Canagliflozin (hemihydrate)_LOX-IMVI Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Canagliflozin (hemihydrate) perturbation in LOX-IMVI cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Canagliflozin (hemihydrate)_LOX-IMVI drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RPS3 ribosomal protein S3 0.0825542
FTL ferritin, light polypeptide 0.0768885
VIM vimentin 0.0688605
TMSB10 thymosin beta 10 0.0597275
RPS12 ribosomal protein S12 0.0592101
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0524876
MT2A metallothionein 2A 0.0477034
RPL18 ribosomal protein L18 0.0464912
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0442428
DDIT4 DNA-damage-inducible transcript 4 0.040813
RPL36 ribosomal protein L36 0.0396628
ATP13A3 ATPase type 13A3 0.0395424
RPL12 ribosomal protein L12 0.0393813
PTMA prothymosin, alpha 0.0392217
YBX3 Y box binding protein 3 0.0388538
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.034994
RPS2 ribosomal protein S2 0.034986
RPLP2 ribosomal protein, large, P2 0.0329676
PNISR PNN-interacting serine/arginine-rich protein 0.0327849
RPS7 ribosomal protein S7 0.0322995
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0320122
DTNA dystrobrevin, alpha 0.0312209
NUP58 nucleoporin 58 0.0303674
CD109 CD109 molecule 0.0301179
SRRM2 serine/arginine repetitive matrix 2 0.0294124
WDR43 WD repeat domain 43 0.0290944
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.028606
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0285513
HILPDA hypoxia inducible lipid droplet-associated 0.02846
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0282103
RNF145 ring finger protein 145 0.0281363
KMT2E lysine (K)-specific methyltransferase 2E 0.027671
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.0273464
MXI1 MAX interactor 1, dimerization protein 0.0270963
GPBP1 GC-rich promoter binding protein 1 0.0266727
FTH1 ferritin, heavy polypeptide 1 0.0266448
RPS17 ribosomal protein S17 0.0264499
ANXA2 annexin A2 0.0255865
RPL21 ribosomal protein L21 0.0254128
WDR45B WD repeat domain 45B 0.0245697
ZNF292 zinc finger protein 292 0.0243816
RPL13A ribosomal protein L13a 0.0240643
CHD1 chromodomain helicase DNA binding protein 1 0.023871
RPL37A ribosomal protein L37a 0.023647
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0235221
CSDE1 cold shock domain containing E1, RNA-binding 0.0233046
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0225843
RPL7 ribosomal protein L7 0.022277
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.0222701
BHLHE40 basic helix-loop-helix family, member e40 0.0222647
RLF rearranged L-myc fusion 0.0220992
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0215377
RPL26 ribosomal protein L26 0.0214841
SET SET nuclear proto-oncogene 0.0211561
VEZT vezatin, adherens junctions transmembrane protein 0.0209637
SPAG9 sperm associated antigen 9 0.0204554
KLF6 Kruppel-like factor 6 0.0199367
PRRC2A proline-rich coiled-coil 2A 0.0199086
CSTB cystatin B (stefin B) 0.0196458
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.019281
CCL20 chemokine (C-C motif) ligand 20 0.019118
UBA6 ubiquitin-like modifier activating enzyme 6 0.0188588
GOLGA4 golgin A4 0.0186874
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0184101
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0183948
SRSF11 serine/arginine-rich splicing factor 11 0.0182829
RPS27 ribosomal protein S27 0.0182481
RACK1 receptor for activated C kinase 1 0.0181466
GADD45A growth arrest and DNA-damage-inducible, alpha 0.0180187
PRRC2C proline-rich coiled-coil 2C 0.0177012
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.017555
TMF1 TATA element modulatory factor 1 0.0172591
SERINC1 serine incorporator 1 0.0171103
NRP2 neuropilin 2 0.0169862
FLNA filamin A, alpha 0.016881
ARGLU1 arginine and glutamate rich 1 0.0167272
PICALM phosphatidylinositol binding clathrin assembly protein 0.0166035
DHX36 DEAH (Asp-Glu-Ala-His) box polypeptide 36 0.016367
YTHDC1 YTH domain containing 1 0.0163508
TOP1 topoisomerase (DNA) I 0.0162704
RPL35 ribosomal protein L35 0.0162571
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 0.0157934
FGFR1 fibroblast growth factor receptor 1 0.0157918
ZFP36L1 ZFP36 ring finger protein-like 1 0.0155574
SEC62 SEC62 homolog (S. cerevisiae) 0.015372
MTF2 metal response element binding transcription factor 2 0.01526
USP3 ubiquitin specific peptidase 3 0.0151506
RAB8B RAB8B, member RAS oncogene family 0.0149436
RAI1 retinoic acid induced 1 0.0148857
BRD2 bromodomain containing 2 0.0147134
KMT2C lysine (K)-specific methyltransferase 2C 0.0145799
ABI1 abl-interactor 1 0.0144306
KDM3A lysine (K)-specific demethylase 3A 0.0143275
ARHGAP21 Rho GTPase activating protein 21 0.0141554
B2M beta-2-microglobulin 0.0140736
ITSN2 intersectin 2 0.0140275
HDAC3 histone deacetylase 3 0.0136851
UGCG UDP-glucose ceramide glucosyltransferase 0.0136763
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0136176
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0135182

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.578404
ACTG1 actin gamma 1 -0.147967
RPL35A ribosomal protein L35a -0.0889308
POTEF POTE ankyrin domain family, member F -0.0780257
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0779996
AHNAK AHNAK nucleoprotein -0.0777377
EXT1 exostosin glycosyltransferase 1 -0.0771428
ASPH aspartate beta-hydroxylase -0.0738295
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0730217
PRKG1 protein kinase, cGMP-dependent, type I -0.0611897
GPC6 glypican 6 -0.0576227
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0561517
PTPRG protein tyrosine phosphatase, receptor type, G -0.051041
SAMD3 sterile alpha motif domain containing 3 -0.0501783
NAV1 neuron navigator 1 -0.0499232
CD44 CD44 molecule (Indian blood group) -0.0466312
PTK2 protein tyrosine kinase 2 -0.0464559
RPS23 ribosomal protein S23 -0.0451913
PHACTR1 phosphatase and actin regulator 1 -0.0445643
AKAP12 A kinase (PRKA) anchor protein 12 -0.0442667
EFNA5 ephrin-A5 -0.0434514
CDH13 cadherin 13 -0.0431777
NDRG1 N-myc downstream regulated 1 -0.0416998
TM4SF1 transmembrane 4 L six family member 1 -0.0411848
NTM neurotrimin -0.0405036
TRIO trio Rho guanine nucleotide exchange factor -0.0401252
KIAA1549L KIAA1549-like -0.0393603
UBC ubiquitin C -0.0391791
RPS6 ribosomal protein S6 -0.0389033
CDK6 cyclin-dependent kinase 6 -0.0375497
PDE4D phosphodiesterase 4D, cAMP-specific -0.0359535
TPT1 tumor protein, translationally-controlled 1 -0.0355476
HMGA2 high mobility group AT-hook 2 -0.0355102
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0353221
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0350732
KIAA1217 KIAA1217 -0.0340432
NALF1 NALCN channel auxiliary factor 1 -0.0330559
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0330022
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0325939
MAPKAP1 mitogen-activated protein kinase associated protein 1 -0.0314298
NLGN1 neuroligin 1 -0.0312807
RIGI RNA sensor RIG-I -0.0304567
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0302095
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0301977
RPS24 ribosomal protein S24 -0.0289566
KDM4C lysine (K)-specific demethylase 4C -0.0288027
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0284867
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0281019
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0280212
MSR1 macrophage scavenger receptor 1 -0.027429
LIMCH1 LIM and calponin homology domains 1 -0.0273031
EMP1 epithelial membrane protein 1 -0.0270017
SLC38A2 solute carrier family 38, member 2 -0.026923
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0266288
RPL34 ribosomal protein L34 -0.0265309
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0265282
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0263726
RPL8 ribosomal protein L8 -0.0262199
SAMD4A sterile alpha motif domain containing 4A -0.0260328
SASH1 SAM and SH3 domain containing 1 -0.0260277
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0258869
CDK12 cyclin-dependent kinase 12 -0.0257268
FNDC3B fibronectin type III domain containing 3B -0.0257201
RPS11 ribosomal protein S11 -0.0256105
MACF1 microtubule-actin crosslinking factor 1 -0.025557
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0254405
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0248769
SDCCAG8 serologically defined colon cancer antigen 8 -0.0247156
INTS6 integrator complex subunit 6 -0.0246377
CFAP251 cilia and flagella associated protein 251 -0.0246049
LSAMP limbic system-associated membrane protein -0.0244516
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0244098
LPP LIM domain containing preferred translocation partner in lipoma -0.0240665
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0240506
ZBTB20 zinc finger and BTB domain containing 20 -0.0236905
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0236362
PBX3 pre-B-cell leukemia homeobox 3 -0.0236307
SP100 SP100 nuclear antigen -0.0236258
ANTXR2 anthrax toxin receptor 2 -0.0235429
RPL38 ribosomal protein L38 -0.0234094
BPTF bromodomain PHD finger transcription factor -0.0233532
S100A10 S100 calcium binding protein A10 -0.0231108
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0230373
VCL vinculin -0.0229682
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0227577
DSCAM Down syndrome cell adhesion molecule -0.0222573
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0222518
OSMR oncostatin M receptor -0.0222455
PARD3 par-3 family cell polarity regulator -0.0222229
MAP1B microtubule-associated protein 1B -0.0219818
TXNRD1 thioredoxin reductase 1 -0.0218994
ZNF804A zinc finger protein 804A -0.0218005
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.021713
MBD5 methyl-CpG binding domain protein 5 -0.0216355
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0215968
PRKCE protein kinase C, epsilon -0.0215008
RAD51B RAD51 paralog B -0.021377
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0212188
C2CD2 C2 calcium-dependent domain containing 2 -0.0210981
EIF1 eukaryotic translation initiation factor 1 -0.0210755