| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Canagliflozin (hemihydrate) perturbation in HOP62 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Canagliflozin (hemihydrate)_HOP62 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.165069 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.106695 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.106436 |
| FAM13A | family with sequence similarity 13, member A | 0.0820628 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0731826 |
| STC1 | stanniocalcin 1 | 0.0606723 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0550734 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0491842 |
| PTMA | prothymosin, alpha | 0.0461558 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0439004 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0430217 |
| RNF24 | ring finger protein 24 | 0.0429312 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0380554 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.037967 |
| HMGB2 | high mobility group box 2 | 0.0374586 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0372348 |
| ZNF292 | zinc finger protein 292 | 0.0368452 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0356001 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0346277 |
| RNMT | RNA (guanine-7-) methyltransferase | 0.0341257 |
| KLF6 | Kruppel-like factor 6 | 0.0329593 |
| CDCP1 | CUB domain containing protein 1 | 0.0321782 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0312025 |
| RPL12 | ribosomal protein L12 | 0.031003 |
| NUP58 | nucleoporin 58 | 0.0307292 |
| SYAP1 | synapse associated protein 1 | 0.0305739 |
| SPAG9 | sperm associated antigen 9 | 0.0296199 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0293601 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0291102 |
| DUSP6 | dual specificity phosphatase 6 | 0.0289891 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0278753 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0268593 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0265141 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0263417 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0263174 |
| WDR45B | WD repeat domain 45B | 0.0257291 |
| ANGPTL4 | angiopoietin-like 4 | 0.0256828 |
| RLF | rearranged L-myc fusion | 0.0245242 |
| SEPTIN7 | septin 7 | 0.0237822 |
| USP3 | ubiquitin specific peptidase 3 | 0.0237078 |
| MORF4L2 | mortality factor 4 like 2 | 0.0237046 |
| MIMS1 | mitochondrial inner membrane scaffold 1 | 0.0236046 |
| RNF145 | ring finger protein 145 | 0.0231365 |
| HELZ | helicase with zinc finger | 0.0229652 |
| YBX3 | Y box binding protein 3 | 0.0225335 |
| OGA | O-GlcNAcase | 0.0224894 |
| GOLGA4 | golgin A4 | 0.0221358 |
| LDHA | lactate dehydrogenase A | 0.0219114 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.0216411 |
| ATP13A3 | ATPase type 13A3 | 0.0216041 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0212267 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0210875 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0204988 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0204956 |
| RPS2 | ribosomal protein S2 | 0.0203378 |
| RPS7 | ribosomal protein S7 | 0.0200864 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0199609 |
| ARRDC3 | arrestin domain containing 3 | 0.0195752 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0195511 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0195145 |
| DOT1L | DOT1-like histone H3K79 methyltransferase | 0.0194329 |
| NR2F2 | nuclear receptor subfamily 2, group F, member 2 | 0.0192317 |
| SFXN1 | sideroflexin 1 | 0.0186496 |
| CLEC1B | C-type lectin domain family 1, member B | 0.0185955 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0184424 |
| RPL7 | ribosomal protein L7 | 0.0184239 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0177701 |
| SRP54 | signal recognition particle 54kDa | 0.0177483 |
| MATR3 | matrin 3 | 0.017653 |
| FAM162A | family with sequence similarity 162, member A | 0.0176161 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0175602 |
| DEPP1 | DEPP autophagy regulator 1 | 0.0175399 |
| SQSTM1 | sequestosome 1 | 0.0175037 |
| SET | SET nuclear proto-oncogene | 0.0174578 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0172973 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.017093 |
| TAC4 | tachykinin 4 (hemokinin) | 0.0170835 |
| YTHDC1 | YTH domain containing 1 | 0.0170317 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | 0.0169207 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0166939 |
| CHSY1 | chondroitin sulfate synthase 1 | 0.0165848 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.016395 |
| SEC24A | SEC24 family member A | 0.0162092 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0160793 |
| NOP58 | NOP58 ribonucleoprotein | 0.0160719 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0159794 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.015915 |
| RACK1 | receptor for activated C kinase 1 | 0.0158519 |
| IRS2 | insulin receptor substrate 2 | 0.0157648 |
| UBE2B | ubiquitin-conjugating enzyme E2B | 0.0157203 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | 0.0156627 |
| DTNA | dystrobrevin, alpha | 0.0156269 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0153917 |
| RPL18 | ribosomal protein L18 | 0.015364 |
| ENTPD7 | ectonucleoside triphosphate diphosphohydrolase 7 | 0.0152751 |
| KIF5B | kinesin family member 5B | 0.0151661 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0150783 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0149473 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0148686 |
| ENO1 | enolase 1, (alpha) | 0.0148359 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.362504 |
| CDH13 | cadherin 13 | -0.204452 |
| HMGA2 | high mobility group AT-hook 2 | -0.15553 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.152382 |
| COL5A1 | collagen, type V, alpha 1 | -0.138477 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.128826 |
| EXT1 | exostosin glycosyltransferase 1 | -0.121951 |
| ACTG1 | actin gamma 1 | -0.116105 |
| RAI14 | retinoic acid induced 14 | -0.104231 |
| ASPH | aspartate beta-hydroxylase | -0.0980701 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.096688 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.092928 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0911783 |
| GLIS3 | GLIS family zinc finger 3 | -0.0880423 |
| DST | dystonin | -0.0861701 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0831599 |
| NAV1 | neuron navigator 1 | -0.078917 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0788563 |
| COL1A1 | collagen, type I, alpha 1 | -0.0749061 |
| CLMP | CXADR-like membrane protein | -0.0705333 |
| COL6A3 | collagen, type VI, alpha 3 | -0.0699171 |
| CCND1 | cyclin D1 | -0.066188 |
| TENM2 | teneurin transmembrane protein 2 | -0.0657758 |
| AHNAK | AHNAK nucleoprotein | -0.0639219 |
| FMN1 | formin 1 | -0.063126 |
| IGF2 | insulin-like growth factor 2 | -0.0603404 |
| VCL | vinculin | -0.0597274 |
| MYO10 | myosin X | -0.05888 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0585556 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0584616 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0567409 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | -0.0556122 |
| RPL35A | ribosomal protein L35a | -0.0552441 |
| TMSB10 | thymosin beta 10 | -0.0511341 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0510461 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0491042 |
| CD44 | CD44 molecule (Indian blood group) | -0.0489139 |
| RRBP1 | ribosome binding protein 1 | -0.0488243 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0475132 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0473244 |
| COL7A1 | collagen, type VII, alpha 1 | -0.0470651 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | -0.0459214 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0449894 |
| EGFR | epidermal growth factor receptor | -0.0449434 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0448151 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0447977 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0442483 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0437866 |
| INTS6 | integrator complex subunit 6 | -0.0437348 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | -0.0430576 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0423137 |
| TNNC1 | troponin C type 1 (slow) | -0.0419789 |
| ATXN1 | ataxin 1 | -0.0411365 |
| DIAPH2 | diaphanous-related formin 2 | -0.0408686 |
| CUX1 | cut-like homeobox 1 | -0.0404927 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0404774 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0400616 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0398462 |
| MAP4 | microtubule-associated protein 4 | -0.0392802 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.039166 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.0382345 |
| IL1B | interleukin 1, beta | -0.0379217 |
| EGR1 | early growth response 1 | -0.0378133 |
| CHD9 | chromodomain helicase DNA binding protein 9 | -0.0370654 |
| TUBB6 | tubulin, beta 6 class V | -0.0370404 |
| RAD51B | RAD51 paralog B | -0.0368329 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0357856 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0356977 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0350563 |
| FRMD4A | FERM domain containing 4A | -0.0348847 |
| PTK2 | protein tyrosine kinase 2 | -0.0345144 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0343877 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0342953 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0334321 |
| LAMB3 | laminin, beta 3 | -0.0333161 |
| GLG1 | golgi glycoprotein 1 | -0.033128 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0330794 |
| CCDC91 | coiled-coil domain containing 91 | -0.0321397 |
| INHBA | inhibin, beta A | -0.0319799 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0317042 |
| NAV3 | neuron navigator 3 | -0.0316887 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0316315 |
| AFF3 | AF4/FMR2 family, member 3 | -0.0313926 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0310416 |
| EHBP1 | EH domain binding protein 1 | -0.0309063 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | -0.0307811 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0302084 |
| ATG7 | autophagy related 7 | -0.0298623 |
| S100A10 | S100 calcium binding protein A10 | -0.0297452 |
| NDRG1 | N-myc downstream regulated 1 | -0.0295928 |
| BPTF | bromodomain PHD finger transcription factor | -0.029524 |
| USP34 | ubiquitin specific peptidase 34 | -0.0293271 |
| NLK | nemo-like kinase | -0.029319 |
| KLF12 | Kruppel-like factor 12 | -0.0292412 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0291428 |
| PCNX4 | pecanex 4 | -0.0291001 |
| TPM1 | tropomyosin 1 (alpha) | -0.0290782 |
| RIN2 | Ras and Rab interactor 2 | -0.0290221 |
| TPM4 | tropomyosin 4 | -0.0289165 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.028768 |
