| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Canagliflozin (hemihydrate) perturbation in J82 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Canagliflozin (hemihydrate)_J82 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FTH1 | ferritin, heavy polypeptide 1 | 0.105419 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0512158 |
| ADM | adrenomedullin | 0.0497206 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0494581 |
| B2M | beta-2-microglobulin | 0.043121 |
| ATP13A3 | ATPase type 13A3 | 0.0421268 |
| GOLGA4 | golgin A4 | 0.0411773 |
| HMGB2 | high mobility group box 2 | 0.0408556 |
| CALR | calreticulin | 0.0402025 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0397545 |
| NUP58 | nucleoporin 58 | 0.0382842 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0381726 |
| HLA-E | major histocompatibility complex, class I, E | 0.0355399 |
| FTL | ferritin, light polypeptide | 0.0312886 |
| HLA-A | major histocompatibility complex, class I, A | 0.0294442 |
| PLK2 | polo-like kinase 2 | 0.0288481 |
| ENO1 | enolase 1, (alpha) | 0.0272303 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0272222 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0262453 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0235565 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0232011 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0229799 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0224309 |
| KPNB1 | karyopherin (importin) beta 1 | 0.0222684 |
| MKI67 | marker of proliferation Ki-67 | 0.0220301 |
| COPB1 | coatomer protein complex, subunit beta 1 | 0.0218862 |
| ZNF841 | zinc finger protein 841 | 0.0217696 |
| ACBD3 | acyl-CoA binding domain containing 3 | 0.0216389 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0215797 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0214134 |
| PTX3 | pentraxin 3, long | 0.0211455 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0209783 |
| MT1X | metallothionein 1X | 0.0206999 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0206222 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | 0.0199861 |
| SUCO | SUN domain containing ossification factor | 0.0198897 |
| PTPN1 | protein tyrosine phosphatase, non-receptor type 1 | 0.0198246 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0195045 |
| TMEM41B | transmembrane protein 41B | 0.0189807 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0181567 |
| WDR45B | WD repeat domain 45B | 0.0177839 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0175042 |
| RLF | rearranged L-myc fusion | 0.0173485 |
| DPM1 | dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit | 0.017132 |
| SRP54 | signal recognition particle 54kDa | 0.0170701 |
| GPR107 | G protein-coupled receptor 107 | 0.0168554 |
| SEC24A | SEC24 family member A | 0.0167607 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0167224 |
| LDHA | lactate dehydrogenase A | 0.0166904 |
| NOP58 | NOP58 ribonucleoprotein | 0.0161681 |
| MORF4L2 | mortality factor 4 like 2 | 0.0161489 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0161252 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | 0.016004 |
| DHX36 | DEAH (Asp-Glu-Ala-His) box polypeptide 36 | 0.0159962 |
| WDR43 | WD repeat domain 43 | 0.0158031 |
| CTDSPL2 | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 | 0.0157996 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0156385 |
| RAB18 | RAB18, member RAS oncogene family | 0.0155394 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0153897 |
| SET | SET nuclear proto-oncogene | 0.0153721 |
| UBQLN1 | ubiquilin 1 | 0.0151949 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0151038 |
| TMF1 | TATA element modulatory factor 1 | 0.0150784 |
| LOX | lysyl oxidase | 0.0150616 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0149329 |
| HMGN2 | high mobility group nucleosomal binding domain 2 | 0.0148378 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.014805 |
| OLR1 | oxidized low density lipoprotein (lectin-like) receptor 1 | 0.0147255 |
| TXNRD1 | thioredoxin reductase 1 | 0.0145597 |
| SLC31A1 | solute carrier family 31 (copper transporter), member 1 | 0.014474 |
| COQ10B | coenzyme Q10 homolog B (S. cerevisiae) | 0.014399 |
| ARL5B | ADP-ribosylation factor-like 5B | 0.0142933 |
| SNX4 | sorting nexin 4 | 0.0142541 |
| GOLT1B | golgi transport 1B | 0.0141648 |
| WDFY1 | WD repeat and FYVE domain containing 1 | 0.0141377 |
| VMP1 | vacuole membrane protein 1 | 0.0140227 |
| GOLGA2 | golgin A2 | 0.0139166 |
| MATR3 | matrin 3 | 0.0138897 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0138783 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0138498 |
| HNRNPUL2 | heterogeneous nuclear ribonucleoprotein U-like 2 | 0.0138137 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | 0.0137176 |
| TPX2 | TPX2, microtubule-associated | 0.0136489 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0135092 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0134616 |
| CALU | calumenin | 0.0134115 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0133804 |
| KIF5B | kinesin family member 5B | 0.0133571 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0132875 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.013283 |
| PPP1R11 | protein phosphatase 1, regulatory (inhibitor) subunit 11 | 0.0131981 |
| MIS18BP1 | MIS18 binding protein 1 | 0.0130751 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0130196 |
| RYBP | RING1 and YY1 binding protein | 0.0128532 |
| VPS53 | vacuolar protein sorting 53 homolog (S. cerevisiae) | 0.0128528 |
| CYP51A1 | cytochrome P450, family 51, subfamily A, polypeptide 1 | 0.012849 |
| EIF2A | eukaryotic translation initiation factor 2A, 65kDa | 0.0128489 |
| OSBP | oxysterol binding protein | 0.0127389 |
| TPD52 | tumor protein D52 | 0.0127269 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | 0.0127193 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NALF1 | NALCN channel auxiliary factor 1 | -0.221687 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.159075 |
| EXT1 | exostosin glycosyltransferase 1 | -0.114576 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.113992 |
| FN1 | fibronectin 1 | -0.105505 |
| PHACTR1 | phosphatase and actin regulator 1 | -0.0829982 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0707736 |
| ASPH | aspartate beta-hydroxylase | -0.0654949 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0649045 |
| GLIS3 | GLIS family zinc finger 3 | -0.0586945 |
| NDRG1 | N-myc downstream regulated 1 | -0.0564919 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.054599 |
| INTS6 | integrator complex subunit 6 | -0.0532439 |
| POTEF | POTE ankyrin domain family, member F | -0.0527007 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0520244 |
| PLCB4 | phospholipase C, beta 4 | -0.0515732 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0515013 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0511977 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0507244 |
| PTK2 | protein tyrosine kinase 2 | -0.0505918 |
| DST | dystonin | -0.0498563 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0484671 |
| AHNAK | AHNAK nucleoprotein | -0.0476604 |
| DIAPH3 | diaphanous-related formin 3 | -0.0464053 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0460621 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.0451915 |
| FLNB | filamin B, beta | -0.0451666 |
| NAV2 | neuron navigator 2 | -0.0450441 |
| DTNA | dystrobrevin, alpha | -0.0423836 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0413149 |
| ACTG1 | actin gamma 1 | -0.0408584 |
| CCBE1 | collagen and calcium binding EGF domains 1 | -0.0397231 |
| ZNF804A | zinc finger protein 804A | -0.0392503 |
| SLIT2 | slit homolog 2 (Drosophila) | -0.0390114 |
| RAD51B | RAD51 paralog B | -0.0382982 |
| TLE4 | transducin-like enhancer of split 4 | -0.0381605 |
| SMYD3 | SET and MYND domain containing 3 | -0.0380768 |
| FHIT | fragile histidine triad | -0.0360746 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0360648 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0355444 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0354636 |
| COL5A1 | collagen, type V, alpha 1 | -0.0352387 |
| ATXN1 | ataxin 1 | -0.0350676 |
| EGFR | epidermal growth factor receptor | -0.0345995 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.0345484 |
| PRELID2 | PRELI domain containing 2 | -0.0344728 |
| NAV1 | neuron navigator 1 | -0.0339567 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.03374 |
| SLC12A8 | solute carrier family 12, member 8 | -0.0336022 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | -0.0334718 |
| TENM3 | teneurin transmembrane protein 3 | -0.0326088 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0325144 |
| RIGI | RNA sensor RIG-I | -0.0324453 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0317105 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0314764 |
| SAMD12 | sterile alpha motif domain containing 12 | -0.031334 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.030976 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | -0.0293261 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0293189 |
| VEGFC | vascular endothelial growth factor C | -0.0292828 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0291504 |
| SBF2 | SET binding factor 2 | -0.0290775 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -0.028617 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0285186 |
| ERBIN | erbb2 interacting protein | -0.028289 |
| PACS1 | phosphofurin acidic cluster sorting protein 1 | -0.0281432 |
| DEK | DEK proto-oncogene | -0.0274365 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | -0.0273449 |
| MAP4 | microtubule-associated protein 4 | -0.0272962 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0271668 |
| RUNX1 | runt-related transcription factor 1 | -0.0264908 |
| PARD3B | par-3 family cell polarity regulator beta | -0.026236 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0262291 |
| TMEM178B | transmembrane protein 178B | -0.0262201 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0260054 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | -0.0254301 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0252022 |
| TMSB10 | thymosin beta 10 | -0.0251136 |
| RPS6 | ribosomal protein S6 | -0.024887 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0248663 |
| PLSCR1 | phospholipid scramblase 1 | -0.0248253 |
| MAP1B | microtubule-associated protein 1B | -0.024816 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0245945 |
| RPL35A | ribosomal protein L35a | -0.0245175 |
| TNS3 | tensin 3 | -0.0242649 |
| DNAH11 | dynein, axonemal, heavy chain 11 | -0.0242243 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0235951 |
| E2F3 | E2F transcription factor 3 | -0.0234906 |
| CDK6 | cyclin-dependent kinase 6 | -0.0234818 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0232473 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0232353 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.023031 |
| CAST | calpastatin | -0.0230149 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0227727 |
| EXOC4 | exocyst complex component 4 | -0.0227266 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.022557 |
| BBX | bobby sox homolog (Drosophila) | -0.0223301 |
| GALNT18 | polypeptide N-acetylgalactosaminyltransferase 18 | -0.0222627 |
| FNIP1 | folliculin interacting protein 1 | -0.0221658 |
| RAI14 | retinoic acid induced 14 | -0.0221152 |
