GTPase activating protein 22 | -0.0200088 |
| CCDC88A | coiled-coil domain containing 88A | -0.0199164 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0199008 |
