| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Canagliflozin (hemihydrate) perturbation in HEC-1-A cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Canagliflozin (hemihydrate)_HEC-1-A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.096089 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0806478 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0769782 |
| ENO1 | enolase 1, (alpha) | 0.0751167 |
| B2M | beta-2-microglobulin | 0.069453 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0643601 |
| SET | SET nuclear proto-oncogene | 0.0611997 |
| VMP1 | vacuole membrane protein 1 | 0.0597664 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | 0.0584221 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0520256 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0442951 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0428861 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0424078 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0417348 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0414035 |
| MT2A | metallothionein 2A | 0.0409862 |
| PKM | pyruvate kinase, muscle | 0.0386366 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0375725 |
| TNFAIP2 | tumor necrosis factor, alpha-induced protein 2 | 0.037065 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0365351 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0364295 |
| NUP58 | nucleoporin 58 | 0.03567 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0353352 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.035085 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0346777 |
| MACROD2 | MACRO domain containing 2 | 0.0345712 |
| TPM3 | tropomyosin 3 | 0.0345273 |
| HMGB2 | high mobility group box 2 | 0.0344352 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0339936 |
| TMBIM6 | transmembrane BAX inhibitor motif containing 6 | 0.0335456 |
| AXL | AXL receptor tyrosine kinase | 0.0335032 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0334524 |
| RPS12 | ribosomal protein S12 | 0.032053 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0312737 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0309186 |
| DSTN | destrin (actin depolymerizing factor) | 0.0303521 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0299153 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0297747 |
| RPS7 | ribosomal protein S7 | 0.0296298 |
| FOSL1 | FOS-like antigen 1 | 0.0295465 |
| TMF1 | TATA element modulatory factor 1 | 0.0293848 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | 0.0285872 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0284655 |
| HDGF | hepatoma-derived growth factor | 0.0284469 |
| SNX3 | sorting nexin 3 | 0.0279214 |
| APOLD1 | apolipoprotein L domain containing 1 | 0.02765 |
| SKAP2 | src kinase associated phosphoprotein 2 | 0.027579 |
| PTMA | prothymosin, alpha | 0.0274181 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0266956 |
| RPS2 | ribosomal protein S2 | 0.0265128 |
| KIF5B | kinesin family member 5B | 0.0263267 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0262802 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0258586 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0258295 |
| RPL3 | ribosomal protein L3 | 0.0254928 |
| MKI67 | marker of proliferation Ki-67 | 0.0254379 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | 0.0254344 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0253122 |
| S100A6 | S100 calcium binding protein A6 | 0.0249821 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | 0.024668 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0246625 |
| ANXA3 | annexin A3 | 0.0243413 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0242853 |
| WEE1 | WEE1 G2 checkpoint kinase | 0.0242184 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0241745 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.024007 |
| RNASEH2A | ribonuclease H2, subunit A | 0.0237806 |
| ZNF148 | zinc finger protein 148 | 0.0237745 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0237322 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.0236371 |
| RAD51B | RAD51 paralog B | 0.0234714 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | 0.0232995 |
| BCL9L | B-cell CLL/lymphoma 9-like | 0.0232662 |
| CDK19 | cyclin-dependent kinase 19 | 0.023038 |
| CYP51A1 | cytochrome P450, family 51, subfamily A, polypeptide 1 | 0.022954 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0224366 |
| FLNA | filamin A, alpha | 0.0224145 |
| HLTF | helicase-like transcription factor | 0.0220155 |
| SRSF5 | serine/arginine-rich splicing factor 5 | 0.0216976 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0216545 |
| SMARCC2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 | 0.0216444 |
| CBX3 | chromobox homolog 3 | 0.0215483 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.0214868 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0214126 |
| CLDN4 | claudin 4 | 0.0211882 |
| LAMB3 | laminin, beta 3 | 0.0211614 |
| CD46 | CD46 molecule, complement regulatory protein | 0.0210817 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.020685 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0206601 |
| NT5C3A | 5'-nucleotidase, cytosolic IIIA | 0.0206566 |
| MCL1 | myeloid cell leukemia 1 | 0.020571 |
| DIAPH3 | diaphanous-related formin 3 | 0.020544 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0204019 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0203318 |
| SQSTM1 | sequestosome 1 | 0.0202371 |
| RPS3 | ribosomal protein S3 | 0.0201552 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | 0.0201028 |
| CPVL | carboxypeptidase, vitellogenic-like | 0.0199527 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0197739 |
| SPOPL | speckle-type POZ protein-like | 0.0196969 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.217448 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.178084 |
| AHNAK | AHNAK nucleoprotein | -0.156229 |
| ACTG1 | actin gamma 1 | -0.14601 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.112949 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0917046 |
| TMSB10 | thymosin beta 10 | -0.0860528 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0852011 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0785207 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0677865 |
| RPL35A | ribosomal protein L35a | -0.0637837 |
| ASPH | aspartate beta-hydroxylase | -0.0635386 |
| CANX | calnexin | -0.0622348 |
| ITGB8 | integrin, beta 8 | -0.0582514 |
| ACTN4 | actinin, alpha 4 | -0.057796 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0572279 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0568616 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0558152 |
| CCND1 | cyclin D1 | -0.0557812 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0556167 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0551818 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | -0.0520746 |
| OSBPL10 | oxysterol binding protein-like 10 | -0.0515396 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0512386 |
| H1-0 | H1.0 linker histone | -0.0502838 |
| RPL19 | ribosomal protein L19 | -0.048926 |
| SVIL | supervillin | -0.0471632 |
| RPS24 | ribosomal protein S24 | -0.0463049 |
| WWC1 | WW and C2 domain containing 1 | -0.0461966 |
| EMP1 | epithelial membrane protein 1 | -0.04564 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0454541 |
| NF1 | neurofibromin 1 | -0.0442882 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.0437513 |
| KRT7 | keratin 7, type II | -0.0435178 |
| CD2AP | CD2-associated protein | -0.0431445 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0426195 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0423355 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0419949 |
| RPL34 | ribosomal protein L34 | -0.0418446 |
| FBXL2 | F-box and leucine-rich repeat protein 2 | -0.0411917 |
| TUBB | tubulin, beta class I | -0.040999 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0409315 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0407132 |
| UBC | ubiquitin C | -0.0404857 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0401809 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0398088 |
| MAP4 | microtubule-associated protein 4 | -0.0395054 |
| PLEKHB2 | pleckstrin homology domain containing, family B (evectins) member 2 | -0.0389734 |
| EWSR1 | EWS RNA-binding protein 1 | -0.038783 |
| S100A10 | S100 calcium binding protein A10 | -0.038775 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0378459 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.037762 |
| LMAN1 | lectin, mannose-binding, 1 | -0.037495 |
| TMSB4X | thymosin beta 4, X-linked | -0.0374344 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0372864 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0371833 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | -0.0365434 |
| NAP1L4 | nucleosome assembly protein 1-like 4 | -0.0365087 |
| TJP1 | tight junction protein 1 | -0.036505 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0363785 |
| PGK1 | phosphoglycerate kinase 1 | -0.0361662 |
| ARHGEF10 | Rho guanine nucleotide exchange factor (GEF) 10 | -0.0357696 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0356615 |
| PPP2CA | protein phosphatase 2, catalytic subunit, alpha isozyme | -0.0355176 |
| PDIA5 | protein disulfide isomerase family A, member 5 | -0.0354887 |
| HMGA2 | high mobility group AT-hook 2 | -0.0354691 |
| RPL4 | ribosomal protein L4 | -0.035298 |
| RPL8 | ribosomal protein L8 | -0.0352343 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0348997 |
| ECT2 | epithelial cell transforming 2 | -0.0345 |
| RPL38 | ribosomal protein L38 | -0.0336925 |
| FIGN | fidgetin | -0.0336876 |
| HMGB1 | high mobility group box 1 | -0.0333214 |
| DSG2 | desmoglein 2 | -0.0327939 |
| LARP4B | La ribonucleoprotein domain family, member 4B | -0.0326117 |
| PTK2 | protein tyrosine kinase 2 | -0.0324749 |
| CALM3 | calmodulin 3 (phosphorylase kinase, delta) | -0.0321125 |
| LRCH3 | leucine-rich repeats and calponin homology (CH) domain containing 3 | -0.032109 |
| SCLT1 | sodium channel and clathrin linker 1 | -0.0319852 |
| RPL32 | ribosomal protein L32 | -0.0319401 |
| CCDC138 | coiled-coil domain containing 138 | -0.0315626 |
| SLC20A2 | solute carrier family 20 (phosphate transporter), member 2 | -0.03149 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0314671 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0313759 |
| USP9X | ubiquitin specific peptidase 9, X-linked | -0.0313499 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0312585 |
| GOLGB1 | golgin B1 | -0.0312449 |
| RPS11 | ribosomal protein S11 | -0.0308127 |
| SEC24D | SEC24 family member D | -0.0308105 |
| OGA | O-GlcNAcase | -0.0303624 |
| ANKLE2 | ankyrin repeat and LEM domain containing 2 | -0.0303512 |
| CLINT1 | clathrin interactor 1 | -0.0296775 |
| FUS | FUS RNA binding protein | -0.0291943 |
| SRSF1 | serine/arginine-rich splicing factor 1 | -0.0290251 |
| PLCB4 | phospholipase C, beta 4 | -0.0289759 |
| COMMD10 | COMM domain containing 10 | -0.0287612 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.028704 |
| TAOK1 | TAO kinase 1 | -0.0286438 |
| DEK | DEK proto-oncogene | -0.0283907 |
| PCSK5 | proprotein convertase subtilisin/kexin type 5 | -0.0283002 |
