| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Canagliflozin (hemihydrate) perturbation in HCT15 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Canagliflozin (hemihydrate)_HCT15 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0871832 |
| GOLGA4 | golgin A4 | 0.082765 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0816323 |
| FTL | ferritin, light polypeptide | 0.0688239 |
| TMF1 | TATA element modulatory factor 1 | 0.0577223 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.0548521 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.052944 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0518187 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0470011 |
| TXNRD1 | thioredoxin reductase 1 | 0.0455809 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0431007 |
| TMEM41B | transmembrane protein 41B | 0.04299 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0426338 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0413466 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0409991 |
| SRSF11 | serine/arginine-rich splicing factor 11 | 0.0399332 |
| MORF4L2 | mortality factor 4 like 2 | 0.0397134 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0396359 |
| MON2 | MON2 homolog (S. cerevisiae) | 0.0386353 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0383931 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | 0.0373463 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0372257 |
| SRP54 | signal recognition particle 54kDa | 0.0370988 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.036676 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0363724 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0362937 |
| NUP58 | nucleoporin 58 | 0.0361843 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0350307 |
| MATR3 | matrin 3 | 0.0350149 |
| RLF | rearranged L-myc fusion | 0.0346858 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | 0.0340081 |
| ACBD3 | acyl-CoA binding domain containing 3 | 0.0338963 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0333991 |
| ZNF292 | zinc finger protein 292 | 0.0330558 |
| HMGB2 | high mobility group box 2 | 0.0326996 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0322129 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.032196 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0315378 |
| ROCK1 | Rho-associated, coiled-coil containing protein kinase 1 | 0.0314025 |
| SFXN1 | sideroflexin 1 | 0.031023 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 0.0306643 |
| ARL5B | ADP-ribosylation factor-like 5B | 0.0305886 |
| KDELR1 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 | 0.0304897 |
| KIF5B | kinesin family member 5B | 0.0303578 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.030281 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | 0.0300661 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0298989 |
| OGA | O-GlcNAcase | 0.0297609 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0296205 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0295214 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | 0.0290998 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0290218 |
| SQSTM1 | sequestosome 1 | 0.0290005 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0289007 |
| GOLGA2 | golgin A2 | 0.0285141 |
| RARS1 | arginyl-tRNA synthetase 1 | 0.0281364 |
| COPB1 | coatomer protein complex, subunit beta 1 | 0.0279008 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0276247 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | 0.0275041 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | 0.0274726 |
| CDK19 | cyclin-dependent kinase 19 | 0.0272054 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.027172 |
| TMEM87A | transmembrane protein 87A | 0.0269861 |
| USP37 | ubiquitin specific peptidase 37 | 0.0269238 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0266808 |
| MSMO1 | methylsterol monooxygenase 1 | 0.0266072 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | 0.026543 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.0265181 |
| JMJD1C | jumonji domain containing 1C | 0.0264532 |
| RBBP6 | retinoblastoma binding protein 6 | 0.0264217 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | 0.0261357 |
| WDR26 | WD repeat domain 26 | 0.0260607 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0259279 |
| SON | SON DNA binding protein | 0.0258949 |
| METTL15 | methyltransferase like 15 | 0.02585 |
| CTDSPL2 | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 | 0.025707 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0256804 |
| RBM25 | RNA binding motif protein 25 | 0.0256337 |
| SETD2 | SET domain containing 2 | 0.0255183 |
| ZNF654 | zinc finger protein 654 | 0.0252713 |
| CCDC186 | coiled-coil domain containing 186 | 0.0250913 |
| SUCO | SUN domain containing ossification factor | 0.025078 |
| HYOU1 | hypoxia up-regulated 1 | 0.0250611 |
| WDFY3 | WD repeat and FYVE domain containing 3 | 0.0250421 |
| TMED2 | transmembrane emp24 domain trafficking protein 2 | 0.0249226 |
| STRN3 | striatin, calmodulin binding protein 3 | 0.0248498 |
| FAM117B | family with sequence similarity 117, member B | 0.0248077 |
| RPS2 | ribosomal protein S2 | 0.024472 |
| YME1L1 | YME1-like 1 ATPase | 0.0244085 |
| RC3H1 | ring finger and CCCH-type domains 1 | 0.0242667 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0239677 |
| UBR3 | ubiquitin protein ligase E3 component n-recognin 3 (putative) | 0.0238433 |
| CD46 | CD46 molecule, complement regulatory protein | 0.0234191 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0233178 |
| PHF3 | PHD finger protein 3 | 0.0232356 |
| UFL1 | UFM1-specific ligase 1 | 0.0231011 |
| PCM1 | pericentriolar material 1 | 0.0230775 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | 0.022924 |
| TMEM39A | transmembrane protein 39A | 0.0228282 |
| TMEM14B | transmembrane protein 14B | 0.0227331 |
| Symbol | Name | Standardized Value |
|---|---|---|
| AHNAK | AHNAK nucleoprotein | -0.317263 |
| FAT1 | FAT atypical cadherin 1 | -0.211839 |
| NDRG1 | N-myc downstream regulated 1 | -0.118087 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.116899 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.104115 |
| PTMA | prothymosin, alpha | -0.0984781 |
| TMSB10 | thymosin beta 10 | -0.0881489 |
| PKM | pyruvate kinase, muscle | -0.0799725 |
| UBC | ubiquitin C | -0.0783869 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0715112 |
| KRT8 | keratin 8, type II | -0.0618563 |
| ASPH | aspartate beta-hydroxylase | -0.059694 |
| INTS6 | integrator complex subunit 6 | -0.0596137 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0585972 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0585283 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0562683 |
| ACTG1 | actin gamma 1 | -0.0486127 |
| POTEF | POTE ankyrin domain family, member F | -0.0482526 |
| SERINC5 | serine incorporator 5 | -0.0477656 |
| ENO1 | enolase 1, (alpha) | -0.0456084 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0444959 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.042019 |
| TBC1D22A | TBC1 domain family, member 22A | -0.04185 |
| EGFR | epidermal growth factor receptor | -0.0403647 |
| MCL1 | myeloid cell leukemia 1 | -0.0401548 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | -0.0401437 |
| S100A10 | S100 calcium binding protein A10 | -0.0389361 |
| CTBP2 | C-terminal binding protein 2 | -0.0381809 |
| FHIT | fragile histidine triad | -0.0377419 |
| SDC4 | syndecan 4 | -0.0377037 |
| WWOX | WW domain containing oxidoreductase | -0.036231 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.0361634 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0350155 |
| PGK1 | phosphoglycerate kinase 1 | -0.0342305 |
| KRT18 | keratin 18, type I | -0.0340264 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.032359 |
| CCND1 | cyclin D1 | -0.0320883 |
| RPL4 | ribosomal protein L4 | -0.0320036 |
| RPS27A | ribosomal protein S27a | -0.0304739 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0304728 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0302535 |
| FUS | FUS RNA binding protein | -0.029632 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | -0.0296112 |
| MSI2 | musashi RNA-binding protein 2 | -0.0294951 |
| SLCO1B3-SLCO1B7 | SLCO1B3-SLCO1B7 readthrough | -0.0291754 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0282604 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | -0.0267732 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0267731 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.026725 |
| H1-0 | H1.0 linker histone | -0.0266415 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0265746 |
| TUBB | tubulin, beta class I | -0.0264696 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0262389 |
| VCL | vinculin | -0.0262279 |
| LRRC23 | leucine rich repeat containing 23 | -0.0260197 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0259352 |
| RPL35A | ribosomal protein L35a | -0.0259257 |
| ACTN4 | actinin, alpha 4 | -0.0256998 |
| KDM4B | lysine (K)-specific demethylase 4B | -0.0250731 |
| HMGA2 | high mobility group AT-hook 2 | -0.0248723 |
| ITGB4 | integrin, beta 4 | -0.02475 |
| CDCP1 | CUB domain containing protein 1 | -0.0246422 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0246106 |
| TGFB1 | transforming growth factor, beta 1 | -0.024202 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0241128 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.0240026 |
| EGR1 | early growth response 1 | -0.023637 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | -0.0233841 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0230957 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | -0.0229219 |
| TUBA1B | tubulin, alpha 1b | -0.0228958 |
| HMGB1 | high mobility group box 1 | -0.0228439 |
| GPC5 | glypican 5 | -0.0227875 |
| CADPS | Ca++-dependent secretion activator | -0.0226597 |
| RPS11 | ribosomal protein S11 | -0.0223619 |
| CANX | calnexin | -0.0218531 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | -0.0212853 |
| RPS15 | ribosomal protein S15 | -0.0211559 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0210664 |
| DPYSL2 | dihydropyrimidinase-like 2 | -0.0207656 |
| DEK | DEK proto-oncogene | -0.0205535 |
| RRM2 | ribonucleotide reductase M2 | -0.0205049 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0204485 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0203422 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | -0.0202349 |
| ATP1A4 | ATPase, Na+/K+ transporting, alpha 4 polypeptide | -0.0201573 |
| TPM4 | tropomyosin 4 | -0.0201371 |
| ATP2A2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | -0.0198598 |
| TPI1 | triosephosphate isomerase 1 | -0.0194238 |
| DENND1A | DENN/MADD domain containing 1A | -0.0191577 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0191184 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | -0.0190826 |
| KLHL29 | kelch-like family member 29 | -0.0189397 |
| HELLS | helicase, lymphoid-specific | -0.0188502 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0186268 |
| RCC1 | regulator of chromosome condensation 1 | -0.0185124 |
| HOMER1 | homer scaffolding protein 1 | -0.0185015 |
| FAM107B | family with sequence similarity 107, member B | -0.0184096 |
| RCOR1 | REST corepressor 1 | -0.0181788 |
| IGFBP4 | insulin-like growth factor binding protein 4 | -0.0181117 |
