| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Canagliflozin (hemihydrate) perturbation in HT-29 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Canagliflozin (hemihydrate)_HT-29 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ITPKC | inositol-trisphosphate 3-kinase C | 0.0946923 |
| TXNRD1 | thioredoxin reductase 1 | 0.0906631 |
| PTMA | prothymosin, alpha | 0.0878435 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0807227 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0719939 |
| B2M | beta-2-microglobulin | 0.0590983 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0564823 |
| NECTIN2 | nectin cell adhesion molecule 2 | 0.0523847 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0478675 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0457234 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0453858 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0450324 |
| FTL | ferritin, light polypeptide | 0.0440295 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0415289 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0408735 |
| HMGB2 | high mobility group box 2 | 0.0397742 |
| RPLP1 | ribosomal protein, large, P1 | 0.039344 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0390196 |
| S100A6 | S100 calcium binding protein A6 | 0.0384777 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0383992 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0383523 |
| RPS6 | ribosomal protein S6 | 0.036515 |
| MKI67 | marker of proliferation Ki-67 | 0.0352376 |
| RTN4 | reticulon 4 | 0.0347607 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0343778 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0341832 |
| ST14 | suppression of tumorigenicity 14 (colon carcinoma) | 0.0338162 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | 0.0332541 |
| DNM2 | dynamin 2 | 0.0331281 |
| RPL23 | ribosomal protein L23 | 0.0315907 |
| SET | SET nuclear proto-oncogene | 0.0309983 |
| TMC5 | transmembrane channel-like 5 | 0.0308017 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0300511 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | 0.0298484 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0296916 |
| EZR | ezrin | 0.0296544 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0293261 |
| GOLGA4 | golgin A4 | 0.0292286 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.0292214 |
| ZNF292 | zinc finger protein 292 | 0.0289454 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0284469 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0279086 |
| RPS19 | ribosomal protein S19 | 0.0274844 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0271463 |
| SINHCAF | SIN3-HDAC complex associated factor | 0.0271206 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0270519 |
| KIF5B | kinesin family member 5B | 0.0265256 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 0.0264975 |
| RPLP0 | ribosomal protein, large, P0 | 0.0262725 |
| KPNB1 | karyopherin (importin) beta 1 | 0.0262185 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0261511 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | 0.025677 |
| EPCAM | epithelial cell adhesion molecule | 0.0255864 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0254929 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0254755 |
| FNBP4 | formin binding protein 4 | 0.0252254 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0251794 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0249273 |
| TMEM45B | transmembrane protein 45B | 0.0247239 |
| RHPN2 | rhophilin, Rho GTPase binding protein 2 | 0.0246602 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0246556 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0243126 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0242892 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0241428 |
| TMEM87A | transmembrane protein 87A | 0.0239639 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.0235348 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0235182 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0233202 |
| RPS8 | ribosomal protein S8 | 0.023247 |
| DSTN | destrin (actin depolymerizing factor) | 0.0231442 |
| SCAF11 | SR-related CTD-associated factor 11 | 0.0229061 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0227262 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.0225272 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0221977 |
| NSMCE2 | non-SMC element 2, MMS21 homolog (S. cerevisiae) | 0.022093 |
| SLC25A5 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 | 0.022047 |
| JMJD1C | jumonji domain containing 1C | 0.0218218 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0217907 |
| SUZ12 | SUZ12 polycomb repressive complex 2 subunit | 0.0216505 |
| CBX3 | chromobox homolog 3 | 0.0216293 |
| NUP58 | nucleoporin 58 | 0.0215897 |
| MATR3 | matrin 3 | 0.0214648 |
| ARL5B | ADP-ribosylation factor-like 5B | 0.0214275 |
| YPEL2 | yippee-like 2 (Drosophila) | 0.0214027 |
| CENPF | centromere protein F, 350/400kDa | 0.0210371 |
| XPO1 | exportin 1 | 0.0210344 |
| GCC2 | GRIP and coiled-coil domain containing 2 | 0.0208766 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0207019 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0206488 |
| CREBRF | CREB3 regulatory factor | 0.0205208 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | 0.0203787 |
| YTHDC1 | YTH domain containing 1 | 0.0202927 |
| LGR4 | leucine-rich repeat containing G protein-coupled receptor 4 | 0.020262 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | 0.0202071 |
| LSM14A | LSM14A, SCD6 homolog A (S. cerevisiae) | 0.0201154 |
| STK24 | serine/threonine kinase 24 | 0.0200168 |
| HMGN2 | high mobility group nucleosomal binding domain 2 | 0.0199635 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0198468 |
| RBM25 | RNA binding motif protein 25 | 0.019845 |
| TPM3 | tropomyosin 3 | 0.0197025 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | -0.0994618 |
| SMAD3 | SMAD family member 3 | -0.0989719 |
| INTS6 | integrator complex subunit 6 | -0.0985551 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0950921 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0827681 |
| AHNAK | AHNAK nucleoprotein | -0.0816645 |
| MYH14 | myosin, heavy chain 14, non-muscle | -0.0752293 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0724194 |
| NDRG1 | N-myc downstream regulated 1 | -0.0716948 |
| LAMA4 | laminin, alpha 4 | -0.0713064 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0706368 |
| KRT20 | keratin 20, type I | -0.0701435 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | -0.0683573 |
| SLC45A4 | solute carrier family 45, member 4 | -0.0669411 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0662289 |
| LMO7 | LIM domain 7 | -0.0622894 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0619608 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | -0.0605092 |
| POF1B | premature ovarian failure, 1B | -0.0550302 |
| CTBP2 | C-terminal binding protein 2 | -0.0541422 |
| PRR5L | proline rich 5 like | -0.0540561 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.053279 |
| TMEM65 | transmembrane protein 65 | -0.0507968 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0491497 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | -0.0487888 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | -0.04583 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0436946 |
| TJP1 | tight junction protein 1 | -0.0417493 |
| CAPN8 | calpain 8 | -0.0412362 |
| ATXN1 | ataxin 1 | -0.0399008 |
| KRT8 | keratin 8, type II | -0.0398505 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0372206 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0367394 |
| AGR2 | anterior gradient 2 | -0.0360772 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | -0.0355307 |
| SAMD12 | sterile alpha motif domain containing 12 | -0.0349812 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | -0.0347851 |
| TRAPPC9 | trafficking protein particle complex 9 | -0.0343384 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0343073 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0341802 |
| GCNT3 | glucosaminyl (N-acetyl) transferase 3, mucin type | -0.0336021 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0328872 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0328717 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0321027 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0317573 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0316367 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | -0.0305458 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0301483 |
| HIVEP1 | human immunodeficiency virus type I enhancer binding protein 1 | -0.0298425 |
| MCL1 | myeloid cell leukemia 1 | -0.0293801 |
| FOXO3 | forkhead box O3 | -0.0292579 |
| SERTAD2 | SERTA domain containing 2 | -0.0289149 |
| PRKCA | protein kinase C, alpha | -0.0285183 |
| PPARD | peroxisome proliferator-activated receptor delta | -0.028439 |
| EFNA5 | ephrin-A5 | -0.0283155 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0281842 |
| SLC7A1 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 | -0.0278935 |
| KLF5 | Kruppel-like factor 5 (intestinal) | -0.0278037 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | -0.0276002 |
| MMP7 | matrix metallopeptidase 7 | -0.0275811 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0273131 |
| SDCBP | syndecan binding protein (syntenin) | -0.02687 |
| GAREM1 | GRB2 associated regulator of MAPK1 subtype 1 | -0.0267418 |
| PLEKHA6 | pleckstrin homology domain containing, family A member 6 | -0.0266138 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | -0.0265702 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -0.026437 |
| ACTN4 | actinin, alpha 4 | -0.0262053 |
| EPB41L5 | erythrocyte membrane protein band 4.1 like 5 | -0.0260324 |
| FLNB | filamin B, beta | -0.0260237 |
| GSN | gelsolin | -0.0259088 |
| LOC112694756 | uncharaterized LOC112694756 | -0.025591 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0255033 |
| SGMS2 | sphingomyelin synthase 2 | -0.0254235 |
| PGK1 | phosphoglycerate kinase 1 | -0.025411 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0251821 |
| PRELID2 | PRELI domain containing 2 | -0.0251539 |
| ASPH | aspartate beta-hydroxylase | -0.0250546 |
| UTRN | utrophin | -0.0250293 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.025026 |
| TRIB1 | tribbles pseudokinase 1 | -0.0245724 |
| CCNYL1 | cyclin Y-like 1 | -0.0241514 |
| FRY | furry homolog (Drosophila) | -0.0241189 |
| WNT2B | wingless-type MMTV integration site family, member 2B | -0.0240953 |
| ATP2A2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | -0.0240525 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | -0.0237724 |
| VCL | vinculin | -0.0235546 |
| LARP1B | La ribonucleoprotein domain family, member 1B | -0.0235044 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0233155 |
| FAT1 | FAT atypical cadherin 1 | -0.0230947 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | -0.0228922 |
| CBL | Cbl proto-oncogene, E3 ubiquitin protein ligase | -0.0228351 |
| NTN4 | netrin 4 | -0.0223874 |
| EGR1 | early growth response 1 | -0.0222617 |
| DIAPH2 | diaphanous-related formin 2 | -0.0221338 |
| CATSPERB | catsper channel auxiliary subunit beta | -0.0218975 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0216189 |
| RASEF | RAS and EF-hand domain containing | -0.0215349 |
| EMP1 | epithelial membrane protein 1 | -0.0215236 |
| USP53 | ubiquitin specific peptidase 53 | -0.0211652 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.02105 |
