| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Canagliflozin (hemihydrate) perturbation in LoVo cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Canagliflozin (hemihydrate)_LoVo drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| RPS12 | ribosomal protein S12 | 0.130034 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.108578 |
| RPS3 | ribosomal protein S3 | 0.0857262 |
| SLCO1B3 | solute carrier organic anion transporter family, member 1B3 | 0.0771931 |
| ITGA6 | integrin, alpha 6 | 0.0690396 |
| ANXA2 | annexin A2 | 0.065702 |
| MYO1E | myosin IE | 0.0611745 |
| SQSTM1 | sequestosome 1 | 0.0604316 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0575943 |
| CLDN4 | claudin 4 | 0.0574708 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0564909 |
| RPS2 | ribosomal protein S2 | 0.0560882 |
| MKI67 | marker of proliferation Ki-67 | 0.0534828 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | 0.0534471 |
| VCL | vinculin | 0.053101 |
| GCNT3 | glucosaminyl (N-acetyl) transferase 3, mucin type | 0.0525106 |
| RPS7 | ribosomal protein S7 | 0.0517129 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0513768 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0494785 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0487311 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0485711 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0466621 |
| RPS17 | ribosomal protein S17 | 0.0462848 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.045812 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0456569 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0444429 |
| PLAC8 | placenta-specific 8 | 0.0408204 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | 0.0404211 |
| RHPN2 | rhophilin, Rho GTPase binding protein 2 | 0.0398251 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0397827 |
| AREG | amphiregulin | 0.0397001 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | 0.0393099 |
| ENO1 | enolase 1, (alpha) | 0.0384061 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0380615 |
| UGT1A6 | UDP glucuronosyltransferase 1 family, polypeptide A6 | 0.0377923 |
| AHCYL2 | adenosylhomocysteinase-like 2 | 0.0373871 |
| RPL21 | ribosomal protein L21 | 0.0372771 |
| FAT1 | FAT atypical cadherin 1 | 0.0371558 |
| FLNB | filamin B, beta | 0.0365848 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0365374 |
| TMF1 | TATA element modulatory factor 1 | 0.0361246 |
| GDF15 | growth differentiation factor 15 | 0.0358914 |
| ABHD17C | abhydrolase domain containing 17C | 0.0354257 |
| TNRC18 | trinucleotide repeat containing 18 | 0.0353546 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | 0.0350351 |
| MT2A | metallothionein 2A | 0.0347844 |
| MYOF | myoferlin | 0.0346162 |
| MUC13 | mucin 13, cell surface associated | 0.0338763 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0331461 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0328903 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0322112 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0320264 |
| EPHA2 | EPH receptor A2 | 0.031671 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0315716 |
| LIMA1 | LIM domain and actin binding 1 | 0.0313337 |
| LAMA4 | laminin, alpha 4 | 0.03076 |
| WWC1 | WW and C2 domain containing 1 | 0.0307459 |
| RPL26 | ribosomal protein L26 | 0.0303826 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0302705 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | 0.0296382 |
| EZR | ezrin | 0.029574 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.0291323 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0289319 |
| SLTM | SAFB-like, transcription modulator | 0.0287079 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0284097 |
| CHMP5 | charged multivesicular body protein 5 | 0.0283566 |
| VMP1 | vacuole membrane protein 1 | 0.0283254 |
| HMGB2 | high mobility group box 2 | 0.0280243 |
| PTPRR | protein tyrosine phosphatase, receptor type, R | 0.0280136 |
| RPL3 | ribosomal protein L3 | 0.0279861 |
| BCL2L1 | BCL2-like 1 | 0.0274955 |
| RPL13A | ribosomal protein L13a | 0.0274675 |
| EGR1 | early growth response 1 | 0.0274182 |
| CENPF | centromere protein F, 350/400kDa | 0.0273077 |
| SRSF11 | serine/arginine-rich splicing factor 11 | 0.0271216 |
| FHL2 | four and a half LIM domains 2 | 0.0271198 |
| RPL18 | ribosomal protein L18 | 0.0270793 |
| MYO6 | myosin VI | 0.0269757 |
| S100P | S100 calcium binding protein P | 0.0267975 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | 0.0264295 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0264053 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0257408 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0253373 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0252915 |
| MX2 | MX dynamin-like GTPase 2 | 0.024448 |
| TMEM45B | transmembrane protein 45B | 0.0243789 |
| RACK1 | receptor for activated C kinase 1 | 0.0243369 |
| UBE3A | ubiquitin protein ligase E3A | 0.024222 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0241743 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0241134 |
| RPS27L | ribosomal protein S27-like | 0.0240729 |
| PSAT1 | phosphoserine aminotransferase 1 | 0.0240189 |
| KIAA1549 | KIAA1549 | 0.0239187 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0235941 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0235148 |
| CSTPP1 | centriolar satellite-associated tubulin polyglutamylase complex regulator 1 | 0.0234722 |
| SERBP1 | SERPINE1 mRNA binding protein 1 | 0.0234222 |
| MX1 | MX dynamin-like GTPase 1 | 0.0233263 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0233076 |
| SLC25A3 | solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 | 0.0232187 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.243415 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.224184 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.191939 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.145397 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.117461 |
| CANX | calnexin | -0.109451 |
| RPL35A | ribosomal protein L35a | -0.109333 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0777543 |
| RPL34 | ribosomal protein L34 | -0.0771981 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0678238 |
| ACTG1 | actin gamma 1 | -0.0655632 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0648453 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0641227 |
| AHNAK | AHNAK nucleoprotein | -0.0610737 |
| RPL4 | ribosomal protein L4 | -0.0601171 |
| RPS23 | ribosomal protein S23 | -0.0589264 |
| FRMD5 | FERM domain containing 5 | -0.0564346 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0554542 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0549132 |
| UBC | ubiquitin C | -0.0542725 |
| LMO7 | LIM domain 7 | -0.0517682 |
| AGR2 | anterior gradient 2 | -0.0506805 |
| RPS24 | ribosomal protein S24 | -0.0481785 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0477753 |
| RPS19 | ribosomal protein S19 | -0.0464249 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0437704 |
| RPS11 | ribosomal protein S11 | -0.0426997 |
| COG5 | component of oligomeric golgi complex 5 | -0.0420139 |
| KLF5 | Kruppel-like factor 5 (intestinal) | -0.0414468 |
| S100A10 | S100 calcium binding protein A10 | -0.0413304 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0412879 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0403218 |
| RPL8 | ribosomal protein L8 | -0.040093 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0400422 |
| CD2AP | CD2-associated protein | -0.0400175 |
| JMJD1C | jumonji domain containing 1C | -0.0379702 |
| PALLD | palladin, cytoskeletal associated protein | -0.0373526 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0361385 |
| FBXO11 | F-box protein 11 | -0.0360323 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0360068 |
| HDLBP | high density lipoprotein binding protein | -0.0357086 |
| GOLGB1 | golgin B1 | -0.0357016 |
| SLCO1B3-SLCO1B7 | SLCO1B3-SLCO1B7 readthrough | -0.0353243 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0347995 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | -0.034789 |
| RPS6KA5 | ribosomal protein S6 kinase, 90kDa, polypeptide 5 | -0.034653 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0344034 |
| RPS6 | ribosomal protein S6 | -0.033245 |
| INTS6 | integrator complex subunit 6 | -0.0325385 |
| RPL14 | ribosomal protein L14 | -0.0324699 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0324094 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0322822 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0322781 |
| ST13 | suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) | -0.031828 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0318136 |
| RRBP1 | ribosome binding protein 1 | -0.0318052 |
| DEK | DEK proto-oncogene | -0.0317999 |
| HLA-B | major histocompatibility complex, class I, B | -0.0316568 |
| CCNI | cyclin I | -0.0311006 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0308742 |
| RPS15 | ribosomal protein S15 | -0.0302363 |
| ARF1 | ADP-ribosylation factor 1 | -0.0293396 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0292038 |
| PTMA | prothymosin, alpha | -0.0290092 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0289391 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0287046 |
| RPL6 | ribosomal protein L6 | -0.0284827 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | -0.0282058 |
| IFRD1 | interferon-related developmental regulator 1 | -0.0281839 |
| FUS | FUS RNA binding protein | -0.028132 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.027788 |
| DENND1A | DENN/MADD domain containing 1A | -0.0275763 |
| RPS21 | ribosomal protein S21 | -0.0274526 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | -0.0274323 |
| FER | fer (fps/fes related) tyrosine kinase | -0.0272622 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | -0.0271439 |
| RPL38 | ribosomal protein L38 | -0.0269387 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0268632 |
| RPL32 | ribosomal protein L32 | -0.0267103 |
| ATP2A2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | -0.0266602 |
| PDE8A | phosphodiesterase 8A | -0.0263503 |
| ABLIM1 | actin binding LIM protein 1 | -0.0263317 |
| PPIB | peptidylprolyl isomerase B (cyclophilin B) | -0.0263165 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | -0.0262288 |
| MCU | mitochondrial calcium uniporter | -0.0261499 |
| H1-0 | H1.0 linker histone | -0.0261252 |
| TCF12 | transcription factor 12 | -0.0261228 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0258289 |
| NFIA | nuclear factor I/A | -0.0256788 |
| DSG2 | desmoglein 2 | -0.0255892 |
| CUX1 | cut-like homeobox 1 | -0.0254241 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | -0.0253729 |
| RBM39 | RNA binding motif protein 39 | -0.0250791 |
| MAP4 | microtubule-associated protein 4 | -0.0247342 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.02472 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.0246872 |
| PPP1CC | protein phosphatase 1, catalytic subunit, gamma isozyme | -0.0246159 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0245442 |
| OSBPL3 | oxysterol binding protein-like 3 | -0.0244072 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -0.0242371 |
