| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Canagliflozin (hemihydrate) perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Canagliflozin (hemihydrate)_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.373155 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.250132 |
| APOB | apolipoprotein B | 0.151006 |
| C3 | complement component 3 | 0.0856062 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.0783195 |
| APOA2 | apolipoprotein A-II | 0.0573789 |
| GPAM | glycerol-3-phosphate acyltransferase, mitochondrial | 0.0547786 |
| RPS6 | ribosomal protein S6 | 0.0507846 |
| CCL20 | chemokine (C-C motif) ligand 20 | 0.0406615 |
| TF | transferrin | 0.040493 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.0401746 |
| RPL11 | ribosomal protein L11 | 0.0401536 |
| PTMA | prothymosin, alpha | 0.0357105 |
| FTL | ferritin, light polypeptide | 0.0322582 |
| SLC6A14 | solute carrier family 6 (amino acid transporter), member 14 | 0.0321817 |
| TRIM26 | tripartite motif containing 26 | 0.0307949 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0288244 |
| DSPP | dentin sialophosphoprotein | 0.0278623 |
| CFB | complement factor B | 0.0277165 |
| CPE | carboxypeptidase E | 0.0273501 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.026774 |
| RPS19 | ribosomal protein S19 | 0.024893 |
| RPLP1 | ribosomal protein, large, P1 | 0.0248895 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | 0.0243596 |
| RPS8 | ribosomal protein S8 | 0.0236689 |
| APOA1 | apolipoprotein A-I | 0.0235104 |
| RPL37A | ribosomal protein L37a | 0.0231688 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0230709 |
| GDF15 | growth differentiation factor 15 | 0.0230699 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | 0.0226946 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0212989 |
| B2M | beta-2-microglobulin | 0.0204935 |
| RPS23 | ribosomal protein S23 | 0.020243 |
| ISG15 | ISG15 ubiquitin-like modifier | 0.0191027 |
| RPL35A | ribosomal protein L35a | 0.0189935 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0188816 |
| RPL23 | ribosomal protein L23 | 0.0185165 |
| RPL12 | ribosomal protein L12 | 0.0182584 |
| RNASEH2A | ribonuclease H2, subunit A | 0.0181272 |
| ENO1 | enolase 1, (alpha) | 0.018109 |
| RPS14 | ribosomal protein S14 | 0.0178446 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0176575 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0176106 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | 0.0175916 |
| IGFBP1 | insulin-like growth factor binding protein 1 | 0.0175338 |
| PLAC8 | placenta-specific 8 | 0.0174499 |
| RPL36A | ribosomal protein L36a | 0.0174467 |
| KIF5B | kinesin family member 5B | 0.0173969 |
| CALR | calreticulin | 0.0172806 |
| VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | 0.0172632 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0172624 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0170822 |
| MATR3 | matrin 3 | 0.0170796 |
| RPS13 | ribosomal protein S13 | 0.0167767 |
| APOE | apolipoprotein E | 0.0166954 |
| MKI67 | marker of proliferation Ki-67 | 0.0164575 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0164048 |
| ABCA5 | ATP-binding cassette, sub-family A (ABC1), member 5 | 0.0162954 |
| RPS17 | ribosomal protein S17 | 0.0162111 |
| VEGFA | vascular endothelial growth factor A | 0.0161682 |
| GPC3 | glypican 3 | 0.0160271 |
| SET | SET nuclear proto-oncogene | 0.0159652 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.015848 |
| CAMK2N1 | calcium/calmodulin-dependent protein kinase II inhibitor 1 | 0.0157049 |
| JMJD1C | jumonji domain containing 1C | 0.0157022 |
| RPL31 | ribosomal protein L31 | 0.0156461 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0155642 |
| RPLP2 | ribosomal protein, large, P2 | 0.015274 |
| ESF1 | ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) | 0.0152333 |
| DCAF7 | DDB1 and CUL4 associated factor 7 | 0.0150642 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | 0.0149681 |
| EML4 | echinoderm microtubule associated protein like 4 | 0.014914 |
| PEG10 | paternally expressed 10 | 0.0147912 |
| TCERG1 | transcription elongation regulator 1 | 0.0147478 |
| PCBP2 | poly(rC) binding protein 2 | 0.0146131 |
| EGR1 | early growth response 1 | 0.0146119 |
| ECE1 | endothelin converting enzyme 1 | 0.0146032 |
| VIM | vimentin | 0.0145957 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0143839 |
| ID2 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | 0.0143509 |
| RPS27A | ribosomal protein S27a | 0.0142928 |
| PDGFB | platelet-derived growth factor beta polypeptide | 0.0142021 |
| ITSN2 | intersectin 2 | 0.0141472 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0140572 |
| TAB2 | TGF-beta activated kinase 1/MAP3K7 binding protein 2 | 0.0140285 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | 0.0138874 |
| FABP1 | fatty acid binding protein 1, liver | 0.0136402 |
| SMARCA1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 | 0.0136164 |
| PERP | PERP, TP53 apoptosis effector | 0.013583 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0135551 |
| RPL7A | ribosomal protein L7a | 0.0134643 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | 0.0134633 |
| CRLS1 | cardiolipin synthase 1 | 0.0134478 |
| IFNGR1 | interferon gamma receptor 1 | 0.01312 |
| SMYD3 | SET and MYND domain containing 3 | 0.012974 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0129441 |
| HP1BP3 | heterochromatin protein 1, binding protein 3 | 0.0129247 |
| RPL5 | ribosomal protein L5 | 0.012849 |
| RPL10A | ribosomal protein L10a | 0.0128036 |
| MATN3 | matrilin 3 | 0.0126144 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | -0.519382 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.260961 |
| GPC6 | glypican 6 | -0.0942323 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0844607 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0842921 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0803567 |
| ASPH | aspartate beta-hydroxylase | -0.0767408 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0751107 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0748279 |
| EHBP1 | EH domain binding protein 1 | -0.0734432 |
| ATXN1 | ataxin 1 | -0.0721241 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0687431 |
| FMNL2 | formin-like 2 | -0.0593709 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0569351 |
| DTNA | dystrobrevin, alpha | -0.0568472 |
| FNDC3B | fibronectin type III domain containing 3B | -0.055316 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0549165 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0533711 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0524536 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0508381 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.049028 |
| DST | dystonin | -0.0489985 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.045059 |
| PEG3 | paternally expressed 3 | -0.0441902 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0432859 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0414317 |
| FRMD5 | FERM domain containing 5 | -0.0409297 |
| PLIN2 | perilipin 2 | -0.040616 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0397926 |
| INTS6 | integrator complex subunit 6 | -0.0394995 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0394511 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0384853 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0384594 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0376634 |
| CANX | calnexin | -0.0346615 |
| FAM107B | family with sequence similarity 107, member B | -0.0342256 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0340896 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0336213 |
| RNF213 | ring finger protein 213 | -0.0335474 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0333615 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0330095 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0323893 |
| ZHX2 | zinc fingers and homeoboxes 2 | -0.0323075 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0321218 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0320319 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.0319395 |
| STK17A | serine/threonine kinase 17a | -0.0301706 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0301466 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0299745 |
| MSI2 | musashi RNA-binding protein 2 | -0.0296344 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0291081 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0289479 |
| AGO2 | argonaute RISC catalytic component 2 | -0.0288434 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0282355 |
| FLNB | filamin B, beta | -0.0280792 |
| HPCAL1 | hippocalcin-like 1 | -0.0273907 |
| GK | glycerol kinase | -0.0272288 |
| SMAD3 | SMAD family member 3 | -0.027082 |
| ATP10A | ATPase, class V, type 10A | -0.0269227 |
| AFF1 | AF4/FMR2 family, member 1 | -0.0261535 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0260511 |
| PHF3 | PHD finger protein 3 | -0.0245878 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | -0.0245782 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0240897 |
| PLXDC2 | plexin domain containing 2 | -0.0236895 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0235639 |
| ITGAV | integrin, alpha V | -0.0228745 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | -0.0227021 |
| DENND1A | DENN/MADD domain containing 1A | -0.0226531 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | -0.0223637 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0223434 |
| FILIP1L | filamin A interacting protein 1-like | -0.0223394 |
| ALDH1A2 | aldehyde dehydrogenase 1 family, member A2 | -0.0214841 |
| ENKUR | enkurin, TRPC channel interacting protein | -0.0214046 |
| PARD3 | par-3 family cell polarity regulator | -0.0213666 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | -0.0213338 |
| MAP4K3 | mitogen-activated protein kinase kinase kinase kinase 3 | -0.0212966 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0210471 |
| RIGI | RNA sensor RIG-I | -0.0209067 |
| KDM4C | lysine (K)-specific demethylase 4C | -0.0209036 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | -0.0207919 |
| LARGE1 | LARGE xylosyl- and glucuronyltransferase 1 | -0.0207396 |
| H1-0 | H1.0 linker histone | -0.0206621 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0206283 |
| SVIL | supervillin | -0.0205169 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0204792 |
| SERTAD2 | SERTA domain containing 2 | -0.0203749 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0201284 |
| PALLD | palladin, cytoskeletal associated protein | -0.0200523 |
| MYO1E | myosin IE | -0.0196001 |
| PAWR | PRKC, apoptosis, WT1, regulator | -0.0195373 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0194864 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0194707 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0194394 |
| KIAA1217 | KIAA1217 | -0.0193974 |
| KDM4B | lysine (K)-specific demethylase 4B | -0.0190756 |
| GNAS | GNAS complex locus | -0.0190399 |
| HMGA1 | high mobility group AT-hook 1 | -0.0190028 |
| SLC20A2 | solute carrier family 20 (phosphate transporter), member 2 | -0.0189774 |
| RYBP | RING1 and YY1 binding protein | -0.0187698 |
