| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Canagliflozin (hemihydrate) perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Canagliflozin (hemihydrate)_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | 0.116784 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0696743 |
| ATP13A3 | ATPase type 13A3 | 0.062379 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0542908 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0466352 |
| IGFBP7 | insulin-like growth factor binding protein 7 | 0.0454504 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0372457 |
| POSTN | periostin, osteoblast specific factor | 0.0356594 |
| SQLE | squalene epoxidase | 0.0350267 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0330027 |
| ANXA2 | annexin A2 | 0.0299662 |
| ARRDC3 | arrestin domain containing 3 | 0.0294565 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0293207 |
| LDHA | lactate dehydrogenase A | 0.0293066 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0286939 |
| MT1X | metallothionein 1X | 0.0279127 |
| CAVIN1 | caveolae associated protein 1 | 0.0277989 |
| SMAD3 | SMAD family member 3 | 0.0276583 |
| KLF6 | Kruppel-like factor 6 | 0.0275777 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0274491 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0265231 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.026484 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0261223 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0258955 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0254162 |
| ZNF292 | zinc finger protein 292 | 0.0251834 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0245794 |
| SPAG9 | sperm associated antigen 9 | 0.0242605 |
| STC1 | stanniocalcin 1 | 0.0236892 |
| HMGB2 | high mobility group box 2 | 0.0235984 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0232355 |
| RIPK2 | receptor-interacting serine-threonine kinase 2 | 0.0230076 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0228204 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0228179 |
| FN1 | fibronectin 1 | 0.0220605 |
| COL4A1 | collagen, type IV, alpha 1 | 0.0215829 |
| RASA2 | RAS p21 protein activator 2 | 0.0213178 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0210596 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0210529 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0207842 |
| ARHGAP29 | Rho GTPase activating protein 29 | 0.0202916 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0202901 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.0200393 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0198498 |
| CALR | calreticulin | 0.0194985 |
| RLF | rearranged L-myc fusion | 0.0192154 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0191091 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | 0.0180152 |
| VIM | vimentin | 0.0178444 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0176981 |
| FNBP1L | formin binding protein 1-like | 0.0175717 |
| MKI67 | marker of proliferation Ki-67 | 0.0174677 |
| RPL18 | ribosomal protein L18 | 0.0173191 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0171881 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0169559 |
| APP | amyloid beta (A4) precursor protein | 0.0168409 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0168335 |
| HYOU1 | hypoxia up-regulated 1 | 0.0166199 |
| OGA | O-GlcNAcase | 0.0165995 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0165694 |
| MATR3 | matrin 3 | 0.0165158 |
| SERINC1 | serine incorporator 1 | 0.0161947 |
| PTMA | prothymosin, alpha | 0.0159599 |
| B2M | beta-2-microglobulin | 0.0159596 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0159529 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0158434 |
| USP3 | ubiquitin specific peptidase 3 | 0.0155761 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0155635 |
| NFIX | nuclear factor I/X (CCAAT-binding transcription factor) | 0.0155533 |
| SEPTIN7 | septin 7 | 0.0152953 |
| VCAN | versican | 0.0149158 |
| RNF145 | ring finger protein 145 | 0.0148866 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0146758 |
| KDELR1 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 | 0.0145236 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0145124 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0143387 |
| RNF24 | ring finger protein 24 | 0.0139896 |
| TPX2 | TPX2, microtubule-associated | 0.0139695 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0139124 |
| TBC1D10A | TBC1 domain family, member 10A | 0.0138049 |
| RPS3 | ribosomal protein S3 | 0.0137152 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0136451 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | 0.0135347 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0134359 |
| PTPN1 | protein tyrosine phosphatase, non-receptor type 1 | 0.0134117 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0133856 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0133681 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0133631 |
| CYP51A1 | cytochrome P450, family 51, subfamily A, polypeptide 1 | 0.0131809 |
| RAB8B | RAB8B, member RAS oncogene family | 0.0131677 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0130356 |
| RPS2 | ribosomal protein S2 | 0.0128536 |
| LOX | lysyl oxidase | 0.0127303 |
| DRAP1 | DR1-associated protein 1 (negative cofactor 2 alpha) | 0.0126847 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0126825 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0124588 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0124154 |
| CENPF | centromere protein F, 350/400kDa | 0.0122941 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0120555 |
| MIER1 | mesoderm induction early response 1, transcriptional regulator | 0.0119409 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.501421 |
| NDRG1 | N-myc downstream regulated 1 | -0.21411 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.168876 |
| COL1A1 | collagen, type I, alpha 1 | -0.168574 |
| CDH13 | cadherin 13 | -0.133338 |
| RPL35A | ribosomal protein L35a | -0.0874154 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0732991 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0673317 |
| ACTG1 | actin gamma 1 | -0.0620541 |
| CADM1 | cell adhesion molecule 1 | -0.059957 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0595163 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | -0.0588809 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0586329 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0556787 |
| COL5A1 | collagen, type V, alpha 1 | -0.0543682 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0533199 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0485002 |
| FBN1 | fibrillin 1 | -0.0475308 |
| UBC | ubiquitin C | -0.0474849 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0465861 |
| HLA-B | major histocompatibility complex, class I, B | -0.0453763 |
| VEGFA | vascular endothelial growth factor A | -0.0453214 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0423515 |
| GOLGB1 | golgin B1 | -0.0419934 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0415137 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0410087 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -0.0396482 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0389164 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0386249 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0380049 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0373408 |
| RPS6 | ribosomal protein S6 | -0.0370611 |
| EGFR | epidermal growth factor receptor | -0.035977 |
| IER3 | immediate early response 3 | -0.0345581 |
| TMSB10 | thymosin beta 10 | -0.0344602 |
| GLIS3 | GLIS family zinc finger 3 | -0.033901 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0338391 |
| NAV1 | neuron navigator 1 | -0.0320463 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0320118 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0308024 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0302535 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0299298 |
| FTL | ferritin, light polypeptide | -0.0298922 |
| JARID2 | jumonji, AT rich interactive domain 2 | -0.0298167 |
| RPS8 | ribosomal protein S8 | -0.0297328 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0297122 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0289463 |
| ATXN1 | ataxin 1 | -0.0285497 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0284987 |
| RPL37A | ribosomal protein L37a | -0.0283367 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0280706 |
| CALD1 | caldesmon 1 | -0.0276343 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0273478 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.0263806 |
| SEC61A1 | Sec61 alpha 1 subunit (S. cerevisiae) | -0.0261482 |
| ASPH | aspartate beta-hydroxylase | -0.0260334 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0255861 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.0254542 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0253965 |
| PDE10A | phosphodiesterase 10A | -0.0252432 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0251491 |
| HLA-A | major histocompatibility complex, class I, A | -0.0247455 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0247247 |
| RPS11 | ribosomal protein S11 | -0.0243917 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | -0.0242104 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0241406 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.023945 |
| CMIP | c-Maf inducing protein | -0.0238322 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0237599 |
| FNIP1 | folliculin interacting protein 1 | -0.0236664 |
| AHNAK | AHNAK nucleoprotein | -0.0232543 |
| RPL28 | ribosomal protein L28 | -0.0232217 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.0232063 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | -0.0227046 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0226997 |
| PPIB | peptidylprolyl isomerase B (cyclophilin B) | -0.0222999 |
| IL6 | interleukin 6 | -0.0222291 |
| CLMP | CXADR-like membrane protein | -0.0221743 |
| HM13 | histocompatibility (minor) 13 | -0.02183 |
| RPS23 | ribosomal protein S23 | -0.0217241 |
| PRELID2 | PRELI domain containing 2 | -0.0213416 |
| CD44 | CD44 molecule (Indian blood group) | -0.0212713 |
| VCL | vinculin | -0.0211903 |
| CUX1 | cut-like homeobox 1 | -0.0211299 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0211241 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.020881 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0203401 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0199154 |
| PPP3CC | protein phosphatase 3, catalytic subunit, gamma isozyme | -0.0198858 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0198028 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0196603 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0195406 |
| PDIA5 | protein disulfide isomerase family A, member 5 | -0.0193645 |
| RPS15 | ribosomal protein S15 | -0.0192729 |
| RPL34 | ribosomal protein L34 | -0.0192155 |
| AGO3 | argonaute RISC catalytic component 3 | -0.0189733 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0189694 |
| TPM2 | tropomyosin 2 (beta) | -0.0188487 |
| SP100 | SP100 nuclear antigen | -0.0187693 |
| KDM4B | lysine (K)-specific demethylase 4B | -0.0187043 |
