| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Canagliflozin (hemihydrate) perturbation in LS 180 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Canagliflozin (hemihydrate)_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MUC6 | mucin 6, oligomeric mucus/gel-forming | 0.136912 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.110637 |
| AREG | amphiregulin | 0.100937 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0957137 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0722635 |
| MUC5AC | mucin 5AC, oligomeric mucus/gel-forming | 0.0702785 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0699084 |
| RPS12 | ribosomal protein S12 | 0.0610475 |
| KIF5B | kinesin family member 5B | 0.060461 |
| MLEC | malectin | 0.0521427 |
| VEGFA | vascular endothelial growth factor A | 0.0505787 |
| RPS3 | ribosomal protein S3 | 0.0503389 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0502451 |
| TXNIP | thioredoxin interacting protein | 0.0496253 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0487174 |
| FTL | ferritin, light polypeptide | 0.0464033 |
| RPS2 | ribosomal protein S2 | 0.0448806 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0437633 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0431321 |
| RPS7 | ribosomal protein S7 | 0.0431307 |
| LDHA | lactate dehydrogenase A | 0.0430612 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0426446 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0423169 |
| RPL13A | ribosomal protein L13a | 0.0414586 |
| DSPP | dentin sialophosphoprotein | 0.0410885 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0406282 |
| PTMA | prothymosin, alpha | 0.0400213 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0385841 |
| ENO1 | enolase 1, (alpha) | 0.0381912 |
| EREG | epiregulin | 0.0370616 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | 0.0370052 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0369302 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0358175 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0357831 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0355831 |
| ANXA2 | annexin A2 | 0.0350494 |
| RPL26 | ribosomal protein L26 | 0.0345672 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0345639 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0344311 |
| ITGA6 | integrin, alpha 6 | 0.0338117 |
| EZR | ezrin | 0.0333747 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0330617 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.032816 |
| KDELR1 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 | 0.0327974 |
| S100P | S100 calcium binding protein P | 0.0325829 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0324461 |
| TMF1 | TATA element modulatory factor 1 | 0.0319756 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.031586 |
| GDF15 | growth differentiation factor 15 | 0.0315333 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0314581 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0313963 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | 0.0303939 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0299968 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0292767 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0288419 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0288263 |
| UBE2B | ubiquitin-conjugating enzyme E2B | 0.0283812 |
| HMGB2 | high mobility group box 2 | 0.0280088 |
| DNM2 | dynamin 2 | 0.0275242 |
| TMED2 | transmembrane emp24 domain trafficking protein 2 | 0.0273907 |
| CD9 | CD9 molecule | 0.0270737 |
| RPL37A | ribosomal protein L37a | 0.0267238 |
| CHMP5 | charged multivesicular body protein 5 | 0.0264598 |
| GCC2 | GRIP and coiled-coil domain containing 2 | 0.0256286 |
| ATP8B1 | ATPase, aminophospholipid transporter, class I, type 8B, member 1 | 0.0253748 |
| LIPH | lipase, member H | 0.024978 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0247769 |
| RPL21 | ribosomal protein L21 | 0.0245736 |
| RPL18 | ribosomal protein L18 | 0.0243911 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | 0.0243455 |
| DUSP4 | dual specificity phosphatase 4 | 0.0240342 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0239591 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0238167 |
| ABI1 | abl-interactor 1 | 0.023733 |
| B2M | beta-2-microglobulin | 0.0236738 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | 0.0235714 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | 0.0235218 |
| GADD45A | growth arrest and DNA-damage-inducible, alpha | 0.023498 |
| SRSF11 | serine/arginine-rich splicing factor 11 | 0.0233093 |
| RACK1 | receptor for activated C kinase 1 | 0.0231695 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0230292 |
| CYP51A1 | cytochrome P450, family 51, subfamily A, polypeptide 1 | 0.022998 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0229924 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0228906 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | 0.0227088 |
| NARS1 | asparaginyl-tRNA synthetase 1 | 0.0225621 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0225543 |
| KLF6 | Kruppel-like factor 6 | 0.0225114 |
| CLIP2 | CAP-GLY domain containing linker protein 2 | 0.0224866 |
| ZBTB7A | zinc finger and BTB domain containing 7A | 0.0223877 |
| ST14 | suppression of tumorigenicity 14 (colon carcinoma) | 0.0221959 |
| SET | SET nuclear proto-oncogene | 0.0219758 |
| ARGLU1 | arginine and glutamate rich 1 | 0.0219743 |
| ISG15 | ISG15 ubiquitin-like modifier | 0.0219724 |
| IWS1 | IWS1 homolog (S. cerevisiae) | 0.0218276 |
| RNF145 | ring finger protein 145 | 0.0218243 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | 0.021612 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | 0.0214699 |
| RPL10A | ribosomal protein L10a | 0.0214256 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | 0.0213615 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.3757 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.22199 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.135955 |
| NPSR1 | neuropeptide S receptor 1 | -0.107993 |
| AHNAK | AHNAK nucleoprotein | -0.102398 |
| RPL35A | ribosomal protein L35a | -0.101295 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0986294 |
| TMSB10 | thymosin beta 10 | -0.0969546 |
| ACTG1 | actin gamma 1 | -0.0793152 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0778333 |
| FAT1 | FAT atypical cadherin 1 | -0.0720342 |
| GRIN2B | glutamate receptor, ionotropic, N-methyl D-aspartate 2B | -0.0688549 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.0641599 |
| ANTXR2 | anthrax toxin receptor 2 | -0.06373 |
| POTEF | POTE ankyrin domain family, member F | -0.0594226 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0554996 |
| PIGR | polymeric immunoglobulin receptor | -0.0541792 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.053545 |
| GREB1L | growth regulation by estrogen in breast cancer-like | -0.0497971 |
| GPHN | gephyrin | -0.0491595 |
| CALB1 | calbindin 1, 28kDa | -0.0486346 |
| RPL34 | ribosomal protein L34 | -0.0468977 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0467449 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | -0.0455804 |
| H1-0 | H1.0 linker histone | -0.0444898 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0444755 |
| UBC | ubiquitin C | -0.0428823 |
| S100A10 | S100 calcium binding protein A10 | -0.0401607 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0396477 |
| RAB3GAP1 | RAB3 GTPase activating protein subunit 1 (catalytic) | -0.03922 |
| DEK | DEK proto-oncogene | -0.0384366 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.038309 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0382075 |
| AGR2 | anterior gradient 2 | -0.0374965 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0361276 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0359503 |
| LMO7 | LIM domain 7 | -0.0356177 |
| SAMD5 | sterile alpha motif domain containing 5 | -0.0352374 |
| PGK1 | phosphoglycerate kinase 1 | -0.0345133 |
| MSI2 | musashi RNA-binding protein 2 | -0.0344241 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0341779 |
| STT3B | STT3B, subunit of the oligosaccharyltransferase complex (catalytic) | -0.0337793 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0335831 |
| RPS24 | ribosomal protein S24 | -0.0333147 |
| RPS23 | ribosomal protein S23 | -0.0332518 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0328558 |
| ATP8A1 | ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 | -0.0326348 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0324652 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0324196 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0319231 |
| KRT8 | keratin 8, type II | -0.0318685 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0318098 |
| ACTN4 | actinin, alpha 4 | -0.0317875 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0316533 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0316236 |
| RPS11 | ribosomal protein S11 | -0.0314468 |
| CADPS | Ca++-dependent secretion activator | -0.0313036 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.0308568 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0306117 |
| FHIT | fragile histidine triad | -0.0303515 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0301153 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.029779 |
| ATP2A2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | -0.0297169 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | -0.029296 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.028727 |
| ASPH | aspartate beta-hydroxylase | -0.0285992 |
| RAD51B | RAD51 paralog B | -0.0283278 |
| CANX | calnexin | -0.028155 |
| DSG2 | desmoglein 2 | -0.0277598 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0276269 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0274719 |
| UFM1 | ubiquitin-fold modifier 1 | -0.0274296 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | -0.0273627 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0273259 |
| DENND1A | DENN/MADD domain containing 1A | -0.0272879 |
| NRXN3 | neurexin 3 | -0.0271926 |
| GLG1 | golgi glycoprotein 1 | -0.027107 |
| HMGA1 | high mobility group AT-hook 1 | -0.0269893 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | -0.0268738 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0267516 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0265397 |
| TUBB | tubulin, beta class I | -0.0264576 |
| FRMD5 | FERM domain containing 5 | -0.0264473 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0263724 |
| ARHGAP32 | Rho GTPase activating protein 32 | -0.026315 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0262258 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0261869 |
| CD44 | CD44 molecule (Indian blood group) | -0.0261866 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.02618 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0261117 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0260185 |
| CCND1 | cyclin D1 | -0.0258053 |
| SLCO1B3-SLCO1B7 | SLCO1B3-SLCO1B7 readthrough | -0.025804 |
| RPS21 | ribosomal protein S21 | -0.0257978 |
| SVIL | supervillin | -0.0256822 |
| FLNB | filamin B, beta | -0.0255929 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0255424 |
| NDRG1 | N-myc downstream regulated 1 | -0.0254255 |
| PPIB | peptidylprolyl isomerase B (cyclophilin B) | -0.025365 |
| RPS15 | ribosomal protein S15 | -0.0253115 |
